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Biomedical and Environmental Sciences 2004年第4期17卷 402-409页

作者： seema joshi S. K. HASAN RAMESH CHANDRA M. M. HUSAIN R. C. SRIVASTAVA Isabella Thoburn P. G. College Faizabad Road Lucknow 226 007 IndiaIndustrial Toxicology Research Centre P. O. Box. 80 M. G. Marg Lucknow 226 001 IndiaIndustrial Toxicology Research Centre P. O. Box. 80 M. G. Marg Lucknow 226 001 IndiaIndustrial Toxicology Research Centre P. O. Box. 80 M. G. Marg Lucknow 226 001 IndiaR.C.Srivastava Scientist 'F'and Area Coordinator Analytical Toxicology Industrial Toxicology Research Centre P.O.Box80M.G.Marg Lucknow226001UP.INDIA

Objective Toxic metal ions have been implicated in the generation of reactive oxygen species (ROS) and nitric oxide (NO). Metallothionines (MT) and plant flavonoids have been reported in the intervention against oxidative damage. We investigated the effect of zinc induced MT and green tea polyphenol (GTP) in reducing the oxidative responses induced by nickel and platinum. Methods Zinc (10 mg/kg b. wt, sc) was administered to rats twice at a gap of 24hrs and GTP (10 mg/100 mL in drinking water) was fed ad libitum for 8 days. Nickel chloride (150 umol/***, ip) and cisplatin (50 mmol/kg ***, sc) was administered to rats 24 h after Zn or GTP pre-treatment. Animals of all the groups were sacrificed 16 hrs after treatment and biochemical markers for toxicity were monitored. Results Zinc or GTP pre-treatment caused significant protection against nickel or cisplatin enhanced mortality in rats, and reduction in lipid peroxidation and NO. Conclusion It is proposed that inhibition of ROS and NO by GTP and zinc may prove useful as a selective pharmacological agent in the amelioration of metal toxicity.

关键词： Green tea polyphenol Zinc Nitric oxide Lipid Peroxidation Nickel Cisplatin

Sedimentological evidence of climate-tectonic interaction in the upper Satluj catchment of NW Himalaya

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Journal of Mountain Science 2024年第6期21卷 1978-1991页

作者： joshi Moulishree JALAL Poonam Department of Geology Kumaun UniversityNainitalUttarakhand 263001India

Quaternary valley fill deposits in the Upper Satluj Valley of NW Himalaya act as archives of changing climate-tectonic dynamics in a *** landforms help in decoding the relationship between climate and *** region is traversed by several active faults and thrusts such as the Kaurik-Chango Fault(KCF)and Sangla Detachment(SD),thereby making upper Satluj Valley tectonically *** parameters such as width of valley floor(Vfw),Normalized Steepness Index(KSn)and geomorphological evidences such as the presence of huge strath terraces,narrowing of the river valley and palaeolake deposits point towards the tectonically active nature of the *** arid,high elevation region is also climatically sensitive as it falls in a transient climatic zone which receives rainfall only during abnormal monsoon *** rainfall causes outburst floods,a common phenomenon in the area due to the blocking of headwater in the upper reaches of the Satluj *** a result,the Quaternary sequence is modified from time to *** transition from hypo concentrated deposits to channel deposits and ponding events are prominent in the depositional sequence,resulting from a response to *** studied Quaternary sediments reveal that the Trans-Himalayan region of the upper Satluj valley is affected by tectonic-climate variability,making it vulnerable to geohazards.

关键词： Himachal Pradesh Quaternary Lithofacies association Tectonics Climate

Temperature field characteristics of CF/PEEK thermoplastic composites formed by automated fiber placement using hot gas torch with slit structure nozzle

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Chinese Journal of Aeronautics 2024年第6期37卷 392-409页

作者： Ziang JIN Shouzheng SUN Sunil Chandrakant joshi Zhenyu HAN Hongya FU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

In-situ consolidation forming of high-performance thermoplastic composites by Automated Fiber Placement(AFP)is of significant interest in *** the laying process,the heating temperature has a great influence on the quality of the formed components.A threedimensional heat transfer finite element model of Carbon Fiber(CF)/Polyether Ether Ketone(PEEK)heated by Slit Structure Nozzle Hot Gas Torch(SSNHGT)assisted AFP is *** influence of gas flow rate,heat transfer distance,and laying speed on heating temperature is *** results show that the overall temperature increases and then decreases as the gas flow rate *** the increase in heat transfer distance and laying speed,the overall temperature ***,the gas flow rate has the greatest influence on the temperature of CF/PEEK being heated,followed by the laying speed and finally the heat transfer ***,the model can also be extended to other fiber-reinforced polymer composites formed by hot gas torch assisted AFP,which can guide the optimization of process parameters for subsequent heating temperature control.

