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国际医学放射学杂志 2025年第1期 121-122页

作者： D.W.Yoon D.Kang Y.J.Jeon J.Lee s.shin J.H.Cho 李晗

摘要目的旨在利用CT上原发肿瘤的影像学特征来评估非小细胞肺癌（NsCLC）病人隐匿性淋巴结转移（OLNM）的风险。方法回顾性分析2 042例接受根治性肺切除的临床

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Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements

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Journal of Otology 2015年第1期10卷 13-17页

作者： Misun Hwang Ryan Marovich samuel s.shin David Chi Barton F.Branstetter IV Department of Radiology University of Pittsburgh Medical Center Department of Otolaryngology University of Pittsburgh Medical Center Department of Neurosurgery University of Pittsburgh Medical Center Department of Otolaryngology Children's Hospital of Pittsburgh

Enlarged vestibular aqueduct(EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multidetector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients(ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements; ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss.

关键词： Enlarged vestibular aqueduct Hearing loss Computed

Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury

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Neural Regeneration Research 2015年第10期10卷 1552-1554页

作者： samuel s.shin C.Edward Dixon Department of Neurological surgery University of Pittsburgh Medica Center

Traumatic brain injury （TBI） poses a significant socioeconomic burden in the world. The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear. In this perspective, cholinergic dysfunction and thera-peutic strategy targeting this will be reviewed. Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and are at various stages of development, which include AR-R 17779, GTs-21, ssR- 180711A, AR-R17779, and PNU-282987. A detailed review on this topic has been previously published （shin and Dixon, 2015）.

关键词： TBI nicotinic acetylcholine receptors Targeting a future potential for neuroprotection from traumatic brain injury ACh

Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration

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Neural Regeneration Research 2014年第17期9卷 1573-1577页

作者： Christian B.Ricks samuel s.shin Christopher Becker Ramesh Grandhi Department of Neurological surgery University of Pittsburgh Medical CenterPittsburghPAUSA University of Pittsburgh school of Medicine PittsburghPAUSA

Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting.

关键词： extraceUular matrix neurogenesis scaffolds neural stem cells

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用氯化钠释出细胞内的西索米星

国外医药（抗生素分册） 1989年第1期10卷 29-29,35页

作者： Chul s.shin 廖福荣

引言大多数氨基糖苷类抗生素在细胞内生物合成之后均释放至培养液中。但其中有些抗生素,如小单孢菌所产生的庆大霉素、西索米星、Verdamicin等则大部分同细胞结合,只有部分进入培养液。当培养产生的抗生素大部分均留在胞内时,尽管菌株... 详细信息

引言大多数氨基糖苷类抗生素在细胞内生物合成之后均释放至培养液中。但其中有些抗生素,如小单孢菌所产生的庆大霉素、西索米星、Verdamicin等则大部分同细胞结合,只有部分进入培养液。当培养产生的抗生素大部分均留在胞内时,尽管菌株经过诱变改良,但因细胞的最大容积有限,故最后产物效价很低。然而,如果在发酵期间所形成的抗生素能够不断地从细胞释出,即可获得较高效价或产量。在此项试验中,作者将NaCl加至培养基中以提高西索米星效价。菌种与培养本研究使用艾袅小单孢菌(Micromonospora inyoensis)IFO13156。制备的种子与发酵培养基在灭菌前调pH至8.0。

关键词：西索米星氨基糖苷类氯化钠

延边牛PLIN2基因CDs区克隆、生物信息学分析及其表达规律研究

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中国畜牧兽医 2021年第3期48卷 829-838页

作者：孙建富崔岩张军芳王英孙斌李强 seong H.Choi Jong s.shin 李香子延边大学东北寒区肉牛科技创新教育部工程研究中心韩国江原国立大学校动物生命科学大学韩国忠北国立大学校动物生命科学大学

本研究旨在克隆延边牛脂肪分化相关蛋白PLIN2基因完整CDs区,通过生物信息学分析PLIN2基因CDs区序列和蛋白质基本特性,探讨其在延边牛不同组织及前体脂肪细胞成脂过程中的表达规律。选取18月龄去势的延边牛为研究对象,利用RT-PCR和基因... 详细信息

