检索结果-南通市图书馆

Precipitation Behaviors in the Diffusion Affected Zone of TLP Bonded Single Crystal Superalloy Joint

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2015年第2期31卷 129-134页

作者： Naicheng sheng Jide Liu Tao Jin xiaofeng Sun Zhuangqi Hu Superalloys Division Institute of Metal ResearchChinese Academy of Sciences

The single crystal superalloys were joined by transient liquid phase(TLP) bonding. The precipitating behavior in the diffusion affected zone(DAZ) was studied and the hardness across the DAZ was analyzed. Results have shown that there existed M3B2,M5B3 and M23B6 borides in the DAZ. With increasing bonding time,fine M3B2 precipitates formed first near the isothermal solidification zone(ISZ)/matrix interface. Then,the dendritic M5B3 precipitates formed with an obvious orientation relationship with the substrate. The acicular precipitates were constituted by M23B6 and M5B3 phases with continuous or discontinuous morphologies. The hardness of the DAZ reached a summit in the fine M3B2 region and decreased with the increase of the distance away from the ISZ/matrix interface.

关键词： Single crystal superalloy Transient liquid phase b

在线全文

学校读者我要写书评

暂无评论

儿科临床药师参与抗菌药物应用管理的实践

医药导报 2020年第5期39卷 705-707页

作者：蔡和平罗志红詹迪迪徐小倩陈慧颖盛小凤尹传高安徽省儿童医院药剂科合肥230000 安徽省儿童医院医务处合肥230000

目的:研究儿童医院专科临床药师在抗菌药物临床应用管理中的作用,探讨合适的抗菌药物使用强度计算方法,为临床合理用药提供参考。方法:回顾性分析安徽省儿童医院2017年1—7月(临床药师干预前)、2018年1—7月(临床药师干预后)住院患儿抗... 详细信息

目的:研究儿童医院专科临床药师在抗菌药物临床应用管理中的作用,探讨合适的抗菌药物使用强度计算方法,为临床合理用药提供参考。方法:回顾性分析安徽省儿童医院2017年1—7月(临床药师干预前)、2018年1—7月(临床药师干预后)住院患儿抗菌药物使用情况和合理用药率。结果:抗菌药物使用率由干预前(64.80±4.80)%降至干预后(54.59±4.70)%(P<0.05);按药品消耗量计算,抗菌药物使用强度由干预前(44.04±1.70)降至干预后(32.75±3.30);按实际使用量计算,抗菌药物使用强度由干预前(27.26±2.60)降至干预后(20.93±2.70);住院患儿药物总金额占药品总金额百分比由干预前(23.27±0.80)%降到干预后(21.65±1.50)%;出院患儿人均抗菌药物费用由干预前(856.03±25.70)元降至干预后(767.20±50.20)元(P<0.05);抗菌药物病历点评不合理率持续下降。结论:儿童医院临床药师对抗菌药物应用管理的干预有效,并提出了适合儿童医院抗菌药物使用强度的计算方法。

关键词：抗菌药物使用率抗菌药物使用强度儿科临床药师

Structural modeling of Nav1.5 pore domain in closed state

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2021年第4期7卷 341-354页

作者： xiaofeng Ji Yanzhao Huang Jun sheng Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences School of Physics Huazhong University of Science and Technology

The voltage-dependent cardiac sodium channel plays a key role in cardiac excitability and conduction and it is the drug target of medically important. However, its atomic-resolution structure is still ***, we report a modeled structure of Na;v;1.5 pore domain in closed state. The structure was constructed by Rosetta-membrane homology modeling method based on the template of eukaryotic Nav channel Na;v;PaS and selected by energy and direct coupling analysis（DCA）. Moreover, this structure was optimized through molecular dynamical simulation in the lipid membrane bilayer. Finally, to validate the constructed model, the binding energy and binding sites of closed-state local anesthetics（LAs）in the modeled structure were computed by the MM-GBSA method and the results are in agreement with experiments. The modeled structure of Na;v;1.5 pore domain in closed state may be useful to explore molecular mechanism of a state-dependent drug binding and helpful for new drug development.

