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Particuology 2009年第2期7卷 106-113页

作者： Roberto moreno-Atanasio Simon J.Antony Richard A.Williams Institute of Particle Science and Engineering University of LeedsLeedsLS2 9JTUnited Kingdom

Computer simulations based on Discrete Element Method have been performed in order to investigate the influence of interparticle interactions on the kinetics of self-assembly and the mechanical strength of nanoparticle aggregates. Three different systems have been considered. In the first system the interaction between particles has been simulated using the JKR （Johnson, Kendall and Roberts） contact theory, while in the second and third systems the interaction between particles has been simulated using van der Waals and electrostatic forces respectively. In order to compare the mechanical behaviour of the three systems, the magnitude of the maximum attractive force between particles has been kept the same in all cases. However, the relationship between force and separation distance differs from case to case and thus, the range of the interparticle force. The results clearly indicate that as the range of the interparticle force increases, the self-assembly process is faster and the work required to produce the mechanical failure of the assemblies increases by more than one order of magnitude.

关键词： Nanoparticles Discrete Element Method (DEM) self-assembly JKR model van der Waals force

Optimal seismic retrofit model for steel moment resisting frames with brittle connections

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 835-847页

作者： Hyo seon Park se Woon Choi Byung Kwan Oh Department of Architectural Engineering Yonsei University Center for Structural Health Care Technology in Building Yonsei University Department of Architecture Catholic University of Daegu Department of Civil and Environmental Engineering Princeton University

Based on performance-based seismic engineering, this paper proposes an optimal seismic retrofit model for steel moment resisting frames（SMRFs） to generate a retrofit scheme at minimal cost. To satisfy the acceptance criteria for the Basic Safety Objective（BSO） specified in FEMA 356, the minimum number of upgraded connections and their locations in an SMRF with brittle connections are determined by evolutionary computation. The performance of the proposed optimal retrofitting model is evaluated on the basis of the energy dissipation capacities, peak roof drift ratios, and maximum interstory drift ratios of structures before and after retrofitting. In addition, a retrofit efficiency index, which is defined as the ratio of the increment in seismic performance to the required retrofitting cost, is proposed to examine the efficiencies of the retrofit schemes derived from the model. The optimal seismic retrofit model is applied to the SAC benchmark examples for threestory and nine-story SMRFs with brittle connections. Using the retrofit efficiency index proposed in this study, the optimal retrofit schemes obtained from the model are found to be efficient for both examples in terms of energy dissipation capacity, roof drift ratio, and maximum inter-story drift ratio.

关键词： steel moment resisting frame performance-based seismic engineering optimal seismic retrofit evolutionarycomputation

邓小平调查研究重要论述的主要内容及当代启示

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齐齐哈尔大学学报（哲学社会科学版） 2024年第1期 96-101页

作者：龚秀勇莫色阿木西南石油大学马克思主义学院四川成都610500

调查研究是做好各项工作的基本功,是我们党科学认识世界和改造世界的重要方法。邓小平历来十分重视调查研究,并将其作为全党同志有效开展工作的首要前提和重要基础,以此成功指导了改革开放和社会主义现代化建设的伟大实践。今天,学习邓... 详细信息

调查研究是做好各项工作的基本功,是我们党科学认识世界和改造世界的重要方法。邓小平历来十分重视调查研究,并将其作为全党同志有效开展工作的首要前提和重要基础,以此成功指导了改革开放和社会主义现代化建设的伟大实践。今天,学习邓小平调查研究重要论述,总结邓小平调查研究的宝贵历史经验,对于新时代全党大兴调查研究之风,推动实现党的第二个百年奋斗目标具有重要的理论和现实意义。

关键词：邓小平调查研究重要论述当代启示

Dynamic observation of dendrite growth on lithium metal anode during battery charging/discharging cycles

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npj Computational Materials 2022年第1期8卷 960-972页

作者： Hae Gon Lee se Young Kim Joon Sang Lee Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)12Jeongiui-gilSeongsan-guChangwon-siGyeongsangnam-do51543Republic of Korea Department of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Republic of Korea

Lithium metal is considered one of the most promising anode materials for application in next-generation ***,despite decades of research,practical application of lithium metal batteries has not yet been achieved because the fundamental interfacial mechanism of lithium dendrite growth is not yet fully *** this study,a series of reactive molecular dynamics (MD) simulations was performed to investigate the electrochemical dynamic reactions at the electrode/electrolyte *** allows quantitative characterization of morphological phenomena and real-time interfacial visualization of the dynamic growth of dead lithium and dendrites during repeated *** computational protocol was utilized to investigate the dendrite mitigation mechanism when an electrolyte additive (hydrogen fluoride) is dissolved in an organic ethylene carbonate (EC) electrolyte *** was confirmed that beneficial decomposition reactions between electrolyte components form a protective film on the anode surface,suppressing large interphase volume changes and unnecessary degradation reactions.

