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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao sheng-Lan xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期 74-93页

作者： Ye YANG Steven A.BINNIE sheng xu Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

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Prospects for the application of transcranial magnetic stimulation in diabetic neuropathy

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Neural Regeneration Research 2021年第5期16卷 955-962页

作者： Xi xu Dong-sheng xu Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina

Encouraging results have been reported for the use of transcranial magnetic stimulationbased nerve stimulation in studies of the mechanisms of neurological regulation,nerve injury repair,and nerve ***,to date,there are only a few reviews on the use of transcranial magnetic stimulation for diabetic *** with diabetic neuropathy vary in disease progression and show neuropathy in the early stage of the disease with mild symptoms,making it difficult to screen and *** the later stage of the disease,irreversible neurological damage occurs,resulting in treatment *** this review,we summarize the current state of diabetic neuropathy research and the prospects for the application of transcranial magnetic stimulation in diabetic *** review significant studies on the beneficial effects of transcranial magnetic stimulation in diabetic neuropathy treatment,based on the outcomes of its use to treat neurodegeneration,pain,blood flow change,autonomic nervous disorders,vascular endothelial injury,and ***,the studies suggest that transcranial magnetic stimulation can produce excitatory/inhibitory stimulation of the cerebral cortex or local areas,promote the remodeling of the nervous system,and that it has good application prospects for the localization of the injury,neuroprotection,and the promotion of nerve ***,transcranial magnetic stimulation is useful for the screening and early treatment of diabetic *** magnetic stimulation can also alleviate pain symptoms by changing the cortical threshold and inhibiting the conduction of sensory information in the thalamo-spinal pathway,and therefore it has therapeutic potential for the treatment of pain and pain-related depressive symptoms in patients with diabetic ***,based on the effect of transcranial magnetic stimulation on local blood flow and its ability to change heart rate and urine protein conten

关键词： autonomic neuropathy central nervous system depression inflammation oxidative stress pain peripheral nerve plasticity recovery regeneration vascular

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Vanishing Theorem for Irreducible Symmetric Spaces of Noncompact Type

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Acta Mathematica Sinica,English Series 2010年第2期26卷 361-368页

作者： xu sheng LIU School of Mathematical Sciences Fudan University Shanghai 200433 P. R. China

We prove the following vanishing theorem. Let M be an irreducible symmetric space of noncompact type whose dimension exceeds 2 and M ≠SO0（2, 2）/SO（2） × SO（2）. Let π ： E →＊ M be any vector bundle. Then any E-valued L2 harmonic 1-form over M vanishes. In particular we get the vanishing theorem for harmonic maps from irreducible symmetric spaces of noncompact type.

关键词： vanishing theorem symmetric space harmonic form

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Bug Triaging Based on Tossing Sequence Modeling

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Journal of Computer Science & Technology 2019年第5期34卷 942-956页

作者： sheng-Qu Xi Yuan Yao xu-sheng Xiao Feng xu Jian Lv State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China Department of Electrical Engineering and Computer Science Case Western Reserve UniversityCleveland Ohio 44106-7071U.S.A.

Bug triaging, which routes the bug reports to potential fixers, is an integral step in software development and maintenance. To make bug triaging more efficient, many researchers propose to adopt machine learning and information retrieval techniques to identify some suitable fixers for a given bug report. However, none of the existing proposals simultaneously take into account the following three aspects that matter for the efficiency of bug triaging: 1) the textual content in the bug reports, 2) the metadata in the bug reports, and 3) the tossing sequence of the bug reports. To simultaneously make use of the above three aspects, we propose iTriage which first adopts a sequence-to-sequence model to jointly learn the features of textual content and tossing sequence, and then uses a classification model to integrate the features from textual content, metadata, and tossing sequence. Evaluation results on three different open-source projects show that the proposed approach has significantly improved the accuracy of bug triaging compared with the state-of-the-art approaches.

关键词： bug triaging tossing sequence software repository mining

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An Iterative Two-Fluid Pressure Solver Based on the Immersed Interface Method

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Communications in Computational Physics 2012年第7期12卷 528-543页

作者： sheng xu Department of Mathematics Southern Methodist UniversityDallasTX 75275-0156USA

An iterative solver based on the immersed interface method is proposed to solve the pressure in a two-fluid flow on a Cartesian grid with second-order accuracy in the infinity *** iteration is constructed by introducing an unsteady term in the pressure Poisson *** each iteration step,a Helmholtz equation is solved on the Cartesian grid using *** combination of the iteration and the immersed interface method enables the solver to handle various jump conditions across twofluid *** solver can also be used to solve Poisson equations on irregular domains.

关键词： Poisson solver the immersed interface method two-fluid flow jump conditions

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Influences of harmonic cavities on single-bunch instabilities in electron storage rings

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Nuclear Science and Techniques 2021年第9期32卷 1-8页

作者： Hai-sheng xu Jing-Ye xu Na Wang Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of the Chinese Academy of Sciences Beijing 100049China

Harmonic cavities(HCs)are widely used in electron storage rings,mainly to increase the Touschek lifetime by lengthening *** have become critical components of almost all fourth-generation synchrotron light *** addition to the benefits of increasing the Touschek lifetime,they also affect the collective beam instabilities in electron storage ***,the influ-ence of HC settings on collective beam instabilities is still not well *** are typically designed to operate under so-called ideal lengthening conditions,which do not necessarily optimize the suppression of collective beam *** therefore extended earlier studies of col-lective beam instabilities to consider more general HC *** present preliminary studies and analyses of the influences of different HC settings on microwave and transverse mode-coupling instabilities.

