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CRIsPR/Cas9: Development and Application in Rice Breeding

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Rice science 2019年第5期26卷 265-281页

作者： Fernando matías ROMERO Andrés GATICA-ARIAs Laboratory of Plant Biotechnology School of Biology/Research Center in Cellular and Molecular Biology University of Costa Rica

Rice(Oryza sativa L.)is an important staple food crop worldwide due to its adaptability to different environmental *** of its great economic and social importance,there is a constant requirement for new varieties with improved agronomic characteristics,such as tolerance to different biotic(such as bacterium,fungus,insect and virus)and abiotic stresses(such as salinity,drought and temperature),higher yield and better organoleptic and nutritional *** the new genome editing technologies,the clustered regularly interspaced short palindromic repeats(CRIsPR)/CRIsPR-associated protein(Cas)(CRIsPR/Cas)system allows precise and specific edition in a targeted genome *** is one of the most frequently used techniques for the study of the function of new genes and for the development of mutant lines with enhanced tolerance to biotic and abiotic stresses,herbicide resistance or improved *** wide varieties of applications for this technology include simple non-homologous end joining,homologous recombination,gene replacement,and base *** this review,we analyzed how some of these applications have been used in rice cultivars to obtain rice varieties better adapted to current environmental conditions and market requirements.

关键词： rice CRIsPR Cas genome editing biotic stress abiotic stress yield off-target mutation

Anti-inflammatory effects of Morninga oleifera lam extract in rats

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 133-135页

作者： Georgewill OA Georgewill uo Nwankwoala RNP Department of Pharmacology College of Health SciencesUniversity of Port Harcourt

Objective:To investigate the acute and delayed anti-inflammatory effects of Morning oleifera lam（MOL） crude methanolic ***:Compared the anti-inflammatory effects of MOL with that of standard anti-inflammatory agents like indomethacin and hydrocortisone using Air Pouch ***:In both acute and delayed inflammation,the MOL extract produced dose dependent anti-inflammatory effect[acute ICsub>50sub>=（399.30±5.43） mg/kg;delayed ICsub>50sub>=（510.26±4.53） mg/kg].The order of anti-inflammatory potency for the three drugs was hydrocortisone> indomethacin > ***:These observations indicate that MOL possesses potential anti-inflammatory property.

关键词： Extract Moringa oleifera lam Anti-nflammatory,indomethacin Hydrocortisone

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

A statistical model to predict total column ozone in Peninsular Malaysia

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Frontiers of Earth science 2016年第1期10卷 63-73页

作者： K. C. TAN H. s. LIM M. Z. mat JAFRI school of Physics Universiti Sains Malaysia Penang 11800 Malaysia

This study aims to predict monthly columnar ozone in Peninsular Malaysia based on concentrations of several atmospheric gases. Data pertaining to five atmo- spheric gases （CO2, 03, CH4, NO2, and H2O vapor） were retrieved by satellite scanning imaging absorption spectro- metry for atmospheric chartography from 2003 to 2008 and used to develop a model to predict columnar ozone in Peninsular Malaysia. Analyses of the northeast monsoon （NEM） and the southwest monsoon （sWM） seasons were conducted separately. Based on the Pearson correlation matrices, columnar ozone was negatively correlated with HzO vapor but positively correlated with COz and NO2 during both the NEM and sWM seasons from 2003 to 2008. This result was expected because NO/is a precursor of ozone. Therefore, an increase in columnar ozone concentration is associated with an increase in NO2 but a decrease in H/O vapor. In the NEM season, columnar ozone was negatively correlated with H20 （-0.847）, NO2 （0.754）, and CO2 （0.477）; columnar ozone was also negatively but weakly correlated with CH4 （-0.035）. In the sWM season, columnar ozone was highly positively correlated with NO2 （0.855）, CO2 （0.572）, and CH4（0.321） and also highly negatively correlated with H2O（-0.832）. Both multiple regression and principal component analyses were used to predict the columnar ozone value in Peninsular Malaysia. We obtained the best-fitting regression equations for the columnar ozone data using four independent variables. Our results show approxi- mately the same R value （≈0.83） for both the NEM and sWM seasons.

