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Comprehensively analyzing the genetic alterations,and identifying key genes in ovarian cancer

Oncology Research 2023年第2期31卷 141-156页

作者： QINGLING TANG WARDA ATIQ shaista mahnoor MOSTAFA A.ABDEL-MAKSOUD MOHAMMED AUFY HAMID YAZ JIANYU ZHU Department of Gynecology and Obstetrics Shanghai Songjiang District Jiuting HospitalShanghai20000China Department of Medicine Fatima Jinnah Medical UniversityLahore42000Pakistan Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaVienna1010Austria Department of Trauma Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Though significant improvements have been made in the treatment methods for ovarian cancer(OC),the prognosis for OC patients is still *** hub genes associated with the development of OC and utilizing them as appropriate potential biomarkers or therapeutic targets is highly *** this study,the differentially expressed genes(DEGs)were identified from an independent GSE69428 Gene Expression Omnibus(GEO)dataset between OC and control *** DEGs were processed to construct the protein-protein interaction(PPI)network using ***,hub genes were identified through Cytohubba analysis of the *** and survival profiling of the hub genes were validated using GEPIA,OncoDB,and *** exploring promoter methylation levels and genetic alterations in hub genes,MEXPRESS and cBioPortal were utilized,***,DAVID,HPA,TIMER,CancerSEA,ENCORI,DrugBank,and GSCAlite were used for gene enrichment analysis,subcellular localization analysis,immune cell infiltration analysis,exploring correlations between hub genes and different diverse states,lncRNA-miRNA-mRNA co-regulatory network analysis,predicting hub gene-associated drugs,and conducting drug sensitivity analysis,*** total,8947 DEGs were found between OC and normal samples in *** STRING and Cytohubba analysis,4 hub genes including TTK(TTK Protein Kinase),(BUB1 mitotic checkpoint serine/threonine kinase B)BUB1B,(Nucleolar and spindle-associated protein 1)NUSAP1,and(ZW10 interacting kinetochore protein)ZWINT were selected as the hub ***,it was validated that these 4 hub genes were significantly up-regulated in OC samples compared to normal controls,but overexpression of these genes was not associated with overall survival(OS).However,genetic alterations in those genes were found to be linked with OS and disease-free(DFS)***,this study also revealed some novel links between TTK,BUB1B,NUSAP1,and ZWINT overexpression and promoter meth

关键词： Ovarian cancer Prognosis Diagnosis Therapeutic targets

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Medical decision support systems based on Fuzzy Cognitive Maps

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International Journal of Biomathematics 2019年第6期12卷 147-180页

作者： shaista Habib Muhaiijmad Akram Punjab University College of Information Technology University of the.Punjab LahorePakistan School of Systems and Technology University of Management and Technology Lahore Pakistan Department of Mathematics University of the Punjab New CampusLahorePakistan

This paper determines the risk for cardiovascular diseases(CVDs).and nutrition level in infants aged 06 montlis using Fuzzy Cognitive Maps(FCMs).The aim of this study is to facilitates the medical experts to early detects these diseases with accuracy,so that overall death ratio can be ***,we have introduced the concepts of FCMs and briefly refer to the applications of these methods in *** that,two intel ligent decision support systems for cardiovascular and malnutrition are developed using *** proposed cardiovascular risk assessment system takes six inputs:chest pain,cholesterol,heart rate,blood pressure,blood sugar,and old peak and determines CVDs *** second decision support system of malnutrition diagnosis takes twelve inputs:breastfeeding,daily income,maternal education,colostrum intake,energy intake,protein intake,vitamin A intake,iron intake,family size,height,weight,head circumference,and skin fold thickness and diagnoses the nutrition level in *** have explained the working of both decision support systems using case studies.

关键词： Fuzzy sets fuzzy cognitive maps algorithm time complexity cardiovascular diseases malnutrition.

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Diagnostic methods and risk analysis based on fuzzy soft information

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International Journal of Biomathematics 2018年第8期11卷 1-34页

作者： shaista Habib Muhammad Akrarn Punjab University College of Information echnology University of the Punjab Old Campus Lahore Pakistan University of Management and Technology Lahore Pakistan Department of Mathematics University of the Punjab New Campus Lahore Pakistan

In our daily life problem we face uncertainties in making right decisions. In this study, we propose two different decision-making problems in medical field. The first problem is fever diagnosing and second problem is mouth cancer risk analysis. In the first problem, we use fuzzy soft similarity measures and fuzzy soft matrix operations to diagnose the type of fever. We consider a hypothetical case study and manipulate similarity measures on it. Our work diagnoses different patients having similar symptoms. We also develop a small application using JAVA. In the second problem, we perform risk analysis of mouth cancer. The proposed fuzzy soft expert system takes two biochemical parameters as inputs that is, serum total malondialdehyde (MDA), and serum proton donors capacity (donors_protons) and determines the risk of mouth cancer. Our study facilitates doctors by diagnosing mouth cancer at its earlier stages. There are four main components of our fuzzy soft expert system. The first component is named as fuzzification which converts crisp input into linguistic variables and formulates fuzzy sets. The second component transforms fuzzy sets into their respective fuzzy soft sets. The third coinponent determines indispensable parameters and perforins parameter reduction. The fourth component performs risk analysis by using algorithm. We use exemplary dataset and run all the components of fuzzy soft expert system to compute cancer risk.

