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Bacteria and host: what does this mean for sepsis bottleneck?

World Journal of Emergency Medicine 2025年第1期16卷 10-17页

作者： Azzah s Alharbi Raghad Hassan sanyi Esam I Azhar Department of Clinical Microbiology and Immunology Faculty of MedicineKing Abdulaziz UniversityJeddah 21362Saudi Arabia special Infectious Agent Unit King Fahad Medical Research CenterKing Abdulaziz UniversityJeddah 21362Saudi Arabia College of Health and Medical Technology Middle Technical UniversityBaghdad 10047Iraq Department of Medical Laboratory sciences Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddah 21362Saudi Arabia

BACKGROUND: sepsis is a life-threatening inflammatory condition in which the invading pathogen avoids the host's defense mechanisms and continuously stimulates and damages host cells. Consequently, many immune responses initially triggered for protection become harmful because of the failure to restore homeostasis, resulting in ongoing hyperinflammation and immunosuppression. METHODs: A literature review was conducted to address bacterial sepsis, describe advances in understanding complex immunological reactions, critically assess diagnostic approaches, and emphasize the importance of studying bacterial bottlenecks in the detection and treatment of ***: Diagnosing sepsis via a single laboratory test is not feasible;therefore, multiple key biomarkers are typically monitored, with a focus on trends rather than absolute values. The immediate interpretation of sepsis-associated clinical signs and symptoms, along with the use of specific and sensitive laboratory tests, is crucial for the survival of patients in the early stages. However, long-term mortality associated with sepsis is now recognized, and alongside the progression of this condition, there is an in vivo selection of adapted ***: Bacterial sepsis remains a significant cause of mortality across all ages and societies. While substantial progress has been made in understanding the immunological mechanisms underlying the inflammatory response, there is growing recognition that the ongoing host-pathogen interactions, including the emergence of adapted virulent strains, shape both the acute and long-term outcomes in sepsis. This underscores the urgent need for novel high-throughput diagnostic methods and a shift toward more pre-emptive, rather than reactive, treatment strategies in sepsis care.

关键词： sepsis Bacteria Bottleneck Inflammation

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali N.Ali Arshad Majid sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNs)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNs paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

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Neural network analysis for prediction of heat transfer of aqueous hybrid nanofluid flow in a variable porous space with varying film thickness over a stretched surface

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Chinese Physics B 2025年第2期34卷 316-326页

作者： Abeer s Alnahdi Taza Gul Department of Mathematics and statistics Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia Mathematics Department City University of Science and Information TechnologyPeshawar25000Pakistan DosT-Directorate General of science and Technology Khyber Pakhtunkhwa Peshawar25000Pakistan

The high thermal conductivity of the nanoparticles in hybrid nanofluids results in enhanced thermal conductivity associated with their base *** heat transfer is a result of this high thermal conductivity,which has significant applications in heat exchangers and engineering *** optimize heat transfer,a liquid film of Cu and TiO_(2)hybrid nanofluid behind a stretching sheet in a variable porous medium is being considered due to its *** nature of the fluid is considered time-dependent and the thickness of the liquid film is measured variable adjustable with the variable porous space and favorable for the uniform flow of the liquid *** solution of the problem is acquired using the homotopy analysis method HAM,and the artificial neural network ANN is applied to obtain detailed information in the form of error estimation and validations using the fitting curve *** data is utilized to train the ANN in this study,which uses Cu and TiO_(2)hybrid nanofluids in a variable porous space for unsteady thin film flow,and it is used to train the *** results indicate that Cu and TiO_(2)play a greater role in boosting the rate.

关键词： thin film of Cu and TiO_(2)hybrid nanofluids variable porous space unsteady stretching sheet viscous dissipation heat transfer optimization artificial neural network

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Microstructure and mechanical properties of welds of AZ31B magnesium alloy produced by different gas tungsten arc welding variants

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Defence Technology(防务技术) 2025年第2期44卷 98-110页

作者： s.srinivasan R.Ravi Bharath A.Atrens P.Bala srinivasan school of Mechanical Engineering SASTRA Deemed to be UniversityThanjavur 613401India Welding Research Institute Bharat Heavy Electricals LimitedTiruchirappalli 620014India school of Mechanical and Mining Engineering Centre for Advanced Materials Processing and Manufacturing(AMPAM)University of QueenslandSt LuciaQLD 4072Australia High Energy Batteries(India)Limited MathurTiruchirappalli 622515India

This work aimed to(i)understand conventional and pulse gas tungsten arc welding(GTAW)of AZ31B,and(ii)explore high frequency welding(100 Hz-1500 Hz).GTA welding with alternating current(AC)and direct current electrode positive(DCEP)polarities yielded crack-free partial penetration welds for6 mm thick AZ31B alloy *** under direct current electrode negative(DCEN)polarity with identical parameters as that for AC and DCEP resulted in full penetration welds that had ***-free full-penetration welds could be accomplished with pulse GTA welding using DCEN polarity at a pulse frequency of 1 Hz with a pulse duration ratio of 1:*** resultant DCEN P 1:1 weld metal had a microstructure finer than the conventional DCEN *** produced with pulse duration ratios of 1:2and 1:4 lacked penetration but had a much finer microstructures because of the lower heat *** arc constriction by the high frequency pulsing in the Activ Arc■-High frequency(AA-HF)mode welding was responsible for deeper *** produced under DCEN pulsing and AA-HF conditions had hardness higher than conventional DCEN,DCEP and AC GTA welds,attributed to the finer ***-HF GTA welding produced defect free deeper penetration welds with good microstructural features/mechanical properties and also gave an advantage of 50%enhanced productivity when welded at1500 Hz.