关键词： ozone sCIAMACHY principal componentanalysis Peninsular Malaysia

Carbon Nanotube Coating on Titanium substrate Modified with TiO_2 Nanotubes

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Journal of Wuhan University of Technology(materials science) 2011年第5期26卷 867-871页

作者：白玉 PARK Ilsong BAE Taesung KIM Kyounga WATARI Fumio uo Motohiro LEE Minho Department of Dental Biomaterials School of Dentistry and Institute of Oral BioscienceBrain Korea 21 ProjectChonbuk National University school of materials science and Engineering Inner Mongolia University of Technology Department of Conservative Dentistry Institute of Oral Bioscience and BK 21 ProjectSchool of DentistryChonbuk National University Biomedical Dental Materials and EngineeringDepartment of Oral Health ScienceGraduate School of Dental MedicineHokkaido University Advanced Biomaterials section Graduate School of Medical and Dental SciencesTokyo Medical and Dental University

A combination of carbon nanotubes （CNTs） and titanium （Ti） modified with TiO2 nanotubes （TiO2 NTs） was fulfilled with the aim of improving bioactivity of Ti ***,well-ordered TiO2 NTs were prepared by the electrochemical anodization of Ti in an ethylene glycol electrolyte containing 1 wt% NH4F and 10 wt% H2O at 20 V for 50 min,followed by ***,the carboxylated CNTs were coated onto the TiO2 NTs using electrophoretic deposition （EPD） *** growth of hydroxyapatite （HA） on the samples was investigated by soaking them in simulated body fluid （sBF）.The result showed the CNTs-coated Ti with the modification of TiO2 NTs （CNTs-TiO2 NTs） was more efficient to induce HA formation than the CNTs-coated smooth Ti （CNTs-Ti）.The vitro cell response was evaluated using osteoblast cells （MC3T3-E1）.The good cell proliferation and strong cell adhesion could be obtained on the CNTs-TiO2 *** results indicated that CNT coating on the Ti modified with TiO2 NTs could be potentially useful for the periodontal ligament combination on dental implants.

关键词： carbon nanotubes TiO2 nanotubes apatite-forming ability cell adhesion

Improvement of a Real Gas-sensor for the Origin of Methane selectivity Degradation by l-XAFs Investigation

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Nano-Micro Letters 2015年第3期7卷 255-260页

作者： Takahiro Wada Naoyoshi Murata Takuya suzuki Hiromitsu Uehara Hiroaki Nitani Yasuhiro Niwa Motohiro uo Kiyotaka Asakura Graduate school of Medical and Dental sciences Tokyo Medical and Dental University Corporate R&D Headquarters Fuji Electric Co. Ltd Catalysis Research Center Hokkaido University Photon Factory Institute of Materials Structure Science

We have directly investigated the chemical state of the Pd species in a real l-gas sensor device by examining the l-fluorescence X-ray absorption fine structure. The l-gas sensor device was heavily damaged by a heating process in which the temperature was ill-controlled, resulting in decrease of methane selectivity. We found that the Pd O in the fresh l-gas sensor was reduced to Pd metal particles as the methane selectivity decreased. Based on the investigation results, we modified the device structure so as to heat up homogeneously. The lifetime of the sensor was then successfully increased by more than 5 years.

关键词： Micro gas sensor Micro-XAFs Pd/Al2O3 Deactivation

Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species

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Journal of Animal science and Biotechnology 2019年第2期10卷 375-389页

作者： Cristina soriano-úbeda Jon Romero-Aguirregomezcorta Carmen matás Pablo E.Visconti Francisco A.García-Vázquez Department of Physiology Faculty of Veterinary ScienceInternational Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of Murcia30100 MurciaSpain Institute for Biomedical Research of Murcia(IMIB-Arrixaca) MurciaSpain Department of Physiology Faculty of Medicine and NursingUniversity of the Basque Country UPV/EHULeioaBizkaiaSpain.4Department of Veterinary and Animal SciencesUniversity of MassachusettsAmherstMAUSA.

