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Development and in-vitro evaluation of an optimized carvedilol transdermal therapeutic system using experimental design approach

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Asian Journal of Pharmaceutical sciences 2013年第1期8卷 28-38页

作者： Namrata Vora s.lin P.L.Madan College of Pharmacy and Health sciences St.John’s UniversityQueensNY 11439USA

The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary *** on these results,design of experiments technique was applied followed by regression analysis and response surface methodology to optimize formulation *** Composite IV model design was used with four formulation variables:drug loading,matrix thickness,adhesive layer thickness,and propylene glycol *** formulations were prepared according to the design;and the effect of formulation variables was studied on in-vitro release and permeation profiles of these *** all cases,the permeation profiles paralleled in-vitro release *** drug released at 7 h and 24 h was used as release response parameters while permeation flux obtained was employed as permeation response *** four formulation variables were found to be significant for release properties and three of these exhibited significant effect on permeation profile of carvedilol across artificial *** optimization,using 47.9%of cumulative carvedilol released at 7 h and 99.8%at 24 h as well as 25.7 mg/cm2/h of permeation flux,was applied to obtain desired release and permeation ***,carvedilol was observed to release from the optimized formulation with 51.4%drug release at 7 h and 98.5%at 24 h with an observed flux value of 27.4 mg/cm2/h across artificial membrane,which showed an excellent agreement with the predicted *** results of this investigation show that the quadratic mathematical model developed could be used to further predict formulations with desirable release and permeation properties.

关键词： Transdermal Carvedilol Controlled release Experimental design approach

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A decision aid for the port placement problem in robot-assisted hysterectomy

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Laparoscopic, Endoscopic and Robotic surgery 2023年第2期6卷 43-56页

作者： Mohammad R.Maddah Jean-Marc Classe Isabelle Jaffre Keith A.Watson Katherine s.lin Damien Chablat Cedric Dumas Caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State University3640 Colonel Glenn HwyDaytonOHUSA Department of Automatique Productique et InformatiqueIMT Atlantique4 Rue Alfred KastlerNantesFrance Laboratoire des sciences Du Numerique de Nantes(Ls2N) 2 Chemin de La Houssini?ereNantesFrance Centre Rene Gauducheau ICO Institut de Cancerologie de L'Ouest BD Professeur Jacques MonodSaint-HerblainFrance Brethen Center for surgical Advancement in Robotics and Minimally Invasive surgery Miami Valley HospitalOne Wyoming StreetDaytonOHUSA Department of Computer science IMT AtlantiqueTechnopole Brest-IroiseBrestFrance Laboratoire des sciences et Techniques de L'information de La Communication et de La Connaissance(Lab-sTICC) Technopole Brest-IroiseBrestFrance Future Industries Institute STEMUniversity of South AustraliaMawson Lakes BlvdMawson LakesAustralia

Objective:In robot-assisted minimally invasive surgery,proper port positioning ensures that surgical tools have adequate access to the surgical site and avoids mid-surgery collisions of robotic *** date,several guidelines have been proposed for more accurate port ***,challenges remain due to variations in patient morphology,anatomy,and,in particular,organ displacement due to insuf-flation in certain laparoscopic *** objective of this study was to design and develop a de-cision aid for optimal port placement in robot-assisted hysterectomy that accounts for patient variability and organ displacement due to ***:Three components were constructed:a robot model,a patient-specific model,and an opti-mization *** three components were integrated,and the system was verified using four different patients who underwent robotic *** verified,two expert surgeons were asked to evaluate the decision aid for face and construct validity.A usability test was conducted using a torso phantom with target organs located in three different *** expert surgeons performed a simulated hysterectomy task with and without the decision aid to evaluate performance and ***:The optimization algorithm was sensitive to individual differences in anatomy in the four *** surgeons successfully established face and construct *** test results showed a 28%-40% reduction in time to task completion with the optimized ports compared to expert-determined port locations without using the decision ***:The decision aid,based on an individualized patient-specific model,robot model,and optimization algorithm,was shown to be effective at addressing the challenges of displaced organs due to insufflation in robot-assisted *** face and construct validity of the decision aid was established by expert surgeons,while efficiency gains in task performance were demonstrated experim

关键词： Optimization Planning tool Patient model Robotic hysterectomy

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Contactless Measurement of Permanent Magnet Motor Performances

Contactless Measurement of Permanent Magnet Motor Performanc...

