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射频辉光放电飞行时间质谱法分析薄膜:脉冲模式与连续模式的比较

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冶金分析 2009年第11期29卷 1-7页

作者： BORDEL N LOBO L PISONERO J PEREIRO R TUCCITTO N LICCIARDELLO A TEMPEZ A CHAPON P HOHL M MICHLER J sanz-medel a 奥维多大学科学学院物理系奥维多大学化学学院物理和分析化学系卡塔尼亚大学化学系 Horiba Jobin Yvon公司 Tofwerk AG公司 EMPA材料科技有限公司

高级多层材料的直接表面和深度分布化学分析要求了解多维信息,包括同时了解元素和分子信息。用飞行时间质谱法(TOFMS)检测的脉冲式射频辉光放电(pulsed rf-GDs)可以从种类繁多的材料中直接提供化学信息,且简单快捷。另一方面,脉冲式射... 详细信息

高级多层材料的直接表面和深度分布化学分析要求了解多维信息,包括同时了解元素和分子信息。用飞行时间质谱法(TOFMS)检测的脉冲式射频辉光放电(pulsed rf-GDs)可以从种类繁多的材料中直接提供化学信息,且简单快捷。另一方面,脉冲式射频辉光放电中输入功率的时间分布由于不同的离子化机理产生3个主要放电阶段(峰前,高峰平稳,峰后)。结果证明将辉光放电离子源和一个快速飞行时间质谱仪相结合能够实现在不同的脉冲阶段几乎同时获得元素和分子信息。

关键词：射频辉光放电飞行时间质谱法薄膜脉冲模式连续模式

Quantitative Elemental Speciation :Challenges and Strategies Basedon Multi-Labelled Multi-Species Isotope Dilution ICP-MS

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光谱学与光谱分析 2004年第2期24卷 255-255页

作者： Alfredo sanz-medel Pablo RODR■GUEZ-GONZLEZ Jorge RUIZ ENCINAR J .Ignacio GARC■A ALONSO Department of Physical and Analytical Chemistry Faculty of Chemistry Juliun Clavena833006Oviedo Spain.Department of Physical and Analytical Chemistry Faculty of Chemistry Juliun Clavena833006Oviedo Spain.Department of Physical and Analytical Chemistry Faculty of Chemistry Juliun Clavena833006Oviedo Spain.Department of Physical and Analytical Chemistry Faculty of Chemistry Juliun Clavena833006Oviedo Spain.

According to IUPAC, a chemical species is defined as "the specific form of an element defined as to isotope composition, electronic oxidation state and/or complex or molecular structure . To carry out chemical speciation, new speciation analysis techniques and strategies are needed. Probably the most popular and useful techniques for speciation analysis are hybrid techniques where a powerful separation is coupled (preferable "on-line") to an element-specific detector. In fact, the whole strategy for speciation analysis involves a considerable number of discrete steps. These include usually: solid-liquid extraction (if the sample is solid), preconcentration, derivatization, separation of derivatized analytes (e.g. chromatography) and final specific detection (e. g. "on-line" ICP-MS). It is well known that important errors can occur at any of those individual speciation steps. First, solid-liquid extractions should preserve the molecular form (species) of the analytes. Second, preconcentration, derivatization, separation and detection speciation methods should be fully investigated and understood in order to obtain accurate (reliable) determinations of the sought *** all the above, it is clear that validation of quantitative speciation results is urgently needed. A powerful approach for analytical validation is the use of isotope dilution analysis (IDA). Therefore the application of "speciated" IDA (SIDA) techniques for validation of results for mono-, di-, and tributyltin (MBT, DBT and TBT, respectively) in sediments and seawater samples~[3] will be discussed using a multi-species spike enriched with ~(119)Sn and final measurement by a hybrid GC-ICP-MS technique. Similarly, the synthesis of multi-labelled multi-species spikes will be described. The application of "doubly- and triply-labelled spikes" has allowed the evaluation of the extent of possible decomposition reactions (the corresponding decomposition factors can be quantified) during several solid-liq

