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基于标签集相关性学习的大规模网络图像在线标注

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自动化学报 2014年第8期40卷 1635-1643页

作者：田枫沈旭昆北京航空航天大学虚拟现实技术与系统国家重点实验室北京100191 东北石油大学计算机与信息技术学院大庆163318

传统的网络图像标注方法忽视了标签集整体相关性对标注结果的影响,导致标签集整体相关性缺乏和语义冗余.为了解决上述问题,提出了一种基于标签集相关性学习的大规模网络图像在线语义标注方法.给出了标签集对图像相关性和标签集内部相关... 详细信息

传统的网络图像标注方法忽视了标签集整体相关性对标注结果的影响,导致标签集整体相关性缺乏和语义冗余.为了解决上述问题,提出了一种基于标签集相关性学习的大规模网络图像在线语义标注方法.给出了标签集对图像相关性和标签集内部相关性的概率估计算法,将上述约束形成一个优化问题,采用贪心搜索策略获取近似最优解,找到能合理地平衡上述因素的标签集,并针对大规模图像集和概念集进行了优化.真实环境下大规模网络图像集上的测试表明,相比于目前的代表性网络图像标注方法,该方法获得的标签集能够更好的描述图像语义,性能提升明显.

关键词：网络图像标注图像语义标注标签集相关性标签相关性学习

改革开放四十年中国文化管理顶层设计的历史脉络与路径选择

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理论与改革 2018年第4期 17-24页

作者：申坤中国艺术研究院中共中央党校

文化艺术具有政治性、思想性、公共性和商品属性,而这四个特点也使得文化管理顶层设计要遵循相应的四个原则,即意识形态原则、功利性原则、公益性原则、民族性原则。改革开放四十年来,中国文化管理顶层设计主要围绕管理主体认定、管理... 详细信息

文化艺术具有政治性、思想性、公共性和商品属性,而这四个特点也使得文化管理顶层设计要遵循相应的四个原则,即意识形态原则、功利性原则、公益性原则、民族性原则。改革开放四十年来,中国文化管理顶层设计主要围绕管理主体认定、管理角色分配和管理路径选择三个主要环节展开,并依次呈现计划统治型、政府主导型、市场引导型、合作共治型四种类型的文化管理顶层设计模型。党的十九大以来,在实现中华民族伟大复兴的宏伟目标和新时代中国特色社会主义文化建设的背景之下,文化管理顶层设计呈现新方向、新特点、新趋势,逐步形成政府搭台、市场引导、社会参与、公民创新的文化治理体系。

关键词：改革开放四十年文化管理顶层设计路径选择

Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol

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The Innovation 2022年第3期3卷 73-79页

作者： Ziling Ye Bin Shi Yanglei Huang Tian Ma Zilei Xiang Ben Hu Zhaolin Kuang Man Huang Xiaoying Lin Zhu Tian Zixin Deng kun shen Tiangang Liu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education and School of Pharmaceutical SciencesWuhan UniversityWuhan 430071China J1 Biotech Co. Ltd.Wuhan 430075China

Vitamin E is one of the most widely used *** the classical commercial synthesis of vitamin E(a-tocopherol),the chemical synthesis of isophytol is the key technical ***,we establish a new process for isophytol synthesis from microbial fermented *** achieve an efficient pathway for farnesene production,Saccharomyces cerevisiae was selected as the host ***,b-farnesene synthase genes from different sources were screened,and through protein engineering and system metabolic engineering.

关键词： strain synthesis starting

Optimizing the Diameter of Plugging Balls in Deep Shale Gas Wells

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Fluid Dynamics & Materials Processing 2024年第3期20卷 609-624页

作者： Yi Song Zheyu Hu Cheng shen Lan Ren Xingwu Guo Ran Lin kun Wang Zhiyong Zhao Shale Gas Research Institute PetroChina Southwest Oil&Gasfield CompanyChengdu610056China State Key Laboratory of Oil&Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China National Pipe Network Group Sichuan East Natural Gas Transmission Pipeline Co. Ltd.Wuhan430205China Fracturing Acidizing Company Downhole Operation Company of Chuanqing Drilling Engineering Co.Ltd.Chengdu610213China

Deep shale gas reserves that have been fractured typically have many relatively close perforation holes. Due to theproximity of each fracture during the formation of the fracture network, there is significant stress interference,which results in uneven fracture propagation. It is common practice to use “balls” to temporarily plug fractureopenings in order to lessen liquid intake and achieve uniform propagation in each cluster. In this study, a diameteroptimization model is introduced for these plugging balls based on a multi-cluster fracture propagationmodel and a perforation dynamic abrasion model. This approach relies on proper consideration of the multiphasenature of the considered problem and the interaction force between the involved fluid and solid phases. Accordingly,it can take into account the behavior of the gradually changing hole diameter due to proppant continuousperforation erosion. Moreover, it can provide useful information about the fluid-dynamic behavior of the consideredsystem before and after plugging. It is shown that when the diameter of the temporary plugging ball is1.2 times that of the perforation hole, the perforation holes of each cluster can be effectively blocked.