关键词： Fuzzy soft set similarity measure fuzzy soft metrics algorithm time complexity chikungunya malaria dengue mouth cancer serum total malondialdehyde serumproton donor capacity

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Comparative Analysis of Pythagorean MCDM Methods for the Risk Assessment of Childhood Cancer

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2585-2615页

作者： shaista Habib Muhammad Akram MMAli Al-Shamiri School of Systems and Technology University of Management and TechnologyLahorePakistan Department of Mathematics University of the PunjabNew CampusLahorePakistan Department of Mathematics Faculty of Science and ArtsMahayl AssirKing Khalid UniversityAbhaSaudi Arabia

According to the World Health Organization(WHO),cancer is the leading cause of death for children in low and middle-income *** 400,000 kids get diagnosed with this illness each year,and their survival rate depends on the country in which they *** this article,we present a Pythagorean fuzzy model that may help doctors identify the most likely type of cancer in children at an early stage by taking into account the symptoms of different types of *** Pythagorean fuzzy decision-making techniques that we utilize are Pythagorean Fuzzy TOPSIS,Pythagorean Fuzzy Entropy(PF-Entropy),and Pythagorean Fuzzy PowerWeighted Geometric(PFPWG).Ourmodel is fed with nineteen symptoms and it diagnoses the risk of eight types of cancers in *** develop an algorithm for each method and calculate its ***,we consider an example to make a clear understanding of our *** also compare the final results of various tests that prove the authenticity of this study.

关键词： Risk assessment Pythagorean fuzzy sets TOPSIS method entropy power weighted geometric operators

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Most Effective Leadership Style Selected by Managers in Modern World

Most Effective Leadership Style Selected by Managers in Mode...

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作者： shaista Yaseen 山东大学

学位级别：硕士

In this modern world,education is considered as a basic need of every *** education,people will be considered as a blind in next two decades due to the rapid increase in the digital and electronic world *** is a basic right of every human being and it seems to be considered as a key of success in this modern *** achieve this goal,many educational institutions are working in the world to control these leaders of educational institutions who are as important as blood for human *** improve their efficiency,every institutional manager select their leadership styles because leaders are performing vital role in the department of *** various countries,different leadership styles are *** this dissertation,most effective leadership styles have been discussed and comparison of Pakistan and china leadership style selected by educational management has been *** to the change in behavior of people,it is very necessary to change the leadership *** and qualities of leaders can make their institutions highly ranked in the *** this competitive world,creating stability in educational institutions is considered as one of the biggest challenges for *** research purpose of this dissertation is to show some similarities and differences in different educational systems.

关键词：领导风格领导人制度管理

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Floyd-Warshall Algorithm Based on Picture Fuzzy Information

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2873-2894页

作者： shaista Habib Aqsa Majeed Muhammad Akram Mohammed M.Ali Al-Shamiri School of Systems and Technology University of Management and TechnologyLahorePakistan Department of Mathematics University of the PunjabNew CampusLahorePakistan Department of Mathematics Faculty of Science and ArtsMahayl AssirKing Khalid UniversityAbhaSaudi Arabia Department of Mathematics and Computer Faculty of ScienceIbb UniversityIbbYemen

The Floyd-Warshall algorithm is frequently used to determine the shortest path between any pair of *** works well for crisp weights,but the problem arises when weights are vague and *** us take an example of computer networks,where the chosen path might no longer be appropriate due to rapid changes in network *** optimal path from among all possible courses is chosen in computer networks based on a variety of *** this paper,we design a new variant of the Floyd-Warshall algorithm that identifies an All-Pair Shortest Path(APSP)in an uncertain situation of a *** the proposed methodology,multiple criteria and theirmutual associationmay involve the selection of any suitable path between any two node points,and the values of these criteria may change due to an uncertain *** use trapezoidal picture fuzzy addition,score,and accuracy functions to find *** compute the time complexity of this algorithm and contrast it with the traditional Floyd-Warshall algorithm and fuzzy Floyd-Warshall algorithm.

