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Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide

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Food science and Human wellness 2022年第3期11卷 483-493页

作者： Kumju youn Chi-Tang Ho Mira Jun Department of Food science and Nutrition Dong-A UniversityBusan 49315Korea Department of Food science Rutgers UniversityNJ 08901USA Department of Health sciences The graduate School of Dong-A UniversityBusan 49315Korea

Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory *** lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal *** has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of *** overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of *** is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in *** review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ***,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.

关键词： Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation

Newly-modeled graphene-based ternary nanocomposite for the magnetophotocatalytic reduction of CO_(2) with electrochemical performance

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Frontiers of Chemical science and Engineering 2022年第10期16卷 1438-1459页

作者： Zambaga Otgonbayar Kwang youn Cho Chong-Hun Jung won-Chun Oh Department of Advanced Materials science&Engineering Hanseo UniversitySeosan-Si 31962Korea Korea Institutes of Ceramic Engineering and Technology Jinju-Si 660031Korea Decommissioning Technology Research Division Korea Atomic Energy Research InstituteDaejeon 305-600Korea Anhui International Joint Research Center for Nano Carbon-based Materials and Environmental Health College of Materials Science and EngineeringAnhui University of Science&TechnologyHuainan 232001China

The development of CO_(2)into hydrocarbon fuels has emerged as a green method that could help mitigate global *** novel structured photocatalyst is a promising material for use in a photocatalytic and magneto-electrochemical method that fosters the reduction of CO_(2)by suppressing the recombination of electron−hole pairs and effectively transferring the electrons to the surface for the chemical reaction of CO_(2)*** our study,we have developed a novel-structured AgCuZns_(2)–graphene–TiO_(2)to analyze its catalytic activity toward the selective evolution of CO_(2).The selectivity of each nanocomposite substantially enhanced the activity of the AgCuZns_(2)–graphene–TiO_(2)ternary nanocomposite due to the successful interaction,and the selectivity of the final product was improved to a value 3 times higher than that of the pure AgCuZns_(2)and 2 times higher than those of AgCuZns_(2)–graphene and AgCuZns_(2)–TiO_(2)under ultraviolet(UV)-light(λ=254 nm)irradiation in the photocatalytic *** electrochemical CO_(2)reduction test was also conducted to analyze the efficacy of the AgCuZns_(2)–graphene–TiO_(2)when used as a working electrode in laboratory electrochemical *** electrochemical process was conducted under different experimental conditions,such as various scan rates(mV·s^(–1)),under UV-light and with a 0.07 T *** evolution of CO_(2)substantially improved under UV-light(λ=254 nm)and with 0.07 T magnetic-core treatment;these improvements were attributed to the facts that the UV-light activated the electron-transfer pathway and the magnetic core controlled the pathway of electrontransmission/prevention to protect it from chaotic electron *** all tested nanocomposites,AgCuZns_(2)–graphene–TiO_(2)absorbed the CO_(2)most strongly and showed the best ability to transfer the electron to reduce the CO_(2)to *** believe that our newly-modeled ternary nanocomposite opens up new opportunities for the evolution of C

关键词： ternary nanocomposite photocatalytic electrochemical CO_(2) reduction UV-light magnetic core

The transcriptomic signature of responses to larval crowding in Drosophila melanogaster

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Insect science 2023年第2期30卷 539-554页

作者： Juliano Morimoto Marius wenzel Davina Derous youn Henry Herve Colinet school of Biological sciences University of AberdeenAberdeenUnited Kingdom Programa de Pos-graduacao em Ecologia e Conservacao Universidade Federal do ParanaCuritibaBrazil Institute of Mathematics King's CollegeUniversity of AberdeenAberdeenUnited Kingdom CNRs ECOBIO(Ecosystemesbiodiversiteévolution)—UMR 6553University of RennesRennesFrance Department of Ecology and Evolution University of LausanneLausanneSwitzerland

