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3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway

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BIOCELL 2022年第11期46卷 2425-2432页

作者： sanhua li QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI liNGJIE MENG YUN liU Guizhou Provincial College–Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi563000China life Science Institute of Zunyi Medical University Zunyi563000China School of Preclinical Medicine of Zunyi Medical University Zunyi563000China

Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor ***,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well *** present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in ***,3-epi-bufotalin inhibited the JAK1/STAT3 signaling *** results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells.

关键词： 3-epi-bufotalin Colorectal cancer JAK1/STAT3 signaling pathway Apoptosis

Cultivation and Characterization of the MaMV-DC Cyanophage that Infects Bloom-forming Cyanobacterium Microcystis aeruginosa

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Virologica Sinica 2013年第5期28卷 266-271页

作者： Tong Ou sanhua li Xiangyong liao Qiya Zhang State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of Sciences

The MaMV-DC cyanophage,which infects the bloom-forming cyanobacterium Microcystis aeruginosa,was isolated from Lake Dianchi,Kunming,***-one cyanobacterial strains were used to detect the host range of *** aeruginosa FACHB-524 and plaque purification were used to isolate individual cyanophages,and culturing MaMV-DC with cyanobacteria allowed us to prepare purified cyanophages for further *** microscopy demonstrated that the negatively stained viral particles are tadpole-shaped with an icosahedral head approximately 70 nm in diameter and a contractile tail approximately 160 nm in *** one-step growth experiments,the latent period and burst size of MaMV-DC were estimated to be 24–48 hours and approximately 80infectious units per cell,*** endonuclease digestion and agarose gel electrophoresis were performed using purified MaMV-DC genomic DNA,and the genome size was estimated to be approximately 160 *** dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE)analysis revealed four major structural *** results support the growing interest in using freshwater cyanophages to control bloom-forming cyanobacterium.

关键词：铜绿微囊藻水华蓝藻噬藻体感染聚丙烯酰胺凝胶电泳 SDS-PAGE 基因组DNA 琼脂糖凝胶电泳

Two Virus-like Particles that Cause Lytic Infections in Freshwater Cyanobacteria

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Virologica Sinica 2013年第5期28卷 303-305页

作者： sanhua li Tong Ou Qiya Zhang State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of Sciences

Dear Editor,We report the results of the preliminary isolation of two virus-like particles(VLPs)that are infectious to freshwater cyanobacteria from Lake Donghu,the largest urban lake in China,located in Wuhan City,Hu... 详细信息

关键词：病毒样颗粒水华蓝藻淡水感染裂解透射电子显微镜铜绿微囊藻城市湖泊

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一个有关素数幂的三元丢番图不等式

数学进展 2022年第3期51卷 447-470页

作者：李三华上海立信会计金融学院统计与数学学院上海201620

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关键词：丢番图不等式指数和素数

Hellebrigenin induces apoptosis in colorectal cancer Cells through induction of excessive reactive oxygen species

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BIOCELL 2021年第4期45卷 943-951页

作者： CHUNJIAO liU QINHONG KONG FENG PAN SHAN JIANG liNGJIE MENG GAI HUANG liDAN LU sanhua li YUN liU Guizhou Provincial College-based Key Laboratory for Tumor Prevention and Treatment with DistinctiveMedicines ZunyiMedical UniversityZunyi563000China life Sciences Institute Zunyi Medical UniversityZunyi563000China Department of Biochemistry and Molecular Biology Zunyi Medical UniversityZunyi563000China

Traditional Chinese medicine(TCM)has been increasingly applied in both preventing and treating a variety of cancers in the last decades,attributing to its fewer side effects as compared with chemotherapy ***,a component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported to have an obvious anti-cancer activity on various ***,the effect and mechanism of hellebrigenin on colorectal cancers were still ***,the present study demonstrated hellebrigenin significantly reduced viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in vitro and in ***,hellebrigenin led to a reduction of mitochondrial membrane *** addition,treatment with hellebrigenin could result in the induction of excessive reactive oxygen species,which led to cell *** results indicated that hellebrigenin had anti-cancer potential in the treatment of colorectal cancers.

关键词： Hellebrigenin Colorectal cancer Reactive oxygen species Apoptosis

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与分担全纯函数相关的正规族

数学年刊（A辑） 2016年第1期37卷 89-96页

作者：李三华井冈山大学数理学院江西吉安343009

设F是在区域D内的一族亚纯函数,其零点重级至少为k,k是一个正整数,a(z)(≠0)在区域D内全纯.若对于任意的f∈F,有(1)f(z)与a(z)没有公共的零点;(2)f(z)=0f(k)(z)=a(z)■0<|f^((k+1))(z)-a'(x)|<|a(z)|,则F在D内正规.

