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Role of Prognostic Marker PRR11 in Immune Infiltration for Facilitating Lung Adenocarcinoma Progression

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生物医学与环境科学:英文版 2023年第9期36卷 862-868页

作者： WANG Wen Hao MA Chang Geng CUI Yun Shang BAI Bing Yu sheng zhi mei LIU Jin LI Ao ZHANG Bao Gang Cheeloo College of Medicine Shandong UniversityJinan 250012ShandongChina Affiliated Hospital of Weifang Medical University Weifang 261041ShandongChina Chinese Center for Disease Control and Prevention Beijing 102206China Weifang Medical University Weifang 261053ShandongChina

The PRR11 gene(Proline Rich 11)has been implicated in lung cancer;however,relationship between PRR11 and immune infiltration is not clearly *** this study,we used The Cancer Genome Atlas(TCGA)data to analyze the lung adenocarcinoma patients;PRR11 gene expression,clinicopathological findings,enrichment,and immune infiltration were also ***11immune response expression assays in lung adenocarcinoma(LUAD)were performed using TIMER,and statistical analysis and visualization were conducted using R *** data were verified using Gene Expression Profiling Interactive Analysis(GEPIA),and the Human Protein Atlas(HPA).We found that PRR11 was an important prognostic factor in patients with ***11 expression was correlated with tumor stage and *** Set Enrichment Analysis(GSEA)showed that PRR11was enriched in the cell cycle regulatory *** infiltration analysis revealed that the number of T helper 2(Th2)cells increased when PRR11 was *** results confirm the role of PRR11 as a prognostic marker of lung adenocarcinoma by controlling the cell cycle and influencing the immune system to facilitate lung cancer progression.

关键词： Bioinformatics Lung adenocarcinoma PRR11 Cell cycle Th2 cell

Graphdiyne(C_(n)H_(2n-2))as an"electron transfer bridge"boosting photocatalytic hydrogen evolution over Zn_(0.5)Co_(0.5)S/MoS_(2)S-scheme heterojunction

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Rare Metals 2024年第5期43卷 1999-2014页

作者： mei Li Jing-zhi Wang zhi-Liang Jin School of Chemistry and Chemical Engineering North Minzu UniversityYinchuan 750021China School of Chemistry and Chemical Engineering Ningxia Key Laboratory of Solar Chemical Conversion TechnologyKey Laboratory for Chemical Engineering and TechnologyState Ethnic Affairs CommissionNorth Minzu UniversityYinchuan 750021China

In the process of photocatalytic water cracking,the migration rate and utilization rate of photogenerated charges determine the hydrogen evolution performance of the *** this paper,a carbon isotope superconducting material graphdiyne(GDY)is prepared by mechanical ball milling and introduced into the S-scheme heterojunction Zn_(0.5)Co_(0.5)S/MoS_(2)inorganic *** terms of hydrogen evolution kinetics,GDY acts as an electron bridge,not only accelerating the migration of photogenerated carriers but also improving the utilization of photogenerated ***,the large twodimensional layer provides more loading and anchoring points for Zn_(0.5)Co_(0.5)S/MoS_(2),which increases the number of active *** ternary composite catalyst 20%GDY/Zn_(0.5)Co_(0.5)S/MoS_(2)(20-GCSM)generates 69.94μmol of hydrogen(5 h)in triethanolamine *** is 2.97 and1.80 times higher than Zn_(0.5)Co_(0.5)S and Zn_(0.5)Co_(0.5)S/MoS_(2),*** the cyclic experiment,it still has stable hydrogen evolution performance after standing for24 h(under dark conditions).In addition,the potential mechanism of photocatalytic hydrogen evolution is demonstrated through in-situ X-ray photoelectron *** work provides a reference for further research in the field of introducing carbon materials into photocatalytic systems and improving the utilization of photogenerated charges.

关键词： Graphdiyne S-scheme heterojunction Electron transfer bridge Hydrogen production

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试论清代弹词的文体分化过程及其特点

上海大学学报（社会科学版） 2012年第4期29卷 62-71页

作者：盛志梅天津师范大学文学院天津300387

文学文体作为作品语言的存在体,不仅仅是一个单纯的体裁归类问题,它更多的涵义是包括以"体"来表述作家的个性风格、流派或作品的时代风格特征等。弹词的"文体分化"是指代言体弹词在书场和书斋两个不同的生存领域里,从叙事体弹词中逐渐... 详细信息

文学文体作为作品语言的存在体,不仅仅是一个单纯的体裁归类问题,它更多的涵义是包括以"体"来表述作家的个性风格、流派或作品的时代风格特征等。弹词的"文体分化"是指代言体弹词在书场和书斋两个不同的生存领域里,从叙事体弹词中逐渐分化出来,成长为书场弹词主要的讲唱、创作方式的过程。在这个过程中,不仅仅考察弹词体裁的变化,还包涵了对弹词作者的创作风格、作品叙事体制、演出市场、时代风尚等诸因素的综合考量。总之,清代弹词的文体分化趋势,是文体随着整体文化的成熟而不断向精致化的方向发展的必然结果。

关键词：清代弹词文体分化代言体弹词文化成熟

《红楼梦》著作权问题的“假设”当适可而止——与赵建忠《“家族累积说”:红楼梦作者的新命题》商榷

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河北学刊 2017年第1期37卷 95-100页

作者：盛志梅天津师范大学文学院天津300387

《红楼梦》著作权问题历来是红学研究的热点之一。围绕作者到底是谁,学术界主要有两种倾向:一种认为是与曹家无关的人所著,如纳兰容若、冒辟疆、洪昇等,还有人认为是无名氏所作;另一种认为是曹家子弟所著,支持曹雪芹的居多,近几年还有... 详细信息

