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Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1227-1235页

作者： Wen-Jing Hu Gang Bai yan Wang Dong-Mei Hong Jin-hua Jiang Jia-Xun Li Yin hua Xin-Yu Wang Ying Chen Intensive Care Unit Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Anesthesia and Perioperative Medicine Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical *** To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer *** In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October *** incidence of postoperative delirium was recorded for 7 d *** were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative *** SMOTE technique was applied to enhance the model by oversampling the delirium *** model’s predictive accuracy was then *** In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative *** included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain *** incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of *** comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive *** This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of tradi

关键词： Elderly patients Abdominal cancer Postoperative delirium Synthetic minority oversampling technique Predictive modeling Surgical outcomes

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Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2977-2991页

作者： Ke Lu Ming Zhang Hongyu Qin Siyu shen Haiqing Song hua Jiang Chunxiang Zhang Guozhi Xiao Liping Tong Qing Jiang Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyShenzhen 518055China Oncology Department Johns Hopkins University School of MedicineBaltimoreMD 21205USA Division of Spine Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolState Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210008China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Department of Cardiology Basic Medicine Innovation Center for Cardiometabolic Diseases of Ministry of EducationInstitute of Cardiovascular Researchthe Affiliated HospitalSouthwest Medical UniversityLuzhou 646000China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of ***,we demonstrated that cyclin D1 is SUMOylated,and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating SUMO-induced ubiquitination and proteasome degradation of cyclin *** generated cyclin D1 mutant mice with mutations in the SUMOylation site,phosphorylation site,or both sites of cyclin D1,and found that double mutant mice developed a Mantle cell lymphoma(MCL)-like *** showed that arsenic trioxide(ATO)enhances cyclin D1 SUMOylation-mediated degradation through inhibition of cyclin D1 deSUMOylation enzymes,leading to MCL cell *** of severe combined immunodeficiency(SCID)mice grafted with MCL cells with ATO resulted in a significant reduction in tumor *** this study,we provide novel insights into the mechanisms of MCL tumor development and cyclin D1 regulation and discover a new strategy for MCL treatment.

关键词： Cyclin D1 SUMOylation Mantle cell lymphoma Arsenic trioxide SENP2 Proteasome degradation

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Genotyping on circulating tumor DNA improves mutation detection rate in high-risk diffuse large B-cell lymphoma

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Genes & Diseases 2024年第4期11卷 116-119页

作者： Yi Xia Li Wang Jinhua Liang Haorui shen Jiazhu Wu hua Yin Yue Li huayuan Zhu Jianyong Li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

Diffuse large B-cell lymphoma(DLBCL)is the most common lymphoma with heterogeneous clinical *** who are primarily refractory to the frontline therapy or relapse less than 12 months after diagnosis have an extremely di... 详细信息

关键词： lymphoma diagnosis clinical

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Development and engineering application of integrated safety monitoring systems for China’s high-speed trains

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Transportation Safety and Environment 2024年第2期6卷 36-44页

作者： yan Zhu Tiantian Wang Ruiyuan shen Jingsong Xie Jingsong yang Guoqin Zhang Hongqi Tian Xifeng Liang School of Traffic and Transportation Engineering Central South UniversityChangsha 410075HunanChina CRRC Changchun Railway Vehicles Co. LtdChangchun 130062JilinChina China State Railway Group Co. Ltd.Beijing 100084China

With the improvement of the running speed of China’s high-speed trains,the demands for running status monitoring and security assurance of High-speed Electric Multiple Units(EMU)have increased ***,the current safety monitoring systems are independent,which is not conducive to the comprehensive monitoring and information sharing of the whole *** temperature monitoring of running gear is insensitive to early *** to develop a train operation safety monitoring system with strong engineering implementation and high integration is a key problem to be *** the monitoring of running stationarity,frame stability and running gear health of China’s high-speed trains,an integrated safety monitoring system framework is designed,and the logic and algorithm for the diagnosis of stationarity,stability and health states of rotating parts are *** software which fused the temperature,high and low frequency vibration data is developed,and the design and installation of the vibration temperature composite sensors are *** research results have realized the integration and comprehensive processing of multiple monitoring systems,completed the improvement from single component and vehicle-level safety monitoring to multi-system,train-level and interactive *** the process of real vehicle application,the developed monitoring system acquires the vehicle operation status data accurately and in real *** constructed diagnosis algorithm and logic evaluates the vehicle operation status accurately and in a timely manner,and avoids the progression from fault to *** research results show that the integrated safety monitoring system can provide technical support for train operation safety.