关键词：电感耦合等离子发射光谱 ICP-MS 物种形成物质组成同位素示踪定量分析

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Hummingbird-plant interactions in Chile:An ecological review of the available evidence

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Avian Research 2022年第3期13卷 332-340页

作者： Rodrigo medel Manuel López-Aliste Francisco E.Fontúrbel Departamento de Ciencias Ecol ogicas Facultad de CienciasUniversidad de ChileSantiagoChile Instituto de Biología Facultad de CienciasPontificia Universidad Cat olica de ValparaísoValparaísoChile Millennium Nucleus of Patagonian Limit of Life(LiLi) ValdiviaChile

Hummingbird species have closely evolved with the plants they feed on,which is confirmed by their often tight ecological relationships in natural ***-plant interactions are of interest for research areas such as ecology,evolution,and even agriculture,as they usually inform on the conservation status of interacting species assemblages,and its disappearance may precede the population extinction of the species involved in the *** Chile,there are nine hummingbird species,which interact with a large and diverse number of angiosperm species in forest,desert,and mountain range *** motivation to perform this review is to systematize the available information regarding the flowering plants visited by hummingbird species in Chile,to present some basic plant-hummingbird pollination network metrics,and on this basis to identify the components of the plant-hummingbird relationships in need of further research.A plant-hummingbird metanetwork revealed a low connectance value,low niche overlap,and strong modularity among ***,the fact that most species present a strong allopatric distribution across Chile,suggests that network structure results mostly from the history of colonization rather than from ecological ***,the main threats to Chilean hummingbirds are anthropogenic disturbance and climate change,which disrupt hummingbird-plant interactions,leading to unpredictable ecological consequences at the community *** periods of drought may reduce the resource base for hummingbirds,with dramatic consequences for the maintenance of bird and plant populations.

关键词： Conservation Endemic species Habitat disturbance Pollination Trochilidae

Bohm’s approach to quantum mechanics: Alternative theory or practical picture?

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Frontiers of physics 2019年第1期14卷 75-89页

作者： A. S. sanz Department of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

Since its inception Bohmian mechanics has been generally regarded as a hidden-variable theory aimed at providing an objective description of quantum phenomena. To date, this rather narrow conception of Bohm’s proposal has caused it more rejection than acceptance. Now, after 65 years of Bohmian mechanics, should still be such an interpretational aspect the prevailing appraisal? Why not favoring a more pragmatic view, as a legitimate picture of quantum mechanics, on equal footing in all respects with any other more conventional quantum picture? These questions are used here to introduce a discussion on an alternative way to deal with Bohmian mechanics at present, enhancing its aspect as an efficient and useful picture or formulation to tackle, explore, describe and explain quantum phenomena where phase and correlation (entanglement) are key elements. This discussion is presented through two complementary blocks. The first block is aimed at briefly revisiting the historical context that gave rise to the appearance of Bohmian mechanics, and how this approach or analogous ones have been used in different physical contexts. This discussion is used to emphasize a more pragmatic view to the detriment of the more conventional hidden-variable (ontological) approach that has been a leitmotif within the quantum foundations. The second block focuses on some particular formal aspects of Bohmian mechanics supporting the view presented here, with special emphasis on the physical meaning of the local phase field and the associated velocity field encoded within the wave function. As an illustration, a simple model of Young’s two-slit experiment is considered. The simplicity of this model allows to understand in an easy manner how the information conveyed by the Bohmian formulation relates to other more conventional concepts in quantum mechanics. This sort of pedagogical application is also aimed at showing the potential interest to introduce Bohmian mechanics in undergraduate quantum

关键词： Bohmian mechanics quantum phase velocity field interference Young’s two-slit experiment

Smoothness of the Functional Law Generated by a Nonlinear SPDE

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Chinese Annals of Mathematics,Series B 2008年第2期29卷 113-120页

作者： Marta sanz-SOL Paul MALLIAVIN Facultat de Matemàtiques Universitat de BarcelonaGran Via 585E-08007 BarcelonaSpain. 10 rue Saint Louis-en-I'IleF-74004 ParisFrance

