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转录因子Foxp3在子宫内膜异位症局部组织中的表达及意义

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中国病理生理杂志 2010年第2期26卷 384-385,389页

作者：金风丽齑藤.滋岛.友子云南中医学院云南昆明650500 日本富山大学医药部妇产科日本富山930-0194

目的:检测Foxp3在子宫内膜异位症组织中的表达,探讨内异症的发病机制。方法:通过免疫组化染色,观察21例子宫内膜异位症卵巢巧克力囊肿及同一患者盆腔腹膜中Foxp3的表达,并与10例正常子宫内膜和10例正常腹膜进行比较。结果:子宫内膜异位... 详细信息

目的:检测Foxp3在子宫内膜异位症组织中的表达,探讨内异症的发病机制。方法:通过免疫组化染色,观察21例子宫内膜异位症卵巢巧克力囊肿及同一患者盆腔腹膜中Foxp3的表达,并与10例正常子宫内膜和10例正常腹膜进行比较。结果:子宫内膜异位症患者卵巢巧克力囊肿及其盆腔腹膜中均可见到Foxp3阳性细胞表达,且二者Foxp3阳性细胞计数比较差异无显著;正常子宫内膜和正常腹膜中无Foxp3阳性细胞表达。结论:Foxp3启动了调节性T细胞的免疫抑制功能,使盆腔内免疫环境呈免疫耐受状态,当有活性的子宫内膜细胞进入盆腔后没有被免疫系统识别和清除,而是在盆腔内异位处发生侵袭、种植及进一步生长,这可能是子宫内膜异位症发生的机制之一。

关键词：子宫内膜异位症转录因子Foxp3 CD4+CD25+调节性T细胞

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火箭发动机壳体爆破实验时的声发射

固体火箭技术 1979年第2期 83-99页

作者： T.Kishi s.saito Y.Mori T.Watanabe s.Hashirizaki 杨明纬东京大学宇宙航空研究所东京大学宇宙航空研究所日本大学工学院新日铁新日铁

1.引言用声发射(AE)技术对压力容器和压力边界进行结构评价是声发射的应用中很有吸引力的领域之一。本文介绍了由NAIs系统最先提出的评价缺陷程度的方法应用于东京大学的M—13火箭发动机壳体的爆破实验的情况,目的是为了评价由于水压压... 详细信息

1.引言用声发射(AE)技术对压力容器和压力边界进行结构评价是声发射的应用中很有吸引力的领域之一。本文介绍了由NAIs系统最先提出的评价缺陷程度的方法应用于东京大学的M—13火箭发动机壳体的爆破实验的情况,目的是为了评价由于水压压力上升时该发动机壳体的有害度,而且讨论了断口特征和得到的声发射结果之间的关系。更进一步讨论了在高压

关键词：火箭发动机壳体结构评价事件数声发射爆破实验

Natural Convection Melting in a Rectangular Heat storage Tank of Carbon Nanotube Dispersed Latent Heat storage Material

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Journal of Thermal science 2024年第3期33卷 847-855页

作者： shin-ichi MORITA Tomoya saito Kazunori TAKAI Yasutaka HAYAMIZU Naoto HARUKI Division of Mechanical and Electrical Engineering Kitami Institute of Technology165 Koen-choKitami-shiHokkaido090-8507Japan National Institute of Technology Yonago College4448 Hikona-cyoYonago-shiTottori683-8502Japan Okayama Prefectural University 111 KubokiSoja-shiOkayama719-1197Japan

A dispersion system fluid can convect even if the dispersoid is a solid ***,heat exchange performance can be improved while maintaining fluidity using a material with high thermal conductivity as the *** study presents the melting performance evaluation results of a latent heat storage material with a carbon nanotube(CNT)dispersion system with high thermal conductivity,which enhances the thermal conductivity of the latent heat storage material and does not limit free *** the thermal conductivity and enhancing the melting convection of the heat storage material result in increased latent heat storage *** this study,the thermal conductivity of the latent heat storage material was successfully increased by dispersing CNTs in the *** 0.1%(in mass)of multi-wall CNT(MWCNT)was dispersed in a paraffin-based latent heat storage material,the shear stress increased by 1.5 times at a shear rate of 500 s^(-1),while taking into account the potential effects of convective ***,a latent heat storage experiment was conducted in a rectangular heat storage tank using the CNT dispersion composition ratio as a parameter.A rectangular vessel with a heated vertical surface was used for the latent heat storage *** melting speed was determined by comparing the amount of latent heat stored in a CNT-dispersed latent heat storage material and a single-phase latent heat storage material *** experimental results show that the time required for the latent heat storage material to completely melt in the heat storage tank was the shortest for the single-phase latent heat storage material ***,the fastest melting progress was observed for the sample with 0.02%(in mass)MWCNT content in the melting rate range of up to approximately 40%in the *** results indicate that this phenomenon is caused by the difference in the melting rates in the upper part of the *** generated data are useful for det