关键词： Deep shale gas fracture propagation fluid mechanics fluid-solid coupling perforation hole abrasion

Major royal-jelly proteins intake modulates immune functions and gut microbiota in mice

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Food Science and Human Wellness 2024年第1期13卷 444-453页

作者： Hang Wu Shican Zhou Wenjuan Ning Xiao Wu Xiaoxiao Xu Zejin Liu Wenhua Liu kun Liu Lirong shen Junpeng Wang Infection and Immunity Institute and Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475000China College of Biology Science and Engineering Hebei University of Economics and BusinessShijiazhuang 050061China College of Biosystems Engineering and Food Science Zhejiang Key Laboratory for Agro-Food ProcessingZhejiang UniversityHangzhou 310058China

In this study,we investigated the effects of major royal jelly proteins(MRJPs)on the estrogen,gut microbiota,and immunological responses in *** given 250 or 500 mg/kg,not 125 mg/kg of MRJPs,enhanced the proliferation of splenocytes in response to *** splenocytes and mesenteric lymphocytes activated by T-cell mitogens(Con A and anti-CD3/CD28 antibodies)released high levels of IL-2 but low levels of IFN-γand *** release of IL-4 was unaffected by ***,splenocytes and mesenteric lymphocytes activated by LPS were prevented by MRJPs at the same dose as that required for producing IL-1βand IL-6,two pro-inflammatory *** production of IL-1β,IL-6,and IFN-γwas negatively associated with estrogen levels,which were higher in the MRJP-treated animals than in the control *** of the gut microbiota revealed that feeding mice 250 mg/kg of MRJPs maintained the stability of the natural intestinal microflora of ***,the LEf Se analysis identified biomarkers in the MRJP-treated mice,including Prevotella,Bacillales,Enterobacteriales,Gammaproteobacteria,Candidatus_Arthromitus,and *** results showed that MRJPs are important components of royal jelly that modulate host immunity and hormone levels and help maintain gut microbiota stability.

关键词： Major royal-jelly proteins Immunity Estrogen Gut microbiota Cytokines

JrATHB-12 mediates JrMYB113 and JrMYB27 to control the anthocyanin levels in different types of red walnut

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Journal of Integrative Agriculture 2024年第8期23卷 2649-2661页

作者： Haifeng Xu Guifang Wang Xinying Ji kun Xiang Tao Wang Meiyong Zhang Guangning shen Rui Zhang Junpei Zhang Xin Chen Key Laboratory of Huanghuai Protected Horticulture Engineering/National Germplasm Repository of Walnut and Chestnut Shandong Institute of PomologyTai’an 271000China Research Institute of Forestry Chinese Academy of ForestryBeijing 100091China College of Horticulture and Forestry Tarim UniversityAlaer 843300China

Red walnut has broad market prospects because it is richer in anthocyanins than ordinary ***,the mechanism driving anthocyanin biosynthesis in red walnut is still *** studied two types of red walnut,called red walnut 1(R1),with a red pericarp and seed coat,and red walnut 2(R2),with a red seed coat only.R1 mostly contained cyanidin-3-O-galactoside,while R2 contained a various amounts of cyanidin-3-Ogalactoside,cyanidin-3-O-arabinoside,and *** LDOX-2(LOC109007163)and LDOX-3(LOC109010746)genes,which encode leucoanthocyanidin dioxygenase/anthocyanidin synthase(LDOX/ANS),were preliminarily indicated as the crucial genes for anthocyanin biosynthesis in R1 and R2,*** MYB differential genes analysis showed that MYB27 and MYB113 are specifically expressed in the red parts of R1 and R2,respectively,and they are regarded as candidate regulatory *** expression in Arabidopsis and transient injection in walnut showed that both MYB27 and MYB113 were located in the nucleus and promoted anthocyanin accumulation,while MYB27 promoted the expression of LDOX-2,and MYB113 promoted the expression of LDOX-3and *** one-hybrid and electrophoretic mobility shift assays showed that MYB27 could only bind to the LDOX-2 promoter,while MYB113 could bind to the promoters of both LDOX-3 and *** addition,we also identified an HD-Zip transcription factor,ATHB-12,which is specifically expressed in the *** silencing the expression of ATHB-12,the R2 pericarp turned red,and MYB113 expression *** experiments showed that ATHB-12 could specifically interact with MYB113 and bind to its *** suggests that MYB27controls R1 coloration by regulating LDOX-2,while MYB113 controls R2 coloration by regulating LDOX-3 and UAGT-3,but ATHB-12 can specifically bind to and inhibit the MYB113 of the R2 pericarp so that it becomes *** study reveals the anthocyanin biosynthetic mechanisms in two differ