关键词： AZ31B alloy Pulse GTAW High frequency Microstructure Mechanical properties Productivity

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Role of photon-counting computed tomography in pediatric cardiovascular imaging

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World Journal of Clinical Pediatrics 2025年第1期14卷 55-62页

作者： Arosh s Perera Molligoda Arachchige Yash Verma Faculty of Medicine Humanitas UniversityPieve Emanuele 20072Italy Department of Radiology Mayo ClinicRochesterMN 55905United States

Photon-counting computed tomography(PCCT)represents a significant advancement in pediatric cardiovascular *** CT systems employ energy-integrating detectors that convert X-ray photons into visible light,whereas PCCT utilizes photon-counting detectors that directly transform X-ray photons into electric *** direct conversion allows photon-counting detectors to sort photons into discrete energy levels,thereby enhancing image quality through superior noise reduction,improved spatial and contrast resolution,and reduced *** pediatric applications,PCCT offers substantial benefits,including lower radiation doses,which may help reduce the risk of malignancy in pediatric patients,with perhaps greater potential to benefit those with repeated exposure from a young *** spatial resolution facilitates better visualization of small structures,vital for diagnosing congenital heart ***,PCCT’s spectral capabilities improve tissue characterization and enable the creation of virtual monoenergetic images,which enhance soft-tissue contrast and potentially reduce contrast media *** clinical results indicate that PCCT provides superior image quality and diagnostic accuracy compared to conven-tional CT,particularly in challenging pediatric cardiovascular *** PCCT technology matures,further research and standardized protocols will be essential to fully integrate it into pediatric imaging practices,ensuring optimized diagnostic outcomes and patient safety.

关键词： Cardiovascular Photon-counting detectors Pediatric Photon-counting computed tomography Computed tomography

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Transforming osteosarcoma care:from historical milestones to precision medicine advances

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science Bulletin 2025年第3期70卷 290-294页

作者： Jichuan Wang David s.Geller Luyang sun Xiaodong Tang Musculoskleletal Tumor Center Beijing Key Laboratory for Musculoskeletal TumorsPeking University People’s HospitalBeijing 100041China Department of Orthopedic surgery Montefiore Medical CenterAlbert Einstein College of MedicineBronx 10471USA Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Osteosarcoma(Os),one of the earliest recognized cancers in humans,is a rare yet significant malignant bone tumor,diagnosed in 2-6 cases per million annually[1].It predominantly affects adolescents and young adults,with a second peak in incidence occurring around age *** osteosarcoma typically arises in areas of rapid bone growth,such as the knee and shoulder,and often presents persistent bone pain and progressive *** osteosarcoma often has a classic radiographic appearance,diagnosis is ultimately confirmed histologically.

关键词： osteosarcoma diagnosis annually

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The deflection angle and quasi-periodic oscillations of an extended gravitational decoupled black hole solution

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Communications in Theoretical Physics 2025年第2期77卷 132-147页

作者： Farzan Mushtaq Xia Tiecheng Allah Ditta G Mustafa s K Maurya Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai University Department of Physics Zhejiang Normal University Research Center of Astrophysics and Cosmology Khazar University Department of Mathematical and Physical sciences College of Arts and Sciences University of Nizwa

In weak field limits, we compute the deflection angle of a gravitational decoupling extended black hole(BH) solution. We obtained the Gaussian optical curvature by examining the null geodesic equations with the help of Gauss–Bonnet theorem(GBT). We also looked into the deflection angle of light by a black hole in weak field limits with the use of the Gibbons–Werner method. We verify the graphical behavior of the black hole after determining the deflection angle of light. Additionally, in the presence of the plasma medium, we also determine the deflection angle of the light and examine its graphical behavior. Furthermore, we compute the Einstein ring via gravitational decoupling extended black hole solution. We also compute the quasi-periodic oscillations and discuss their graphical behavior.

关键词： deflection of light Gauss-Bonnet theorem gravitational decoupling

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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c MEsONs

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Chinese Physics C 2014年第9期38卷 1248-1335页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi s.Bethke H.Bichsel O.Biebe E.Blucher s.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.s.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards s.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta s.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart s.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz s.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.s.Lugovsky s.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason s.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington s.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt s.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald s.Roesler s.rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.sachrajda Y.sakai G.P.salam s.sarkar F.sauli O.schneider K.scholberg D.scott V.sharma s.R.sharpe M.silari T.sjostrand P.skands J.G.smith G.F.smoot s.spanier H.spieler C.spiering A.stahl T.stanev s.L.stone T.sumiyoshi M.J.syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt s.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAs Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck-Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

The level scheme of the cc states showing experimentally established states with solid lines. singlet states are called cc and he, triplet states ψ and χcJ, and unassigned charmonium-like states X.

关键词： HBC MEsONs

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BOTTOM,CHARMED MEsONs(B=C=±1)B_c^+=c,B_c^-=cb,similarly for B_c~*'s

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Chinese Physics C 2014年第9期38卷 1239-1247页

I（JP） = 0（0-）I, J, P need confirmation.Quantum numbers shown are quark-model predictions.

关键词： B=C HBC B BOTTOM,CHARMED MEsONs B_c cb,similarly for B_c

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