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Brain functional connectivity network studies of acupuncture： a systematic review on resting-state fMRI

Journal of Integrative Medicine 2018年第1期16卷 26-33页

作者： Rong-lin Cai Guo-ming shen Hao Wang Yuan-yuan Guan Graduate School of Anhui University of Chinese Medicine Hefei 230012 Anhui Province China School of Integrated Traditional Chinese & Western Medicine Anhui University of Chinese Medicine Hefei 230012 Anhui Province China

Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research h

关键词： Resting-state functional magnetic resonance Acupuncture Functional connectivity Functional network Complementary medicine Alternative medicine

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Activation of α7 nicotinic acetylcholine receptor protects against oxidant stress damage through reducing vascular peroxidase-1 in a JNK signaling-dependent manner in endothelial cells

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中国药理学通报 2015年第B11期31卷 156-157页

作者： LI Dong-Jie shen Fu-ming DeptofPharmacy ShanghaiTenthPeople'sHospitalTongjiUniversityShanghai200233

Aim Alpha7 nicotinic acetylcholine receptor （α7nAChR）, a subtype of nAChR regulating neurotrans- mission in central nervous system, is an essential regulator of cholinergic antiinflammatory pathway in periphery. The present study was to determine the effects of activation of α7nAChR on oxidant stress-induced injury in endo- thelial cells. Methods Cultured human umbilical vein endothelial cells were treated with H202 （400 μmol · L^-1） or H202plus PNU-282987 （ 10 μmol · L^-1 ）. Cell viability and membrane integrity were measured. AnnexinV ＋ PI assay, immunoblotting of bcl-2, bax and cleaved caspase-3, and immunofluorescence of apoptosis inducing factor （AIF） were performed to evaluate apoptosis. Protein expression of vascular peroxidase-1 （ VPO-1 ） and phosphor- JNK were measured by immunoblotting. Results Activation of α7nAChR by a selective agonist PNU-282987 pre-vented H202-indced decrease of cell viability and increase of lactate dehydrogenase release. Activation of α7nAChR markedly reduced cell apoptosis and intracellular oxidative stress level. Moreover, activation of α7nAChR reduced H2 02 -induced VPO-1 protein upregulation and JNK1/2 phosphorylation. The inhibitory effect of α7nAChR activa- tion on VPO-1 was blocked by JNK inhibitor SP600125. In addition, pretreatment of α7nAChR antagonist methyl- lycaconitine blocked the cytoprotective effect of PNU-282987. Conclusion These results provide the first evidence that activation of α7nAChR protects against oxidant stress-induced damage by suppressing VPO-1 in a JNK signa- ling pathway-dependent manner in endothelial cells.

关键词： Alpha7 nicotinic acetylcholine receptor vascular peroxidase-1 oxidation apoptosis endothelial cells JNK signaling

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SmI_2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched β-amino acid esters

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Science China Chemistry 2011年第1期54卷 61-65页

作者： WANG Li shen Chun XU ming-Hua Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

A facile and efficient method for the stereoselective synthesis of β-amino acid esters via SmI2-promoted imino-Reformatsky reaction is *** addition of tert-butyl bromoacetate to N-tert-butanesulfinyl aldimines afforded β-amino acid esters in moderate to high yields with excellent *** synthetic utilities of the tert-butyl β-amino acid esters were expanded by the preparation of β-lactams and 3-aminoindan-1-ones derivatives.

关键词： β-amino acid ester samarium diiodide N-tert-butanesulfinyl imine Reformatsky reaction β-lactam 3-aminoindan-1-one asymmetric synthesis

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Donut and spheroid mitochondria: eating, regenerating or trash them out?

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Life Metabolism 2023年第3期2卷 2-4页

作者： Wen-Xing Ding Han-ming shen Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160United States Division of Gastroenterology Hepatology and MobilityDepartment of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States Faculty of Health Sciences Ministry of Education Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China

In response to stress,mitochondrion undergoes constant morphological changes,including the formation of donut and spheroid mitochondria,and both are believed to be implicated in its biological *** are critical for cellular metabolic homeostasis and cell survival and death in eukaryotic *** are dynamic organelles that constantly undergo fission and *** homeostasis is tightly regulated by mitophagy for the removal of damaged or excess mitochondria and by mitochondria biogenies of new *** can also undergo other morphological transformation,such as formation of donut-like mitochondria or mitochondrial spheroids,and can also be secreted into the extracellular *** we discuss the mechanistic insights and physiological relevance of the donut-like mitochondria or mitochondrial spheroids and the secretion of mitochondria in cell biology.