关键词： Harmonic cavity Microwave instability Transverse Mode-coupling instability

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Deep carbon recycling viewed from global plate tectonics

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National Science Review 2024年第6期11卷 37-55页

作者： Maoliang Zhang sheng xu Yuji Sano School of Earth System Science Tianjin University Marine Core Research Institute Kochi University Atmosphere and Ocean Research Institute The University of Tokyo

Plate tectonics plays an essential role in the redistribution of life-essential volatile elements between Earth's interior and surface, whereby our planet has been well tuned to maintain enduring habitability over much of its history. Here we present an overview of deep carbon recycling in the regime of modern plate tectonics,with a special focus on convergent plate margins for assessing global carbon mass balance. The up-to-date flux compilation implies an approximate balance between deep carbon outflux and subduction carbon influx within uncertainty but remarkably limited return of carbon to convecting mantle. If correct, carbon would gradually accumulate in the lithosphere over time by（i） massive subsurface carbon storage occurring primarily in continental lithosphere from convergent margins to continental interior and（ii） persistent surface carbon sinks to seafloors sustained by high-flux deep CO2emissions to the atmosphere. Further assessment of global carbon mass balance requires updates on fluxes of subduction-driven carbon recycling paths and reduction in uncertainty of deep carbon outflux. From a global plate tectonics point of view, we particularly emphasize that continental reworking is an important mechanism for remobilizing geologically sequestered carbon in continental crust and sub-continental lithospheric mantle. In light of recent advances,future research is suggested to focus on a better understanding of the reservoirs, fluxes, mechanisms, and climatic effects of deep carbon recycling following an integrated methodology of observation, experiment,and numerical modeling, with the aim of decoding the self-regulating Earth system and its habitability from the deep carbon recycling perspective.

关键词： deep carbon recycling convergent plate margins subduction continental reworking global carbon mass balance

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Incorporating contextual evidence to improve implicit discourse relation recognition in Chinese

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Frontiers of Computer Science 2024年第3期18卷 91-104页

作者： sheng xu Peifeng LI Qiaoming ZHU School of Computer Science and Technology Soochow UniversitySuzhou 215000China

The discourse analysis task,which focuses on understanding the semantics of long text spans,has received increasing attention in recent *** a critical component of discourse analysis,discourse relation recognition aims to identify the rhetorical relations between adjacent discourse units(e.g.,clauses,sentences,and sentence groups),called arguments,in a *** works focused on capturing the semantic interactions between arguments to recognize their discourse relations,ignoring important textual information in the surrounding ***,in many cases,more than capturing semantic interactions from the texts of the two arguments are needed to identify their rhetorical relations,requiring mining more contextual *** this paper,we propose a method to convert the RST-style discourse trees in the training set into dependency-based trees and train a contextual evidence selector on these transformed *** this way,the selector can learn the ability to automatically pick critical textual information from the context(i.e.,as evidence)for arguments to assist in discriminating their *** we encode the arguments concatenated with corresponding evidence to obtain the enhanced argument ***,we combine original and enhanced argument representations to recognize their *** addition,we introduce auxiliary tasks to guide the training of the evidence selector to strengthen its selection *** experimental results on the Chinese CDTB dataset show that our method outperforms several state-of-the-art baselines in both micro and macro F1 scores.

关键词： discourse parsing discourse relation recognition contextual evidence selection

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Phase field simulation of single bubble behavior under an electric field

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Chinese Physics B 2018年第9期27卷 389-395页

作者： Chang-sheng Zhu Dan Han sheng xu School of Computer and Communication Lanzhou University of Technology State Key Laboratory of Gansu Advanced Processing and Recycling of Non-Ferrous Metal Lanzhou University of Technology

Based on the Cahn-Hilliard phase field model, a three-dimensional multiple-field coupling model for simulating the motion characteristics of a rising bubble in a liquid is established in a gas-liquid two-phase flow. The gas-liquid interface motion is simulated by using a phase-field method, and the effect of the electric field intensity on bubble dynamics is studied without electric field, or with vertical electric field or horizontal electric field. Through the coupling effect of electric field and flow field, the deformation of a single rising bubble and the formation of wake vortices under the action of gravity and electric field force are studied in detail. The correctness of the results is verified by mass conservation, and the influences of different electric field directions and different voltages on the movement of bubbles in liquid are considered. The results show that the ratio of the length to axis is proportional to the strength of the electric field when the air bubble is stretched into an ellipsoid along the electric field line under the action of electrostatic gravity and surface tension. In addition, the bubble rising speed is affected by the electric field, the vertical electric field accelerates the bubble rise, and the horizontal direction slows it down.

关键词： electro-hydro dynamics numerical simulation phase field method bubble

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