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Overview of genetic signaling pathway interactions within cutaneous malignancies

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 440-479页

作者： Brittany s.Maner Leonie Dupuis Ashley su Jeremy J Jueng Tanner P.Harding John Meisenheimer Ⅶ Fahad s.siddiqui Mia R.Hardack savina Aneja James A.solomon Ross University school of Medicine MiramarFL 33027USA Ameriderm Research Ormond BeachFL 32174USA University of Central Florida College of Medicine OrlandoFL 32827USA University of south Florida Morsani College of Medicine TampaFL 33612USA Alabama College of Osteopathic Medicine DothanAL 36303USA Advanced Dermatology and Cosmetic surgery OrlandoFL 32806USA Florida state University College of Medicine OrlandoFL 32304USA Kansas City University of Medicine&Biosciences Kansas CityMO 64106USA Carle-Illinois College of Medicine UrbanaIL 61820USA

Melanoma and non-melanoma cutaneous malignancies are some of the leading causes of cancer-related death in the United *** melanoma is more known to have a high mortality rate,the total mortality per year is nearly equal for between melanoma and non-melanoma skin ***,the non-melanoma types of cutaneous malignancies have potential to become locally invasive and even metastasize with very little to no treatment options when *** development of these malignancies involves various genetic pathways through the four hallmarks of cancer development:malignant cell growth,apoptosis evasion,the use of supporting stroma and vascularization,and modulating and promoting an inadequate immune *** genetic signaling pathways of basal cell carcinoma,squamous cell carcinoma,verrucous carcinoma,basosquamous cell carcinoma,melanoma,and cutaneous T-cell lymphoma interact with each other through genetic predisposition as well as with environmental ***,solar ultraviolet radiation and chronic inflammatory states are found to initiate the progression of many of these cutaneous *** paper includes validated models of genetic pathways,emerging pathways,and crosstalk between genetic pathways through the four hallmarks of cancer ***,unlike most reviews addressing oncogenetics of the well-recognized,as well as newly discovered,genetic pathway mutations,this review stresses that these pathways are not fixed but rather exist in dynamic,interrelated,interactive,complex,and adaptive flux states.

关键词： Basal cell carcinoma squamous cell carcinoma verrucous carcinoma basosquamous cell carcinoma melanoma cutaneous T-cell lymphoma genetic pathways cancer hallmarks

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泡沫在低渗透贝雷砂岩岩心中流动的室内研究

国外油气地质信息 2004年第3期 75-84页

作者： s.siddiqui 汪先珍李莉

近37年来，泡沫在多孔介质中的流动因其在EOR和增产措施方面的应用，已成为普遍研究课题。酸化作业中，当层问存在渗透率级差时就是用泡沫促使酸转入低渗透层。人们对泡沫在低渗透岩石(1～10md)中的流动性质研究得比较少，主要因为注入... 详细信息

近37年来，泡沫在多孔介质中的流动因其在EOR和增产措施方面的应用，已成为普遍研究课题。酸化作业中，当层问存在渗透率级差时就是用泡沫促使酸转入低渗透层。人们对泡沫在低渗透岩石(1～10md)中的流动性质研究得比较少，主要因为注入过程中出现高压力梯度造成设备限制。本文讨论用9md烧结贝雷砂岩岩心在额定3500psi(24NPa)装置中进行的几个单岩心、恒定泡沫特征值、稳态泡沫流实验结果。通过改变表面活性剂类型、泡沫特征值、液体和气体流速等因素以研究这些因素对泡沫流度、流度降低系数以及压力梯度的影响。为了模拟酸化过程中泡沫酸后的情况，每次实验先注泡沫，后注盐水，然后研究残余渗透率和泡沫稳定性。实验中泡沫特征值在．55％～90％之间，注入速度在5～25ft／d(1．5～7．5m／d)之间。发现所有稳态注泡沫实验中流度都有很大的降低。本文推荐一个称为残余指数的新参数以量化泡沫酸后的泡沫稳定性。残余指数是预测泡沫转向动态的关键，而且，当用无量纲参数如流度降低系数而不用流度进行比较时，得到的结果更相符。最后，把低渗透岩心实验结果同高渗透岩心进行比较以确定低渗透地层中产生泡沫的独特性。