《红楼梦》著作权问题历来是红学研究的热点之一。围绕作者到底是谁,学术界主要有两种倾向:一种认为是与曹家无关的人所著,如纳兰容若、冒辟疆、洪昇等,还有人认为是无名氏所作;另一种认为是曹家子弟所著,支持曹雪芹的居多,近几年还有提出曹兆页说。随着"曹学"的发展,赵建忠提出结合"曹学"成就的"家族累积说"新命题。新命题建议学术界关注李玺家族的研究,认为《红楼梦》是曹家几代人集体智慧的结晶,曹雪芹是最后的完成者。这一新命题的优点是扩大了学术研究的视野,弊端是缺乏足够的材料和逻辑论证,并不能有效解决《红楼梦》研究的历史遗留难题。鉴于当前学术界的研究能力,尚不能支持新学说的提出。为此,《红楼梦》著作权问题应暂时搁置,这并无碍于《红楼梦》的艺术研究与读者接受。

关键词：《红楼梦》著作权家族累积说

C-F insertion reaction sheds new light on the construction of fluorinated compounds

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Chinese Chemical Letters 2024年第8期35卷 163-169页

作者： Dong-sheng Deng Su-Qin Tang Yong-Tu Yuan Ding-Xiong Xie zhi-Yuan Zhu Yue-mei Huang Yun-Lin Liu Henan Key Laboratory of Function-Oriented Porous Materials and College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The atom-economical C-F insertion chemistry is emerged as a promising technology for the synthesis of various fluorinated scaffolds,which have wide applications both in the academic and the industrial *** past three years have witnessed rapid developments in this *** highlight provides an overview on the evolution according to the fluorinating agents used.

关键词： C-F insertion Benzyl fluoride Acyl fluoride gem-Difluorocyclopropane Fluorinated scaffold

Liquid-phase epitaxial layer by layer brushing fabrication of metalorganic frameworks films

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Nano Research 2024年第6期17卷 5698-5704页

作者： Li-mei Chang Rui Zhai zhi-Zhou Ma Jian-Dong Huang zhi-Gang Gu Jian Zhang College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

Development of metal-organic framework(MOF)films is of great importance to expand their ***,we report a facile and universal method of liquid-phase epitaxial(LPE)layer by layer(LBL)brushing approach for fabricating MOF films on various substrates in a high-throughput *** MOF films preparation method offers a great prospective to cost-effectively construct films with short preparation time and little reagent ***,this LBL brushing approach has been implemented successfully to assemble various MOF films,including HKUST-1,zeolitic imidazolate framework-8(ZIF-8),Cu(bdc),and Cu_(2)(L)_(2)P(L=bdc,ndc,and cam;P=dabco and bipy).Afterwards,the classic MOF HKUST-1 and ZIF-8 films were grown on sensor chip electrode and porous fiber support for good volatile organic compounds(VOCs)selective sensing and water purification *** study demonstrates that this LBL brushing preparation method can be employed to synthesize various MOF films with a variety of characteristics to realize their sensing and separation applications.

关键词： metal-organic framework porous materials layer by layer fabrication film

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research International 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang zhi-hua Gong Quan Li Han-sheng Bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

A Weakly-Supervised Crowd Density Estimation Method Based on Two-Stage Linear Feature Calibration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 965-981页

作者： Yong-Chao Li Rui-sheng Jia Ying-Xiang Hu Hong-mei Sun the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590 the Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266000China the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590China the College of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210000China

In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation *** this paper,we aim to reduce the annotation cost of crowd datasets,and propose a crowd density estimation method based on weakly-supervised learning,in the absence of crowd position supervision information,which directly reduces the number of crowds by using the number of pedestrians in the image as the supervised *** this purpose,we design a new training method,which exploits the correlation between global and local image features by incremental learning to train the ***,we design a parent-child network(PC-Net)focusing on the global and local image respectively,and propose a linear feature calibration structure to train the PC-Net simultaneously,and the child network learns feature transfer factors and feature bias weights,and uses the transfer factors and bias weights to linearly feature calibrate the features extracted from the Parent network,to improve the convergence of the network by using local features hidden in the crowd *** addition,we use the pyramid vision transformer as the backbone of the PC-Net to extract crowd features at different levels,and design a global-local feature loss function(L2).We combine it with a crowd counting loss(LC)to enhance the sensitivity of the network to crowd features during the training process,which effectively improves the accuracy of crowd density *** experimental results show that the PC-Net significantly reduces the gap between fullysupervised and weakly-supervised crowd density estimation,and outperforms the comparison methods on five datasets of Shanghai Tech Part A,ShanghaiTech Part B,UCF_CC_50,UCF_QNRF and JHU-CROWD++.

关键词： Crowd density estimation linear feature calibration vision transformer weakly-supervision learning

Endoscopic band ligation or endoscopic tissue adhesive injection in the treatment of gastric varices:Which is better?

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World Journal of Gastroenterology 2024年第21期30卷 2827-2828页

作者： Li-zhi Yi sheng-Bing Zhao Department of Gastroenterology The People’s Hospital of LeshanLeshan 614000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalThe Second Military Medical University/Naval Medical UniversityShanghai 200433China

The combination of endoscopic ultrasound with endoscopic treatment of type 1 gastric variceal hemorrhage may improve the robustness and generalizability of the findings in future ***,the esophageal varices should also... 详细信息

关键词： Gastric varices Esophageal varices Endoscopic band ligation Endoscopic tissue adhesive injection Endoscopic ultrasound