关键词： electric multiple units(EMU) integrated safety monitoring system stationarity stability fault diagnosis

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基于ZigBee的无线低压电力数据集抄系统终端设计

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电测与仪表 2013年第1期50卷 89-93页

作者：肖勇蔡月宏阎啸申妍华广东电网公司电力科学研究院广州510080 电子科技大学空天科学研究院成都611731 华南理工大学广州510640

研究了符合ZigBee规定的直接序列扩频(DSSS)和偏移正交相移键控(OQPSK)调制的无线低压电力数据集抄系统收发机,重点分析了ZigBee收发机在加性高斯白噪声(AWGN)信道和瑞利信道中的抗噪性能表现。利用Matlab编程工具对直接序列扩频通信收... 详细信息

研究了符合ZigBee规定的直接序列扩频(DSSS)和偏移正交相移键控(OQPSK)调制的无线低压电力数据集抄系统收发机,重点分析了ZigBee收发机在加性高斯白噪声(AWGN)信道和瑞利信道中的抗噪性能表现。利用Matlab编程工具对直接序列扩频通信收发机系统进行仿真,研究了扩频码片长度与通信系统抗噪性能的关系。仿真结果表明,信噪比为6dB时,32位码长扩频通信系统误码率可以降低到16位码长扩频通信系统的1/23,即使用长扩频码片可以提高无线低压集抄系统的抗噪性能。

关键词： ZigBee 直接序列扩频偏移正交相移键控

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矿用自卸车电动轮冷却系统研究

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煤矿机械 2012年第3期33卷 60-62页

作者：张艳申焱华张文明北京科技大学机械工程学院北京100083

新型铰接式矿用自卸汽车的驱动电动机采用定子外水冷系统进行冷却。为了对比轴向和周向2种冷却结构的散热效果,针对这2种冷却水套结构,进行散热性能的热力计算,并利用有限元法对温度场及流场进行模拟。最后对样机进行温升实验,表明周向... 详细信息

新型铰接式矿用自卸汽车的驱动电动机采用定子外水冷系统进行冷却。为了对比轴向和周向2种冷却结构的散热效果,针对这2种冷却水套结构,进行散热性能的热力计算,并利用有限元法对温度场及流场进行模拟。最后对样机进行温升实验,表明周向水冷系统可有效地带走电动机产生的热量,传热模型可以有效地反应实际传热过程。

关键词：铰接自卸车高功率密度水冷电动机温度场

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Evaluating serum CXCL12,sCD22,Lp-PLA2 levels and ratios as biomarkers for diagnosis of Alzheimer's disease

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World Journal of Psychiatry 2024年第3期14卷 380-387页

作者： Zeng-Ling Liu Fei-Fei hua Lei Qu Na yan Hui-Fang Zhang Department of Neurology Dongying People's HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Grasping the underlying mechanisms of Alzheimer's disease(AD)is still a work in progress,and existing diagnostic techniques encounter various ***,the discovery of dependable biomarkers is essential for early detection,tracking the disease's advancement,and steering treatment *** To explore the diagnostic potential of serum CXCL12,sCD22,Lp-PLA2,and their ratios in AD,aiming to enhance early detection and inform targeted treatment *** The study was conducted in Dongying people's Hospital from January 2021 to December *** included 60 AD patients(AD group)and 60 healthy people(control group).Using a prospective case-control design,the levels of CXCL12,sCD22 and Lp-PLA2 and their ratios were detected by enzyme-linked immunosorbent assay kit in the diagnosis of *** differences between the two groups were analyzed by statistical methods,and the corresponding ratio was constructed to improve the specificity and sensitivity of *** Serum CXCL12 levels were higher in the AD group(47.2±8.5 ng/mL)than the control group(32.8±5.7 ng/mL,P<0.001),while sCD22 levels were lower(14.3±2.1 ng/mL vs 18.9±3.4 ng/mL,P<0.01).Lp-PLA2 levels were also higher in the AD group(112.5±20.6 ng/mL vs 89.7±15.2 ng/mL,P<0.05).Significant differences were noted in CXCL12/sCD22(3.3 vs 1.7,P<0.001)and Lp-PLA-2/sCD22 ratios(8.0 vs 5.2,P<0.05)between the *** operating characteristic analysis confirmed high sensitivity and specificity of these markers and their ratios in distinguishing AD,with area under the curves ranging from CONCLUSION Serum CXCL12 and Lp-PLA2 levels were significantly increased,while sCD22 were significantly decreased,as well as increases in the ratios of CXCL12/sCD22 and Lp-PLA2/sCD22,are closely related to the onset of *** biomarkers and their ratios can be used as potential diagnostic indicators for AD,providing an important clinical reference for early intervention and treatment.