关键词：低渗透层注泡沫室内研究岩心实验泡沫酸渗透率注入速度级差设备限制动因

番石榴果对贮藏期间存放姿势的生理和品质反应

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国外农学（果树） 1992年第2期 41-43页

作者： s.siddiqui 莫治雄

在绿熟阶段采收番石榴(Psidium guajava L.)的冬季果实,并在室温条件下贮藏,存放姿势分为三种,(1)正放,果梗端垂直向上;(2)倒放,果梗端垂直向下;(3)平放,果梗端横向。在贮藏过程中,正放果实的生理失重、后熟果百分率、乙稀和二氧化碳释... 详细信息

在绿熟阶段采收番石榴(Psidium guajava L.)的冬季果实,并在室温条件下贮藏,存放姿势分为三种,(1)正放,果梗端垂直向上;(2)倒放,果梗端垂直向下;(3)平放,果梗端横向。在贮藏过程中,正放果实的生理失重、后熟果百分率、乙稀和二氧化碳释放率最小,可溶性固形物和抗坏血酸浓度最大,感官分级和其它特性表明,番石榴果的包装应该取自然姿势(正放),以便较长时期保持良好的品质。

关键词：番石榴果实贮藏生理品质

代表性特殊岩心分析样品在选择标准上的一些改进

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国外油气地质信息 2007年第3期 56-62页

作者： s.siddiqui 谢小箐（译）赵洪才（校）

通过特殊岩心分析（sCAL）测试得到的数据对油藏工程模型具有重要的影响。本文阐述了为sCAL测试选择代表性样品时所需要的一些标准和测试。推荐的这项技术可以保证选取到代表储层内合适的流体封隔箱或者地层岩相的高质量岩心栓。肉眼观... 详细信息

通过特殊岩心分析（sCAL）测试得到的数据对油藏工程模型具有重要的影响。本文阐述了为sCAL测试选择代表性样品时所需要的一些标准和测试。推荐的这项技术可以保证选取到代表储层内合适的流体封隔箱或者地层岩相的高质量岩心栓。肉眼观察、有时还有计算机层析成象术是用于sCAL研究中评价和选择岩心栓的两种主要手段。虽然可以对卤水渗透率进行测量，但没有一种可以直接测量sCAL岩心栓的孔隙度（φ）而不影响其润湿性的方法。其它的选择手段包括使用“姐妹岩心栓”上传统的岩心分析数据（k和φ）作为sCAL样品性质的通用指标。开发出了一种非常适合于保存样品或原状样品的选择技术来识别具有类似孔隙度／渗透率关系的储层层段。它综合应用了电缆测井、伽马扫描、定量CT和原状卤水渗透率数据。该技术利用这些数据来计算合适的深移储层性质指数（RQI）和流动层指标（FZI）数据。然后再用这些数据从每个储层封隔箱中选取具有代表性的岩心栓样品。作为一个实例，采用该选择指标从中东的上侏罗统碳酸盐岩储层申选取了大约400块sCA工。岩心栓。本文阐述了选择性岩心栓的具体步骤以及将这些岩心栓组合起来用于有意义的sCAL测试的选择标准。

关键词：岩心栓 sCAL测试 CT扫描润湿性渗透率切片

Predicting potential invasion risks of Leucaena leucocephala(Lam.)de Wit in the arid area of saudi Arabia

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Journal of Arid Land 2024年第7期16卷 983-999页

作者： Haq s MARIFATUL Darwish MOHAMMED Waheed MUHAMMAD Kumar MANOJ siddiqui H MANZER Bussmann W RAINER Department of Ethnobotany Institute of BotanyIlia State UniversityTbilisi 0162Georgia The Centre of Excellence on sustainable Land Management(CoE-sLM) Indian Council of Forestry Research and EducationDehradun 248006India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Botany State Museum for Natural HistoryKarlsruhe 76133Germany

The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is *** study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in saudi Arabia under present and future climate change *** the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive *** conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological *** focused on the important influence of temperature seasonality,temperature annual range,and precipitation *** distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate *** complex interaction that influenced the invasion of *** was highlighted by the environmental parameters using Jackknife ***,the actual geographic area where *** was found in saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand *** MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC *** and temperature were the primary factors influencing the potential distribution of ***,an estimated area of 216,342 km^(2)in saudi Arabia was at a high probability of invasion by *** investigated the potential for increased invasion hazards in the future due to climate change scenarios(shared socioeconomic Pathways(ssPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substanti

关键词： area under the curve invasive species invasion risks climate change MaxEnt model

Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad sahabjada siddiqui Aditi srivastava Aparna Misra snober s.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

