DNA damage-induced by sodium flouride (NaF) and the effect ofcholicalciferol

作     者：VEYSEL YÜKSEK SEMIHA DEDE AYŞE USTA SEDATÇETIN MEHMET TAŞPINAR 

作者机构：Van Yuzuncu Yil UniversityÖzalp Vocational High SchoolVanTurkey Department of BiochemistryFaculty of Veterinary MedicineVanYuzuncu Yil UniversityVanTurkey Department of ChemistryFaculty of ScienceVanYuzuncu Yil UniversityVanTurkey Department of Medical BiologyFaculty of MedicineVanYuzuncu Yil UniversityVanTurkey 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2020年第44卷第2期

页      面：263-268页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：NaF DNA damage Vitamin D3 Comet assay 

摘      要：It is known that the high electronegativity of fluorine affects various soft tissues,especially the bone structure in *** these tissues are the kidneys,which play an important role in the excretion of fluoride from the *** affects many cellular *** of these effects is DNA *** study aimed to investigate the likely protective effect of cholecalciferol(vitamin D3)on genomic DNA damage-induced NaF depending on concentration and *** IC25 and IC50 values of NaF for 3,12 and 24 h and optimum dose of increase in proliferation to vitamin D3 through MTT assay in NRK-52E kidney cells were *** damage was significantly increased(p0.05)compared to the control group in all groups except for vitamin *** was determined that treatment with NaF together with vitamin D3 decreased the DNA damage compared to NaF treated groups for 3 and 12 *** combined with vitamin D3 was determined statistically to decrease(p0.05)DNA damage compared to NaF treated groups for 24 *** a result,it was determined that the treatment with cytotoxic concentration NaF depending on the time significantly increased(p0.05)the genomic DNA damage,but NaF treatment together with vitamin D3 decreased the DNA damage in renal cells depending on the *** was concluded that vitamin D3 may be useful in preventing DNA damage caused by NaF.