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Lactosylated N-Alkyl polyethylenimine coated iron oxide nanoparticles induced autophagy in mouse dendritic cells

Regenerative Biomaterials 2018年第3期5卷 141-149页

作者： Taipeng shen Wencheng Zhu Li Yang Li Liu Rongrong Jin Jimei Duan James M.Anderson hua ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065People’s Republic of China Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of SciencesShanghai 200031People’s Republic of China Departments of Pathology Macromolecular Science and Biomedical EngineeringCase Western Reserve UniversityClevelandOH 44106USA Department of Radiology West China HospitalSichuan UniversityChengdu 610065People’s Republic of China

Dendritic cell(DC)-based vaccines have shown promising therapeutic results in cancer and some immune *** is critical to track in vivo migration behaviours of DCs and monitor the whole process dynamically and *** iron oxide(SPIO)nanoparticles are chosen for DC labelling under magnetic resonance imaging(MRI)because of their proven biosafety as contrast ***,when used for cell labelling,sensitive biological indicators such as cell autophagy may be helpful to better understand the process and improve the probe ***,lactosylated N-Alkyl polyethylenimine coated SPIO nanoparticles are used for DC *** probe shows satisfactory cell labelling efficiency and low *** this study,autophagy was used as a key factor to understand how DCs react to nanoparticles after *** results demonstrate that the nanoparticles can induce protective autophagy in DCs,as inhibition of the autophagy flux could lead to cell ***,the nanoparticles induced autophagy could promote DC maturation which is an essential process for its migration and antigen *** induced DC maturation is known to enhance the vaccine functions of DCs,therefore,our results suggest that beyond the MRI tracking ability,this probe might enhance therapeutic immune activation as well.

关键词： dendritic cell nanoparticle autophagy cell maturation

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Nucleophilic substitution of hydrogen in naphthalene by chloride(Cl^-)in ionic liquids

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Chinese Chemical Letters 2011年第2期22卷 147-150页

作者： shen Yi Shi ai Guo Kong Xin hua Zhao Han Ming Ding Fan Yang Yong Kui Shan Department of Chemistry East China Normal UniversityShanghai 200062China

Nucleophilic aromatic substitution of hydrogen in non-activated aromatic ring,a very rare phenomenon in organic chemistry,is found in ionic liquids containing Cl^- as anion under mild reaction *** reaction may be carried out by the addition of the halogen-bonding adduct（Br2Cl^-） as nucleophile to aromatic ring carbon atom,leading to the formation of the nucleophilic substitution product.

关键词： Ionic liquid Aromatic compound Naphthalene Nucleophilic reaction Halogen bonding

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Tianmouc vision chip designed for open-world sensing

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Science China Materials 2024年第9期67卷 3046-3048页

作者： Haotian Li Qilin hua Guozhen shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing102488China

Driven by the forward development of highly interactive applications like autonomous robots and artificial intelligence[1,2],image sensors are continuously demanded to improve in terms of high speed,high resolution,wide dynamic range,and high precision[3].However,due to inherent limitations in power and bandwidth,significant enhancements in one aspect often necessitates compromises in others[4].

关键词： artificial interactive autonomous

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Determination of the Refractive Index Profile of a Polymer Waveguide by Photobleaching

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Chinese Physics Letters 2000年第6期17卷 433-434页

作者： SHAN Ji-Xiang shen Qi-Shun ZHANG ai-hua CAO Zhuang-Qi CHEN Ying-Li Department of Applied Physics Jiao Tong UniversityShanghai 200030

The shrinkage effect of polymer films,which was demonstrated in our photobleaching experiment,can be fitted approximately by an exponentially decaying *** taking the shrinkage effect into account,the index profile of the polymer waveguide was determined to be a Fermi function with the help of the m-line method and the exact transfer matrix theory.

关键词： function waveguide Waveguide

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湖山林场赤杨叶人工林的径级结构和空间分布格局研究

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浙江林业科技 2019年第1期39卷 16-20页

作者：赖根伟吴初平邱伟清沈爱华袁位高胡双台焦洁洁湖山林场浙江遂昌323300 浙江省林业科学研究院浙江杭州310023

2016年8月,采用固定样地调查的方法,在遂昌湖山林场的赤杨叶Alniphyllum fortunei人工林中建立1个50m×50m的监测样地,并进行了乔木层调查。结果表明:(1)共记录到乔木树种4种,分别为赤杨叶、杉木Cunninghamia lanceolata,黄檀Dalbergia ... 详细信息

2016年8月,采用固定样地调查的方法,在遂昌湖山林场的赤杨叶Alniphyllum fortunei人工林中建立1个50m×50m的监测样地,并进行了乔木层调查。结果表明:(1)共记录到乔木树种4种,分别为赤杨叶、杉木Cunninghamia lanceolata,黄檀Dalbergia hupeana和青冈Cyclobalanopsis glauca。(2)从空间分布看,该样地林分的混交程度较差,林木分化不明显,林分呈现均匀分布。(3)通过分析环境因子对赤杨叶胸径生长的影响,发现样地内只有土层厚度对赤杨叶的生长有显著影响(P<0.01)。为了促进遂昌湖山林场赤杨叶人工林的生长,本文认为该林分需要及时进行密度调控,并注意加强土壤管理。