超极化气体MR成像作为定量生物标志物构成的治疗反应图评价肺局部通气的变化

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国际医学放射学杂志 2017年第6期 717-718页

作者： F.C.Horn H.Marshall G.J.Collier R.Kay s.siddiqui C.E.Brightling 舒俊 The Unit of Academic Radiology Department of Infection Immunity and Cardiovascular Disease C Floor Royal Hallamshire Hospital University of Sheffield

摘要目的使用超级化气体MR治疗反应图(TRM)评价呼吸治疗药对肺局部变化幅度的影响。TRM定量评估成人哮喘病人使用支气管扩张剂后肺局部生理变化。方法本研

关键词：治疗反应 MR

Insight into Metabolomic Profiling of Tinospora cordifolia: Recent Advances and Future Perspectives of Quality Control

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 137-148页

作者： Atiqul Islam C.Anurag Nazia siddiqui Xianting Ding Alok sharma College of Pharmacy JSS Academy of Technical EducationNoidaUttar PradeshIndia Department of Pharmaceutical Technology MIETMeerutUttar PradeshIndia Institute for Personalized Medicine School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

The objective of this study was to offer a review of previous works on Tinospora cordifolia(TC) metabolomics with a highlight on the use of metabolomics in comparative evaluations between varieties and selection of optimum cultivation, collection, and extraction procedures, providing insights into pharmaceutical and food product quality monitoring. scholarly databases were searched to gather relevant information on TC's therapeutic usefulness, phytoconstituent studies, metabolomics, and applications. Pub Chem was used to learn the structures of several of the metabolites. The various medicinal properties of TC were extensively researched. The most essential portions of the plant in Ayurvedic medicines are the stems. Bioactive phytochemicals such as steroidal lactones, alkaloids, diterpenoids, and phenolic compounds are present in the roots and leaves. Metabolomic analysis revealed that, in addition to the season and geographical region of the sample collected, the metabolite profiles of TC also depend on the parts of the plant taken as a sample and also the plant's stage of growth. The amounts of secondary metabolites differed between morpho/chemotypes within the TC species. Despite the fact that research on TC began several decades ago, the diversity of phytoconstituents was not appreciated because of a lack of reliable techniques for phytochemical fingerprinting. The uncovering of several novel metabolites was aided by advances in chromatography combined with mass spectrometry. To produce a full metabolomic profile, researchers used mutually complementary techniques. Following that, data analysis and searches against spectrum databases allowed for signal annotation and interpretation of metabolites in large quantities without separating them separately. The current review includes a critical assessment of metabolomic data and an overview of the technique's various applications. It is vital to establish the metrics of quality control of herbal medicines in order to

关键词： Analytical tools metabolomics quality control secondary metabolites Tinospora cordifolia

shear wave velocity prediction:A review of recent progress and future opportunities

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Energy Geoscience 2024年第4期5卷 36-54页

作者： John Oluwadamilola Olutoki Jian-guo Zhao Numair Ahmed siddiqui Mohamed Elsaadany AKM Eahsanul Haque Oluwaseun Daniel Akinyemi Amany H.said Zhaoyang Zhao state Key Laboratory of Petroleum Resources and Prospecting CNPC Key Laboratory of Geophysical ExplorationCollege of GeophysicsChina University of PetroleumBeijingChina Center of Excellence in subsurface seismic Imaging and Hydrocarbon Prediction Department of GeoscienceFaculty of Geoscience&Petroleum EngineeringUniversiti Teknologi PETRONAS(UTP)Malaysia Geology Department Faculty of ScienceAssiut UniversityAssiut71516Egypt

shear logs,also known as shear velocity logs,are used for various types of seismic analysis,such as determining the relationship between amplitude variation with offset(AVO)and interpreting multiple types of seismic *** log is an important tool for analyzing the properties of rocks and interpreting seismic data to identify potential areas of oil and gas ***,these logs are often not collected due to cost constraints or poor borehole conditions possibly leading to poor data quality,though there are various approaches in practice for estimating shear wave *** this study,a detailed review of the recent advances in the various techniques used to measure shear wave(s-wave)velocity is carried *** techniques include direct and indirect measurement,determination of empirical relationships between s-wave velocity and other parameters,machine learning,and rock physics ***,this study creates a collection of employed techniques,enhancing the existing knowledge of this significant topic and offering a progressive approach for practical implementation in the field.

关键词： shear wave(s-wave)velocity Direct and indirect measurement Empirical relationship Artificial intelligence(AI) Machine learning Rock physics model