关键词： battery lithium electrolyte

Specific CD8^+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis

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World Journal of Gastroenterology 2016年第28期22卷 6469-6483页

作者： Elia moreno-Cubero Juan-Ramón Larrubia Translational Hepatology Unit Guadalajara University Hospital University of Alcalá Department of Biology of Systems University of Alcalá Department of Medicine and Medical Specialties University of Alcalá

Hepatocellular carcinoma (HCC), chronic hepatitis B (CHB) and chronic hepatitis C (CHC) are characterized by exhaustion of the specific CD8+ T cell response. This process involves enhancement of negative co-stimulatory molecules, such as programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen-4 (CTLA-4), 2B4, Tim-3, CD160 and LAG-3, which is linked to intrahepatic overexpression of some of the cognate ligands, such as PD-L1, on antigen presenting cells and thereby favouring a tolerogenic environment. Therapies that disrupt these negative signalling mechanisms represent promising therapeutic tools with the potential to restore reactivity of the specific CD8+ T cell response. In this review we discuss the impressive in vitro and in vivo results that have been recently achieved in HCC, CHB and CHC by blocking these negative receptors with monoclonal antibodies against these immune checkpoint modulators. The article mainly focuses on the role of CTLA-4 and PD-1 blocking monoclonal antibodies, the first ones to have reached clinical practice. The humanized monoclonal antibodies against CTLA-4 (tremelimumab and ipilimumab) and PD-1 (nivolumab and pembrolizumab) have yielded good results in testing of HCC and chronic viral hepatitis patients. Trelimumab, in particular, has shown a significant increase in the time to progression in HCC, while nivolumab has shown a remarkable effect on hepatitis C viral load reduction. The research on the role of ipilimumab, nivolumab and pembrolizumab on HCC is currently underway.

关键词： Hepatocellular carcinoma CD8+ T cells Immune checkpoint modulation Chronic viral hepatitis Cytotoxic T-lymphocyte antigen-4 Programmed cell death protein-1

基于RNA-seq技术筛选姜曲海猪子宫和卵巢发育相关基因

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江苏农业学报 2024年第1期40卷 130-140页

作者：朱淑斌徐盼周春宝许琴瑟吴嘉韵江苏农牧科技职业学院江苏泰州225300 姜曲海猪保种场江苏泰州225300

母猪的子宫和卵巢组织发育情况直接影响母猪的繁殖性能,进而对养猪业的经济效益造成重大影响。为探究姜曲海猪子宫和卵巢发育的分子机理,本研究选取1月龄和8月龄姜曲海猪各3头,利用转录组测序技术(RNA-seq)对子宫和卵巢组织进行测序,通... 详细信息

母猪的子宫和卵巢组织发育情况直接影响母猪的繁殖性能,进而对养猪业的经济效益造成重大影响。为探究姜曲海猪子宫和卵巢发育的分子机理,本研究选取1月龄和8月龄姜曲海猪各3头,利用转录组测序技术(RNA-seq)对子宫和卵巢组织进行测序,通过生物信息学手段筛选差异表达基因并进行基因本体(Gene ontology,GO)和京都基因和基因组百科全书(Kyoto ncyclopedia of genes and genomes,KEGG)富集分析,再与猪数量性状基因座(Quantitative trait locus,QTL)数据库比对后鉴定出重要的候选基因。结果显示,1月龄和8月龄姜曲海猪子宫组织中有1688个差异表达基因,表达上调和下调的基因各844个;卵巢组织中存在3833个差异表达基因,其中2831个表达上调,1002个表达下调。富集分析结果显示这些差异表达基因主要显著富集于动物器官发育、组织发育和细胞分化等生物学过程。本研究在子宫和卵巢组织中分别筛选出11个和31个与发育性状有关的候选基因,其中共有的候选基因有6个,分别为LHFPL1、MTUS2、LIF、RBP4、EPHB2和TESC。本研究结果为姜曲海猪子宫和卵巢发育分子层面的研究提供了参考,也为今后姜曲海猪繁殖性状的分子改良提供了新的研究方向。

关键词：姜曲海猪子宫卵巢转录组测序

Non-Protein-Coding RNAs and their Interacting RNA-Binding Proteins in the Plant Cell Nucleus

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Molecular Plant 2010年第4期3卷 729-739页

作者： Celine Charon Ana Beatriz moreno Florian Bardou Martin Crespi University Paris-Sud Institut de Biologie des Plantes UMR8618 Orsay Cedex F-91405 France CNRS Orsay Cedex F-91405 France Institut des Sciences du Vegetal CNRS F-91198 Gif-sur-Yvette Cedex France