关键词： functions insight excess

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High Nitrogen Austenitic Stainless Steels Manufactured by Nitrogen Gas Alloying and Adding Nitrided Ferroalloys

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Journal of Iron and Steel Research International 2007年第3期14卷 63-68页

作者： LI Hua-bing JIANG Zhou-hua shen ming-hui YOU Xiang-mi School of Materials and Metalllargy Northeastern University Shenyang 110004 Liaoning China

A simple and feasible method for the production of high nitrogen austenitic stainless steels involves nitrogen gas alloying and adding nitrided ferroalloys under normal atmospheric conditions. Alloying by nitrogen gas bubbling in Fe-Cr-Mn-Mo series alloys was carried out in MoSi2 resistance furnace and air induction furnace under normal atmospheric conditions. The results showed that nitrogen alloying could be accelerated by increasing nitrogen gas flow rate, prolonging residence time of bubbles, increasing gas/molten steel interfaces, and decreasing the sulphur and oxygen contents in molten steel. Nitrogen content of 0.69% in 18Crl8Mn was obtained using air induction furnace by bubbling of nitrogen gas from porous plug. In addition, the nickel-free, high nitrogen austenitic stainless steels with sound and compact macrostructure had been produced in the laboratory using vacuum induction furnace and electroslag remelting furnace under nitrogen atmosphere by the addition of nitrided alloy with the maximum nitrogen content of 0.81%. Pores were observed in the ingots obtained by melting and casting in vacuum induction furnace with the addition of nitrided ferroalloys and under nitrogen atmosphere. After electroslag remelting of the cast ingots, they were all sound and were free of pores. The yield of nitrogen increased with the decrease of melting rate in the ESR process. Due to electroslag remelting under nitrogen atmosphere and the consequential addition of aluminum as deoxidizer to the slag, the loss of manganese decreased obviously. There existed mainly irregular Al2O3 inclusions and MnS inclusions in ESR ingots, and the size of most of the inclusions was less than 5 um. After homogenization of the hot rolled plate at 1 150℃ × 1 h followed by water quenching, the microstructure consisted of homogeneous austenite.

关键词： nitrogen gas alloying nitrided ferroalloy high nitrogen austenitic stainless steel vacuum induction melting electroslag remelting

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外源5-氨基乙酰丙酸对涝渍胁迫下小麦幼苗生长的影响

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安徽农业科学 2024年第19期52卷 30-32,40页

作者：葛猜猜吕享华申明岳李磊青岛市农业科学研究院山东青岛266100

[目的]探究5-氨基乙酰丙酸(5-ALA)浸种对涝渍胁迫下小麦幼苗生长的影响。[方法]以红地95小麦品种为试验材料,利用不同质量浓度梯度的5-ALA对小麦进行浸种处理,采用“浸渍池”法模拟涝渍胁迫,测量小麦苗长、根长及鲜重,评价外源5-ALA在... 详细信息

[目的]探究5-氨基乙酰丙酸(5-ALA)浸种对涝渍胁迫下小麦幼苗生长的影响。[方法]以红地95小麦品种为试验材料,利用不同质量浓度梯度的5-ALA对小麦进行浸种处理,采用“浸渍池”法模拟涝渍胁迫,测量小麦苗长、根长及鲜重,评价外源5-ALA在涝渍胁迫下对于小麦幼苗生长形态的影响;同时测定叶绿素(Chl)、可溶性糖(SS)以及丙二醛(MDA)等相关物质含量,研究其在涝渍胁迫下对于小麦幼苗生理代谢的影响。[结果]随着外源5-ALA质量浓度增大,小麦的生长活力先升高后下降。适宜浓度的5-ALA浸种使小麦在涝渍胁迫下苗长、叶绿素及可溶性糖的含量较CK组升高,降低了小麦组织中丙二醛含量,提高了小麦的抗涝性;而高浓度5-ALA则对小麦生长起抑制作用。[结论]最佳处理质量浓度为50、80、100 mg/L处理下对小麦幼苗生长起抑制作用。

关键词： 5-氨基乙酰丙酸涝渍胁迫小麦抗涝性

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Growth process,defects,and dopants of bulkβ-Ga_(2)O_(3)semiconductor single crystals

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China Foundry 2024年第5期21卷 491-506页

作者： Yan-shen Wang ming-zhi Zhu Yuan Liu School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology(Ministry of Education) Beijing 100084China

β-gallium oxide(β-Ga2O3),as the typical representative of the fourth generation of semiconductors,has attracted increasing attention owing to its ultra-wide bandgap,superior optical properties,and excellent tolerance to high temperature and *** to the single crystals of other semiconductors,high-quality and large-sizeβ-Ga_(2)O_(3)single crystals can be grown with low-cost melting methods,making them highly *** this review,the growth process,defects,and dopants ofβ-Ga_(2)O_(3)are primarily ***,the growth process(e.g.,decomposition,crucible corrosion,spiral growth,and development)ofβ-Ga_(2)O_(3)single crystals are summarized and compared in ***,the defects ofβ-Ga_(2)O_(3)single crystals and the influence of defects on Schottky barrier diode(SBD)devices are emphatically ***,the influences of impurities and intrinsic defects on the electronic and optical properties ofβ-Ga_(2)O_(3)are also briefly *** this comprehensive analysis,the article offers a concise summary of the current state,challenges and prospects ofβ-Ga_(2)O_(3)single crystals.