关键词： latent heat storage phase change carbon nano tube free convection heat transfer

Education Programs for Invasive Procedures Involving Nurses: A scoping Review

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Open Journal of Nursing 2024年第5期14卷 200-224页

作者： Hiromi shibuya Akiko saito Masumi Mugiyama Noyuri Yamaji Chisato Eto satoshi shibuya Department of Nursing Faculty of Health Science Technology Bunkyo Gakuin University Tokyo Japan Department of Health Care Policy and Health Economics Institute of Medicine University of Tsukuba Ibaraki Japan Institute of Clinical Epidemiology Showa University Tokyo Japan Department of Family Nursing Division of Health Science and Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Global Health Nursing Graduate School of Nursing St. Luke&#8217s International University Tokyo Japan school of Nursing Tokyo Women&#8217s Medical University Tokyo Japan Department of Integrative Physiology School of Medicine Kyorin University Tokyo Japan

Background: Implementing invasive procedures is an important part of patient management by clinical nurses;however, there are gaps between nurses’ actual knowledge and skills and expected professional care capacity. Purpose: This scoping review aimed to map the existing literature related to recent institution-provided educational programs for invasive procedures involving clinical nurses. This study seeks to understand the contents of educational programs and the methods for assessing educational effects. Methods: This scoping review was completed using the following four databases: PubMed (MEDLINE), Embase, Cochrane Library, and Emcare for the period 2000-2022. We included studies that used all forms of educational approaches (e.g., didactic lectures, hands-on training, or on-the-job training). This scoping review considered peer-reviewed publications published in English using quantitative, qualitative, or mixed approaches. A total of 83 studies underwent in the final analysis. Results and Conclusion: A combination of didactic lectures and hands-on training was provided as an educational program in most studies. Contrary to our prediction, educational interventions with advanced technologies such as VR are extremely rare, suggesting that the effectiveness of advanced technologies in learning invasive procedures should be examined to facilitate and retain educational effects more efficiently in future studies. Regarding the assessment of educational effects, nurses’ cognitive (i.e., theoretical knowledge about procedures), psychomotor (i.e., implementing procedures), and psychological aspects (e.g., confidence and self-efficacy in procedures) were evaluated using questionnaires and observational methods. While most studies used a one-group pretest-posttest design, the ratio of randomized controlled trials (RCT) was relatively low. Thus, an RCT design should be introduced in future studies to test the validity of the developed educational program more accurately.

关键词： Training Education Invasive Procedure Nurses Assessment

The Role of Jasmonates as Antibulbing substances in the Bulb Formation of Onion

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Agricultural Biotechnology 2024年第1期13卷 1-4,8页

作者： Noboru Takada Atsushi saito Yuuki Matsuzuka Tatsushi Mochiduki Eriko Wakita Meng WANG Yasunori Koda Faculty of Agriculture and Life science Hirosaki University3Bunkyo-choHirosaki 036-8561Japan The United Graduate school of Agricultural science Iwate UniversityMoriokaIwate 020-8550Japan National Institute of Vegitable and Tea science National Agriculture and Food Research Organization360 KusawaAnoTsu 514-2392Japan Research Faculty of Agriculture Hokkaido UniversityKita-9 Nishi-9Kita-kuSapporo 060-8589Japan

Onion plants form spherical bulbs under long-day *** regulating bulb formation remain *** the course of chemical studies on the bulb formation,α-linolenic acid was isolated from onion extracts as an antibulbing substance,the amount of which was synchronized with the bulb *** allene oxide synthase inhibitor canceled the antibulbing activity ofα-linolenic acid,it was disclosed that jasmonic acid concerns this ***-activity-relationship study revealed that its(3R,7s)stereochemistry is necessary for showing its antibulbing *** is concluded that(3R,7s)-jasmonate derived fromα-linolenic acid actually participates in the regulation of bulb formation.