Background: The in vivo concentration of bicarbonate(HCO3-), one of the essential sperm capacitating effectors,varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site. On the contrary, porcine in vitro sperm capacitation and fertilisation media usually contains a standard concentration of25 mmol/L, and one of the main problems presented is the unacceptable high incidence of polyspermy. This work hypothesised that by modifying the HCO3-concentration of the medium, the output of in vitro sperm capacitation and fertilisation could be ***: Once exposed to the capacitation medium, the intracellular pH(pHi) of spermatozoa increased immediately even at low concentrations of HCO3-, but only extracellular concentrations of and above 15 mmol/L increased the substrates protein kinase A phosphorylation(pPKAs). Although with a significant delay, 15 mmol/L of HCO3-stimulated sperm linear motility and increased other late events in capacitation such as tyrosine phosphorylation(Tyr-P) to levels similar to those obtained with 25 mmol/L. This information allowed the establishment of a new in vitro fertilisation(IVF)system based on the optimization of HCO3-concentration to 15 mmol/L, which led to a 25.3% increment of the viable zygotes(8.6% in the standard system vs. 33.9%).Conclusions: Optimising HCO3-concentrations allows for establishing an IVF method that significantly reduced porcine polyspermy and increased the production of viable zygotes. A concentration of 15 mmol/L of HCO3-in the medium is sufficient to trigger the in vitro sperm capacitation and increase the fertilisation efficiency in porcine.

关键词： Adcy10 Boar Monospermy PKA

History-dependent percolation on multiplex networks

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National science Review 2020年第8期7卷 1296-1305页

作者： Ming Li Linyuan Lü Youjin Deng Mao-Bin Hu Hao Wang matú? Medo H.Eugene stanley Department of Thermal science and Energy Engineering University of Science and Technology of China Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of China Alibaba Research Center for Complexity sciences Hangzhou Normal University Beijing Computational science Research Center Hefei National Laboratory for Physical sciences at Microscale Department of Modern Physics and CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of China Department of Physics and Center for Polymer studies Boston University

The structure of interconnected systems and its impact on the system dynamics is a much-studied cross-disciplinary topic. Although various critical phenomena have been found in different models, study of the connections between different percolation transitions is still lacking. Here we propose a unified framework to study the origins of the discontinuous transitions of the percolation process on interacting networks. The model evolves in generations with the result of the present percolation depending on the previous state, and thus is history-dependent. Both theoretical analysis and Monte Carlo simulations reveal that the nature of the transition remains the same at finite generations but exhibits an abrupt change for the infinite generation. We use brain functional correlation and morphological similarity data to show that our model also provides a general method to explore the network structure and can contribute to many practical applications, such as detecting the abnormal structures of human brain networks.

关键词： percolation multiplex networks critical phenomena brain networks

Impact of work environment on job satisfaction and stress among hemodialysis staff in Klang Valley

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Frontiers of Nursing 2023年第4期10卷 481-492页

作者： Zaima mat Yusuf Bit Lian Yee National Guard Health Affairs King Abdul Aziz Medical CityNursing Education ServicesRiyadh 11426Kingdom of Saudi Arabia Faculty of Technology and Applied sciences Open University MalaysiaPetaling JayaSelangor 47301Malaysia

Objective:To investigate the factors contributing to satisfaction with the work environment,job satisfaction(Js),and stress among hemodialysis(HD)staff in the central region of ***:A quantitative cross-sectional study was conducted on 215 HD staff working at private and non-government(NGO)dialysis centers using self-administered *** chi-square test was used to determine factors associated with HD staff's Js,stress,and working ***:The scientific proof was apparent that the working environment had an effect on Js and stress among employees at HD ***:This research offers useful insights into the essence and complexities of HD staff's work and will help nurses,dialysis managers,other dialysis personnel,and organizations to better understand the benefits and stresses faced by these workers.

关键词： hemodialysis staff job satisfaction nurses stress work environment