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Effects of Buyang Huanwu Decoction on Intestinal Barrier, Intestinal Flora, and Trimethylamine Oxide in Rats with Heart Failure

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Chinese Journal of Integrative Medicine 2023年第2期29卷 155-161页

作者： WENG Jie-qiong LI Jie-bai YUAN Meng-fei YAO Ting-ting ZHANG Jing-fang ZENG Yuan-yuan ZHAO Jing LI Ying xu Ke shen xiao-xu Department of Cardiology Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Department of Nuclear Medicine Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Peking University Sixth Hospital Beijing 100700China

Objective: To explore the mechanisms of Buyang Huanwu Decoction(BYHWD) modulating the gut microbiome and trimethylamine oxide(TAMO) to exert cardioprotective effects. Methods: Ligation of the left anterior descending coronary artery was performed in rats to induce heart failure(HF). Except for the shamoperation group(n=10), 36 operation-induced models were randomized into 3 groups using a random number table(n=12 in each group): the model group, the BYHWD group(15.02 g/kg BYHWD), and the positive group(4.99 g/kg metoprolol succinate). After 4-week treatment(once daily by gavage), echocardiography was applied to evaluate the cardiac function and the Tei index(the ratio of ventricular isovolumic contraction time(IVCT)and isovolumic diastolic time(IVRT) to ejection time(ET)) was calculated;hematoxylin-eosin(HE) staining was observed to characterize the pathology of the myocardium and small intestinal villi. D-lactic acid was detected by an enzyme-linked immunosorbent assay(ELISA). Expressions of occludin, claudin-1, and zonula occludens(ZO-1) were detected by Western blot. 16S ribosomal ribonucleic acid(16S rRNA) sequencing was used to explore the changes in the intestinal flora. TMAO was detected via liquid chromatography-tandem mass spectrometry(LC-MS/MS). Results: In the echocardiography, the Tei index was considerably lower in the positive and BYHWD groups compared with the model group(P<0.05). Besides, BYHWD improved the pathology of myocardium and small intestine of HF rats and lowered the D-lactic acid content in the serum, when compared with the model group(P<0.05). BYHWD also improved the expression of occludin and claudin-1(P<0.05);in the gut microbiota analysis, BYHWD slowed down modifications in the structure distribution of gut microbiota and regulated the diversity of intestinal flora in HF rats. The content of TMAO in the serum was significantly lowered by BYWHT compared with the model group(P<0.05). Conclusion: BYHWD may delay progression of HF by enhan

关键词： Buyang Huanwu Decoction heart failure intestinal flora trimethylamine oxide

The expression,function,and coding potential of circular RNA circEDC3 in chicken skeletal muscle development

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Journal of Integrative Agriculture 2022年第5期21卷 1444-1456页

作者： WEI Yuan-hang ZHAO Xi-yu shen xiao-xu YE Lin ZHANG Yao WANG Yan LI Di-yan ZHU Qing YIN Hua-dong Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China

As an emerging class of non-coding transcripts,circular RNAs(circRNAs)are proved to participate in the complex process of myogenesis in diverse species.A previous study has identified circular RNA EDC3(circEDC3)as a typical covalently closed circular RNA abundant in chicken skeletal *** study found that circEDC3 is a conservative circular RNA and performed functional analysis to investigate the role of circEDC3 in chicken muscle *** results indicated that circEDC3 could inhibit(P<0.05)chicken skeletal muscle satellite cells(SMSCs)proliferation and differentiation but had no significant influence on SMSCs ***,bioinformatics analysis showed that circEDC3 had promising coding *** open reading frames(ORF)were found in circEDC3 in this ***,this study predicted that circEDC3 had internal ribosome entry sites(IRES)and N6-methyladenosine(m6A)motifs in different species,implying that circEDC3 might be *** study revealed that circEDC3 might be a negative regulator in chicken muscle development and suggested it has protein-coding potential in different species.

