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Earthquake Engineering and Engineering Vibration 2018年第1期17卷 179-190页

作者： Gabriel Ferrer Esteban sáez Christian Ledezma school of Engineering Pontificia Universidad Católica de Chile National Research Center for Integrated Natural Disaster Management

Copper production is an essential component of the Chilean economy. During the extraction process of copper, large quantities of waste materials（tailings） are produced, which are typically stored in large tailing ponds. Thickened Tailings Disposal（TTD） is an alternative to conventional tailings ponds. In TTD, a considerable amount of water is extracted from the tailings before their deposition. Once a thickened tailings layer is deposited, it loses water and it shrinks, forming a relatively regular structure of tailings blocks with vertical cracks in between, which are then filled up with ＂fresh＂ tailings once the new upper layer is deposited. The dynamic response of a representative column of this complex structure made out of tailings blocks with softer material in between was analyzed using a periodic half-space finite element model. The tailings＇ behavior was modeled using an elasto-plastic multi-yielding constitutive model, and Chilean earthquake records were used for the seismic analyses. special attention was given to the liquefaction potential evaluation of TTD.

关键词： Thickened tailings Liquefaction Periodic modeling

Validation and application of Vierordt’’s spectrophotometric method for simultaneous estimation of tamoxifen/coenzyme Q10 in their binary mixture and pharmaceutical dosage forms

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Asian Journal of Pharmaceutical sciences 2016年第2期11卷 318-325页

作者： Eman s. El-Leithy Rania s. Abdel-Rashid Department of Pharmaceutics Faculty of Pharmacy Helwan University

For the sake of improving patient compliance and sustainability of chemotherapy healthcare system, both TC and CoQ10 were formulated as solid lipid nanoparticles (sLNs). The study was focused on establishing and validating a simple and reproducible spectrophotometric method for simultaneous determination of TC and CoQ10 in their binary mixture or pharmaceutical dosage forms. A new method based on simultaneous estimation of drug mixture without prior separation was developed. Validation parameters were checked with International Conference on Harmonization (ICH) guidelines. The accuracy and reproducibility of proposed method was statistically compared to HPLC. The TC and CoQ10 were quantified at absorptivity wavelengths of 236 nm and 275 nm, respectively. Calibration curves obeyed Beer’s law in range of 2–14 μg/ml with a correlation coefficient (R^2) of 0.999 in both methanol and simplified simulated intestinal fluid (ssIF). The %means recovery of TC and Co Q10 in pure state or binary mixture at various concentration levels were all around 100%.The low values of sD and %RsD (sion and accuracy of the proposed method. Formulated sLNs showed different %means recovery in range 81–92% for TC and 32–59% for CoQ10. The data obtained by applying simultaneous Vierordt’s equations showed no statistical significance in comparison to HPLC. Vierordt’s method was successfully applied as a simple, accurate, precise, and economical analysis method for estimating TC and CoQ10 concentrations in pure state, binary mixture and pharmaceutical dosage forms.

关键词： Tamoxifen citrate Coenzyme Q10 Binary mixture solid lipid nanoparticles Validation

miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study

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Translational Neurodegeneration 2016年第1期5卷 40-51页

作者： sofie sølvsten sørensen Ann-Britt Nygaard Thomas Christensen Department of Neurology Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark Department of Clinical Biochemistry Copenhagen University HospitalNordsjællands HospitalDyrehavevej 293400 HillerødDenmark

Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene *** of miRNAs in cerebrospinal fluid(CsF)and blood have just started gaining attention as a novel diagnostic tool for various neurological *** purpose of this exploratory investigation was to analyze the expression of miRNAs in CsF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of ***:CsF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy *** samples were taken immediately *** RNA was extracted from cell free fractions of CsF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CsF in at least nine out of ten patients in both *** these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to *** hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to ***:Detection of miRNA expression profiles in blood and in particular CsF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant *** this explorative pilot study,the deregulated miRNAs in CsF of AD patients may be associated with relevant targ

关键词： Alzheimer’s disease Dementia Neurodegenerative disease miRNA expression Diagnostic biomarker Cerebrospinal fluid Blood

Grounded theory qualitative approach from Foucault's ethical perspective:Deconstruction of patient self-determination in the clinical setting

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World Journal of Clinical Cases 2021年第28期9卷 8312-8326页

作者： Jesús Molina-Mula Nursing and Physiotherapy Department University of Balearics IslandPalma 07122Illes BalearsSpain

This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and moral ethics *** tried to break loose from the self,which is merely the result of a biopol-itical subjectivation and constituted an interpersonal *** this,different elements involved in the decision-making capacity of patients in a clinical setting were ***,the context in which decision-making occurs has been explained,distinguishing between traditional practices involved in self-care and the more modern conceptions that make certain possible ***,an attempt is made to explain the formation of the medicalisation of society using the transformations of what Foucault called"techniques of the self".Finally,the ethical framework for a subject's"self-creation",insisting more on the exercises of self-subjectivation,reinforcing the ethics of the self by itself,the"care of the self",has been *** role of the patient is understood as an autonomous subject to the extent that the clinical institution and the professionals involved comprehend how the patient’s autonomy in the clinical environment is *** these elements could generate grounded theory on the qualitative methodology of this *** current ethical model based on universal principles is not useful to provide a capacity for patients decision-making,relegating to the background their opinions and ***,a new ethical perspective emerges that aims to return the patient to the fundamental axis of attention.

