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Total knee arthroplasty in patients with Paget's disease of bone: A systematic review

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World Journal of Orthopedics 2018年第10期9卷 229-234页

作者： Ravi Popat Konstantinos Tsitskaris steven millington sebastian Dawson-Bowling sammy A Hanna Department of Trauma and Orthopaedic surgery the Hillingdon Hospitals NHS Foundation Trust Department of Trauma and Orthopaedic surgery Barts Health NHS Trust

AIM To determine the functional outcomes, complications and revision rates following total knee arthroplasty(TKA) in patients with Paget's disease of bone(PDB). METHODs A systematic review of the literature was performed. Four studies with a total of 54 TKAs were included for analysis. Functional outcomes, pain scores, complications and revision rates were assessed. The mean age was 72.0 years and the mean follow-up was 7.5 *** All studies reported significant improvement in knee function and pain scores following TKA. There were 2 cases of aseptic loosening, with one patient requiring revision of the femoral component 10 years after the index procedure. Malalignment, bone loss, soft tissue contractures were the most commonly reported intraoperative challenges. There were five cases(9%) that were complicated by intra-operative patellar tendon *** The findings support the use of TKA in patients with PDB. The post-operative functional outcomes are largely similar to other patients, however there are specific perioperative challenges that have been highlighted, in particular the high risk for patellar tendon avulsion.

关键词： Total knee arthroplasty Paget’s disease of bone Revision Loosening Paget’s disease

Total hip arthroplasty in patients with Paget's disease of bone: A systematic review

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World Journal of Orthopedics 2017年第4期8卷 357-363页

作者： sammy A Hanna sebastian Dawson-Bowling steven millington Rej Bhumbra Pramod Achan Department of Trauma and Orthopaedic surgery Royal London HospitalBarts Health NHS Trust

AIM To investigate the clinical and functional outcomes following total hip arthroplasty(THA) in patients with Paget's *** We carried out a systematic review of the literature to determine the functional outcome, complications and revision rates of THA in patients with Paget's disease. Eight studies involving 358 hips were reviewed. The mean age was 70.4 years and follow-up was 8.3 years. There were 247 cemented THAs(69%), 105 uncemented THAs(29%) and 6 hybrid THAs(2%). REsULTs All studies reported significant improvement in hip function following THA. There were 19 cases of aseptic loosening(5%) at a mean of 8.6 years. Three cases occurred in the uncemented cohort(3%) at a mean of 15.3 years and 16 cases developed in the cemented group(6%) at a mean of 7.5 years(P = 0.2052). There were 27 revisions in the 358 cases(8%) occurring at a mean of 7 years. six revisions occurred in the uncemented cohort(6%) at a mean of 8.6 years and 21 in the cemented cohort(9%) at a mean of 6.5 years(P = 0.5117). CONCLUsION The findings support the use of THA in patients with Paget's disease hip arthropathy. The post-operative functional outcome is largely similar to other patients; however, the revision rate is higher with aseptic loosening being the most common reason for revision. Uncemented implants appear to be associated with a lower failure rate, however, there were no modern stem designs fixed using current generation cementing techniques used in the reported studies, and as such, caution is advised when drawing any conclusions.

关键词： Total hip arthroplasty Paget’s disease Revision Loosening Heterotopic ossification

Location patterns of urban industry in shanghai and implications for sustainability

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Journal of Geographical sciences 2017年第7期27卷 857-878页

作者： CAO Weidong LI Yingying CHENG Jianquan steven millington College of Territorial Resources and Tourism Anhui Normal University Wuhu 241003 Anhui China Key Laboratory of Beibu Gulf Environmental Change and Resources Utilization under Ministry of Education Guangxi Teachers Education University Nanning 530001 China school of science and the Environment Manchester Metropolitan University (MMU) Chester Street Manchester M1 5GD UK

