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Mitochondrial dysfunction: A promising therapeutic target for liver diseases

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Genes & Diseases 2024年第3期11卷 324-337页

作者： ping Chen lichao Yao Mengqin Yuan Zheng Wang Qiuling Zhang Yingan Jiang Lanjuan li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430060China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China

The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the *** tissues of pa-tients with alcohol-related or non-alcohol-related liver diseases contain ultrastructural mito-chondrial lesions,mitochondrial DNA damage,disturbed mitochondrial dynamics,and compromised ATP *** of mitochondrial reactive oxygen species in-duces oxidative damage to mitochondrial proteins and mitochondrial DNA,decreases mito-chondrial membrane potential,triggers hepatocyte inflammation,and promotes programmed cell death,all of which impair liver *** DNA may be a poten-tial novel non-invasive biomarker of the risk of progression to liver cirrhosis and hepatocellular carcinoma in patients infected with the hepatitis b *** herein present a review of the mechanisms of mitochondrial dysfunction in the development of acute liver injury and chronic liver diseases,such as hepatocellular carcinoma,viral hepatitis,drug-induced liver injury,alcoholic liver disease,and non-alcoholic fatty liver *** review also discusses mito-chondrion-centric therapies for treating liver diseases.

关键词： Chronic diseases liverdamage Mesenchymalstem cell Mitochondrial dysfunction Oxidativestress

High-resolution single-photon liDAR without range a.biguity using hybrid-mode imaging [Invited]

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Chinese Optics Letters 2024年第6期22卷 33-37页

作者： Xin-Wei Kong Wen-Long Ye Wenwen li Zheng-ping li Feihu Xu Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

We proposed a hybrid imaging scheme to estimate a high-resolution absolute depth map from low photon counts. It leverages measurements of photon arrival times from a single-photon liDAR and an intensity image from a conventional high-resolution camera. Using a tailored fusion algorithm, we jointly processed the raw measurements from both sensors and output a high-resolution absolute depth map. We scaled up the resolution by a factor of 10, achieving 1300 × 2611 pixels and extending ~4.7 times the una.biguous range. These results demonstrated the superior capability of long-range high-resolution 3D imaging without range a.biguity.

关键词： single-photon liDAR single-photon imaging hybrid-mode imaging

Unveiling the critical role of TiO_(2)-supported atomically dispersed Cu species for enhanced photofixation of N_(2)to nitrate

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Fundamental Research 2024年第4期4卷 934-940页

作者： Dong li Yunxuan Zhao Chao Zhou li-ping Zhang Junwang Tang Tierui Zhang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBejing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBejing 100049China School of Future Technology University of Chinese Academy of SciencesBejing 100049China Department of Chemical Engineering University College LondonLondon WC1E7JEUnited Kingdom

Nitrate products are widely used in manufacturing as crucial raw materials and *** traditional nitrate synthesis process involves high energy consumption and emission,thereby opposing the goals of zero-ca.bon emission and green ***,a sustainable roadmap for nitrate synthesis that uses green energy input,clean N sources,and direct catalytic processes is urgently required(e.g.,developing a novel photosynthesis system).Here,we synthesized TiO2-supported atomically dispersed Cu species for N_(2)photofixation to nitrate in a flow *** optimized photocatalyst yielded a high nitrate photosynthesis rate of 0.93μmol h-1 and selectivity of~90%,which is superior to most of the values reported thus ***,experimental results and in-situ investigations revealed that the atomically dispersed Cu sites in the as-designed sample significantly enhanced the separation and transfer efficiency of photogenerated carriers,adsorption and activation of reactants,and the formation of chemisorbed O_(x)intermediates,thereby realizing the excellent photofixation of N_(2)to nitrate.

关键词： N_(2) photofixation TiO_(2) Nitrate photosynthesis Cu species NO_(x),intermediates

Enhancement of polymyxin b1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu Wei Qiu-Man Xu Wei shang Qing li Jing-Sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic biology and Key Laboratory of Systems bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin b,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin b1 in the total of polymyxin b analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin b1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin b1 production was increased to 0.97 g/***,the polymyxin b1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin b1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

biobased Furfurylated Poplar Wood for Flame-Retardant Modification with boric Acid and Ammonium Dihydrogen Phosphate

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Journal of Renewable Materials 2024年第8期12卷 1355-1368页

作者： Ming Ni Lei li Yiqiang Wu Jianzheng Qiao Yan Qing ping li Yingfeng Zuo College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha410004China College of Furniture and Art Design Central South University of Forestry and TechnologyChangsha410004China

Furfurylated wood exhibits excellent dimensional stability and corrosion resistance,making it a promising material for constructing buildings,but it is highly ***,flame-retardant furfurylated poplar wood was produced via a two-step process utilizing boric acid(bA)and ammonium dihydrogen phosphate(ADP)as flame-retardant components,and biomass-derived furfuryl alcohol(FA)as a *** acidity of bA and ADP allowed them to catalyze the polymerization of FA,which formed a cross-linked network that immobilized bA and ADP inside the *** addition of bA/ADP substantially delayed the time to ignition from 10 to 385 s and reduced the total heat release and total smoke release by 58.75%and 77.31%,*** of the pyrolysis process showed that the decomposition products of bA and ADP protected the underlying furfurylated wood and diluted combustible *** method significantly improved the fire retardancy and smokeless properties of furfurylated wood,providing promising prospects for its application as an engineering material.

关键词： Poplar wood furfuryl alcohol furfurylated wood flame retardancy boric acid ammonium dihydrogen phosphate

Sturgeon Cartilage-Derived Chondroitin Sulfate Exhibited Anti-inflammatory Activity against DSS-induced Colitis via Modification of Gut Microbiota

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Food Science and Human Wellness 2024年

作者： Ruiyun Wu Zixin Han Zhenyu Wang pinglan li Nan shang Institute of Food Science and Technology， Chinese Academy of Agricultural Sciences， Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products， Ministry of Agriculture and Rural Affairs College of Food Science and Nutritional Engineering， China Agricultural University College of Engineering， China Agricultural University

Chondroitin sulfate (CS) is one of the main bioactive compounds in animal cartilage. In this study， the anti-inflammatory activity of sturgeon-derived chondroitin sulfate (SCS) was evaluated in the DSS-induced ba.b/c mice model. Orally administration of SCS significantly alleviated the DSS-induced colitis symptoms， including the reduction of crypt depth， inhibition of the abnormal crypt foci formation， down-regulation of the proinflammatory biomarkers (NO， IL-6， IL-1β and TNF-α) and up-regulation of the anti-inflammatory biomarkers (IL-10 and IL-4). The gut microbiota analysis revealed that SCS alters the intestinal microbiota composition in colitis mice， especially the increase of the relative abundance of Ruminococcaceae and Lachnospiracea. This alternation further induced primary bile acids convert into secondary bile acids. With SCS administration， the levels of deoxycholic acid (DCA) and litho cholic acid (LCA) were increased by ～1.5 and ～2.5-fold， respectively. The stimulated secretion of DCA and LCA showed further activation of the NF-κb signaling pathway， thereby suppressing the inflammatory response and attenuating IbD in mice. This study provided a valuable strategy for colitis prevention and treatment with sturgeon cartilage by-products.

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Two-dimensional conjugated coordination polymer monolayer as anode material for lithium-ion batteries:A DFT study

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Chinese Chemical Letters 2024年第6期35卷 180-184页

作者： Xin-Tong Zhao Jin-Zhi Guo Wen-liang li Jing-ping Zhang Xing-Long Wu MOE Key Laboratory for UV light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

Nowadays,lithium-ion batteries(libs)play a crucial role in modern society in the aspect of portable electronic devices and large-scale smart ***,the current performance of lithium-ion batteries has been unable to meet the growing expectations of society and scientific ***,we have synthetically investigated availability of 2D Ni-TAbQ monolayer as anode based on DFT for libs *** findings have demonstrated that 2D Ni-TAbQ monolayer is a semiconductor with a small band gap of 0.2 eV,which suggest that the electronic property of 2D Ni-TAbQ monolayer would take place an evident shift from semiconductor property to metallic property after li ***,we checked the stability of 2D Ni-TAbQ monolayer and investigated the viability of exfoliation from bulk multilayer Ni-TAbQ to form 2D Ni-TAbQ monolayer in the light of exfoliation energy and binding *** continuously studied electrochemical properties of 2D Ni-TAbQ monolayer with respect of theoretical specific capacity,li-ion diffusion barriers and open-circuit *** the charging process,2D Ni-TAbQ monolayer can achieve a high specific capacity of 722 m Ah/g with an open-circuit voltage range from 1.12 V to 0.22 *** aforementioned results make the 2D Ni-TAbQ monolayer a promising anode for libs.

