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Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

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Nuclear Science and Techniques 2024年第1期35卷 108-123页

作者： Hao Yang Ji-shen Li zhi-Ran Zhang bin Zhang Jian-Qiang Shan School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The phenomenology involved in severe accidents in nuclear reactors is highly ***,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable ***,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and *** study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation *** an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant *** uncertainty parameters of the ISAA program were meticulously *** Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch *** analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure *** calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,*** ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

关键词： Gen-III PWR Severe accident mitigation Wilks’formula Hydrogen Fission products Uncertainty and sensitivity analysis

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Data Mining Study on Prescription Patterns of Different Dosage Forms of Chinese Herbal Medicines for Treating and Improving Immune-Inflammatory Indices in Patients with Rheumatoid Arthritis

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Chinese Journal of Integrative Medicine 2022年第3期28卷 215-222页

作者： HUANG Dan LIU Jian XIN Ling XIE Jin-gui ZHU Qiang CHEN Pei-sheng shen zhi-bin MENG Qing-he WANG Hai-yan Department of Rheumatology First Affiliated Hospital of Anhui University of Chinese MedicineHefei(230031)China The School of Management University of Science and Tech no logy of ChinaHefei(230026)China An hui Jiren Pharmaceutical Co. Ltd.BozhouAnhui Provinee(236800)China Department of Acupuncture Huangshan Hospital of Chinese MedicineHuangshanAnhui Province(245000)China Department of Internal Medicine Bozhou Hospital of Chinese MedicineBozhouAnhui Province(236800)China

Objective:To explore the prescription patterns of different dosage forms of Chinese herbal medicines(CHMs)for the treatment of rheumatoid arthritis(RA)and their effects on immune-inflammatory ***:Clinical data were collected from patients with RA in 4 hospitals(3 Class A comprehensive hospitals and 1 Class B comprehensive hospital)in Anhui Province,China,from August 2012 to June 2018 via the electronic medical record gathering *** extraction of prescription information,each prescribed herb was quantified and standardized according to the knowledge base to establish a database of RA treatment *** medical records were divided into the granules group and decoction pieces *** herbs and their combination patterns were obtained from the two groups of cases using Liquorice *** in immune-inflammatory and hepatic and renal function indices were compared between the two groups using SPSS 23.0 *** Aprior module of SPSS Clementine 11.1 software was applied to analyse the correlation between CHMs and improvement in ***,the ORACLE 10 g tool was used to evaluate the random walk model of the immune-inflammatory indices between the two ***:(1)We retrospectively analysed 35,898 prescriptions for 6,829 patients with RA who received CHM *** were 3,816 patients in the granules group and 3,013 in the decoction pieces group.(2)The core herbs were Pi(Spleen)-strengthening and dampness-resolving drugs,blood-activating and stasis-resolving drugs,wind/dampness-dispelling drugs and heatclearing and detoxifying drugs.(3)Both dosage forms could improve immune-inflammatory indices in RA patients,with similar efficacy and no influence on hepatic or renal function.(4)Herba Siegesbeckiae and Oldenlandia had a stronger association with immune-inflammatory indices in the two groups.(5)The immune-inflammatory indices showed obvious improvement after treatment with granules and decoction pieces of CHMs,and

关键词： rheumatoid arthritis Chinese heral medicine granules decoction pieces data mining

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Study of primordial deuterium abundance in Big Bang nucleosynthesis

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Nuclear Science and Techniques 2024年第3期35卷 208-215页

作者： zhi-Lin shen Jian-Jun He Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China

Big Bang nucleosynthesis(BBN)theory predicts the primordial abundances of the light elements^(2) H(referred to as deuterium,or D for short),^(3)He,^(4)He,and^(7) Li produced in the early *** these,deuterium,the first nuclide produced by BBN,is a key primordial material for subsequent *** date,the uncertainty in predicted deuterium abundance(D/H)remains larger than the observational *** this study,the Monte Carlo simulation code PRIMAT was used to investigate the sensitivity of 11 important BBN reactions to deuterium *** found that the reaction rate uncertainties of the four reactions d(d,n)^(3)He,d(d,p)t,d(p,γ)^(3)He,and p(n,γ)d had the largest influence on the calculated D/H ***,the calculated D/H uncertainty cannot reach observational precision even with the recent LUNA precise d(p,γ)^(3) He *** the nuclear physics aspect,there is still room to largely reduce the reaction-rate uncertainties;hence,further measurements of the important reactions involved in BBN are still necessary.A photodisintegration experiment will be conducted at the Shanghai Laser Electron Gamma Source Facility to precisely study the deuterium production reaction of p(n,γ)d.

