Role of Prognostic Marker PRR11 in Immune Infiltration for Facilitating Lung Adenocarcinoma Progression

作     者：WANG Wen Hao MA Chang Geng CUI Yun Shang BAI Bing Yu SHENG Zhi Mei LIU Jin LI Ao ZHANG Bao Gang WANG Wen Hao;MA Chang Geng;CUI Yun Shang;BAI Bing Yu;SHENG Zhi Mei;LIU Jin;LI Ao;ZHANG Bao Gang

作者机构：Cheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Affiliated Hospital of Weifang Medical UniversityWeifang 261041ShandongChina Chinese Center for Disease Control and PreventionBeijing 102206China Weifang Medical UniversityWeifang 261053ShandongChina 

出 版 物：《生物医学与环境科学:英文版》 (Biomedical and Environmental Sciences)

年 卷 期：2023年第36卷第9期

页      面：862-868页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Traditional Chinese Medicine Science and Technology Project of Shandong Province [grant number 2020Q139] 

主　　题：Bioinformatics Lung adenocarcinoma PRR11 Cell cycle Th2 cell 

摘      要：The PRR11 gene(Proline Rich 11)has been implicated in lung cancer;however,relationship between PRR11 and immune infiltration is not clearly *** this study,we used The Cancer Genome Atlas(TCGA)data to analyze the lung adenocarcinoma patients;PRR11 gene expression,clinicopathological findings,enrichment,and immune infiltration were also ***11immune response expression assays in lung adenocarcinoma(LUAD)were performed using TIMER,and statistical analysis and visualization were conducted using R *** data were verified using Gene Expression Profiling Interactive Analysis(GEPIA),and the Human Protein Atlas(HPA).We found that PRR11 was an important prognostic factor in patients with ***11 expression was correlated with tumor stage and *** Set Enrichment Analysis(GSEA)showed that PRR11was enriched in the cell cycle regulatory *** infiltration analysis revealed that the number of T helper 2(Th2)cells increased when PRR11 was *** results confirm the role of PRR11 as a prognostic marker of lung adenocarcinoma by controlling the cell cycle and influencing the immune system to facilitate lung cancer progression.