关键词： Fiber reinforced plastics Thermoplastics Heating temperature Automated fiber placement CF/PEEK

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

Technological advancements in millet dehulling and polishing process: An insight into pretreatment methods, machineries and impact on nutritional quality

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Grain & Oil Science and Technology 2024年第3期7卷 186-195页

作者： Shagolshem Mukta Singh Jayasree joshi T P.Srinivasa Rao Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Millets are widely recognized for their nutritional significance;however, the methods employed for their processing are currently lacking. This article primarily focuses on the advanced technologies and progressions in millet dehulling and polishing. These technologies operate based on the fundamental principles of compression-shearing, abrasion-friction, and centrifugal-impact forces. Processing of millets can be challenging because of the physical characteristics and tight attachment of hull and bran to the endosperm. However, several dehullers have been designed to solve this problem for different kinds of millets. In addition, the nutritional and anti-nutritional characteristics undergo alterations due to both dehulling and polishing processes. These alterations are thoroughly examined and discussed in this article. Specifically, anti-nutrients such as tannins and phytate are predominantly found in the outer pericarp of the grain and experience a reduction after undergoing dehulling and polishing. The nutritional properties are also subjected to a reduction;however, this reduction can be mitigated by subjecting the grains to certain pretreatments before dehulling and polishing. These treatments serve to enhance dehulling efficiency and nutrient digestibility while simultaneously reducing the presence of anti-nutrients. Novel thermal and non-thermal methodologies such as microwave, hydrothermal, high-pressure processing, and ohmic heating can be employed for processing millets, thereby diminishing the loss of nutrients. Additional research can be carried out to investigate their impact on the dehulling and polishing of millets.

关键词： Millets Dehulling Polishing Pretreatment Novel thermal and non-thermal techniques

Hydrothermal treatment of pearl millet grains:Effects on nutritional composition,antinutrients and flour properties

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Grain & Oil Science and Technology 2024年第2期7卷 87-95页

作者： P.Prashanth T.Jayasree joshi Shagolshem Mukta Singh P.Srinivasa Rao Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Pearl millet(Pennisetum glaucum)is one of the major millets with high nutritional *** crop exhibits exceptional resilience to drought and high ***,the processing of pearl millet poses a significant challenge due to its high lipid content,enzyme activity,and presence of ***,it becomes imperative to enhance the quality and prolong the shelf life of pearl millet flour by employing suitable *** treatment in the food industry has long been seen as promising due to its potential to reduce microbial load,inactivate enzymes,and improve nutrient *** study aims to investigate the effects of hydrothermal treatment on the quality characteristics of pearl *** independent variables of the study were soaking temperature(35,45,55℃),soaking time(2,3,4 h),and steaming time(5,10,15 min).Treatment conditions had a statistically significant effect on nutrient *** antinutrients like tannins and phytates were reduced by 0.99% to 5.94% and 0.36% to 6.00%,respectively,after the *** activity decreased significantly up to 10% with the treatment *** findings of this study could potentially encourage the use of pearl millet flour in the production of various food items and promote the application of hydrothermal treatment in the field of food processing.

关键词： Pearl millet Hydrothermal treatment Nutritional properties Antinutrients

Poplar Plantation as an Agroforestry Approach:Economic Benefits and Its Role in Carbon Sequestration in North India

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Journal of Resources and Ecology 2024年第4期15卷 880-888页

作者： Rajeev joshi Bharat SHARMA Hukum SINGH Nabin DHAKAL Santosh AYER Tek MARASENI College of Natural Resource Management Faculty of ForestryAgriculture and Forestry UniversityUdayapurKatari 56310Nepal Sustainable Initiatives for the Community(SIFC) Kathmandu 44600Nepal Forest Research Institute PO New ForestDehradun 248006India Institute for Life Sciences and the Environment University of Southern QueenslandToowoombaQLD 4350Australia

Poplar has gained popularity among farmers of Punjab,Haryana,Western Uttar Pradesh,and the foothills of Uttarakhand and Himachal Pradesh due to their fast growth rate and suitability for industrial uses such as pulp and timber *** poplar trees into agroforestry systems optimizes land resources and economic gains,as successful techniques have been developed to coordinate crop timing and arrangements *** poplar trees with agricultural crops provides additional income streams for farmers and contributes to soil conservation,biodiversity enhancement,and other environmental *** in these regions typically employ effective spacing of 5 m×4 m for block plantation and 1 m×3 m for row *** the present study,a systematic literature review encompassing 137 English-language journal articles was conducted to assess the economic benefits of Poplar using discounted cash flow(DCF)analysis,considering short-rotation poplar(SRC)and very short-rotation poplar(vSRC)plantations alongside annual *** findings revealed that increasing canopy density led to a decline in crop yields by 37%,70%,and 99% at canopy densities of 30%,60%,and 90%,respectively,from early spring to ***-benefit analysis in Saharanpur district,India,indicated average annual net returns of USD 346.36 for Poplar-based agrisilviculture,while monoculture yielded USD 140.73 per ***,economic analysis in Yamunanagar and Haridwar districts showed benefit-cost ratios ranging from 2.35 to ***,Poplar block and boundary plantations were found to sequester significantly more carbon in long-lived biomass,serving as substitutes for fossil fuels(5.45 and 1.84 t ha-1 yr-1)in poplar-based systems with block and boundary *** study suggested expanding spacing between tree rows may mitigate resource competition between plantations and *** study inferred that Poplar-based agroforestry may play a crucial role in climate mit