关键词： Big Bang nucleosynthesis Abundance of deuterium Reaction cross section Reaction rate Monte Carlo method

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基于推进剂复杂本构模型的药柱结构分析模块开发

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固体火箭技术 2014年第3期37卷 336-341,359页

作者：唐国金邓斌申志彬国防科技大学航天科学与工程学院长沙410073

为研究固体火箭发动机药柱的非线性粘弹性行为,基于商用有限元软件二次开发技术建立了一种新型药柱结构分析模块。针对一种考虑变泊松比、老化和损伤效应的三维热粘弹性本构模型,采用增量法对其进行了数值离散,导出了本构方程的增量形式... 详细信息

为研究固体火箭发动机药柱的非线性粘弹性行为,基于商用有限元软件二次开发技术建立了一种新型药柱结构分析模块。针对一种考虑变泊松比、老化和损伤效应的三维热粘弹性本构模型,采用增量法对其进行了数值离散,导出了本构方程的增量形式,并提出了相应的应力更新方法;基于***和Abaqus软件的二次开发技术,编写了相应的材料子程序,并开发了药柱结构分析模块;考虑本构模型的8种不同形式,先后采用该模块分析了某发动机药柱在全寿命周期过程的结构响应。结果表明,相比于传统线粘弹性本构模型,本文的粘弹性本构模型能更好地表征推进剂真实的力学行为,所开发的分析模块可用于实际型号固体发动机药柱结构分析与寿命预估。

关键词：本构模型老化损伤变泊松比二次开发药柱结构分析模块

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Function-reversible facets enabling SrTiO_(3)nanocrystals for improved photocatalytic hydrogen evolution

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Frontiers in Energy 2024年第1期18卷 101-109页

作者： bin WANG Bei AN Xiaoqian LI Shaohua shen School of Physics Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter(Ministry of Education)Key Laboratory of Shaanxi for Advanced Materials and Mesoscopic PhysicsXi’an Jiaotong UniversityXi’an 710049China International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

It has been widely reported that,for faceted nanocrystals,the two adjacent facets with different band levels contribute to promoted charge separation,and provide active sites for photocatalytic reduction and oxidation reaction,*** such cases,only one family of facets can be used for photocatalytic hydrogen ***,by using SrTiO_(3)nanocrystals enclosed by{023}and{001}facets as a model photocatalyst,this paper proposed a strategy to achieve the full-facets-utilization of the nanocrystals for photocatalytic hydrogen via chemically depositing Pt nanoparticles on all *** photo-deposition experiment of CdS provided direct evidence to demonstrate that the{023}facets which were responsible for photooxidation reaction can be function-reversed for photocatalytic hydrogen evolution after depositing Pt nanoparticles,together with the{001}***,the full-facets-utilization led to a much-improved activity for photocatalytic hydrogen,in contrast to those SrTiO_(3)nanocrystals with only{001}facets deposited by Pt nanoparticles via a photo-deposition method.

关键词： SrTiO_(3)nanocrystals crystal facets photocatalysis hydrogen evolution

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Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFC

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Journal of Energy Chemistry 2024年第2期89卷 422-433,I0010页

作者： bin Liu Jiawang Li Bowen Yan Qi Wei Xingyu Wen Huarui Xie Huan He Pei Kang shen zhi Qun Tian Collaborative Innovation Center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-C)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-HC)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized S-Fe-N-HC features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-C with soft or graphitic carbon *** unique characteristics endow S-Fe-N-HC with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFC performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-C catalysts,providing a new guidance for developing advanced M-N-C catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction Hard carbon Amide based polymer reaction Proton exchange membrane cells

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Shape embedding and retrieval in multi-ﬂow deformation

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Computational Visual Media 2024年第3期10卷 439-451页

作者： Baiqiang Leng Jingwei Huang Guanlin shen bin Wang School of Software Tsinghua UniversityBeijingChina Huawei Technologies ShenzhenChina

We propose a unified 3D ﬂow frameworkfor joint learning of shape embedding and deformationfor different categories. Our goal is to recovershapes from imperfect point clouds by fitting thebest shape template in a shape repository afterdeformation. Accordingly, we learn a shape embeddingfor template retrieval and a ﬂow-based network forrobust deformation. We note that the deformationﬂow can be quite different for different shapecategories. Therefore, we introduce a novel multi-hubmodule to learn multiple modes of deformation toincorporate such variation, providing a network whichcan handle a wide range of objects from differentcategories. The shape embedding is designed to retrievethe best-fit template as the nearest neighbor in a latentspace. We replace the standard fully connected layerwith a tiny structure in the embedding that significantlyreduces network complexity and further improvesdeformation quality. Experiments show the superiorityof our method to existing state-of-the-art methods viaqualitative and quantitative comparisons. Finally, ourmethod provides efficient and flexible deformation thatcan further be used for novel shape design.

