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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Cross-sections for the 27Al(γ,x)22Na multichannel reaction with the 28.3 meV difference of reaction thresholds

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Chinese Physics C 2022年第6期46卷 129-137页

作者： O.s.Deiev I.s.Timchenko s.N.olejnik V.A.Kushnir V.V.mytrochenko s.A.Perezhogin National science Center"Kharkov Institute of Physics and Technology" 1 Akademichna St.61108 KharkivUkraine

The bremsstrahlung flux-averaged cross-sections(σ(Eγmax))and the cross-sections per equivalent photon(σ(Eγmax)Q)were first measured for the photonuclear multichannel reaction ^(27)Al(γ,x)22 Na at end-point bremsstrahlung gamma energies ranging from 35 meV to 95 *** experiments were performed with the beam from the NsC KIPT electron linear accelerator LUE-40 using theγ-activation *** bremsstrahlung quantum flux was calculated with the GEANT4.9.2 program and was also monitored via the ^(100)mo(γ,n)^(99)mo *** flux-averaged cross-sections were calculated using the partial cross-sectionσ(E)values computed with the TALYs1.95 code for different level density *** is given to special features of calculating the cross-sectionsmax)>andmax)Q>for the case of the final nucleus ^(22)Na via several partial channels x:nα+dt+npt+2 n^(3) He+n2d+2 npd+2 p3 n.

关键词： bremsstrahlung flux-averaged cross-section bremsstrahlung end-point energy of 35-95 meV activation and off-lineγ-ray spectrometric technique TALYs1.95 GEANT4.9.2

Isomeric ratio of the ^(181)Ta(γ,3n)^(178m,g)Ta reaction products at energy Eγmax up to 95 meV

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Chinese Physics C 2022年第1期46卷 102-109页

作者： O.s.Deiev I.s.Timchenko s.N.olejnik V.A.Kushnir V.V.mytrochenko s.A.Perezhogin National science Center"Kharkiv Institute of Physics and Technology" 1 Akademicheskaya St.61108 KharkivUkraine

The photoneutron reaction^(18)Ta(y,3m)(178m,g)Ta was investigated with the beam from the NsC KIPT electron linear accelerator *** measurements were performed using the residual y-activity *** bremsstrahlung flux-averaged cross sections((E_(γmax))>.(r(E_(γmax))>m.max))g and the isomerie ratio of the re-action products d(E_(γmax))were *** theoretical values of the averaged cross-sections and isomeric ratio were calculated using the partial cross-sections from the TALYs1.95 code for different level density models LD 1-6..The obtained experimental d(E_(γmax))agree with the data in the lterature,but differ from the theoretical values in ab-solute magnitude and the behavior of the energy dependence.A comparison of the determined averaged cross-sec-tions with the calculated cross sections showed the best agreement for the case of the LD 5 model.

关键词： bremsstrahlung flux-averaged cross-section isomeric ratio bremsstrahlung end-point energy of 35-95 meV activation and off-line 7-ray spectrometric technique TALYs1.95 GEANT4.9.2

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the Pubmed database was completed to identify relevant studies published up to march *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek manukjan Daniel Fulton Zubair Ahmed Wmatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIm-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK mHeNs-school for mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

semantic segmentation of Lumbar Vertebrae Using meijering U-Net(mU-Net)on spine magnetic Resonance Images

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Computer modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： Lakshmi s V V shiloah Elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely mU-Net,consisting of the meijering convolutional layer that incorporates the meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal mRI images of 515 patients in the Lumbar spine mRI Dataset publicly available from mendeley *** proposed mU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(mRI) semantic segmentation lumbar vertebrae deep learning U-Net model

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of mechanical and materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEm), and an in-house code is developed in the mATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： finite element method (FEm) nonlinear Green-Lagrange inverse hyperbolic shear deformation theory (IHsDT) bio-inspired composite plate helicoidal O322