关键词： Nav1.5 ion channel Closed state Homology modeling Direct coupling analysis Local anesthetics Drug binding

Numerical Study on Rock Breaking Mechanism of Supercritical CO_(2)Jet Based on Smoothed Particle Hydrodynamics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2020年第3期122卷 1141-1157页

作者： xiaofeng Yang Yanhong Li Aiguo Nie sheng Zhi Liyuan Liu School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing100083China. Department of Energy and Mineral Engineering EMS Energy Institute and G3 CenterPennsylvania State UniversityUniversity ParkState CollegePA 16802USA. School of Civil and Resource Engineering University of Science&Technology BeijingBeijingChina.

Supercritical carbon dioxide(Sc-CO_(2))jet rock breaking is a nonlinear impact dynamics problem involving many *** the complexity of the physical properties of the Sc-CO_(2)jet and the mesh distortion problem in dealing with large deformation problems using the finite element method,the smoothed particle hydrodynamics(SPH)method is used to simulate and analyze the rock breaking process by Sc-CO_(2)jet based on the derivation of the jet velocity-density evolution mathematical *** results indicate that there exists an optimal rock breaking temperature by Sc-CO_(2).The volume and length of the rock fracture increase with the rising of the jet temperature but falls when the jet temperature exceeds 340 *** more complicated perforation shapes and larger fracture volumes,the Sc-CO_(2)jet can yield a rock breaking more effectively than water jet,The stress analysis shows that the Sc-CO_(2)rock fracturing process could be reasonably divided into three stages,namely the fracture accumulation stage,the rapid failure stage,and the breaking stabilization *** high diffusivity of Sc-CO_(2)is identified as the primary cause of the stress fluctuation and W-shaped fracture *** simulated and calculated results are generally in conformity with the published experimental *** study provides theoretical guidance for further study on Sc-CO_(2)fracturing mechanism and rock breaking efficiency.

关键词： Supercritical carbon dioxide jet rock breaking SPH stress distribution erosion morphology.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

同工酶分析技术及其在植物研究中的应用

生态学杂志 2003年第6期22卷 63-69页

作者：邹春静盛晓峰韩文卿徐文铎上海交通大学生命科学技术学院上海200030 中国科学院沈阳应用生态研究所沈阳110016

同工酶几乎存在于所有生物的所有组织中 ,是生物化学和分子生态学的重要研究内容。本文阐明了同工酶分析技术的特点 ,及其在植物系统学、植物生理生态学研究中的应用 ,并着重阐述了同工酶分析技术在云杉研究中的应用。

关键词：同工酶染色法植物系统学植物生理生态学云杉

在线全文

学校读者我要写书评

暂无评论

机械功率在呼吸机相关性肺损伤中的研究进展

国际生物医学工程杂志 2023年第4期46卷 360-364页

作者：李咏臻张奕盛晓峰陈正龙宋元林上海理工大学健康科学与工程学院上海200093 上海健康医学院医疗器械学院上海201318 复旦大学附属中山医院呼吸科与危重医学科上海200032

重症加强护理病房(ICU)急性呼吸窘迫综合征具有较高的发病率和死亡率,该类患者治疗过程中通常需要机械通气来维持其呼吸功能。然而,机械通气参数设置不当可能会导致呼吸机相关性肺损伤(VILI)。为了有效防止VILI的发生,急性呼吸窘迫综合... 详细信息

重症加强护理病房(ICU)急性呼吸窘迫综合征具有较高的发病率和死亡率,该类患者治疗过程中通常需要机械通气来维持其呼吸功能。然而,机械通气参数设置不当可能会导致呼吸机相关性肺损伤(VILI)。为了有效防止VILI的发生,急性呼吸窘迫综合征研究联盟推荐使用小潮气量和限制气道平台压的保护性通气策略,但是从呼吸机能量传递的角度来看,VILI实际上是潮气量、气道压力和呼吸频率等呼吸参数综合作用的结果。机械功率能很好地体现了上述参数的共同作用,正日益成为临床研究的热点。主要介绍了机械能与机械功率的定义,并对不同呼吸模式下机械功率的计算方法进行系统地综述,同时总结回顾了机械功率与VILI有关的基础研究和临床研究,进一步探究机械功率的安全阈值可望为未来临床制定个性化机械通气策略,有效预防VILI的发生提供新的思路。

关键词：机械功率呼吸机相关性肺损伤机械能急性呼吸窘迫综合征个性化机械通气

条斑紫菜中磷和钙的亚细胞分布及其与富集砷的关系

在线全文

学校读者我要写书评

暂无评论

生态毒理学报 2016年第4期11卷 258-264页

作者：尚德荣宁劲松赵艳芳翟毓秀李风铃盛晓风丁海燕徐正段德麟周永东中国水产科学研究院黄海水产研究所国家水产品质量监督检验中心农业部水产品质量安全检测与评价重点实验室青岛266071 中国科学院海洋研究所青岛266071 江苏盐城海瑞食品有限公司大丰224100

