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基于人群的乳腺癌筛查中从屏片乳腺摄影向全数字化乳腺摄影过渡前、中、后的钼靶X线片的效能

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国际医学放射学杂志 2014年第5期 471-471页

作者： s.Hofvind P.skaane J.G.Elmore s.sebu deg rd s.r.hoff C.I.Lee 倪倩倩 Faculty of Health science Oslo and Akershus University College of Applied Sciences

摘要目的在基于人群的乳腺癌筛查项目中,比较屏片乳腺摄影(sFM)向全数字化乳腺摄影(FFDM)过渡前、中、后的性能测量指标。材料与方法这项分析数据来自于1996—

关键词：全数字化乳腺摄影 sFM 乳腺癌筛查 FFDM

Crushed rocks stabilized with organosilane and lignosulfonate in pavement unbound layers:repeated load triaxial tests

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Frontiers of structural and Civil Engineering 2021年第2期15卷 412-424页

作者： Diego Maria BArBIErI Inge hoff Chun-Hsing HO Department of Civil and Environmental Engineering Norwegian University of Science and TechnologyTrondheimTrøndelag7491Norway Department of Civil and Environmental Engineering Northern Arizona UniversityFlagstaffAZ86011USA

The creation of the new“Ferry-Free Coastal Highway route E39”in southwest Norway entails the production of a remarkable quantity of crushed *** resources could be beneficially employed as aggregates in the unbound courses of the highway itself or other road pavements present *** innovative stabilizing agents,organosilane and lignosulfonate,can significantly enhance the key properties,namely,resilient modulus and resistance against permanent deformation,of the aggregates that are excessively weak in their natural *** beneficial effect offered by the additives was thoroughly evaluated by performing repeated load triaxial *** study adopted the most common numerical models to describe these two key mechanical *** increase in the resilient modulus and reduction in the accumulated vertical permanent deformation show the beneficial impact of the ***,a finite element model was created to simulate the repeated load triaxial test by implementing nonlinear elastic and plastic constitutive relationships.

关键词： organosilane lignosulfonate crushed rocks pavement unbound layers repeated load triaxial test finite element analysis

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On the Navier-stokes Equations for Exothermically reacting Compressible Fluids

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Acta Mathematicae Applicatae sinica 2002年第1期18卷 15-36页

作者： David hoff Konstantina Trivisa Department of Mathematics Indiana University BloomingtonIN 47405-4301USADepartment of Mathematics University of MarylandCollege Park MD 20742-4015USA

We analyze mathematical models governing planar flow of chemical reaction from unburnt gases to burnt gases in certain physical regimes in which diffusive effects such as viscosity and heat conduction are significant. These models can be then formulated as the Navier-stokes equations for exothermically reacting compressible fluids. We first establish the existence and dynamic behavior, including stability, regularity, and large-time behavior, of global discontinuous solutions of large oscillation to the Navier-stokes equations with constant adiabatic exponent γ and specific heat Cv. Our approach for the existence and regularity is to combine the difference approximation techniques with the energy methods, total variation estimates, and weak convergence arguments to deal with large jump discontinuities; and for large-time behavior is an a posteriori argument directly from the weak form of the equations. The approach and ideas we develop here can be applied to solving a more complicated model where γand cv vary as the phase changes; and we then describe this model in detail and contrast the results on the asymptotic behavior of the solutions of these two different models. We also discuss other physical models describing dynamic combustion.

关键词： Global discontinuous solutions discontinuous initial data large oscillation evolution of large jump discontinuities asymptotic behavior combustion Navier-stokes equations difference approximations energy estimates total variation estim

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Primary prevention of colorectal cancer:Myth or reality?

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World Journal of Gastroenterology 2014年第41期20卷 15060-15069页

作者： Marcela Crosara Teixeira Maria Ignez Braghiroli Jorge sabbaga Paulo M hoff Division of Medical Oncology Instituto do Cancer do Estado de S?o PauloHospital Sírio Libanês

Colorectal cancer incidence has been rising strongly in parallel with economic *** the past few decades,much has been learned about the lifestyle,dietary and medication risk factors for this *** respect to lifestyle,compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the *** there is controversy about the role of specific nutritional factors,consideration of dietary pattern as a whole appears useful for formulating *** quite often recommended,the role for many supplements,including omega-3,vitamin D,folate,and vitamin B6,remains *** calcium and vitamin D supplementation appear to add a modest benefit,particularly in those with a low daily *** regard to chemoprevention,medications such as aspirin and nonsteroidal antiinflammatory drugs,and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk,though their utility is affected by their side effect ***,the role of agents such as statins,bisphosphonates and antioxidants have yet to be ***,primary prevention strategies focusing on modifying environmental,lifestyle risk factors,and chemopreventive drugs are options that have already been tested,and may impact on colon cancer incidence.