关键词： Trapezoidal picture fuzzy number score function accuracy function shortest path problem Floyd-Warshall algorithm

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Maximum Modulus of Polynomials

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Analysis in Theory and Applications 2017年第2期33卷 110-117页

作者： B.A.Zargar Bashir shaista Department of Mathematics University of KashmirSrinagar190006Jammu&KashmirIndia

The result is best possible. In this paper we shall present a refinement of this result and some other related results.

关键词： Maximum modulus growth of polynomial derivative.

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Determinants of China’s outward foreign direct investment in Asia:a panel data analysis

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Economic and Political Studies 2019年第1期7卷 66-86页

作者： Badar Alam Iqbal shaista Sami Abdul Turay School of Economics and Finance Monarch UniversityZugSwitzerland Shyam Lal College Department of CommerceUniversity of DelhiDelhiIndia College of Business and Computational Sciences Kentucky State UniversityFrankfortUSA

This paper is an attempt to examine the trends and significant determinants of China’s outward foreign direct investment(OFDI)in *** order to find out the important determinants of China’s OFDI in Asia,this study applies the panel data regression *** time period from 2006 to 2015 is taken into *** analysis has been done based on three data sets:the first includes 27 Asian countries/regions which attract Chinese *** Chinese Hong Kong is excluded from the sample,the second data set consists of 26 countries the same as those in data set *** third data set comprises China’s top 12 destination countries of OFDI in *** findings show that China’s OFDI has risen rapidly and secured the second rank globally,only behind the United States and surpassing *** the first time,the flow of Chinese OFDI exceeded the level of inward foreign direct investment(IFDI),and Asia attracted a 74.4%share out of China’s total OFDI in *** results reveal that inflation rate,export,import,corruption,infrastructure and geographic distance are the significant determinants of China’s investment in *** paper provides new evidence on the determinants of China’s OFDI in *** using currently available data of 27 Asian host countries,this paper offers a new insight into significant determinants of China’s OFDI in the region.

关键词： Outward foreign direct investment(OFDI) China Asia financial development inflation rate infrastructure corruption

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Petrographical and geochemical signatures of Jurassic rocks of Chari Formation, Western India： implications for provenance and tectonic setting

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Acta Geochimica 2016年第2期35卷 184-202页

作者： shaista Khan A. H. M. Ahmad M. Masroor Alam Adnan Quasim Department of Geology Aligarh Muslim University AligarhUP. India Geology Section Civil Engineering Z.H. College of Engineering and Technology Aligarh Muslim UniversityAligarh UP India

members The sandstones of the Ridge and Athleta of Chari Formation （Callovian-Oxfordian） exposed at Jara have been analyzed for their petrographical and geochemical studies. Texturally, these sandstones are medium to coarse grained, poorly to well sorted, sub-an- gular to sub-rounded, and show low to medium sphericity. These sandstones were derived from a mixed provenance including granites, granite-gneisses, low and high-grade metamorphic, and some basic rocks of Aravalli range and Nagarparkar massif. The petrofacies analysis reveals that these sandstones belong to the continental block and recycled orogen tectonic regime. The studied sandstones are modified by paleoclimate, distance of transport, and diagenesis. Mineralogically and geochemically, sandstones are classified as quartzarenite, subarkose, arkose, sublithic arenite, and wacke, respectively. The A-CN-K ternary plot and CIA, CIW, PIA, and ICV values suggest that the similar source rocks suffered moderate to high chemical weathering under a hot-humid climate in an acidic envi- ronment with higher Pco2. Generally good to strong cor- relations between AI2O3 and other oxides in these sediments indicate clay mineral control. The K2O/Na2O versus SiO2 diagram indicates that the studied samples occupy passive margin fields but the SiO2/A12O3 versus K2O/Na20 plot suggests that the Athleta Sandstone and Ridge Sandstone fall within the passive margin field, while Ridge Shale falls within the active continental margin field.

关键词： Petrography Geochemistry Jurassic rocks Chari Formation Kachchh Gujarat

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Gold-catalysed synthesis of phosphonatesubstituted oxetan-3-ones–an easy access to highly strained HWE reagents

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Organic Chemistry Frontiers 2022年第1期9卷 117-122页

作者： shaista Tahir Jonas F.Wunsch Matthias Rudolph Frank Rominger A.Stephen K.Hashmi Organisch-Chemisches Institut Heidelberg UniversityIm Neuenheimer Feld 27069120 HeidelbergGermany Chemistry Department Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

A convenient approach for the attainment of strained phosphonate-substituted oxetan-3-ones,starting from easy to synthesise alkynyl phosphonates,is *** the aid of a pyridine-N-oxide,in a goldcatalysed step anα-oxo carbene species is generated as a key *** formal OH-insertion,synthetically useful HWE reagents can be *** synthetic utility of the obtained building blocks could be demonstrated,which yielded the 2-alkenyl oxetan-3-one scaffold in high yields after the HWE reaction.

关键词： reaction substituted synthesis

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