研究条斑紫菜中磷和钙的亚细胞分布,并探讨其与条斑紫菜富集砷的关系。结果表明:条斑紫菜吸收磷、钙主要分布在细胞壁组分中,平均占总磷含量的53.9%,占总钙含量的61.25%,其次为细胞液。与对照组相比(砷暴露浓度0.5 mg·L^(-1)),在添加... 详细信息

研究条斑紫菜中磷和钙的亚细胞分布,并探讨其与条斑紫菜富集砷的关系。结果表明:条斑紫菜吸收磷、钙主要分布在细胞壁组分中,平均占总磷含量的53.9%,占总钙含量的61.25%,其次为细胞液。与对照组相比(砷暴露浓度0.5 mg·L^(-1)),在添加磷浓度为0.1 mg·L^(-1)和1.0 mg·L^(-1)处理组中,条斑紫菜中磷、砷之间呈现协同效应;当添加磷浓度为5.0 mg·L^(-1)和10.0 mg·L^(-1)时,条斑紫菜中磷、砷之间则呈现拮抗作用,砷的富集量分别比照组下降61.37%和72.73%。经添加钙液暴露过的条斑紫菜,当钙暴露浓度为1 000 mg·L^(-1)时其对砷的富集量比对照组减少15.51%。可知,5.0 mg·L^(-1)磷处理条斑紫菜,条斑紫菜对砷的富集受到明显的抑制。

关键词：砷磷钙条斑紫菜亚细胞定位富集

NANOIMPRINT LITHOGRAPHY TECHNOLOGY WITH AUTOMATIC ALIGNMENT

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2007年第3期20卷 1-5页

作者： FAN Xiqiu ZHANG Honghai HU xiaofeng JIA Ke LIU sheng School of Electromechanical Engineering Zhejiang Ocean University Zhoushan 316000 China School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074. China School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Nanoimprint lithography （NIL） is recognized as one of the most promising candidates for the next generation lithography （NGL） to obtain sub-100 nm patterns because of its simplicity, high-throughput and low-cost. While substantial effort has been expending on NIL for producing smaller and smaller feature sizes, considerably less effort has been devoted to the equally important issue—alignment between template and substrate. A homemade prototype nanoimprint lithography tool with a high precision automatic alignment system based on Moiré signals is presented. Coarse and fine pitch gratings are adopted to produce Moiré signals to control macro and micro actuators and enable the substrate to move towards the desired position automatically. Linear motors with 300 mm travel range and 1 μm step resolution are used as macro actuators, and piezoelectric translators with 50 μm travel range and 1 nm step resolution are used as micro actuators. In addition, the prototype provides one translation （z displacement） and two tilting motion（α and β ） to automatically bring uniform intact contact between the template and substrate surfaces by using a flexure stage. As a result, 10 μm coarse alignment accuracy and 20 nm fine alignment accuracy can be achieved. Finally, some results of nanostructures and micro devices such as nanoscale trenches and holes, gratings and microlens array fabricated using the prototype tool are presented, and hot embossing lithography, one typical NIL technology, are depicted by taking nanoscale gratings fabrication as an example.

关键词： Nanoimprint lithography Alignment Moire signals

Influence of the Substrate Orientation on the Isothermal Solidification during TLP Bonding Single Crystal Superalloys

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2014年第3期30卷 213-216页

作者： Naicheng sheng Bo Li Jide Liu Tao Jin xiaofeng Sun Zhuangqi Hu Superalloys Division Institute of Metal Research Chinese Academy of Sciences

Angle deviations between the two substrates during transient liquid phase （TLP） bonding single crystal superalloys cannot be avoided. In the present work, specimens have been prepared to investigate the influences of the various substrate orientations. It is found that the width of the non-isothermal solidification zone （NSZ） is linear with the square root of the isothermal solidification time. This suggests that the isothermal solidification process is B-diffusion controlled in different substrate orientation deviations. And also the width of the NSZ increases with increasing angle deviation, indicating that the isothermal solidification time needed in the TLP bonding increases with increasing orientation deviation between the two substrates.

关键词： Transient liquid phase (TLP) bonding Single crystal superalloys Orientation deviation Bonding time