关键词： β-Ga_(2)O_(3) single-crystal growth defects dopants semiconductor

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NUMERICAL STUDY ON SALINITY STRATIFICATION IN THE OUJIANG RIVER ESTUARY

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Journal of Hydrodynamics 2009年第6期21卷 835-842页

作者： JIANG Heng-zhi shen Yong-ming WANG Shou-dong State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China Transport Planning and Research Institute Beijing 100048 China

The variations of current, salt intrusion and vertical stratification under different conditions of river flow and wind in the Oujiang River Estuary （ORE） were investigated in this article using the Environmental Fluid Dynamics Code （EFDC）. The model was verified against water level variation, velocity, and salinity variations in June 2005. The simulation results agreed well with measured data. Six sensitivity tests were conducted for different conditions of river flow and wind specified in the model. Model results show that salinity intrudes further upstream under scenarios with low flow and downriver local wind conditions. In contrast, the responses of salinity stratification to different environmental forcing functions were different in different portions of the estuary. Salinity stratification was enhanced under high flow condition. Model results also show that wind is not crucial to the salt intrusion and salinity stratification in the ORE.

关键词： salinity stratification wind river discharge Oujiang River Estuary(ORE)

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糖尿病肾病蛋白质摄入水平与患者肾脏功能损害进展及预后的关联性

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中国食物与营养 2024年第8期30卷 78-83页

作者：沈晴明戚洪陈珍珍袁玲安徽理工大学第一附属医院(淮南市第一人民医院)肾脏内科安徽淮南232000

目的:探讨不同的蛋白质摄入水平与糖尿病肾病(DKD)患者肾功能损伤程度进展的关系。方法:采用前瞻性队列研究方法,选取早期DN患者进行随访观察,根据患者入组前1周监控的24小时尿尿素氮评估蛋白质摄入量,参考2020年肾病预后质量建议(KDOQI... 详细信息

目的:探讨不同的蛋白质摄入水平与糖尿病肾病(DKD)患者肾功能损伤程度进展的关系。方法:采用前瞻性队列研究方法,选取早期DN患者进行随访观察,根据患者入组前1周监控的24小时尿尿素氮评估蛋白质摄入量,参考2020年肾病预后质量建议(KDOQI)标准,符合低蛋白饮食标准的早期DN患者53例[蛋白质摄入量0.6~0.8 g/(kg·d)(低蛋白组)]、符合高蛋白饮食标准的早期DN患者54例[蛋白质摄入量>0.8 g/(kg·d)(高蛋白组)],对两组患者进行连续随访12个月,对比肾功能相关指标的变化及预后差异。结果:在入组时,低蛋白组和高蛋白组的FPG、HbA1c、SBP、DBP、TG、TC水平比较,差异均无统计学意义(P>0.05);随访24个月,低蛋白组的FPG、HbA1c、SBP、DBP、TG、TC水平与高蛋白组比较,差异均无统计学意义(P>0.05);在入组时,低蛋白组和高蛋白组的BUN、Scr、24小时尿蛋白、ALB、血尿酸、β2-MG水平比较,差异均无统计学意义(P>0.05);随访24个月,低蛋白组的BUN、Scr、24小时尿蛋白、血尿酸、β2-MG水平均低于高蛋白组,差异均具有统计学意义(P<0.05);随访24个月,低蛋白组有7例患者发生终点事件,高蛋白组有17例患者发生终点事件,低蛋白组的终点事件发生率显著低于高蛋白组(P<0.05)。对两组患者进行生存分析,低蛋白组患者的无疾病进展生存时间长于高蛋白组(χ^(2)=3.953、P=0.047<0.05)。结论:对于早期DKD患者,采取低蛋白饮食控制干预,有利于延缓肾功能损伤进展,降低临床期DKD的发生率。

关键词：蛋白质糖尿病肾病肾功能损伤预后尿素氮

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“自然活水”生态特性与水体自净潜能开发研究

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海河水利 2024年第7期 1-7页

作者：李荣福徐悦申宝明俞茜扬州大学苏中发展研究院江苏扬州225001 江苏农环生态环境工程有限公司江苏扬州225002 扬州市蜀冈瘦西湖风景名胜区管委会江苏扬州225003 中国水利水电科学研究院北京100038

为探索“自然活水”生态特性与净化潜能开发利用,运用流体力学、生物化学和生态学原理观察、分析“自然活水”理化特性和生态过程,提出了“自然活水”是持续流动的“微生态系统”,其生态净化效能远胜封闭“呆水”。因“自然活水”成因... 详细信息

为探索“自然活水”生态特性与净化潜能开发利用,运用流体力学、生物化学和生态学原理观察、分析“自然活水”理化特性和生态过程,提出了“自然活水”是持续流动的“微生态系统”,其生态净化效能远胜封闭“呆水”。因“自然活水”成因、水流性状、化学反应、生物构成和生态过程等不确定性影响了其生态净化效率与效能稳定性,提出了开发水体自净潜能的思路和对策,包括仿生态化改造水体、连通活化水系和优化生态系统等。

关键词：自然活水生态活水微生态系统自然净化

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