关键词： Onion(Allim cepa L.cv.Higuma) Isolation Bulb formation Antibulbing substance α-Linolenic acid Methyl jasmonate

The paleoclimatic events and cause in the Okinawa Trough during 50 kaBP

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Chinese science Bulletin 2001年第2期46卷 153-157页

作者： s.Berne Y.saito Key Laboratory of Marine science and Numerical Modeling State Oceanic Administration (SOA) Qingdao China First Institute of Oceanography SOA Qingdao China Institute of Oceanology Chinese Academy of Sciences Qingdao China Taiwan University Taibei China French Oceanographic Institute IFREMER Plouzane France Geological survey of Japan Tsukuba Japan

Planktonic foraminiferal δ18O record for core DGKs9603 from the Okinawa Trough shows a series of climatic fluctuations and sudden cooling events in short time scale during 50 kaBP, which appear to correlate closely tothe Younger Dryas and Heinrich events H1-5 recorded in Chinese loess, the south China sea, the North Atlantic cores and the Greenland ice cores. Three polarity reversal events, correlating to Gothenburg, Mungo and Laschamp events, approximately correspond to Heinrich events H1, H3 and H5 respectively, which could be a cause of global climate changes. The δ18O curve of the Okinawa Trough is well associated with the grain size record of the Lijiayuan loess profile in northwestern China and is somewhat different from the climate fluctuations documented in the Greenland ice cores. These correlation results indicate that regional factors play an important role in controlling the climate changes in the East Asia, and the East Asian Monsoon could be the prominent regional controlling factor.

关键词： Okinawa Trough sudden paleoclimatic change events polarity reversal events Late Quaternary.

Rendering Grass Blowing in the Wind with Global Illumination

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Tsinghua science and Technology 2010年第2期15卷 133-137页

作者： N Max s.saito K Watanabe M Nakajima Computer science Department University of California Department of Computer science Tokyo Institute of Technology

We have simulated a time varying wind field using the lattice Boltzmann model, and its effect on blades of grass with a simple mass-spring model. We present a global illumination model for multiple scattering of incident sun and sky illumination within the field of grass. We model the grass as a continuous distribution of infinitesimal colored scattering flakes and solve a system of differential equations for the radiance transport. We repeat this for a collection of grass bending directions and amounts, and then interpolate the solutions when rendering animations of blowing grass.

关键词： global illumination lattice Boltzmann method plane parallel radiation transport

Resourceability on nuclear fuel cycle by transmutation approach

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science China Chemistry 2012年第9期55卷 1746-1751页

作者： OZAWA Masaki saito Masaki Research Laboratory for Nuclear Reactors Tokyo Institute of Technology2-12-1-N1-1 OokayamaMeguro-kuTokyo 152-8550Japan

A resourceability on nuclear fuel cycle by transmutation of fission products in the spent fuel of nuclear reactors is discussed in this paper to investigate the feasibility of ＂creation and utilization＂ of Apr6s ORIENT from Adv.-ORIENT cycle, in which chemical ＂separation and utilization＂ of nuclear rare metals （platinum group metals, Mo, Tc, rare earth, etc.） has been proposed since FY2006. Apr6s ORIENT research program was newly initiated in FY2011 for nuclear transmutation of fission products into stable or short-lived highly-valuable elements. In the resourceability of rare earth metals from fission products, non-radioactive Nd and Dy can be created from Pr and Tb, respectively, by transmutation. Especially, the Dy creation has relatively high feasibility of about 10-20 %/y in creation rate. A proper moderation of neutrons in blanket of fast reactors may be required to provide a high creation rate of La from Ba. In light platinum group metals, non-radioactive Ru can be created from Tc by transmutation, of which creation rate is about 4-5 %/y in blanket of fast reactors. Pd created from Rh is almost non-radioactively depending on the isotope fraction of 107pd. Rh creation from Ru is not feasible under the neutron irradiation of typical nuclear reactors.

关键词： Apres ORIENT Advanced ORIENT cycle nuclear rare metal transmutation nuclear fuel cycle

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu saito Akira saito Yuichiro Ohe shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko shimada Takaaki Mizuno Hiromi sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto sonobe shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse satoshi s.Nishizuka Noriko Motoi Norie sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General surgical science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract surgery Fukushima Medical University School of MedicineFukushimaJapan staGen Co. LtdTokyoJapan Division of Thoracic surgery National Cancer Center HospitalTokyoJapan Department of Thoracic surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung