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DNA damage-induced by sodium flouride (NaF) and the effect ofcholicalciferol

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BIOCELL 2020年第2期44卷 263-268页

作者： VEYSEL YÜKSEK semiha dede AYŞE USTA SEDATÇETIN MEHMET TAŞPINAR Van Yuzuncu Yil UniversityÖzalp Vocational High School VanTurkey Department of Biochemistry Faculty of Veterinary MedicineVanYuzuncu Yil UniversityVanTurkey Department of Chemistry Faculty of ScienceVanYuzuncu Yil UniversityVanTurkey Department of Medical Biology Faculty of MedicineVanYuzuncu Yil UniversityVanTurkey

It is known that the high electronegativity of fluorine affects various soft tissues,especially the bone structure in *** these tissues are the kidneys,which play an important role in the excretion of fluoride from the *** affects many cellular *** of these effects is DNA *** study aimed to investigate the likely protective effect of cholecalciferol(vitamin D3)on genomic DNA damage-induced NaF depending on concentration and *** IC25 and IC50 values of NaF for 3,12 and 24 h and optimum dose of increase in proliferation to vitamin D3 through MTT assay in NRK-52E kidney cells were *** damage was significantly increased(p<0.05)compared to the control group in all groups except for vitamin *** was determined that treatment with NaF together with vitamin D3 decreased the DNA damage compared to NaF treated groups for 3 and 12 *** combined with vitamin D3 was determined statistically to decrease(p<0.05)DNA damage compared to NaF treated groups for 24 *** a result,it was determined that the treatment with cytotoxic concentration NaF depending on the time significantly increased(p<0.05)the genomic DNA damage,but NaF treatment together with vitamin D3 decreased the DNA damage in renal cells depending on the *** was concluded that vitamin D3 may be useful in preventing DNA damage caused by NaF.

关键词： NaF DNA damage Vitamin D3 Comet assay

Evaluation of periglacial landforms and formation of soil properties on the Mount Honaz,SW Türkiye

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Journal of Mountain Science 2024年第9期21卷 3047-3067页

作者： SERİN Soner UNCU Levent dede Volkan TÜRKEŞMurat Institute of Social Sciences İstanbul Universityİstanbul 34119Türkiye Department of Geography BilecikŞeyh Edebali UniversityBilecik 11234Türkiye Department of Geography Ardahan UniversityArdahan 75002Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul 34342Türkiye

The main aim of this study is to explain periglacial processes on the summits of Mount Honaz(2571 m a.s.l.),define periglacial landforms,and determine the relationships between morphometric features and topographic *** circles,stony earth circles,non sorted steps,and non sorted stripes were identified on the summits of Mount ***'s correlation coefficient(r)and linear regression analyses were performed by taking metric measurements from 125 periglacial landforms to describe their morphometric features(length,width,height)of periglacial landforms and explain the relationships between them and topographic factors(elevation,slope).To explain the relationships between periglacial landforms and soil properties,soil samples from 11 periglacial landforms were taken and *** landforms,which continue to develop on the summits of Mount Honaz today,have been evaluated with present climate *** of soil samples indicates a notable impact of parent material on the genesis of periglacial *** high ratio of organic matter in mud circle and non sorted step landforms and the high lime ratio in stony earth circle landforms prove a strong relationship between the formation mechanisms of landforms and the soil ***,it is consistent with the findings obtained from the analysis that severe periglacial processes and washing and scavenging events are experienced more on the northern slopes.

关键词： Periglacial processes and geomorphology Soil analysis Morphometric analysis Mount Honaz Türkiye

Influence of Formulation and Hot-Pressing Conditions on the Performance of Bio-Based Molasses Adhesive for Plywood

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Journal of Renewable Materials 2024年第8期12卷 1383-1397页

作者： Jajang Sutiawan Alifah Syahfitri Sukma Surya Kusumah dede Hermawan Rita Kartika Sari Luthfi Hakim Efri Mardawati Muhammad Adly Rahandi Lubis Research Center for Biomass and Bioproducts National Research and Innovation AgencyCibinong16911Indonesia Forest Product Department Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia Department of Forest Products Faculty of ForestryUniversitas Sumatera UtaraMedan20155Indonesia Research Collaboration Center for Biomass and Biorefinery BRIN and Universitas PadjadjaranBandung40600Indonesia Department of Agro-Industrial Technology Universitas PadjadjaranBandung40600Indonesia

Molasses can serve as a natural adhesive for plywood and ***,several disadvantages remain,including lower dimensional stability and low bonding strength compared to other ***,modifications are needed to use molasses as an adhesive for *** research aims to improve bio-based molasses(MO)adhesive for plywood using citric acid(CA)*** addition,this research aims to analyze the effect of adding citric acid and to investigate the optimum hot-pressing temperature to produce the best quality *** the first stage,the molasses and citric acid were combined in a ratio of 100:0,75:25,50:50,25:75,0:100 w/w%.Then,the second stage focuses on analyzing the influences of pressing temperature based on an optimum first *** research demonstrated that the addition of CA altered the gelation time,solid content,viscosity,and pH of the molasses *** addition,the thermal properties of molasses adhesives were changed after mixing with citric *** phenomena indicate changes in characteristics,such as the curing of ***,the characteristics of plywood showed a steady improvement as the CA ratio increased but revealed a significant decline for the 25:75 MO-CA *** raising the pressing temperature from 180°C to 200°C,the quality of plywood was effectively *** plywood that was bonded using adhesives with a 50:50 MO-CA ratio exhibited superior mechanical properties and improved dimensional stability compared to the plywood bonded solely with ***,the optimal mechanical and physical properties resulted in plywood bonded with a 50:50 MO-CA ratio when subjected to a pressing temperature of 200°*** Thermal and FTIR measurements revealed that CA established ester bonds with both the MO and wood *** conclusion,the mechanical characteristics of plywood were improved,while maintaining its excellent dimensional stability.

关键词： Citric acid composite molasses pressing temperature plywood

伊尔加兹山脉冰缘地貌发育和土壤形成及其气候的影响(土耳其黑海西岸)

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Journal of Geographical Sciences 2024年第3期34卷 543-570页

作者： dede Volkan DENGIZ Orhan DEMIRAG TURAN inci TüRKES Murat SENOL Hüseyin SERIN Soner Department of Geography Ardahan UniversityArdahan75002Türkiye Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayıs UniversitySamsun55139Türkiye Department of Geography Faculty of Human and Social SciencesSamsun UniversitySamsun55080Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul34342Türkiye Faculty of Agriculture Department of Soil Science and Plant NutritionIsparta University of Applied SciencesIsparta32200Türkiye Institute of Social Sciences İstanbul Universityİstanbul34119Türkiye

The main aims of the current study are to determine the morphological features of the periglacial landforms(non-sorted step,mud circle,stony earth circle,thufur,and congeliturbation)located on the Ilgaz Mountains,examine the physicochemical and mineralogical properties with pedological processes of the soils,and assess of the effects of climatic conditions controlling the development of *** Ilgaz Mountains(2587 m a.s.l.),located in the Western Black Sea Region,within the Anatolian Mountains,are important in terms of periglacial landforms(mud circles,stony earth circles,thufurs,non-sorted steps,non-sorted stripes,congeliturbation deposits,and block currents).The descriptive statistics of 123 periglacial landforms measured by fieldworks were *** distribution of freezing and thawing in the Ilgaz Mountains throughout the year was evaluated,and it was found that freezing takes place between December and March,freezing-thawing takes place in April,May,October and November,and thawing takes place between June and *** to soil properties,organic matter content changes from 1.88%to 12.72%in non-sorted step soils,while it is between 2.03%and 12.24%in stony earth circle *** organic matter is observed to be close to congeliturbation deposits at lower ratios compared to non-sorted steps,stony earth circles and mud *** soil reactions on stony earth circles and non-sorted steps vary between slightly acidic and slightly *** the other hand,soil samples taken from the mud circles are different from those taken from the non-sorted steps and stony earth *** soil reaction is acidic,and pH changes between 4.86 and *** lime content also varies between 2.81%and 32.08%,with an average of 12.02%.The texture properties of soils are dominantly loam and clay loam,as in the non-sorted steps,stony earth circles,and mud *** their mineralogical properties,the XRD study was carried out to determine the primer mineral

关键词： periglacial landforms soil formation climate effect Ilgaz Mountains Türkiye

Isogeometric Analysis of a Phase Field Model for Darcy Flows with Discontinuous Data

