检索结果-南通市图书馆

New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第5期13卷 2519-2542页

作者： Xin Liu Di Wu yi shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China Institute for Global Food Security School of Biological SciencesBelfast B795DLUnited Kingdom NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Nutrition and Food Safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijing 100021China

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food *** advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food *** review explores the international landscape of new food sources and production systems(NFPS),focusing on China’s role and regulatory approaches compared to global *** this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s *** comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

关键词： New food sources Food production system Food safety International regulation Synthetic biology China

同方期刊数据库

Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong shao Ming-yi FU Yu ZHAO Rui-xia WANG Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

采用有限元+边界元方法研究非饱和地基中群桩基础的动力阻抗

在线全文

学校读者我要写书评

暂无评论

岩土力学 2024年第3期45卷 895-907页

作者：李绍毅吉首大学土木工程与建筑学院湖南张家界427000

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,... 详细信息

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,根据伴随矩阵性质推导其Green函数基本解答。基于桩体和地基土接触面作用力平衡条件和位移相容原理,建立非饱和地基边界元模型和群桩基础有限元模型的耦合数值模型;研究土体饱和度、桩体间距、长度、数目和地基分层等参数对群桩基础动力阻抗的影响。研究发现:地基饱和度增加可降低群桩基础刚度系数;荷载频率较低时增大饱和度可减小群桩基础阻尼系数。增加桩基数目和地基饱和度可增大桩基与地基土相互作用。下卧基岩分层地基可提高桩基与土体的相互作用,且对群桩水平阻抗影响显著。

关键词：非饱和介质群桩基础动力阻抗有限元+边界元方法分层地基

Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan Ang Xiao Lin Yang Yu-Lin Tao yi shao Qiong Zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated C kinase 1(RACK1)activates protein kinase C-ε(PKC-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RACK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RACK1 in mediating PKC-εin early ***,the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RACK1 and PKC-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RACK1 significantly downregulated the expression of PKC-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated C kinase 1 Protein kinase C-ε Adult retinal pigment epithelium cell line-19

Emotional differences based on comments on doctor-patient disputes with varying levels of severity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第7期14卷 1068-1079页

作者： Jing-Ru Lu Yu-Han Wei Xin Wang Yu-Qing Zhang Jia-yi shao Jiang-Jie Sun School of Health Care Management Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Management Hefei University of TechnologyHefei 230039Anhui ProvinceChina

BACKGROUND The risks associated with negative doctor-patient relationships have seriously hindered the healthy development of medical and healthcare and aroused wide-spread concern in *** number of public comments on doctor-patient relationship risk events reflects the degree to which the public pays attention to such *** incidents of doctor-patient disputes were collected from Weibo and TikTok,and 3655 related comments were *** number of comment sentiment words was extracted,and the comment sentiment value was *** Kruskal-Wallis H test was used to compare differences between each variable group at different levels of ***’s correlation analysis was used to examine associations between *** analysis was used to explore factors influencing scores of comments on *** The study results showed that public comments on media reports of doctor-patient disputes at all levels are mainly dominated by“good”and“disgust”emotional *** was a significant difference in the comment scores and the number of partial emotion words between comments on varying levels of severity of doctor-patient *** comment score was positively correlated with the number of emotion words related to positive,good,and happy)and negatively correlated with the number of emotion words related to negative,anger,disgust,fear,and *** The number of emotion words related to negative,anger,disgust,fear,and sadness directly influences comment scores,and the severity of the incident level indirectly influences comment scores.

关键词： Doctor-patient relationship Doctor-patient dispute Comments Emotional differences Weibo TikTok

Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1665-1674页

作者： Xue-Lin Wang Xu-Jun Zheng Li-Juan Zhang Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen yi-Xin Wang Xu Chen yi shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Jiangxi Medical College Shangrao 334000Jiangxi ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiff CF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands

AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)***:Twenty HR patients and 20 healthy controls(HCs)were respectively *** age,gender,and educational background characteristics of the two groups were *** functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF *** operating characteristic(ROC)curve analysis was used to classify the ***,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with ***:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual *** contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR *** results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.

关键词： hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

费雪货币论述与清代北京虚数钱计物价

清华大学学报（哲学社会科学版） 2024年第2期39卷 201-217,240页

作者：邵义中国香港999077

清代北京流通的钱币主要有制钱、当十钱和当十铜元。这三种不同钱币流通的时间分别为1644年—1856年、1853年—1907年、1901年—1935年。如何将历史文献中的钱计物价折合成当时流通钱币的文数并非易事,其原因是清代北京的钱计物价有虚... 详细信息

清代北京流通的钱币主要有制钱、当十钱和当十铜元。这三种不同钱币流通的时间分别为1644年—1856年、1853年—1907年、1901年—1935年。如何将历史文献中的钱计物价折合成当时流通钱币的文数并非易事,其原因是清代北京的钱计物价有虚实之分。北京的虚数物价具有以下的特征:第一,当制钱流通时,1文制钱作虚数2文,虚数1吊钱等于500文制钱;第二,咸丰七年至光绪三十一年,1枚当十钱作虚数20文,虚数1吊钱等于50枚当十钱;第三,光绪三十一年后,1枚当十铜元文作虚数100文,虚数1吊钱折合10枚当十铜元;第四,文献中虚数与实数的出现毫无规律可言。与以往的研究不同,运用费雪的货币论述可证明清代北京物价虚数的产生与演变,很可能是朝廷决策的经济后果。

关键词：清代北京虚数物价制钱京钱费雪

From Perspective of Hippocampal Plasticity:Function of Antidepressant Chinese Medicine Xiaoyaosan

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第8期30卷 747-758页

作者： ZHANG Wu-jing GUO Ze-xuan WANG yi-di FANG shao-yi WAN Chun-miao YU Xiao-long GUO Xiao-fang CHEN Yue-yue ZHOU Xuan HUANG Jun-qing LI Xiao-juan CHEN Jia-xu FAN Li-li Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhou510632China

The hippocampus is one of the most commonly studied brain regions in the context of *** volume of the hippocampus is significantly reduced in patients with depression,which severely disrupts hippocampal ***,antidepressant therapies that target hippocampal neuroplasticity have not been identified as *** medicine(CM)can slow the progression of depression,potentially by modulating hippocampal ***(XYS)is a CM formula that has been clinically used for the treatment of *** is known to protect Gan(Liver)and Pi(Spleen)function,and may exert its antidepressant effects by regulating hippocampal *** this review,we have summarized the association between depression and aberrant hippocampal ***,we have discussed the researches published in the last 30 years on the effects of XYS on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against *** results of this review can aid future research on XYS for the treatment of depression.

关键词： depression hippocampal neuroplasticity Xiaoyaosan Chinese medicine

Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1869-1879页

作者： Li-Ming Chen Min Kang Jun-yi Wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou yi-Xin Wang Xu Chen Ping ying Hui Huang yi shao Rui Wu Department of Rheumatology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First School of Clinical Medicine of Nanchang University Jiangxi Medical College of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200030China

AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal ***:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD *** 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control *** macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual *** densities of retinal microvascular(MIR),macrovascular(MAR),and total microvascular(TMI)were calculated and *** in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson ***:The OCTA data demonstrated a statistically significant difference(Pying the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation m

关键词： connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface retina