关键词： Alzheimer's disease Biomarkers CXCL12 sCD22 Lp-PLA2

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Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

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World Journal of Clinical Cases 2024年第4期12卷 835-841页

作者： yan Song hua Li Xia Zhang Lei Wang Hong-yan Xu Zhi-Chao Lu Xiao-Gang Wang Bo Liu Department of Clinical Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Cardiology Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Imaging Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pulmonary and Critical Care Medicine Department of Clinical MicrobiologyZibo City Key Laboratory of Respiratory Infection and Clinical MicrobiologyZibo City Engineering Technology Research Center of Etiology Molecular DiagnosisZibo Municipal HospitalZibo 255400Shandong ProvinceChina

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains *** is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating *** study significantly contributes to the medical *** SUMMARY The blood-thinning treatment of a patient with AMI and LVT was *** blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice *** 15 d,the patient’s LVT did not decrease but instead *** pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug *** drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six *** clinical pharmacist provided the patient with professional and standardized pharmaceutical *** patient’s condition was discharged after meeting the international normalized ratio value(2-3)*** patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical *** Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

关键词： Myocardial infarction Left ventricular thrombus Dabigatran etexilate Warfarin Clinical pharmacist Case report

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Experimental investigation of the polarityswitching process with different bipolar ionic liquid thruster operating frequencies

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Plasma Science and Technology 2024年第6期26卷 1-13页

作者：吴湘蓓杨铖罗嘉伟沈岩 School of Aeronautics and Astronautics Sun Yat-sen UniversityShenzhen 518107People’s Republic of China shenzhen Key Laboratory of Intelligent Microsatellite Constellation Shenzhen 518107People’s Republic of China

The bipolar ionic liquid thruster employs ionic liquid as a propellant to discharge positively and negatively charged high-energy particles under an alternating current(AC)power source,effectively suppressing electrochemical reaction and ensuring charge *** an optimal AC supply power source frequency is critical for sustained stable thruster *** study focuses on the emission characteristics of the ionic liquid thruster under varied AC *** AC power supply was set within the frequency range of 0.5-64 Hz,with eight specific frequency conditions selected for *** experimental results indicate that the thruster operates steadily within a voltage range of±1470 to±1920 V,with corresponding positive polarity current ranging from 0.41 to 4.91μA and negative polarity current ranging from−0.49 to−4.10μ*** voltage polarity switching,an emission delay occurs,manifested as a prominent peak signal caused by circuit capacitance characteristics and a minor peak signal resulting from liquid *** emission test was conducted at 16 Hz,demonstrating approximately 1 h and 50 min of consistent emission before intermittent *** findings underscore the favorable impact of AC conditions within the 8-16 Hz range on the self-neutralization capability of the ionic liquid thruster.

关键词： space electric propulsion ionic liquid thruster bipolar operation mode frequency

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Impact of early refined nursing program on prognosis of middleaged and elderly patients with cognitive dysfunction combined with cerebral infarction

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World Journal of Psychiatry 2024年第7期14卷 1034-1042页

作者： Hui-Lian Xiong Zhi-Xin Li Xin Lu yan-hua Lu Ping Zhong Ganzhou City Central Blood Station Ganzhou 341000Jiangxi ProvinceChina Department of Rehabilitation Medicine Ganzhou People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Cerebral infarction is a local or extensive necrosis of brain ***,the corresponding neurological deficits *** incidence of cerebrovascular diseases in China is increasing *** the onset of cerebrovascular disease,the most common sequelae include movement disorders,language disorders,and cognitive *** To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive *** A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group(n=32)and a control group(n=28).The experimental group received early intensive care every day,and the control group received daily routine *** scores of the Mini-Mental State Examination(MMSE)and the Trail Making Test(TMT),as well as the latency and amplitude of the event-related potential P300,were used as main indicators to evaluate changes in cognitive function,and changes in BDNF,TGF-β,and GDNF expression were used as secondary *** Both groups experienced notable enhancements in MMSE scores,with the experi-mental group demonstrating higher scores than the control group(experimental:28.75±2.31;control:25.84±2.87).Moreover,reductions in TMT-A and TMT-B scores were observed in both groups(experimental:TMT-A 52.36±6.18,TMT-B 98.47±10.23;control:TMT-A 61.48±7.92,TMT-B 112.63±12.55),with the experimental group displaying lower scores.P300 Latency decreased(experimental:270.63 ms±14.28 ms;control:285.72 ms±16.45 ms),while amplitude increased(experimental:7.82μV±1.05μV;control:6.35μV±0.98μV)significantly in both groups,with superior outcomes in the experimental ***,the levels of the growth factors BDNF,TGF-β1,and GDNF surged(experimental:BDNF 48.37 ng/mL±5.62 ng/mL,TGF-β152.14 pg/mL±4.28 pg/mL,GDNF 34.76 ng/mL±3.89 ng/mL;control:BDNF 42.58 ng/mL±4.73 ng/mL,TGF-β146.23 pg/m

关键词： Early refined nursing program Cerebral infraction Cognitive impairment Psychiatry Trajectory test

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