关键词： Decision making Personal autonomy Foucault Principle-based Ethics Bioethics,Qualitative methodology,Grounded theory

Risk factors for neoplastic progression in Barrett's esophagus

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World Journal of Gastroenterology 2011年第32期17卷 3672-3683页

作者： Elizabeth F Wiseman Yeng s Ang Department of Gastroenterology Royal Albert Edward Infirmary Wigan Lane Wigan Greater Manchester WN1 2NN United Kingdom Faculty of Medical and Human sciences School of Translational Medicine The University of Manchester Oxford Road Manchester M13 9PL United Kingdom

Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.

关键词： Barrett’s esophagus Esophageal adeno-carcinoma Metaplasia-dysplasia-carcinoma Neoplastic progression Risk factors

Pathophysiology and treatment of Barrett's esophagus

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World Journal of Gastroenterology 2010年第30期16卷 3762-3772页

作者： Daniel s Oh steven R DeMeester Department of surgery The University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States

Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United states. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared.

关键词： Gastroesophageal reflux disease Barrett’s esophagus Lower esophageal sphincter Esophageal motility Proton pump inhibitors Antireflux surgery

Timing of surgery in Crohn’s disease: A key issue in the management

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World Journal of Gastroenterology 2008年第36期14卷 5532-5539页

作者： Rafael Alós Joaquín Hinojosa servicio de Cirugía General Unidad de Coloproctología Hospital de Sagunto Valencia Spain Unidad de Digestivo Servicio de Medicina Interna Hospital de Sagunto Valencia Spain

The timing of the decision for operation in Crohn’s disease is based on an evaluation of the several factors such as the failure of medical treatment, complications due to the Crohn’s disease or to the farmacological therapy, development of dysplasia or cancer and growth retardation. A complete evaluation of these factors should result in operation timed to the patient’s best advantage, achieving maximal relief of symptoms with improvement of quality of life. Given the complexity and heterogeneity of the disease and the different options for treatment, is difficult to systematize when the optimal moment for the surgery is arrived. A very important factor in the management of Crohn’s disease is the multidisciplinary approach and the patient preference should be a significant factor in determining the choice of therapy. The surgery should be considered such another option in the sequential treatment of Crohn’s disease. We have analyzed the factors that are involved in the decision taking of the surgical treatment regarding to the experience and the published literature. When did the medical therapy fail? when is the appropriate moment to operate on the patient? Or which complications of Crohn’s disease need a surgery? These are some of the questions we will try to answer.

关键词： Crohn's disease surgical treatment Medical therapy

Current status of thiopurine analogues in the treatment in Crohn's disease

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World Journal of Gastroenterology 2011年第39期17卷 4372-4381页

作者： Peter Laszlo Lakatos Lajos s Kiss 1st Department of Medicine Semmelweis University

In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously *** studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,accelerated stepup and top-down *** addition,much emphasis has been placed in recent years on the de-termination of important predictive factors that could enable early patient stratification,which would lead to a tailored management *** this review,the authors try to highlight new evidence on the optimal timing,benefits,and risks of immunosupressants alone,or in combination,in patients with Crohn＇s disease.

关键词： Crohn's disease Immunosuppressives Azathioprine Thiopurine methyltrans ferase Biologicals

A new age in understanding adult hippocampal neurogenesis in Alzheimer’s disease

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Neural Regeneration Research 2022年第12期17卷 2615-2618页

作者： Maya A.Hanspal sébastien Gillotin MRL London Discovery MSDLondon Bioscience Innovation CentreLondonUK

several lines of evidence have established that proliferation and differentiation of neural stem cells into neurons within the sub-granular zone of the dentate gyrus,a process named adult hippocampal neurogenesis,contribute to maintaining healthy cognitive functions throughout *** rate of adult hippocampal neurogenesis decreases with aging and a premature impairment of adult hippocampal neurogenesis has been observed both in animal models of Alzheimer’s disease and human post-mortem *** causal relationship between adult hippocampal neurogenesis and the development of Alzheimer’s disease pathology has,however,not been *** is partly due to the limitation of recapitulating the development of Alzheimer’s disease pathology in rodent models and the lack of translatable biomarkers to identify tractable targets in *** it is tempting to postulate that adult hippocampal neurogenesis could be leveraged to improve cognitive deficits in Alzheimer’s disease,consensual results have yet to be reached to fully explore this *** this review,we discuss how the recent progress in identifying molecular pathways in adult hippocampal neurogenesis provides a good framework to initiate strategies for drug-based intervention in neurodegenerative diseases,especially in Alzheimer’s *** outline how discrepancies in pre-clinical disease models and experimental methodology have resulted in contradictory findings and propose a shift towards using more translatable approaches to model neurogenesis in Alzheimer’s *** particular,we review how exploring novel experimental paradigms including the use of human induced pluripotent stem cells and more complex cell culture systems,as well as standardizing protocols used to investigate evidence of neurogenesis in human tissues,could deliver deeper mechanistic insights that would kick-start innovative drug discovery efforts to promote healthy aging and cellular rejuvenation.

关键词： adult hippocampal neurogenesis Alzheimer’s disease cognition human tissue induced pluripotent stem cell mouse models neurodegeneration therapeutics tractable target

Abscisic acid, a promising therapeutic molecule to prevent Alzheimer’s and neurodegenerative diseases

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Neural Regeneration Research 2020年第6期15卷 1035-1036页

作者： Ana María sánchez-Pérez Department of Medicine Universitat Jaume I

Neuroinflammatory processes induce neuronal damage and underlie the onset of neurodegenerative pathologies,including Alzheimer’s disease(AD)(Calsolaro and Edison,2016).several conditions,ranging from emotional stress to metabolic syndrome,including traumatic brain injury,chronic infections or gut microbiota disruption can cause or aggravate ***,aging is the major factor associated with neurodegenerative diseases.

关键词： degenerative Alzheimer diseases