Intraspecific competition at the larval stage is an important ecological factor affecting life-history,adaptation and evolutionary trajectory in holometabolous ***,the molecular pathways underpinning these ecological processes are poorly *** reared Drosophila melanogaster at three egg densities(5,60,and 300 eggs/mL)and sequenced the transcriptomes of pooled third-instar *** also examined emergence time,egg-to-adult viability,adult mass,and adult sex-ratio at each *** crowding had minor detrimental effects on adult phenotypes compared to low density and yielded 24 differentially expressed genes(DEGs),including several chitinase *** contrast,high crowding had substantial detrimental effects on adult phenotypes and yielded 2107 *** these,upregulated gene sets were enriched in sugar,steroid and amino acid metabolism as well as DNA replication pathways,whereas downregulated gene sets were enriched in ABC transporters,taurine,Toll/Imd signaling,and P450 xenobiotics metabolism ***,our findings show that larval crowding has a large consistent effect on several molecular pathways(i.e.,core responses)with few pathways displaying density-specific regulation(i.e.,idiosyncratic responses).This provides important insights into how holometabolous insects respond to intraspecific competition during development.

关键词： intraspecific competition larval crowding life-history trade-offs transcriptomics

Epidural blood patch for spontaneous intracranial hypotension with subdural hematoma: A case report and review of literature

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world Journal of Clinical Cases 2022年第1期10卷 388-396页

作者： se Hee Choi youn young Lee won-Joong Kim Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Anesthesiology and Pain Medicine School of MedicineEwha Womans UniversitySeoul 07985South Korea

BACKGROUND Cerebrospinal fluid(CsF)leakage at C1/2 in spontaneous intracranial hypotension(sIH)is *** hematoma(sDH),a serious complication of sIH,may lead to neurological *** report presents a case of sDH after spontaneous C1/2 CsF leakage,which was treated with a targeted epidural blood patch(EBP).CAsE sUMMARY A 60-year-old man with no history of trauma was admitted to our hospital with orthostatic headache,nausea,and *** computed tomography imaging revealed bilateral,subacute to chronic *** magnetic resonance imaging(MRI)findings were sDH with dural enhancement in the bilateral cerebral convexity and posterior fossa and mild sagging,suggesting *** the patient underwent burr hole trephination,the patient’s orthostatic headache was *** myelography led to a suspicion of CsF leakage at C1/***,we performed a targeted cervical EBP using an epidural catheter under fluoroscopic *** 5 d after EBP,a follow-up MR myelography revealed a decrease in the interval size of the CsF *** his symptoms improved,the patient still complained of headaches;therefore,we repeated the targeted cervical EBP 6 d after the initial ***,his headache had almost disappeared on the 8th day after the repeated *** Targeted EBP is an effective treatment for sDH in patients with sIH due to CsF leakage at C1/2.

关键词： Cerebrospinal fluid Chronic subdural hematoma Epidural blood patch Myelography spontaneous intracranial hypotension Case report

Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine:An online survey of public health doctors

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world Journal of Clinical Cases 2022年第28期10卷 10053-10065页

作者： Byungsoo Kang Hongmin Chu Bo-young youn Jungtae Leem College of Korean Medicine Dongshin UniversityNaju-si 58245South Korea Daecheong Public Health subcenter Ongjin Public HealthcenterIncheon 23105IncheonSouth Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea College of Korean Medicine Wonkwang UniversityIksan 54538Jeollabuk-doSouth Korea

BACKGROUND since February 2021,vaccination against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 has started in *** To perform a questionnaire survey about the prevention and management of adverse events of COVID-19 vaccination among public health doctors of Korean Medicine(PHKMDs).METHODs An online questionnaire was developed,comprising categories about adverse events of vaccination(AEVs)and perception of using Korean medicine(KM)in managing vaccine adverse events(AEs)among ***’experience of AEVs,usage of Korean medicine for AEVs,and perception and attitude in using KM for AEVs were *** survey web-link was emailed to the association of *** links were sent through survey Monkey to all PHKMDs in *** A total of 143 participants were recruited for this study;65%of participants were vaccinated at the same of the survey(n=93).Although most participants did not take any medication for prevention of the adverse events,62%(n=58)of participants had taken herbal medicine to treat the adverse events(n=52).Approximately 35%of participants(n=33)said that they would recommend taking herbal medicine to prevent any *** various KM interventions,the participants strongly recommended taking an herbal medicine(n=69,74.19%)to treat AEs,and the second-highest was acupuncture treatment(n=19,20.43%).CONCLUsION Overall,this research demonstrated a high prevalence of KM usage by the ***,this study’s results may serve as fundamental evidence for health professionals to consider using KM treatments when treating or preventing AEVs in the near future.