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 487-512页

作者： Luca dede Alfio QUARTERONI Modeling and Scientific Computing Mathematics Department"F.Brioschi"Politecnico di MilanoP.zza Leonardo da Vinci 3220133 MilanoItaly Modeling and Scientific Computing Math-section of MathematicsEcole Polytechnique Federale de LausanneCH-1015Switzerland(Honorary Professor)

The authors consider a phase field model for Darcy flows with discontinuous data in porous media;specifically,they adopt the Hele-Shaw-Cahn-Hillard equations of[Lee,Lowengrub,Goodman,Physics of Fluids,2002]to model flows in the Hele-Shaw cell through a phase field formulation which incorporates discontinuities of physical data,namely density and viscosity,across *** the spatial approximation of the problem,the authors use NURBS—based isogeometric analysis in the framework of the Galerkin method,a computational framework which is particularly advantageous for the solution of high order partial differential equations and phase field problems which exhibit sharp but smooth *** this paper,the authors verify through numerical tests the sharp interface limit of the phase field model which in fact leads to an internal discontinuity interface problem;finally,they show the efficiency of isogeometric analysis for the numerical approximation of the model by solving a benchmark problem,the so-called"rising bubble"problem.

关键词： Darcy flows Phase field Hele-Shaw cell Cahn-Hilliard equation Sharpinterface limit Isogeometric analysis

Performance-driven design methodology for habitation shell design in extreme conditions on Mars

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Frontiers of Architectural Research 2022年第2期11卷 224-238页

作者： Gokhan dede Department of Architecture Built Environment and Construction EngineeringPolitecnico di MilanoVia Giuseppe Ponzio3120133 MilanoItaly

The research project illustrates how performance-driven design tools can be conducted as an architectural design methodology that suggests an innovative approach to design a habitation shell in extreme environmental conditions without human *** research study attempts to use environmental data revealed by NASA and its habitat design requirements to develop a conceptual design for an innovative habitation form and then simulate it with Mars conditions to analyze the habitation shell’s structural behavior according to finite element *** this regard,research phases,including layout configuration,form-finding,and structural analysis,have been conducted to explore a habitation concept implemented with generative design tools as a decision-maker in extreme *** conclusion,two generated typologies of proposed habitation forms will be compared in terms of their structural performance under extreme loads of the martian *** this research project,due to the numerous extreme challenges of design and construction of habitation in extreme conditions using conventional approaches,a performance-driven design methodology will provide a rational and sustainable design methodology to tackle extreme barriers to Mars’s environment.

关键词： Performance-driven shell design Finite element model In-situ material Extreme conditions Mars habitation

润肺益肾饮对肺癌荷瘤大鼠的抑瘤作用和肿瘤免疫微环境的影响

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天津医药 2024年第4期52卷 362-366页

作者：张彩蝶靳艳张德德武汉市中医医院急诊科 430014

目的探讨润肺益肾饮对肺癌荷瘤大鼠的抑瘤作用和肿瘤免疫微环境的影响。方法将Lewis肺癌细胞接种于大鼠右季肋部皮下建立肺癌大鼠模型,随机分为模型组、润肺益肾饮低剂量(润肺益肾饮-L)组(3.5 g/kg)、润肺益肾饮中剂量(润肺益肾饮-M)... 详细信息

目的探讨润肺益肾饮对肺癌荷瘤大鼠的抑瘤作用和肿瘤免疫微环境的影响。方法将Lewis肺癌细胞接种于大鼠右季肋部皮下建立肺癌大鼠模型,随机分为模型组、润肺益肾饮低剂量(润肺益肾饮-L)组(3.5 g/kg)、润肺益肾饮中剂量(润肺益肾饮-M)组(7.0 g/kg)、润肺益肾饮高剂量(润肺益肾饮-H)组(14.0 g/kg)以及阳性药组(6 mg/kg顺铂),并以正常大鼠为对照组;干预结束后,计算各组大鼠肺指数、脾脏指数及抑瘤率;收集血液,酶联免疫吸附试验(ELISA)检测血清中转化生长因子(TGF)-β、白细胞介素(IL)-2、γ干扰素(IFN-γ)水平;流式细胞术检测外周血T淋巴细胞亚群;分离肺肿瘤组织,HE染色检测其病理学变化,Western blot检测肿瘤组织程序性死亡受体1(PD-L1)和B淋巴细胞瘤-2(Bcl-2)表达。结果与对照组相比,模型组病理损伤严重,肺指数、TGF-β、CD8^(+)、PD-L1、Bcl-2表达水平升高,脾指数、IL-2、IFN-γ、CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)降低(P0.05)。结论润肺益肾饮可显著抑制肺癌荷瘤大鼠的肿瘤生长,改善肿瘤免疫微环境。