关键词： deformation shape retrieval embedding reconstruction

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Growth process,defects,and dopants of bulkβ-Ga_(2)O_(3)semiconductor single crystals

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China Foundry 2024年第5期21卷 491-506页

作者： Yan-shen Wang Ming-zhi Zhu Yuan Liu School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology(Ministry of Education) Beijing 100084China

β-gallium oxide(β-Ga2O3),as the typical representative of the fourth generation of semiconductors,has attracted increasing attention owing to its ultra-wide bandgap,superior optical properties,and excellent tolerance to high temperature and *** to the single crystals of other semiconductors,high-quality and large-sizeβ-Ga_(2)O_(3)single crystals can be grown with low-cost melting methods,making them highly *** this review,the growth process,defects,and dopants ofβ-Ga_(2)O_(3)are primarily ***,the growth process(e.g.,decomposition,crucible corrosion,spiral growth,and development)ofβ-Ga_(2)O_(3)single crystals are summarized and compared in ***,the defects ofβ-Ga_(2)O_(3)single crystals and the influence of defects on Schottky barrier diode(SBD)devices are emphatically ***,the influences of impurities and intrinsic defects on the electronic and optical properties ofβ-Ga_(2)O_(3)are also briefly *** this comprehensive analysis,the article offers a concise summary of the current state,challenges and prospects ofβ-Ga_(2)O_(3)single crystals.

关键词： β-Ga_(2)O_(3) single-crystal growth defects dopants semiconductor

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Advances in MET tyrosine kinase inhibitors in gastric cancer

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Cancer Biology & Medicine 2024年第6期21卷 484-498页

作者： Yifan Zhang Lin shen zhi Peng Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Gastric cancer is among the most frequently occurring cancers and a leading cause of cancer-related deaths *** gastric cancer is highly heterogenous and comprised of different subtypes with distinct molecular and clinical characteristics,the management of gastric cancer calls for better-defined,biomarker-guided,molecular-based treatment *** is a receptor tyrosine kinase mediating important physiologic processes,such as embryogenesis,tissue regeneration,and wound ***,mounting evidence suggests that aberrant MET pathway activation contributes to tumour proliferation and metastasis in multiple cancer types,including gastric cancer,and is associated with poor patient *** such,MET-targeting therapies are being actively developed and promising progress has been demonstrated,especially with MET tyrosine kinase *** review aims to briefly introduce the role of MET alterations in gastric cancer and summarize in detail the current progress of MET tyrosine kinase inhibitors in this disease area with a focus on savolitinib,tepotinib,capmatinib,and *** on current knowledge,this review further discusses existing challenges in MET alterations testing,possible resistance mechanisms to MET inhibitors,and future directions of MET-targeting therapies.

关键词： Gastric cancer MET alterations MET tyrosine kinase inhibitors savolitinib MET testing

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考虑人工脱粘层接触效应的药柱粘弹性分析

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固体火箭技术 2013年第3期36卷 338-341,352页

作者：岳健邓斌申志彬李道奎国防科技大学航天科学与工程学院长沙410073

考虑人工脱粘层的接触效应,以承受轴向过载的某型导弹二级固体发动机为例,应用有限元软件***/Marc对其药柱进行了粘弹性有限元分析。通过对比8种情况下药柱Von Mises应力/应变计算结果,探讨了动静态计算模式下接触效应对药柱应力/应变... 详细信息

考虑人工脱粘层的接触效应,以承受轴向过载的某型导弹二级固体发动机为例,应用有限元软件***/Marc对其药柱进行了粘弹性有限元分析。通过对比8种情况下药柱Von Mises应力/应变计算结果,探讨了动静态计算模式下接触效应对药柱应力/应变计算结果的影响,提出了一种判断是否需要考虑接触效应的方法。结果表明,考虑人工脱粘层接触效应的药柱Von Mises应力/应变结果要比忽略接触效应的结果偏大;采用动态模式对药柱结构完整性进行仿真比采用准静态的计算模式所得到的结果要偏大;采用动态模式对接触效应进行仿真的计算结果更合理。所得结论和分析方法可为固体发动机研制提供参考。

关键词：接触效应固体火箭发动机有限元法人工脱粘层粘弹性

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