关键词： COVID-19 Vaccination Adverse events Herbal medicine Korean medicine

Topic Models to Analyze Disaster-Related Newspaper Articles: Focusing on COVID-19

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International Journal of Mental Health Promotion 2023年第3期25卷 421-431页

作者： Yun-Jung Choi youn-Joo Um Red Cross College of Nursing Chung-Ang UniversitySeoul06974South Korea Department of Nursing Dong-Yang UniversityYeongjuGyeongbuk36040South Korea

Major media outlets have run many articles on the COVID-19 *** the public suffers cognitive and emotional effects related to COVID-19 from such reports,we analyzed and reviewed the topics of news *** searched newspaper articles with the term‘COVID-19’term in four Korean daily newspapers from January 20,2020,when thefirst patient in Korea was found,to June 15,*** modeling analysis was conducted through text mining using *** themes were found:“Changes in people’s everyday life,”“socio-economic shock,”“Trends in infection,”“Role of the government and business,”and“Increased psychological anxiety,”which all showed sharp increases in articles from mid-February to early March and then *** the increased psychological anxiety people suffered from the COVID-19 pandemic,this topic showed the fewest articles.“Changes in people’s everyday life”showed the most,focusing attention on stimulating lifestyle articles of general *** the COVID-19 pandemic can lead to mental health problems due to severe changes and isolation in everyday life,a comprehensive response to the news focusing on the impact on the mental health of the population around the world should be made.

关键词： COVID-19 mental health newspaper article text mining

Usefulness of the acromioclavicular joint cross-sectional area as a diagnostic image parameter of acromioclavicular osteoarthritis

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world Journal of Clinical Cases 2022年第7期10卷 2087-2094页

作者： young Joo Jee youn Moon Jung youn Han Yun-sic Bang Keum Nae Kang young su Lim young-soonChoi young-Uk Kim Department of Anesthesiology and Pain Medicine CHA Ilsan Medical CenterSchool of MedicineCHA UniversityIlsanGyeonggi-do 10414South Korea Department of Anesthesiology and Pain Medicine Seoul National University Hospital College of MedicineSeoul 03080South Korea Department of Anesthesiology and Pain Medicine CHA Bundang Medical CenterSchool of MedicineSeongnamGyeonggi-do 13496South Korea Department of Anesthesiology and Pain Medicine National Police HospitalSeoul 05715South Korea Department of Anesthesiology and Pain Medicine Catholic Kwandong UniversityCollege of MedicineInternational St.Mary’s HospitalIncheon 22711South Korea

BACKGROUND Acromioclavicular joint(ACJ)space narrowing has been considered to be an important diagnostic image parameter of ACJ osteoarthritis(ACJO).However,the morphology of the ACJ space is irregular because of osteophyte formation,subchondral irregularity,capsular distention,sclerosis,and ***,we created the ACJ cross-sectional area(ACJCsA)as a new diagnostic image parameter to assess the irregular morphologic changes of the *** To hypothesize that the ACJCsA is a new diagnostic image parameter for *** ACJ samples were obtained from 35 patients with ACJO and 30 healthy individuals who underwent shoulder magnetic resonance(s-MR)imaging that revealed no evidence of *** coronal,T2-weighted,fat-suppressed sMR images were acquired at the ACJ level from the two *** measured the ACJCsA and the ACJ space width(ACJsw)at the ACJ on the s-MR images using our imaging analysis *** ACJCsA was measured as the cross-sectional area of the *** ACJsw was measured as the narrowest point between the acromion and the *** The average ACJCsA was 39.88±10.60 mm;in the normal group and 18.80±5.13 mm;in the ACJO *** mean ACJsw was 3.51±0.58 mm in the normal group and 2.02±0.48 mm in the ACJO *** individuals had significantly lower ACJCsA and ACJsw than the healthy *** operating characteristic curve analyses demonstrated that the most suitable ACJCsA cutoff score was 26.14 mm^(2),with 91.4%sensitivity and 90.0%*** The optimal ACJsw cutoff score was 2.37 mm,with 88.6%sensitivity and 96.7%*** though both the ACJCsA and ACJsw were significantly associated with ACJO,the ACJCsA was a more sensitive diagnostic image parameter.