关键词： JrATHB-12 JrMYB113 JrMYB27 red walnut anthocyanin biosynthesis

百令胶囊联合肺康复医疗体操对缓解期COPD的疗效观察

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中国中药杂志 2008年第8期33卷 942-944页

作者：沈志坤湖州师范学院医学院临床医学教研室浙江湖州313000

目的:探讨百令胶囊与肺康复医疗体操联合治疗对缓解期慢性阻塞性肺疾病的影响。方法:采用前瞻性研究方法将50例缓解期慢性阻塞性肺疾病患者随机分成2组,对照组(25例)单用常规西药治疗;治疗组(25例)加服百令胶囊并联合肺康复医疗体操治疗... 详细信息

目的:探讨百令胶囊与肺康复医疗体操联合治疗对缓解期慢性阻塞性肺疾病的影响。方法:采用前瞻性研究方法将50例缓解期慢性阻塞性肺疾病患者随机分成2组,对照组(25例)单用常规西药治疗;治疗组(25例)加服百令胶囊并联合肺康复医疗体操治疗;疗程均为6个月,观察患者肺通气、呼吸困难、抗病能力的改善状况。结果:治疗组疗效明显优于对照组,患者呼吸困难状况改善,呼吸困难分级的平均级数的下降率:治疗组为24.53%,对照组仅3.7%;各项肺通气指标均明显升高(P<0.05或P<0.01);治疗组治疗前后免疫功能提高(P<0.01)。结论:中药百令胶囊结合肺康复医疗体操是缓解期慢性阻塞性肺疾病患者,尤其是肺肾气虚者提高免疫力,改善肺功能的良好方案。

关键词：百令胶囊医疗体操慢性阻塞性肺疾病疗效观察

儿童EB病毒相关性噬血细胞淋巴组织细胞增生症

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中华儿科杂志 2009年第12期47卷 956-959页

作者：卢根申昆玲首都医科大学附属北京儿童医院呼吸感染科 100045

噬血细胞淋巴组织细胞增生症（hemophagocytic lymphohistioc）rtosis，HLH）是指一组以良性组织细胞增生和活化伴随其噬血细胞现象的一类综合征。主要发牛在有各种遗传性或获得性免疫缺陷的基础上，包括原发性和继发性两种形式。其显... 详细信息

噬血细胞淋巴组织细胞增生症（hemophagocytic lymphohistioc）rtosis，HLH）是指一组以良性组织细胞增生和活化伴随其噬血细胞现象的一类综合征。主要发牛在有各种遗传性或获得性免疫缺陷的基础上，包括原发性和继发性两种形式。其显著特征为淋巴细胞和组织细胞大量活化、增殖伴高细胞因子血症。其发病主要足被感染诱发。

关键词：噬血细胞淋巴组织细胞增生症病毒相关性获得性免疫缺陷 EB 儿童高细胞因子淋巴细胞综合征

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肺炎支原体肺炎合并脑梗死三例分析

中华儿科杂志 2009年第12期47卷 946-949页

作者：王维申昆玲首都医科大学附属北京儿童医院内科 100045

目的分析探讨儿童肺炎支原体肺炎合并脑梗死的病例特点和诊断方法。方法总结3例肺炎支原体肺炎合并脑梗死患儿的临床表现、影像学改变，并复习相关文献。结果3例患儿均为学龄或学龄前期儿童，以呼吸道感染起病，出现急性偏瘫，伴或不伴... 详细信息

目的分析探讨儿童肺炎支原体肺炎合并脑梗死的病例特点和诊断方法。方法总结3例肺炎支原体肺炎合并脑梗死患儿的临床表现、影像学改变，并复习相关文献。结果3例患儿均为学龄或学龄前期儿童，以呼吸道感染起病，出现急性偏瘫，伴或不伴抽搐发作。血清肺炎支原体抗体IgM测定阳性。肺部影像学提示大片炎性实变，有合并肺不张或胸腔积液，头颅影像学提示大脑中动脉栓塞及相应供血区脑梗死。予阿奇霉素抗感染治疗及抗凝、溶栓等对症治疗，神经系统症状、体征有不同程度好转。结论根据3例患儿呼吸道症状及肺部影像学改变，肺炎支原体肺炎诊断成立，同时神经系统症状体征及头颅影像学改变，诊断合并脑梗死。

关键词：肺炎支原体脑梗塞支原体肺炎