The complex responses of eukaryotic cells to external factors are governed by several transcriptional and post-transcriptional processes. several of them occur in the nucleus and have been linked to the action of non-proteincoding RNAs （or npcRNAs）, both long and small npcRNAs, that recently emerged as major regulators of gene expression. Regulatory npcRNAs acting in the nucleus include silencing-related RNAs, intergenic npcRNAs, natural antisense RNAs, and other aberrant RNAs resulting from the interplay between global transcription and RNA processing activities （such as Dicers and RNA-dependent polymerases）. Generally, the resulting npcRNAs exert their regulatory effects through interactions with RNA-binding proteins （or RBPs） within ribonucleoprotein particles （or RNPs）. A large group of RBPs are implicated in the silencing machinery through small interfering RNAs （siRNAs） and their localization suggests that several act in the nucleus to trigger epigenetic and chromatin changes at a whole-genome scale. Other nuclear RBPs interact with npcRNAs and change their localization. In the fission yeast, the RNA-binding Mei2p protein, playing pivotal roles in meiosis, interact with a meiotic npcRNA involved in its nuclear re-localization. Related processes have been identified in plants and the ENOD40 npcRNA was shown to re-localize a nuclear-speckle RBP from the nucleus to the cytoplasm in Medicago truncatula. Plant RBPs have been also implicated in RNA-mediated chromatin silencing in the FLC locus through interaction with specific antisense transcripts. In this review, we discuss the interactions between RBPs and npcRNAs in the context of nuclear-related processes and their implication in plant development and stress responses. We propose that these interactions may add a regulatory layer that modulates the interactions between the nuclear genome and the environment and, consequently, control plant developmental plasticity.

关键词： Abiotic/environmental stress gene silencing Arabidopsis RNA-binding proteins non-protein-coding RNAs nucleus.

Spectrum of anemia associated with chronic liver disease

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World Journal of Gastroenterology 2009年第37期15卷 4653-4658页

作者： Rosario Gonzalez-Casas E Anthony Jones Ricardo moreno-Otero Digestive Disease service and Center for Investigation of Hepatic and Digestive Diseases University Hospital La Princesa Autonomous University of Madrid Madrid 28006 Spain

Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically signif icant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirininduced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by defi ciency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption.

关键词： Anemia Liver disease Liver failure Aplastic anemia Pegylated interferon Ribavirin Alcohol

Antioxidant,hepatoprotective and hypolipidemic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 126-132页

作者： Ottu OJ Atawodi se Onyike E Department of Biochemistry Ahmadu Bello UniversityZariaNigeria

Objective:To evaluate in vivo antioxidant and hepatoprotective activities of the methanolic extract of the root of Cassia singueana in rats following acute and chronic carbon tetrachloride ***:Malondialdehyde（MDA）,aspartate aminotransferase（AST）,alanine aminotransferase（ALT） and bilirubin as indices of liver damage and lipid peroxidation were detected in rats after intraperitoneal administration of extract（5 mg/kg）.Results:The liver, kidney and heart showed significant reduction（P4 control to（0.15±0.03）,（0.17±0.04） and（0.17±0.07） nmol/mg protein in groups pre-treated with the extract for three days at 5 mg/kg(.Similarly, compared to the CCl4 control,significant reduction（Pserum AST,ALT and bilirubin as well as in level of total cholesterol and MDA with concomitant increase in HDL cholesterol, superoxide dismutase and catalase levels when CCl4-intoxicated rats were treated with Cassia singueana root extract for two ***:These results suggest that methanolic extract of Cassia singueana contain potent antioxidant compounds that can offer significant protection against hepatic and oxidative injuries.

关键词： Antioxidant effect Hepatoprotective effect Disease chemoprevention Medicinal plant Oxidative stress Cassia singueana

COVID-19 disease in children: not as mild as we have been led to believe

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World Journal of Pediatrics 2020年第4期16卷 426-427页

作者： Laura moreno-Galarraga Elsie M.Taveras Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080PamplonaSpain IdiSNA Navarra Institute for Health ResearchPamplonaSpain Department of Preventive Medicine and Public Health School of MedicineUniversity of NavarraPamplonaSpain Division of General Academic Pediatrics Massachusetts General Hospital for ChildrenBostonMAUSA Department of Pediatrics Harvard Medical SchoolBostonMAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA

Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)emerged,we have followed this pandemic with great interest and concern from Europe(Navarra-Spain)and the United States(Boston-Massachusetts).We were expecting children to present to emergency departments with the“classical COVID-19 symptoms-triad”such as fever,cough,and a range of respiratory distress[1]and we had learned from countries affected earlier by the virus,that it appeared to be less common and relatively mild in children[2,3].

关键词： respiratory distress acute