关键词： agroforestry poplar economic viability carbon sequestration India

评估农林业适应气候变化的潜力:尼泊尔拉姆琼案例研究

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Journal of Resources and Ecology 2024年第2期15卷 280-292页

作者： joshi Rajeev TAMANG Gyanu Maya BHANDARI Prativa SHARMA Bharat joshi Dikshya BHUSAL Shushma 尼泊尔农林大学林学院自然资源管理学院尼泊尔卡塔里56310 特里布万大学林业研究所(博卡拉校区) 尼泊尔博卡拉33700 森林和土壤保护部森林部门办公室尼泊尔久姆拉21200 森林研究所印度德拉敦248001 远西大学农学院尼泊尔提卡波10901

农林系统具有多种效益,包括通过使用肥用树种来提高土壤质量,通过树冠改善小气候,以及生产薪柴和其他医药产品等森林产品以提高经济效益。农林复合经营有助于更好的土地管理、生计多样化和提高土地生产力。然而,政策制定者和其他利益相... 详细信息

农林系统具有多种效益,包括通过使用肥用树种来提高土壤质量,通过树冠改善小气候,以及生产薪柴和其他医药产品等森林产品以提高经济效益。农林复合经营有助于更好的土地管理、生计多样化和提高土地生产力。然而,政策制定者和其他利益相关方在农林业作为气候变化适应战略中作用的争辩却越来越多。本研究的目的是评估农林业作为气候变化适应战略的潜力。数据主要通过问卷调查从拉姆琼县Taksar的120名受访者中收集,采用卡方检验和二元logistic模型分析了影响气候变化适应策略的家庭选择因素。同样,通过访谈、讨论和观察以及后续的文件分析,对所获得的数据进行三角互证和验证。研究表明,农民采取了许多应对气候变化的策略,这些策略包括农牧多样化(71%)、使用改良作物品种、化肥和农药(73%)、农林复合经营(68%)、创收多样化(72%)、改变作物种植日期(57%)和复种措施(67%)等。从卡方检验和二元logistic模型中发现,“耕作经验”、“教育水平”、“农场规模”和“性别”对气候变化适应策略具有显著影响。农林复合经营具有不同的效益,如增加河流汇水(79.2%)、改善小气候(80.8%)、增加木材产品(71.7%)、提高粮食产量(83.3%)、改善牲畜健康和畜产品(77.5%)、提高土壤肥力(84.2%)和多样化生计选择(82.2%)。基于这些发现,该研究得出结论:农林复合经营是一种可以减少气候变化对当地环境影响的农业生产方法,推广和采用农林业可以帮助当地社区减少气候变化的影响。

关键词：气候变化适应策略当地社区复种

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尼泊尔巴迪亚国家公园缓冲区的人象冲突

Journal of Resources and Ecology 2024年第2期15卷 412-421页

作者： PAHARI Sagar joshi Rajeev PAUDEL Umesh 南十字星大学澳大利亚利斯莫尔2480 尼泊尔农林大学自然资源管理学院林学系尼泊尔卡塔里56310 尼泊尔巴迪亚自然保护国家信托基金会尼泊尔巴迪亚21800

亚洲象(Elephasmaximus)是尼泊尔特莱(Terai)低地保护区重要的大型动物之一,它们经常在保护区森林边界附近遇到人类及其生计支持活动。人象冲突一直是保护区附近人类居住区的主要问题之一,每年都会造成经济损失,甚至威胁人类的生命安全... 详细信息

亚洲象(Elephasmaximus)是尼泊尔特莱(Terai)低地保护区重要的大型动物之一,它们经常在保护区森林边界附近遇到人类及其生计支持活动。人象冲突一直是保护区附近人类居住区的主要问题之一,每年都会造成经济损失,甚至威胁人类的生命安全,这一问题阻碍了保护区的可持续管理。本研究的目的是分析巴迪亚国家公园缓冲区人象冲突的原因,并评估人们对这种大型动物的感知。为此,在巴迪亚国家公园缓冲区内的三个市镇进行了结构化问卷调查。此外,作为问卷调查的补充,还对关键知情人士进行了访谈。结果显示,93%的受访者在过去三年中曾遭遇大象的袭击。由于大象袭击,去年每个家庭平均损失了大约9690尼泊尔卢比。大象的攻击行为大多数发生在7月至9月,其次是10月至12月。这表明大象对作物的偏好是研究区大象发起攻击/袭击行为的主要原因。大象袭击的第二个重要原因是由于农田向森林的扩张而导致大象食物不足。90%的受访者对大象攻击的反应是驱赶它们(使用火或噪音);51%的受访者接受人象共存,他们认为大象具有生物学和经济价值;然而,还有41%的人拒绝与大象共存,因为大象对当地居民及其生计构成了威胁。人象冲突已对保护区管理活动产生了负面影响,因此,必须通过保护区、当地居民和行政利益相关者的合作来解决相关问题。建议以后开展更多的研究,以了解大象在森林边界和邻近定居点附近人们的居住和迁徙模式。

关键词：攻击补偿作物的损害感知偏好