关键词： Acromioclavicular joint Osteoarthritis Cross-sectional area Diagnosis

Brassinosteroids enhance salicylic acid-mediated immune responses by inhibiting BIN2 phosphorylation of clade I TGA transcription factors in Arabidopsis

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Molecular Plant 2022年第6期15卷 991-1007页

作者： Yeong-woo Kim Ji-Hyun youn Jeehee Roh Jeong-Mok Kim seong-Ki Kim Tae-wuk Kim Department of Life science Hanyang UniversitySeoul 04763Republic of Korea Department of Life science Chung-Ang UniversitySeoul 06973Republic of Korea Research Institute for Convergence of Basic science Hanyang UniversitySeoul 04763Republic of Korea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoul 04763Republic of Korea

salicylic acid (sA) plays an important role in plant immune response, including resistance to pathogens and systemic acquired resistance. Two major components, NONEXPREssOR OF PATHOGENEsIs-RELATED GENEs (NPRs) and TGACG motif-binding transcription factors (TGAs), are known to mediate sA signaling, which might also be orchestrated by other hormonal and environmental changes. Nevertheless, the molecular and functional interactions between sA signaling components and other cellular signaling pathways remain poorly understood. Here we showed that the steroid plant hormone brassinosteroid (BR) promotes sA responses by inactivating BR-INsENsITIVE 2 (BIN2), which inhibits the redox-sensitive clade I TGAs in Arabidopsis. we found that both BR and the BIN2 inhibitor bikinin synergistically increase sA-mediated physiological responses, such as resistance to Pst DC3000. Our genetic and biochemical analyses indicated that BIN2 functionally interacts with TGA1 and TGA4, but not with other TGAs. we further demonstrated that BIN2 phosphorylates ser-202 of TGA4, resulting in the suppression of the redox-dependent interaction between TGA4 and NPR1 as well as destabilization of TGA4. Consistently, transgenic Arabidopsis overexpressing TGA4-YFP with a s202A mutation displayed enhanced sA responses compared to the wild-type TGA4-YFP plants. Taken together, these results suggest a novel crosstalk mechanism by which BR signaling coordinates the sA responses mediated by redox-sensitive clade I TGAs.

关键词： brassinosteroid salicylic acid immune responses BIN2 clade I TGA

strong enhancement of magnetic order from bulk to stretched monolayer Fese as Hund’s metals

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npj Computational Materials 2020年第1期6卷 448-453页

作者： Chang-youn Moon Advanced Instrumentation Institute Korea Research Institute of Standards and ScienceYuseongDaejeonRepublic of Korea

Despite of the importance of magnetism in possible relation to other key properties in iron-based superconductors,its understanding is still far from complete especially for Fese *** one hand,the origin of the absence of magnetic orders in bulk Fese is yet to be *** the other hand,it is still not clear how close monolayer Fese on srTiO_(3),with the highest transition temperature among iron-based superconductors,is to a magnetic *** we investigate magnetic properties of bulk and monolayer Fese using dynamical mean-field theory combined with density-functional *** find that suppressed magnetic order in bulk Fese is associated with the reduction of interorbital charge fluctuations,an effect of Hund’s coupling,enhanced by a larger crystal-field ***,spatial isolation of Fe atoms in expanded monolayer Fese leads into a strong magnetic order,which is completely destroyed by a small electron *** work provides a comprehensive understanding of the magnetic order in iron-based superconductors and other general multi-orbital correlated systems as Hund’s metals.

关键词： theory monolayer orbital