关键词： Primary prevention Colorectal cancer Physical activity Diet Chemoprevention

Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors

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World Journal of Gastroenterology 2017年第45期23卷 7945-7951页

作者： Ahmad Al-Hader rami N Al-rohil Haiyong Han Daniel Von hoff Division of Hematology/Oncology Indiana University School of Medicine Department of Pathology Vanderbilt University School of Medicine Molecular Medicine Division Translational Genomics Research Institute (TGen)

Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma(PACC),pancreatoblastoma,and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than pancreatic neuroendocrine tumors. reports of overall survival range from 18 to 47 mo. A literature review on PACCs included comprehensive genomic profiling and whole exome sequencing on a series of more than 70 patients as well as other diagnostic studies including immunohistochemistry. surgical resection of PACC is the preferred treatment for localized and resectable tumors. The efficacy of adjuvant treatment is unclear. Metastatic PACCs are generally not curable and treated with systemic chemotherapy. They are moderately responsive to chemotherapy with different regimens showing various degrees of response in case reports/series. Most of these regimens were developed to treat patients with pancreatic ductal adenocarcinomas or colorectal adenocarcinomas. review of PACC's molecular profiling showed a number of gene alterations such as: sMAD4,BrAF,BrCA2,TP53,rB1,MEN1,JAK-1,BrCA-1,BrCA-2,and DNA mismatch repair abnormalities. PACCs had multiple somatic mutations with some targetable with available drugs. Therefore,molecular profiling of PACC should be an option for patients with refractory PACC.

关键词： Pancreatic acinar cell carcinoma Molecular profiling Targeted therapy

Gitmo＇s Folly II： Torture, Trials, and Tribulations of Us Detention Policy in the Wake of 9/11

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International relations and Diplomacy 2016年第7期4卷 454-464页

作者： samuel B. hoff Delaware state University Delaware USA

Tapping declassified Us senate and Central Intelligence Agency reports, United Nations studies, and other primary sources, this study investigates the etiology, policies, and consequences of Us detention policy as a part of the War on Terror. The record of the last two presidential administrations in dealing with detainees at Guantanamo Bay Naval Base in Cuba （GITMO） and elsewhere is examined and the legal rationale for the tactics used on those in captivity is scrutinized. The study reveals that although certain features of detention policy changed from the George W. Bush administration to the Barack Obama presidency, others remained the same. The benefits of information acquired from detainees is weighed and detention policy itself is evaluated according to fundamental American values.

关键词： 9/11 Guantanamo Bay Naval Base in Cuba (GITMO) torture detainees

Gastric fundoplication with endoscopic technique:A novel approach for gastroesophageal reflux disease treatment

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World Journal of Gastrointestinal Endoscopy 2024年第10期16卷 557-565页

作者： Eyad Gadour Anna Carolina hoff Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan Bariatric Endoscopy Angioskope ClinicSão Josédos Campos 12243-680São PauloBrazil

BACKGrOUND Gastric fundoplication with endoscopic technique(GFET)is an innovative approach to managing gastroesophageal reflux disease(GErD).This minimally invasive procedure utilizes the GEN-2 Apollo endosuture device and Olympus H2T180 gastroscope to perform partial fundoplication by strategically placing Prolene 2-0 sutures at the 11,7,5,1,and 3 o’clock positions around the gastroesophageal *** To evaluate whether GFET enhances the lower esophageal sphincter function by creating comprehensive plication to improve the barrier against *** This single-center prospective study included patients undergoing *** beginning GFET,pH metrics and subsequent manometric measurements were *** analysis of variance was performed to determine statistically significant differences between quality of life(QOL)and DeMeester scores at the time of the procedure and 6 and 12 months ***’sχ2 test was performed to identify statistically significant differences between categorical variables at the time of the procedure and 6 and 12 months *** Eighteen participants were enrolled(11 males and 7 females;mean age,35 years).More than 70%had an initial Hill grade of *** adverse event was recorded after the *** patient underwent valve reinforcement at 12 *** mean QOL score was markedly higher at the time of the procedure(39.9±4.0)compared to those at 6 and 12 months postoperatively(Pscores at 12 months were slightly higher than those at 6 *** highest mean QOL score was observed at the time of the procedure,followed by those at 6 and 12 months postoperatively(Psimilar trend was noted for the mean DeMeester scores(PsION GFET is a minimally invasive alternative to traditional surgical interventions and endoscopic techniques for managing *** research is warranted to validate its long-term efficacy and effectiveness over existing treatments.

关键词： Gastric fundoplication with endoscopic technique Gastroesophageal reflux disease Therapeutic endoscopy