关键词：癌 Lewis肺肿瘤微环境润肺益肾饮抑瘤

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Review of self-referenced measurement algorithms： Bridging lateral shearing interferometry and multi-probe error separation

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Frontiers of Mechanical Engineering 2017年第2期12卷 143-157页

作者： dede ZHAI Shanyong CHEN Ziqiang YIN Shengyi LI College of Mechatronic Engineering and Automation National University of Defense Technology Changsha 410073 China Hu'nan Key Laboratory of Ultra-precision Machining Technology Changsha 410073 China

With the development of new materials and ultra-precision processing technology, the sizes of mea- sured objects increase, and the requirements for machining accuracy and surface quality become more exacting. The traditional measurement method based on reference datum is inadequate for measuring a high-precision object when the quality of the reference datum is approximately within the same order as that of the object. Self-referenced measurement techniques provide an effective means when the direct reference-based method cannot satisfy the required measurement or calibration accuracy. This paper discusses the reconstruction algorithms for self-referenced measurement and connects lateral shearing interferometry and multi-probe error separation. In lateral shearing interferometry, the reconstruction algorithms are generally categorized into modal or zonal methods. The multi-probe error separation techniques for straightness measurement are broadly divided into two-point and three-point methods. The common features of the lateral sheafing interferometry method and the multi-probe error separation method are identified. We conclude that the reconstruction principle in lateral shearing interferometry is similar to the two-point method in error separation on the condition that no yaw error exists. This similarity may provide a basis or inspiration for the development of both classes of methods.

关键词： self-referenced measurement lateral sheafing interferometry multi-probe error separation surfacemetrology

精乌胶囊联合艾司唑仑治疗心肾不交型失眠症的临床研究

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现代药物与临床 2024年第2期39卷 367-371页

作者：胡亚丹周芳张德德马湘玉陈博蒋进枝刘玲武汉市中医医院急诊科湖北武汉430014 武汉市中医医院护理部湖北武汉430014 武汉市中医医院内科湖北武汉430014

目的探讨精乌胶囊联合艾司唑仑治疗心肾不交型失眠症的临床疗效。方法选取2021年9月—2023年9月在武汉市中医医院诊治的128例心肾不交型失眠患者,按随机数字法分为对照组(64例)和治疗组(64例)。对照组患者睡前口服艾司唑仑片,1 mg/次,1... 详细信息

目的探讨精乌胶囊联合艾司唑仑治疗心肾不交型失眠症的临床疗效。方法选取2021年9月—2023年9月在武汉市中医医院诊治的128例心肾不交型失眠患者,按随机数字法分为对照组(64例)和治疗组(64例)。对照组患者睡前口服艾司唑仑片,1 mg/次,1次/d。在对照组的基础上,治疗组口服精乌胶囊,6粒/次,3次/d。两组连服药30 d。观察两组患者临床疗效,比较治疗前后两组患者症状好转时间,匹兹堡睡眠质量指数(PSQI)评分,血清因子白细胞介素-1β(IL-1β)、前列腺素D2(PGD2)、5-羟色胺(5-HT)和肿瘤坏死因子-α(TNF-α)水平,及不良反应。结果治疗后,治疗组总有效率为98.43%,明显高于对照组(84.38%,P<0.05)。治疗后,治疗组入睡困难、睡眠较浅、容易惊醒、醒后难以入睡好转时间均明显短于对照组(P<0.05)。治疗后,两组患者PSQI评分明显降低(P<0.05),且治疗组患者PSQI评分明显低于对照组(P<0.05)。治疗后,两组患者血清因子IL-1β和TNF-α明显降低,而PGD2和5-HT水平明显升高(P<0.05),且治疗组这些血清因子水平均明显好于对照组(P<0.05)。药物期间,对照组不良反应发生率为12.57%,明显高于治疗组(4.69%,P<0.05)。结论艾司唑仑与精乌胶囊协同治疗,可有效改善临床失眠症状,有效减弱失眠相关因子水平,明显提升睡眠质量。

关键词：精乌胶囊艾司唑仑片心肾不交型失眠匹兹堡睡眠质量指数前列腺素D2 5-羟色胺