本研究旨在克隆延边牛脂肪分化相关蛋白PLIN2基因完整CDs区,通过生物信息学分析PLIN2基因CDs区序列和蛋白质基本特性,探讨其在延边牛不同组织及前体脂肪细胞成脂过程中的表达规律。选取18月龄去势的延边牛为研究对象,利用RT-PCR和基因克隆获得延边牛PLIN2基因,与其他物种进行同源性比对及系统进化树构建,利用生物信息学方法预测PLIN2编码蛋白质的理化性质、潜在磷酸化位点及糖基化位点、二硫键分析、信号肽、亚细胞定位、蛋白高级结构,利用实时荧光定量PCR检测PLIN2基因在延边牛不同组织中的表达水平。结果显示,延边牛PLIN2基因CDs长1 353 bp,编码450个氨基酸;同源性比对发现延边牛PLIN2基因与黄牛、水牛、绵羊、山羊、野猪、人、小鼠和野鸡的同源性分别为100%、98.7%、96.7%、97.1%、85.5%、86.3%、47.3%和49.1%;系统进化树表明,延边牛与黄牛、水牛的亲缘关系最近,与野鸡的亲缘关系最远。PLIN2蛋白为不稳定蛋白,具有一定亲水性,存在61个潜在的磷酸化位点、16个O-糖基化潜在位点、12个N-糖基化潜在位点,存在2个二硫键,不存在信号肽,主要分布于细胞核中,细胞质和线粒体中有少量分布。PLIN2蛋白高级结构预测该蛋白是由α-螺旋、延伸链、无规则卷曲和β-转角组成,为混合型蛋白,通过无规则卷曲连接,以α-螺旋为主。实时荧光定量PCR结果显示,PLIN2基因在延边牛小肠组织中表达量最高,其次为背最长肌和肾脏组织。本研究结果可为进一步研究PLIN2基因的功能提供借鉴。

关键词：延边牛 PLIN2基因克隆生物信息学分析表达

CT冠状动脉成像冠状动脉斑块3D自动定量测量的临床可行性:与血管内超声进行比较

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国际医学放射学杂志 2015年第6期 611-612页

作者： H.B.Park B.K.Lee s.shin R.Heo R.Arsanjani P.H.Kitslaar 于静 Division of Cardiology Severance Cardiovascular HospitalYonseiUniversity Health System

摘要目的评价不同使用者(专家/非专家/自动)冠状动脉斑块自动定量分析(QCT)的诊断效能。方法对142例进行冠状动脉CT成像(CCTA)和血管内超声(IVUs)病人共150

关键词：血管内超声冠状动脉斑块病理过程 CT

冠状动脉CT成像中冠状动脉粥样硬化斑块容积分析的最佳边界测定法和窗值设定:与血管内超声对比

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国际医学放射学杂志 2016年第6期 704-705页

作者： R.Heo H.B.Park B.K.Lee s.shin R.Arsanjani J.K.Min 梁荣 Yonsei-Cedars sinai Integrative Cardiovascular Imaging Research Center Yonsei University Health System

摘要目的评估冠状动脉CT成像定量分析斑块容积(QCT)的最佳方法。方法对51段冠状动脉节段进行评估,采用2种不同方法测量其轮廓[(1)无间隔,(2)内外边界固定

关键词：血管内超声斑块病理过程容积冠状动脉边界 CT

定量动态增强MRI显示轻度颅脑外伤脑震荡后综合征病人广泛的血脑屏障破坏

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国际医学放射学杂志 2019年第3期 370-370页

作者：刘柱娜 R.Yoo s.Choi B.Oh s.shin E.Lee D.shin Department of Radiology Seoul National University HospitalSeoul National University College of Medicine

摘要目的探讨动态增强(DCE) MR成像定量分析轻度颅脑外伤(mTBI)合并脑震荡后综合征(PCs)病人血脑屏障破坏的应用。方法本回顾性研究包括44例m TBI后伴

关键词：颅脑外伤 TBI 对照组脑震荡后综合征血脑屏障动态增强 MRI

Logic-in-memory cell enabling binary and ternary Boolean logics

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science China(Information sciences) 2025年第2期68卷 370-379页

作者： Jeongyun OH Juhee JEON Yunwoo shin Kyougah CHO sangsig KIM Department of Electrical Engineering Korea University

In computing systems, processing and memory units have been integrated into logic-in-memory(LiM) to enhance the computational efficiency and performance. LiM has been attempted to perform not only binary but also ternary logic functions, which reduces computing complexity. Herein, we demonstrate a binary and ternary LiM(BT-LiM) cell with eight triple-gated(TG) feedback field-effect transistors(FBFETs) reconfigured into n-or p-channel modes. The TG FBFETs exhibit symmetrical latch-up voltages and an on-current ratio of 1.02 between the n-and p-channel modes, which indicates a high potential for reconfigurable logic applications. The BT-LiM cell can perform YEs, NOT, AND, OR, NAND, NOR, XNOR, and XOR logic functions in a single cell because of these reconfigurable characteristics. Further, binary and ternary logic functions are realized in the cell without a programming stage, and the cell maintains the results of the logic functions under zero-bias conditions. This study achieves multifunctional LiM that can operate all binary and ternary Boolean logics.

关键词： logic-in-memory reconfigurable channel modes ternary logic triple-gated feedback field-effect transistors

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