China＇s economy has undergone rapid transition and industrial restructuring. The term ＂urban industry＂ describes a particular type of industry within Chinese cities experiencing restructuring. Given the high percentage of industrial firms that have either closed or relo- cated from city centres to the urban fringe and beyond, emergent global cities such as shanghai, are implementing strategies for local economic and urban development, which involve urban industrial upgrading numerous firms in the city centre and urban fringe. This study aims to analyze the location patterns of seven urban industrial sectors within the shanghai urban region using 2008 micro-geography data. To avoid Modifiable Areal Unit Problem （MAUP） issue, four distance-based measures including nearest neighbourhood analysis, Kernel density estimation, K-function and co-location quotient have been exten- sively applied to analyze and compare the concentration and co-location between the seven sectors. The results reveal disparate patterns varying with distance and interesting co-location as well. The results are as follows： the city centre and the urban fringe have the highest intensity of urban industrial firms, but the zones with 20-30 km from the city centre is a watershed for most categories; the degree of concentration varies with distance, weaker at shorter distance, increasing up to the maximum distance of 30 km and then decreasing until 50 km; for all urban industries, there are three types of patterns, mixture of clustered, random and dispersed distribution at a varied range of distances. Consequently, this paper argues that the location pattern of urban industry reflects the stage-specific industrial restructuring and spatial transformation, conditioned by sustainability objectives.

关键词： urban industry industrial location pattern co-location quotient K-function shanghai

WONCA研究论文摘要汇编——全科医学中提供的临终关怀:来自英国国民全科医生问卷调查的结果

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中国全科医学 2016年第30期19卷 3697-3697页

作者： MITCHELL s LOEW J millington - sANDERs C 本刊编辑部

背景越来越多的社区居民生活在共病造成的生活障碍中,必须在提升姑息治疗和提供高质量的临终关怀(EOLC)的机构体制方面给予考虑。目的本文旨在深入了解全科医生为社区提供EOLC的经验,特别是关于优质护理的促进因素和障碍。设计与场所由... 详细信息

背景越来越多的社区居民生活在共病造成的生活障碍中,必须在提升姑息治疗和提供高质量的临终关怀(EOLC)的机构体制方面给予考虑。目的本文旨在深入了解全科医生为社区提供EOLC的经验,特别是关于优质护理的促进因素和障碍。设计与场所由全科医生皇家学院、英国国家医疗服务体系、玛丽居里麦克米伦网络四院开展基于网络的英国国民全科医生问卷调查。方法使用描述性统计和归纳主题分析法进行调查结果的分析。结果收到广泛分布于各实践地点的516例全科医生的回应。其中97%认为全科医学在向临终居民及其家庭提供护理起到了关键作用。数据中显现4个相互依存的主题:护理连续性——由于资源问题,诸如时间、员工数目、渐增的基层医疗工作量以及资金缺乏等问题,实现此目标比较困难;患者和家庭医生因素——存在以下挑战,包括早期识别姑息治疗的需求和认识到生命终末期,讨论护理计划的机会以及提供对家庭的支持;医疗管理——包括有效的症状控制和获得专科姑息治疗服务;专业知识培训——认识到进行培训和专业发展的必要性,从而提升关于EOLC的知识、技能和态度。结论调查结果表明,今后关于基层姑息治疗的政策、调整、实践发展和研究处于持久的优先地位。

关键词： WONCA 全科医学家庭医生麦克米伦专业知识培训社区居民生活问卷调查主题分析优先地位症状控制

铝注入的电力半导体器件产品的优势及其进一步开发

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电气技术 2006年第7期7卷 82-86页

作者： s.柯雷 A.米林顿 A.普鲁姆顿尤金霜丹尼克斯半导体公司北京金自天正公司

Dynex半导体公司用于功率双极半导体器件制造的铝注入技术(“i2”)的问世得到文献的肯定。本文介绍采用这种技术所获得的各种益处,特别讨论满足增加HVDC(高压直流输电)开关功率的需求、改善整流二极管制造能力、提高脉冲电源的极高电压... 详细信息

Dynex半导体公司用于功率双极半导体器件制造的铝注入技术(“i2”)的问世得到文献的肯定。本文介绍采用这种技术所获得的各种益处,特别讨论满足增加HVDC(高压直流输电)开关功率的需求、改善整流二极管制造能力、提高脉冲电源的极高电压/极大电流能力,以及大面积晶闸管并联均流的有效参数匹配等重要课题。本文也涉及到器件键合和150mm直径的硅片制造事项。“i2”技术的灵活性最适合于为可预见的未来提供最佳的功率器件。

关键词：双注入("i2") 铝注入技术功率双极半导体器件高压直流输电 (HVDC)