关键词： circEDC3 chicken SMSCs myogenesis coding potential

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语境论视阈下的理解与解释之争

科学技术哲学研究 2016年第1期33卷 53-59页

作者：申晓旭殷杰山西大学科学技术哲学研究中心太原030006

文章对社会科学与自然科学中解释与理解之争的四个阶段进行了论述,澄清了其问题域和哲学实质,通过分析语境在理解和解释中的作用,主张以语境论整合这一争论。

关键词：语境论社会科学哲学理解解释

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翻译的认知情境性路径探赜

科学技术哲学研究 2024年第2期41卷 41-47页

作者：申晓旭殷杰山西大学科学技术哲学研究中心太原030006

翻译与认知的关系问题是当代认知科学和语言学哲学的核心论题,围绕翻译实践与翻译理论的规范性基础应当锚定于计算表征范式还是非计算的情境性路径,相关研究在方法论和实证层面都呈现出冲突与张力。事实上,以多元性和互动性为特征的认... 详细信息

翻译与认知的关系问题是当代认知科学和语言学哲学的核心论题,围绕翻译实践与翻译理论的规范性基础应当锚定于计算表征范式还是非计算的情境性路径,相关研究在方法论和实证层面都呈现出冲突与张力。事实上,以多元性和互动性为特征的认知情境性路径在求解翻译过程的认知复杂性问题上,将意义、专业技能、情感、情境、社会互动等影响因素全部纳入翻译认知处理过程而加以重新评估,为全面刻画翻译实践所涉及的认知能力与认知过程提供了系统性视角。然而,各种交互式机器翻译模型的不断涌现,对翻译的认知情境性方法论的非计算性视角构成了挑战,从问题空间的结构重新组织翻译认知研究的多样化实践,能够超越狭隘的理论范式之争,为翻译研究建构一种朝向认知整合和认知系统连续性的规范性模式。

关键词：认知翻译研究计算翻译学认知翻译学认知情境性路径认知整合

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基于配网综合检测故障的分析与处理

华东电力 2014年第7期42卷 1398-1400页

作者：沈挺刘梁沈旭晓国网上海市电力公司奉贤供电公司上海201400

现有的配网管理系统只能判断一次变电站10 kV出线或开闭简单信息,而对于输电线路接地故障类型、故障位置等信息无法判断,提供一种小电流接地系统的故障诊断研究方法,判断在配网单相接地故障情况下的故障选线和故障测距,以及小波变换理... 详细信息

现有的配网管理系统只能判断一次变电站10 kV出线或开闭简单信息,而对于输电线路接地故障类型、故障位置等信息无法判断,提供一种小电流接地系统的故障诊断研究方法,判断在配网单相接地故障情况下的故障选线和故障测距,以及小波变换理论在电力系统各领域中的应用前景。

关键词：配电网配网故障故障测距故障定位

Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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Journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen shen Zhenghao Wu Xingying Lan Yi xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An xiao Huang Qian Zhang Chenhao Zhang Tao shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

补阳还五汤对舒张性心衰大鼠心肌线粒体能量代谢及AMPK/PPARα信号通路的影响

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中国实验方剂学杂志 2019年第9期25卷 12-17页

作者：王臻李洁白董昕沈晓旭北京中医药大学东直门医院北京100029

目的:探讨补阳还五汤基于腺苷酸激活蛋白激酶(AMPK)/过氧化物酶体增殖物激活受体α(PPARα)信号通路对舒张性心衰(DHF)大鼠心肌线粒体能量代谢的影响及其机制研究。方法:将48只SD大鼠随机分为假手术组与模型组,模型组大鼠运用腹主动脉... 详细信息

