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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural regeneration research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Macroscopic studies on the Properties of the Anodic Oxide Films on Titanium

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Journal of Materials science & Technology 1998年第3期14卷 241-246页

作者： Mahdy, G.A. mahmoud, s.s. Chemistry Dept. Faculty of Science Helwan University Helwan Cairo Egypt Chemistry Dept. University College for Women Ain-Shams University Helopolis Cairo Egypt

The effect of fluoride ions on the formation and dissolution behaviour of anodic oxide films on Ti has been investigated in acidic fluoride media (pH=1) using impedance and galvanostatic techniques. A5 the fluoride ion concentration and temperature increase the rate of oxide film formation decreases while the dissolution process increases. oxide film formed at high tem-perature and formation voltage was found to contain more defect sites in the film than that formed at a lower one. Activation energies are calculated during the oxide film formation and dissolution and found to be 20.76 and 28.72 kJ/mol, respectively. Formation rate and reciprocal capacitance data are reported as a function of polarizing current density. Values are recorded for the electrolytic parameters A and B. Potentiostatic curves are derived from the galvanostatic results.

关键词： Figure Macroscopic studies on the Properties of the Anodic Oxide Films on Titanium

security strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural regeneration research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Effect of Colouring Process on Pitting susceptibility of Austenitic stainless steel

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Journal of Materials science & Technology 2008年第3期24卷 400-406页

作者： s.s.mahmoud M.M.Ahmed Chemistry Department University College of Girls for ArtsScience and EducationAin Shams University

Colouring of the austenitic stainless steel alloy （20.45% Cr, 8.57% Ni） was carried out in NaNO3-KNO3 eutectic melt without and with additions of Na2O2, NaCl and their mixtures at different temperatures ranging from 400-600℃, under open-circuit and galvanostatic anodic polarization conditions. The produced colours greatly depend on the thickness of oxide films, which in turn depends on the composition of the molten bath and its temperature. The more attractive, bright, adherent and uniform coloured oxide films can be obtained at 400, 450 and 500℃ in molten nitrate bath containing NaCl and Na2O2 mixtures. The pitting corrosion susceptibility of the coloured oxide films was tested in FeCl3 and NaCl as corrosive media. The obtained results indicate that the pitting corrosion susceptibility of the coloured oxide films greatly depends on the previous operating conditions of the colouring process of the stainless steel specimens such as the composition of molten bath, temperature and technique of colouring process.

关键词： stainless steel alloy Pitting corrosion Colouring processes

Theoretical Investigation on the Low-Lying states of LaP Molecule

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Chinese Physics Letters 2018年第10期35卷 14-17页

作者： Nagat Elkahwagy Atif Ismail s.M.A.Maize K.r.mahmoud Department of Physics Faculty of Science Kafrelsheikh University Department of Physics Faculty of Applied Sciences Umm Al Qura University Department of Physics Faculty of Science Menoufia University

The completely unexplored LaP molecule is investigated by ab initio methods. Potential energy curves for the lowlying states of LaP are constructed by means of the diffusion Monte Carlo method combined with three different trial functions. spectroscopic constants are also numerically derived and the ground state is assigned, looking forward to experimental comparisons. Moreover, variations of the permanent dipole moments as a function of the internuclear separation for the two lowest states of the diatomic LaP are studied and analyzed.

关键词： La In DMC Theoretical Investigation on the Low-Lying states of LaP Molecule

repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

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Neural regeneration research 2022年第9期17卷 1913-1918页

作者： Heba M.Mansour Hala M.Fawzy Aiman s.El-Khatib mahmoud M.Khattab Department of Pharmacology Egyptian Drug AuthorityEDAformerly NODCARGizaEgypt Department of Pharmacology and Toxicology Faculty of PharmacyCairo UniversityCairoEgypt

Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s *** studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer’s *** the promising effects of epidermal growth factor receptor inhibitors in Alzheimer’s disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling *** caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical *** this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer’s disease will be ***,their molecular mechanisms in neurodegeneration will be ***,we will shed light on sArs-COVID-19 induced neurological manifestations mediated by epidermal growth factor ***,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more *** conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer’s disease progression.

关键词： Alzheimer’s disease autophagy drug re-positioning epidermal growth factor receptor human epidermal growth factor receptor-2 neurodegenerative diseases neuroinflammation oxidative stress tyrosine kinase inhibitors

The response of the Earth's Lower Ionosphere to Gamma-ray solar Flares and their Associated X-ray

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research in Astronomy and Astrophysics 2022年第4期22卷 137-152页

作者： mahmoud Mohery Hussein M.Farid Alaa Ali Dept.of Phys College of ScienceUniversity of JeddahJeddahSaudi Arabia Astronomy Space Science&Meteorology DepartmentFaculty of ScienceCairo UniversityGiza 12613Egypt Astronomy Dept. Faculty of ScienceKing Abdulaziz University21589 JeddahSaudi Arabia

The present work aims to explore the impact of solar gamma-ray fiares(GrFs),detected by the Fermi-Large Area Telescope(LAT),and their associated X-ray fiares(XrFs)on the Earth’s lower *** data of ionospheric parameter fmin were collected from the Yamagawa mid-latitude ionosonde station in *** most of the GrFs used in this study are associated with soft X-ray(sXr)emissions,detected by the Geostationary Operational Environmental satellite(GOEs),we classified them into three types:simultaneous(s),delayed(D)and not associated(N),refiecting the phase occurrence of the solar ***,the ionospheric D layer responds strongly to XrFs more than *** temporal profiles of the ionospheric parameter fmin show distinct behaviors as a response to the various GrF *** the case of the s-type,a single strong peak,with an average value of 5.2 MHz,emanates in the fmin profile within an average interval of time of less than half an *** the case of the D-type,two successive peaks appear in the fmin profile,with an average value of 6.0 MHz for the second peak through a time interval of one hour after the onset of gamma-ray(Gr)*** response of the fmin parameter to the N-type fiares appears as a single peak with an average value of 4.8 MHz within about an *** notice that the difference between the fmin peak values and the corresponding reference ones(dfmin)is more convenient and representative than the fmin values,where the median Gr fiux of the s-,D-and N-types tends to increase as the average dfmin increases.

关键词： sun:X-rays gamma-rays Earth:ionosphere satellites

Novel synthesis of some Phthalazinone Derivatives

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Chinese Journal of Chemistry 2011年第7期29卷 1446-1450页

作者： mahmoud, mahmoud r. Abou-Elmagd, Wael s.I. Derbala, Hamed A. Hekal, Mohamed H. Chemistry Department Faculty of Science Ain Shams University Abassia 11566 Cairo Egypt

Dimethyl homophthalate condensed with isatin to give the unexpected five membered lactone 3 rather than the half ester 1 and the β-lactone 2. Treatment of compound 3 with excess hydrazine hydrate afforded phthalazinone carbohydrazide 4 which represents a novel method for the synthesis of phthalazinone derivatives. The carhohy- drazide 4 upon treatment with carbon disulphide afforded 1,3,4-oxadiazole derivative 5, which reacted with ethyl- chloroacetate to give the s-alkylated product 6. The structure of compound 3 compared with 2 was discussed using hyperchem professional （7） AM1 calculations, X-ray single crystal structure and complete spectral data.

关键词： phthalazinone carbohydrazide oxadiazole triazolo oxadiazole AMx calculation condensation