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The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NAssER MULLA YOUsEF KATIB AsIM M.ALMUGHAMsI DUAA s.ALKHAYAT MOHAMED MOsAAD sAMIR T.ALFOTIH RAWAN ALAOFI Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(Os).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in Os among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in Os(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the Os in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and Os(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in Os among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for Os were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with Os.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

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Proton therapy for pancreatic cancer

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World Journal of Gastrointestinal Oncology 2015年第9期7卷 141-147页

作者： Romaine C nichols soon Huh Zuofeng Li Michael Rutenberg Department of Radiation Oncology University of Florida

Radiotherapy is commonly offered to patients with pancreatic malignancies although its ultimate utility is compromised since the pancreas is surrounded by exquisitely radiosensitive normal tissues, such as the duodenum, stomach, jejunum, liver, and kidneys. Proton radiotherapy can be used to create dose distributions that conform to tumor targets with significant normal tissue sparing. Because of this, protons appear to represent a superior modality for radiotherapy delivery to patients with unresectable tumors and those receiving postoperative radiotherapy. A particularly exciting opportunity for protons also exists for patients with resectable and marginally resectable disease. In this paper, we review the current literature on proton therapy for pancreatic cancer and discuss scenarios wherein the improvement in the therapeutic index with protons may have the potential to change the management paradigm for this malignancy.

关键词： Proton therapy Pancreatic cancer Review

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Heritage and the COVID-19 pandemic:the meaning of visitation

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Built Heritage 2023年第2期7卷 50-60页

作者： Cut Dewi Matthew Rofe Julie nichols Izziah Izziah Architecture and Planning Department Universitas Syiah KualaJl.Syech Abdulrauf No.7DarussalamBanda AcehAceh 23111Indonesia UnisA Creative University of South AustraliaMagill Campus(B1-04)AdelaideSouth AustraliaSA 5072Australia UnisA Creative University of South AustraliaCity West Campus(K3-14)AdelaideSouth AustraliaSA 5000Australia

The onset of the COVID-19 pandemic has impacted global mobility.‘Lockdowns’and travel bans have been used as control measures by international ***,the ways that we use buildings have also been impacted by these ***,this paper explores the roles of heritage sites in a post-COVID-19 pandemic *** research is part of the Urban Heritage and Community Resilience:Conservation,Tourism,and Pandemic project,and it employs methods such as semistructured interviews,participant observations,archival research,and focus group discussions(FGDs).This paper is based on semistructured interviews conducted with one hundred eighteen participants across ten popular heritage sites in Banda Aceh and Aceh Besar,*** fndings confrm the debated claim in postdisaster studies asserting that some of these Acehnese heritage sites,especially those imbued with religious values,have become places of ***,during the pandemic,these sites have facilitated community resilience by helping people feel closer to *** practising Acehnese Muslims,prayer at home is culturally acceptable,but praying at the mosque,which is one of the essential heritages of the Acehnese,has contributed to and strengthened the sense of community ***,visitation and participation in heritage sites that include experiencing the sense of place and conducting religious and cultural activities is integral to community resilience.

关键词： Heritage Pandemic Visitation Resilience

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Legacy earthen berms influence vegetation and hydrologic complexity in the Altar Valley,Arizona

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International soil and Water Conservation Research 2023年第4期11卷 755-763页

作者： Mary H.nichols sara E.Duke Chandra Holifield Collins Lauren Thompson southwest Watershed Research Center USDA-ARS2000 E.Allen Rd.TucsonAZ85719USA southern Plains Area Research Center USDA-ARSSPARCCollege StationTX77845USA University of Arizona College of Science GraduateTucsonAZ85719USA

Across the American southwest water development has played a critical role in managing *** berms have been constructed throughout Us rangelands to manage runoff and reduce *** berms altered runoff patterns to increase soil moisture with positive local vegetative ***,altered runoff patterns can be considered a disturbance that affects broader scale vegetation *** hypothesized that the hydrologic impacts of earthen berms in semiarid rangelands will be reflected in contrasting upslope and downslope vegetation patterns.A supervised classification of grass,shrubs,and bare soil was performed using orthographic imagery taken in June 2016 to quantify the effects of 181 earthen berms in the uplands and floodplain of the Altar Valley in southern Arizona,*** berms blocked runoff,creating downslope runoff"shadows"within which the precipitation is the dominant water *** documented more bare soil downslope of intact berms in comparison with *** and shrub cover affected by berms were related to soil *** and shrub cover were not different above and below intact berms on fine textured soils,but on sites with coarser textured soil,grass cover was lower downslope of *** breaches occurred on coarser textured soils,the up and downslope differences in grass cover *** study points to the role of conservation structures in adding additional complexity to already heterogeneous landscapes by creating patchwork assemblages of vegetation and bare soil proximal to earthen runoff and erosion control berms.