关键词：亚纯函数零点正规族

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混凝土湿喷机小臂变幅系统机液耦合建模分析

隧道建设（中英文） 2023年第5期43卷 879-886页

作者：李科军李三华陈淼林姚学军刘志辉邓旻涯高龙中南林业科技大学湖南长沙410004 湖南长院悦诚装备有限公司湖南长沙410000 中铁五局集团第一工程有限责任公司湖南长沙410000

为深入研究混凝土湿喷机小臂变幅过程中机液耦合特性,需建立准确的机液联合仿真模型。首先,根据混凝土湿喷机臂架小臂变幅机构组成和液压传动原理,建立小臂俯仰过程的运动学和动力学模型,并基于NX和AMESim分别建立三维机械结构和液压系... 详细信息

为深入研究混凝土湿喷机小臂变幅过程中机液耦合特性,需建立准确的机液联合仿真模型。首先,根据混凝土湿喷机臂架小臂变幅机构组成和液压传动原理,建立小臂俯仰过程的运动学和动力学模型,并基于NX和AMESim分别建立三维机械结构和液压系统仿真分析模型;然后,利用NX的运动分析模块Simcenter 3D建立机液耦合接口,搭建小臂变幅系统机液耦合仿真模型,仿真分析小臂上仰过程中的系统工作压力、流量和变幅角度等工作性能参数变化规律,并进一步计算基于Matlab的小臂变幅运动学、动力学仿真分析结果;最后,对比分析基于NX和AMESim的联合仿真结果、基于Matlab的数值模拟结果和小臂变幅试验测试结果。结果表明:1)传统数学建模方法不能反映小臂变幅时的系统动力学响应特性;2)机液联合仿真模型可以更准确地模拟湿喷机小臂变幅动作过程,且能全面观察变幅系统内部状态变量的工作特性;3)变幅油缸无杆腔压力试验结果与仿真结果吻合较好,验证了所建模型的准确性。

关键词：混凝土湿喷机变幅系统机液耦合联合仿真动力学

基于改进RetinaNet的宫颈异常细胞检测算法

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中国激光 2023年第15期50卷 101-110页

作者：刘润坤党世杰张洪远牛银银米贯勋李三华陈振鑫赵凌霄李鹏中国科学技术大学生物医学工程学院(苏州)生命科学与医学部安徽合肥230026 中国科学院苏州生物医学工程技术研究所江苏苏州215162 河南赛诺特生物技术有限公司河南郑州450001

宫颈异常细胞特征细微难以提取、小目标容易漏检、细胞边界回归不准确导致异常细胞检测精度不高,鉴于此,本文提出了一种结合注意力的全尺度特征融合RetinaNet(AFF-RetinaNet)宫颈异常细胞检测算法.首先,采用ResNeSt-50作为特征提取网络... 详细信息

宫颈异常细胞特征细微难以提取、小目标容易漏检、细胞边界回归不准确导致异常细胞检测精度不高,鉴于此,本文提出了一种结合注意力的全尺度特征融合RetinaNet(AFF-RetinaNet)宫颈异常细胞检测算法.首先,采用ResNeSt-50作为特征提取网络提取宫颈异常细胞的细微特征;其次,引入平衡特征金字塔(BFP)结构,对所有特征层进行全尺度融合,增强小目标的语义信息,并利用BFP中的非局部注意力模块获取图像的全局信息,以进一步增强特征空间的语义信息;最后,采用CIoU Loss作为回归分支的损失函数,以提高对异常细胞边界回归的准确率.另外,针对实际应用场景,基于AFF-RetinaNet算法实现了全视野宫颈细胞病理学图像(WSI)推理流程,并基于该推理流程对WSI中的异常细胞进行了检测.AFF-RetinaNet在宫颈异常细胞数据集上的平均精度均值(mAP)为83.4%,其中对小目标的mAP值(mAP-s)达到了24.4%,相较于基准RetinaNet算法分别提高了3.2个百分点和10.8个百分点.基于AFF-Retina的WSI推理结果在感兴趣区域中的mAP为70.8%.实验结果表明:AFF-RetinaNet算法可以增强对小尺寸异常细胞的检测能力,有效提升宫颈异常细胞的检测精度.基于AFF-RetinaNet的宫颈WSI推理流程可辅助医生快速定位高分辨率宫颈WSI中的异常细胞,有望减轻医生的阅片负担.

关键词：医用光学宫颈细胞病理图像目标检测小目标特征融合注意力机制

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有关殆素数的二元丢番图不等式

数学年刊（A辑） 2021年第2期42卷 179-188页

作者：李三华吴高翔井冈山大学数理学院江西吉安343009

Pr表示最多r个素因子的正整数.作者证明了,对于任一足够大的实数N和1

关键词：丢番图不等式指数和殆素数