关键词：赤杨叶径级结构空间分布格局湖山林场

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A Recognition Method of Hydrometeor in Tropical Cyclones by Using the GPM Dual-Frequency Precipitation Radar

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Journal of Tropical Meteorology 2021年第2期27卷 161-168页

作者： QIAO Jun-qi ai Wei-hua HU Xiong HU shen-sen YAN Wei College of Meteorology and Oceanography National University of Defense TechnologyNanjing 211101 China

In this paper,we propose a fuzzy logic algorithm to recognize the types of hydrometeors by using Ka and Ku reflectivity factors,temperature thresholds and an asymmetric t-form membership *** identifiable types of hydrometeors include snow,graupel,mixed-phase particles,large raindrops,and small *** reflectivity detection data of Ka and Ku with attenuation correction is from dual-frequency precipitation radar onboard the global precipitation measurement *** temperature data from the European Centre for Medium-range Weather Forecasts are used to identify the hydrometeors,and the identified hydrometeors are compared with the vertical profiles of phase from official level-2 DPR *** results show that the identified hydrometeors are reasonable and reveal the evolution process of tropical cyclones,which can be further applied to the study of precipitation microphysical process and artificial precipitation.

关键词： GPM DPR hydrometeor tropical cyclones fuzzy logical phase

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Event-triggered model-free adaptive control for a class of surface vessels with time-delay and external disturbance via state observer

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Journal of Systems Engineering and Electronics 2023年第3期34卷 783-797页

作者： CHEN hua shen Chao huaNG Jiahui CAO Yuhan College of Science Hohai UniversityNanjing 210098China College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China Hohai-Lille College Hohai UniversityNanjing 211100China

This paper provides an improved model-free adaptive control(IMFAC)strategy for solving the surface vessel trajectory tracking issue with time delay and restricted ***,the original nonlinear time-delay system is transformed into a structure consisting of an unknown residual term and a parameter term with control inputs using a local compact form dynamic linearization(local-CFDL).To take advantage of the resulting structure,use a discrete-time extended state observer(DESO)to estimate the unknown residual ***,according to the study,the inclusion of a time delay has no effect on the linearization structure,and an improved control approach is provided,in which DESO is used to adjust for ***,a DESO-based event-triggered model-free adaptive control(ET-DESO-MFAC)is established by designing event-triggered conditions to assure Lyapunov *** when the system’s indicator fulfills the provided event-triggered condition will the control input signal be updated;otherwise,the control input will stay the same as it is at the last trigger moment.A coordinate compensation approach is developed to reduce the steady-state inaccuracy of trajectory ***,simulation experiments are used to assess the effectiveness of the proposed technique for trajectory tracking.

关键词： surface vessels event-triggered condition(ETC) discrete-time extended state observer(DESO) model-free adaptive control(MFAC) coordinate compensation

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A wearable sweat patch for non-invasive and wireless monitoring inflammatory status

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Journal of Semiconductors 2023年第10期44卷 7-9页

作者： Qilin hua Guozhen shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China

Sweat diagnostics are being developed to provide insights into monitoring human health status using an accessi-bly non-invasive technique of sweat analysis[1-3].Abundant compositions,ranging from electrolytes and metabolites to large proteins,can be found in sweat,which have similar types of physiological biomarkers observed in the blood[1].Recent advances in flexible electronics[4-7]have transformed conventional laboratory tests into personalized sweat molecu-lar analysis that facilitates real-time sensing of target biomark-ers[3].

关键词： patch wear analysis

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Strengthening mechanisms of reduced activation ferritic/martensitic steels:A review

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 335-348页

作者： Jin-hua Zhou Yong-feng shen Nan Jia Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China The State Key Lab of Rolling&Automation Northeastern UniversityShenyang 110819China

This review summarizes the strengthening mechanisms of reduced activation ferritic/martensitic(RAFM)***-angle grain boundaries,subgrain boundaries,nano-sized M_(23)C_(6),and MX carbide precipitates effectively hinder dislocation motion and increase high-temperature strength.M23C6 carbides are easily coarsened under high temperatures,thereby weakening their ability to block *** properties are improved through the reduction of M23C6 ***,the loss of strength must be compensated by other strengthening *** review also outlines the recent progress in the development of RAFM *** dispersion-strengthened steels prevent M23C6 precipitation by reducing C content to increase creep life and introduce a high density of nano-sized oxide precipitates to offset the reduced *** plastic deformation methods can substantially refine subgrains and MX carbides in the *** thermal deformation strengthening of RAFM steels mainly relies on thermo-mechanical treatment to increase the MX carbide and subgrain *** procedure increases the creep life of TMT(thermo-mechanical treatment)9Cr-1W-0.06Ta steel by~20 times compared with those of F82H and Eurofer 97 steels under 550℃/260 MPa.

关键词： reduced activation ferritic/martensitic steel strengthening mechanism high-angle grain boundary subgrain boundary precipitate

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From our roots, we grow

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Zoological Research 2019年第6期40卷 471-475页

作者： Yong-Gang Yao hua shen Kunming Institute of Zoology Chinese Academy of SciencesKunming Yunnan 650223China

Located at the head of the Indo-Burma biodiversity hotspot,the Kunming Institute of Zoology (KIZ), Chinese Academy of Sciences (CAS), serves as China’s main center for research into the diverse animal and ecological ... 详细信息

关键词： Kunming Institute of Zoology ecological resources

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