关键词： The first principles Density functional theory lithium-ion battery Anode material Two-dimensional material

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-βsignaling

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Frontiers of Medicine 2024年第1期18卷 128-146页

作者： Yuanyuan Hao Panpan Chen Shanshan Guo Mengyuan li Xueli Jin Minghuan Zhang Wenhai Deng ping li Wen Lei a.bin liang Wenbin Qian Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310009China Department of Hematology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Key Laboratory of Laboratory Medicine Ministry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou325000China Department of Hematology Tongji Hospital of Tongji UniversityShanghai200065China

Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment for refractory and relapsed hematological malignancies, but whether lymphoma TEXs have the same impact on CAR T-cell remains unclear. Here, we demonstrated that b-cell lymphoma-derived exosomes induce the initial activation of CD19-CAR T-cells upon stimulation with exosomal CD19. However, lymphoma TEXs might subsequently induce CAR T-cell apoptosis and impair the tumor cytotoxicity of the cells because of the upregulated expression of the inhibitory receptors PD-1, TIM3, and LAG3 upon prolonged exposure. Similar results were observed in the CAR T-cells exposed to plasma exosomes from patients with lymphoma. More importantly, single-cell RNA sequencing revealed that CAR T-cells typically showed differentiated phenotypes and regulatory T-cell (Treg) phenotype conversion. by blocking transforming growth factor β (TGF-β)-Smad3 signaling with TGF-β inhibitor LY2109761, the negative effects of TEXs on Treg conversion, terminal differentiation, and immune checkpoint expression were rescued. Collectively, although TEXs lead to the initial activation of CAR T-cells, the effect of TEXs suppressed CAR T-cells, which can be rescued by LY2109761. A treatment regimen combining CAR T-cell therapy and TGF-β inhibitors might be a novel therapeutic strategy for refractory and relapsed b-cell lymphoma.

关键词： tumor-derived exosome chimeric antigen receptor T-cell lymphoma TGF-β

Dynamic modulation of nodulation factor receptor levels by phosphorylation-mediated functional switch of a RING-type E3 ligase during legume nodulation

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Molecular Plant 2024年第7期17卷 1090-1109页

作者： Hao li Yajuan Ou Jidan Zhang Kui Huang ping Wu Xiaoli Guo Hui Zhu Yangrong Cao National Key Lab of Agricultural Microbiology Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China National Key Lab of Agricultural Microbiology College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China

The precise control of receptor levels is crucial for initiating cellular signaling transduction in response to specific ligands;however,such mechanisms regulating nodulation factor(NF)receptor(NFR)-mediated perception of NFs to establish symbiosis remain *** this study,we unveil the pivotal role of the NFR-interacting RING-type E3 ligase 1(NIRE1)in regulating NFR1/NFR5 homeostasis to optimize rhizobial infection and nodule development in Lotus *** demonstrated that NiRE1 has a dual function in this regulatory *** associates with both NFR1 and NFR5,facilitating their degradation through K48-linked polyubiquitination before rhizobial ***,following rhizobial inoculation,NFR1 phosphorylates NIRE1ata conserved residue,Tyr-109,inducing a functional switch in NIRE1,which enables NIRE1tomediateK63-linkedpolyubiquitination,thereby stabilizing NFR1/NFR5 in infected root *** introduction of phospho-dead NIRE1Y1osF leads to delayed nodule development,underscoring the significance of phosphorylation at Tyr-1o9 in orchestrating symbiotic ***,expression of the phospho-mimic NIRE1Y0E results in the formation of spontaneous nodules in ***,further emphasizing the critical role of the phosphorylation-dependent functional switch in *** summary,these findings uncover a fine-tuned symbiotic mechanism that a single E3 ligase could undergo a phosphorylationdependent functional switch to dynamically and precisely regulate NF receptor protein levels.

关键词： nodule symbiosis nodulation factor receptors E3 ligase ubiquitination phosphorylation protein degradation protein stabilization Lotus japonicus