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Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.k.B.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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应用胆系MR和MR胆系成像鉴别导管内生长型与结节型胆管细胞癌

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国际医学放射学杂志 2011年第1期34卷 71-页

作者： J.E.kim J.M.Lee s.H.kim J.H.Baek s.k.moon 朱跃强 Department of Radiology Seoul National University Hospital

目的描述导管内生长(IDG)型胆管细胞癌(CC)的MRI表现,确定其与结节型胆管细胞癌的鉴别诊断要点。材料与方法医院伦理委员会同意了此次回顾性研究。

关键词：胆管细胞癌结节型胆系 MR 导管木质部生长型

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小的(≤20mm)胰腺腺癌:多期相多层螺旋CT增强方式和间接征象分析

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国际医学放射学杂志 2011年第4期 375-375页

作者： s.H.Yoon J.M.Lee J.Y.Cho k.B.Lee J.E.kim s.k.moon 任宇靖 Department of Radiology Seoul National University College of Medicine

目的评价在多期相多层螺旋CT影像上直径≤20mm胰腺癌的增强方式、间接征象出现率及组织病理学特性。材料与方法本回顾性研究被审查委员会所认可,不需签署知情同意书。作者回顾了2002年1月—2009年9月共163例连续病人的临床和影像学数据... 详细信息

目的评价在多期相多层螺旋CT影像上直径≤20mm胰腺癌的增强方式、间接征象出现率及组织病理学特性。材料与方法本回顾性研究被审查委员会所认可,不需签署知情同意书。作者回顾了2002年1月—2009年9月共163例连续病人的临床和影像学数据,其中130例病人(男

关键词：胰腺癌等密度出现率间接征象多层螺旋 CT

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行肝脏对比增强CT时根据密度自动调整管电压和管电流调制以减少辐射剂量

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国际医学放射学杂志 2013年第1期 63-63页

作者： k.H.Lee J.M.Lee s.k.moon J.H.Baek J.H.Park T.G.Flohr 纪东旭 Division of Abdominal Imaging Department of RadiologyInstitute of Radiation MedicineSeoul National University College of Medicine28 Yeongon-dongJongnoguSeoul 110-744Korea

目的回顾性分析联合应用自动调整管电压和自动管电流调制技术,与单独使用自动管电流调制比较,是否可在可接受的影像质量情况下降低肝脏对比增强CT的辐射剂量。材料与方法本研究经单位伦理委员会批准,无需知情同意书。怀疑肝脏疾病的314... 详细信息

目的回顾性分析联合应用自动调整管电压和自动管电流调制技术,与单独使用自动管电流调制比较,是否可在可接受的影像质量情况下降低肝脏对比增强CT的辐射剂量。材料与方法本研究经单位伦理委员会批准,无需知情同意书。怀疑肝脏疾病的314例病人,分成3组。其中2组应用自动调整管电压和自动管电流调制技术(A1组,n=97;A2组,n=101),但两组之间采用不同的对比增益设定;第3组,在固定管电压120kV条件下采用自动管电流调制技术(B组,n=116)。评价容积加权CT剂量指数与辐射距离乘积、对比噪声比和平均影像噪声。影像分析由2名具职业执照的放射科医师和1名放射科住院医师完成。统计分析采用单因素方差分析、双尾配对t检验、秩和检验和非劣效性检验。结果 A1和A2组较B组辐射剂量明显降低(P<0.0001)。A1组的辐射剂量平均降低20%,A2组降低31%。此外,A1和A2组的对比噪声比明显高于B组(P<0.0001)。尽管A1和A2组的影像噪声较高,但影像质量总体还是可以接受的。结论与单独采用自动管电流调制技术相比,联合应用自动调整管电压和自动管电流调制技术可在保证影像质量情况下,降低肝脏对比增强CT的检查辐射剂量。

关键词：管电压自动调整自动调节辐射剂量对比增强肝脏 CT

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strong enhancement of magnetic order from bulk to stretched monolayer Fese as Hund’s metals

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npj Computational Materials 2020年第1期6卷 448-453页

作者： Chang-Youn moon Advanced Instrumentation Institute Korea Research Institute of Standards and ScienceYuseongDaejeonRepublic of Korea

Despite of the importance of magnetism in possible relation to other key properties in iron-based superconductors,its understanding is still far from complete especially for Fese *** one hand,the origin of the absence of magnetic orders in bulk Fese is yet to be *** the other hand,it is still not clear how close monolayer Fese on srTiO_(3),with the highest transition temperature among iron-based superconductors,is to a magnetic *** we investigate magnetic properties of bulk and monolayer Fese using dynamical mean-field theory combined with density-functional *** find that suppressed magnetic order in bulk Fese is associated with the reduction of interorbital charge fluctuations,an effect of Hund’s coupling,enhanced by a larger crystal-field ***,spatial isolation of Fe atoms in expanded monolayer Fese leads into a strong magnetic order,which is completely destroyed by a small electron *** work provides a comprehensive understanding of the magnetic order in iron-based superconductors and other general multi-orbital correlated systems as Hund’s metals.

关键词： theory monolayer orbital

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Authentication Methods for 802.11s Mesh Networks

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China Communications 2007年第1期4卷 56-65页

作者： sangJae moon Mobile Network security Technology Research Center

With the rapid development of the WLAN,the 802. 11 s mesh network is ***,adaptability and scalability are the most important attributes of a mesh ***,the security in an 802.11s mesh network is not well defined or specified,and there is no standard method to authenticate a mesh point that is creating a mesh *** this paper,we propose solutions for the authentication of mesh *** the Basic Infrastructure security Mode,we combine the 802.1X/EAP and neighbor graph to realize the fast mutual authentication between a new mesh point and every its mesh *** prove that our scheme maintains the security of the standardized EAP authentication *** the same time,the simulation result shows that the authentication latency of our scheme is much lower than that of the scheme in[2].In the Basic Decentralized security Mode(BDsM),802.11s mesh networks are very similar to ad hoc networks,but they are different in several *** first analyze the differences between *** on this analysis, we investigate the main authentication methods used in ad hoc networks and select the pairwise key pre-distribution model and identity-based model for the WLAN mesh network.

关键词： authentication 802.11s mesh networks ad hoc networks

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