目的:探讨补阳还五汤基于腺苷酸激活蛋白激酶(AMPK)/过氧化物酶体增殖物激活受体α(PPARα)信号通路对舒张性心衰(DHF)大鼠心肌线粒体能量代谢的影响及其机制研究。方法:将48只SD大鼠随机分为假手术组与模型组,模型组大鼠运用腹主动脉缩窄法建立DHF大鼠模型。将造模成功的大鼠随机分为模型组,补阳还五汤组(12.72 g·kg^(-1)·d^(-1)),酒石酸美托洛尔组(0.004 5 g·kg^(-1)·d^(-1)),灌胃给予相应药物,假手术组、模型组给予等量的去离子水,各组均每日灌胃1次。药物连续干预8周后,采用酶联免疫吸附测定(ELISA)检测大鼠外周血中单磷酸腺苷(AMP),二磷酸腺苷(ADP),三磷酸腺苷(ATP)的含量;采用投射电镜检测心肌线粒体超微结构的变化;采用蛋白免疫印迹法(Western blot)检测大鼠心肌组织中AMPK,PPARα,PPARγ辅助激活因子1α(PGC-1α)的蛋白表达量。结果:与假手术组比较,模型组大鼠AMP,ADP含量显著升高,ATP含量显著下降(P<0.05,P<0.01);与模型组比较,补阳还五汤组、酒石酸美托洛尔组大鼠AMP含量明显降低(P<0.01),ADP含量下降(P<0.05),ATP含量升高。与假手术组比较,模型组大鼠线粒体数量减少,形态异常;与模型组比较,补阳还五汤组、酒石酸美托洛尔组大鼠线粒体数量明显增加,形态明显改善。与假手术组比较,各组大鼠AMPK蛋白表达量无统计学差异;与假手术组比较,模型组PPARα,PGC-1α蛋白表达水平明显降低(P<0.05)。与模型组比较,补阳还五汤组、酒石酸美托洛尔组PPARα,PGC-1α蛋白表达水平明显升高(P<0.05)。结论:补阳还五汤可能是通过改善线粒体结构和功能,激活AMPK并上调AMPK/PPARα信号通路的表达,从而改善衰竭心脏的能量代谢,延缓心衰进展。

关键词：补阳还五汤舒张性心衰大鼠心肌线粒体能量代谢腺苷酸激活蛋白激酶(AMPK)/过氧化物酶体增殖物激活受体α(PPARα)信号通路

Pd／Fe3O4-MCNT磁性催化剂的制备、表征及催化性能

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物理化学学报 2011年第8期27卷 1956-1960页

作者：徐玲沈晓旭肖强钟依均叶素芳叶向荣朱伟东浙江师范大学物理化学研究所先进催化材料省部共建教育部重点实验室浙江金华321004 金华职业技术学院浙江金华321007 Pacific Northwest National Laboratory PO.Box 999RichlandWashington 99352USA

利用多元醇法制备了单分散Fe3O4纳米粒子修饰多壁碳纳米管(MCNT)的磁性复合材料,并以X射线衍射(XRD)、透射电镜(TEM)和X射线能量色散谱(EDS)对碳纳米管磁性复合材料的结构和组成进行了表征.研究发现,通过调控Fe3O4前驱体与MCNT载体的质... 详细信息

利用多元醇法制备了单分散Fe3O4纳米粒子修饰多壁碳纳米管(MCNT)的磁性复合材料,并以X射线衍射(XRD)、透射电镜(TEM)和X射线能量色散谱(EDS)对碳纳米管磁性复合材料的结构和组成进行了表征.研究发现,通过调控Fe3O4前驱体与MCNT载体的质量比,可以很好地控制沉积的磁性纳米粒子大小.以碳纳米管磁性复合材料为载体,采用多元醇法成功制备了Pd负载量为3.0%(w)的Pd/Fe3O4-MCNT磁性催化剂.磁性质测试表明碳纳米管磁性复合材料在负载Pd前后都具有良好的超顺磁性.以肉桂醛加氢为探针反应研究了Pd/Fe3O4-MCNT的催化性能,结果表明该催化剂表现出良好的催化加氢性能,在外加磁场下催化剂能与液相反应体系高效分离,循环使用4次后,催化性能没有明显下降,显示了良好的循环利用性能.

关键词：多壁碳纳米管磁性复合催化剂多元醇法肉桂醛选择性加氢