关键词： Legacy conservation structure Earthen bank Earthen berm Land degradation Rangeland

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

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On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins

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Magnetic Resonance Letters 2022年第2期2卷 61-68,I0002页

作者： Alexandra Born Morkos A.Henen Parker J.nichols Beat Vogeli University of Colorado Anschutz Medical Campus Department of Biochemistry and Molecular Genetics12801 East 17th AvenueAuroraCO80045USA Faculty of Pharmacy Mansoura UniversityMansoura35516Egypt

Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of ***,an alignment tensor that defines the orientation of the entire molecule relative to the magnetic field is determined either before refinement of individual bond vectors or simultaneously with this *** single-domain proteins this approach works well since all bond vectors can be described within the same coordinate frame,which is given by the alignment ***,novel approaches are sought after for systems where no universal alignment tensor can be ***,we present an approach that can be applied to two-domain proteins that enables the calculation of multiple states within each domain as well as with respect to the relative positions of the two domains.

关键词： RDC Residual dipolar coupling Two-domain protein Multi-state structure

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Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： Oliver Kann Lennart soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

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Pediatric upper extremity firearm injuries:an analysis of demographic factors and recurring mechanisms of injury

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World Journal of Pediatrics 2021年第5期17卷 527-535页

作者： D.spencer nichols Mitsy Audate Caroline King David Kerekes Harvey Chim Ellen satteson University of Florida College of Medicine.Gainesville FL.USA Department of surgery Division of Plastic and Reconstructive Surgery.University of Florida College of Medicine100138GainesvilleFL 32610USA

Background Little is known regarding risk factors specific to pedialric upper extremity firearm *** purpose of this study is to evaluate pediatric patients treated for these injuries to identify at-risk populations and recurring mechanisms of *** A 20-year retrospective review was *** 17 years of age and younger,with upper extremity injuries related to a firearm,were *** involved Fisher's exact and Chi-square *** One hundred and eighty patients were *** mean age was 12.04±4.3 *** included patients were male(85%).Interestingly,females were more frequently victims of assault(P=0.03),and males were more frequently injured due to accidental discharge(Pst affected race/ethnicity was White-not Hispanic or Latino(48%).The hand was the most frequent location injured(31%)and was more likely to be accidental than proximal injuries(P=0.003).Air rifes were the most common firearm type used(56%).Pistols were implicated in 47(26%)cases,rifles in 17(9%),*** in 10(6%).Ninety-nine(55%)patients had procedures in the operating *** most frequent procedure was foreign body removal(55%).Conclusions Risk factors such as male sex,W hite-not Hispanic or Latino race/ethnicity,and adolescent age were attributed to increased risk for *** sex was associated with increased risk of injury by accidental discharge and female sex with intentional *** rifles were the most common firearm type overall,although female sex was associated with increased risk for injury by powder weapon.

关键词： Firearm Injury Pediatric Trauma Upper extremity

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smelling fit： scent marking exposes parasitic infection status in the banded mongoose

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Current Zoology 2017年第3期63卷 237-247页

作者： Jessica MITCHELL Michael A. CANT Emma I.K. VITIKAINEN Hazel J. nichols school of Natural sciences and Psychology Liverpool John Moores University Liverpool L3 AF UK Centrefor Ecology and Conservation University of Exeter Penryn Campus TRIO 9FE UK

Preference for uninfected mates is presumed beneficial as it minimizes one＇s risk of contracting an infection and infecting one＇s offspring. In avian systems, visual ornaments are often used to indi- cate parasite burdens and facilitate mate choice. However, in mammals, olfactory cues have been proposed to act as a mechanism allowing potential mates to be discriminated by infection status. The effect of infection upon mammalian mate choice is mainly studied in captive rodents where ex- perimental trials support preference for the odors of uninfected mates and some data suggest scent marking is reduced in individuals with high infection burdens. Nevertheless, whether such effects occur in nonmodel and wild systems remains poorly understood. Here, we investigate the interplay between parasite load （estimated using fecal egg counts） and scent marking behavior in a wild population of banded mongooses Mungos mungo. Focusing on a costly protozoan parasite of the genus Isospora and the nematode worm Toxocara, we first show that banded mongooses that engage in frequent, intensive scent marking have lower Isospora loads, suggesting marking behavior may be an indicator trait regarding infection status. We then use odor presentations to demonstrate that banded mongooses mark less in response to odors of opposite sexed individuals with high Isospora and Toxocara loads. As both of these parasites are known to have detrimental effects upon the health of preweaned young in other species, they would appear key targets to avoid during mate choice. Results provide support for scent as an important ornament and mechanism for advertising parasitic infection within wild mammals.

关键词： Isospora olfaction parasite scent scent preferences Toxocara.

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