The authors consider a stochastic heat equation in dimension d=1 driven by an additive space time white noise and having a mild *** is proved that the functional law of its solution is absolutely continuous and posses... 详细信息

关键词： Stochastic heat equation Probability law Absolute continuity Divergence operator Gradient operator

Inhibition of p53 inhibitors:progress,challenges and perspectives

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Journal of Molecular Cell Biology 2019年第7期11卷 586-599页

作者： Gema sanz Madhurendra Singh Sylvain Peuget Galina Selivanova Department of Microbiology Tumor and Cell BiologyBiomedicum 8CKarolinska InstituteSE17165Sweden

p53 is the major tumor suppressor and the most frequently inactivated gene in cancer.p53 could be disabled either by mutations or by upstream negative regulators,including,but not limited to MDM2 and MDMX.p53 activity is required for the prevention as well as for the eradication of *** of p53 activity in mouse models leads to the suppression of established tumors of different *** findings provide a strong support to the anti-cancer strategy aimed for p53 *** this review,we summarize recent progress in the development of small molecules,which restore the tumor suppressor function of wild-type p53 and discuss their clinical *** discuss different aspects of p53-mediated response,which contribute to suppression of tumors,including non-canonical p53 activities,such as regulation of immune *** targeting p53 inhibitors is a very promising approach,there are certain limitations and concerns that the intensive research and clinical evaluation of compounds will hopefully help to overcome.

关键词： p53 tumor suppression anti-cancer therapy targeted drugs transcription factor immune response

Insights of the brain damage response using antibodies identifying surface antigens on neural stem cells and neuroblasts

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Neural Regeneration Research 2015年第10期10卷 1574-1575页

作者： Silvia Santamaria Jose A.Garcia-sanz Department of Cellular and Molecular Medicine Centro de Investigaciones Biologicas (CIB-CSIC)

Similarly to other adult tissues,a hierarchical structure has been established for the brain,where the differentiated cell types（neurons,oligodendrocytes and astrocytes）are generated from primary progenitor cells,known as type B astrocytes or neural stem cells （NSC）, through one or multiple stages of amplification （transient amplifying cells） that generate precursor cells （iPC） with more restricted potential nlPCs （neural）, alPCs （astrocytes）, olPC （oligodendrocytes）（Kriegstein and Alvarez-Buvlla, 2009）.

关键词： NSCs stem

New transcriptomic insights in two RNAi wheat lines with the gliadins strongly down-regulated by two endosperm specific promoters

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The Crop Journal 2022年第1期10卷 194-203页

作者： Miriam Marín-sanz Julio CMasaru Iehisa Francisco Barro Department of Plant Breeding Institute of Sustainable Agriculture(IAS)Spanish Council for Scientific Research(CSIC)14004 CórdobaSpain Department of Biotechnology Faculty of Chemical SciencesNational University of Asunción111421 San LorenzoParaguay

The gluten proteins of wheat grain are responsible for visco-elastic properties of flour,but they also trigger the immune-response of celiac *** this work,two low-gliadin RNA interference(RNAi)wheat lines that differ for the promoter driving the silencing(D-hordein andγ-gliadin promoters for D783 and D793 lines,respectively),were characterized at transcriptomic,and protein fraction levels in the *** of gliadins provides a readjustment in the grain protein fractions that also affects to the nongluten proteins(NGP),which were increased in both RNAi *** of wheat gluten by means of the R5 monoclonal antibody also showed a strong reduction in the content of gluten in both RNAi ***,fructans,an oligosaccharide linked with the development of non-celiac wheat sensitivity(NCWS)were also significantly decreased in RNAi *** down-regulation of gliadins fractions also impacts to other metabolic processes,particularly on carbohydrate metabolism,enzyme regulator activity and response to *** and transcription factors regulated by ABA were up-regulated,which could suggest the implication of this phytohormone on the stress response observed in the RNAi lines.

关键词： Celiac disease Gliadin Protein compensation RNAi lines Triticum aestivum