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第十三届中国小电机技术研讨会

作者： Quan JIANG Chao BI s.lin (A*sTAR Data storage Institute,singapore 117608)

Each year,a huge volume of permanent magnet (PM) motors are produced and *** important quality testing of PM motors are to measure their back EMFs and friction *** paper introduces two contactless methods to measure the back EMFs and their harmonic components only through a freewheeling procedure and the friction torque with self-sensing *** mechanical coupling,the driving motor and the torque sensor can be omitted and the testing procedure can be greatly simplified and *** order to eliminate the influence of the freewheeling speed deceleration,the phase flux-linkages are employed to obtain the back EMF amplitudes and phases of the fundamental and harmonic components by using the finite Fourier series *** proposed method makes the freewheeling measurement of the back EMFs and their harmonics to be an accurate and fast and it is especially useful for PM motors with a small ratio of inertia to *** friction torque,including the bearing,windage and core losses of a PM motor is a key performance *** should be accurately tested during R&D and mass *** the proposed self-sensing method,the friction torque can be measured more precisely and easily

关键词： motor testing permanent magnet motors back emf friction measurement

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老年人睾丸组织退化的基因表达谱研究

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北京大学学报（医学版） 2003年第4期35卷 364-368页

作者：辛钟成刘武江田龙袁亦铭辛华付杰林桂亭 Ching s.lin Tom F.LUE 北京大学第一医院泌尿外科北京100034 Kouppy Urology Laboratory of UCsF

目的 :研究老年人睾丸组织基因表达谱变化 ,为研究老年人睾丸功能衰退机制奠定基础。方法 :知情同意下获取正常青年人和老年人睾丸组织标本各 3例 ,采用QIAGENRNA提取试剂盒提取总RNA ,分别等量混合后制备探针。利用ClonTech公司生产的... 详细信息

目的 :研究老年人睾丸组织基因表达谱变化 ,为研究老年人睾丸功能衰退机制奠定基础。方法 :知情同意下获取正常青年人和老年人睾丸组织标本各 3例 ,采用QIAGENRNA提取试剂盒提取总RNA ,分别等量混合后制备探针。利用ClonTech公司生产的包含 80 0 0个已知基因的人类cDNA基因芯片 [AtlasPlasticHuman 8KMi croarray (Cat.# 790 5 1) ]筛选差异表达基因。按基因功能分类方法对老年睾丸组织中差异表达的基因进行归类分析。用RT -PCR、T -A克隆测序等方法选择目的基因 ,验证基因芯片结果。结果 :筛选到差异表达基因 117个(1.4 6 % ) ,83个基因在老年睾丸组织中表达下调 ,34个基因表达上调。在表达下调的基因中 ,代谢相关基因 16个(19.3% ) ,与基因和蛋白表达相关的基因 18个 (2 1.7% ) ,信号通路相关基因 16个 (19.3% ) ,细胞分化相关基因19个 (2 2 .9% ) ,细胞结构和运动相关基因 6个 (7.2 % ) ,细胞或内环境稳态相关基因 4个 (4 .8% ) ,未知功能基因 4个 (4 .8% )。在表达上调的基因中 ,代谢相关基因 3个 (8.8% ) ,与基因和蛋白表达相关的基因 10个 (2 9.4 % ) ,信号通路相关基因 2个 (5 .9% ) ,细胞分化相关基因 11个 (32 .4 % ) ,细胞结构和运动相关基因 8个 (2 3.5 % )。RT -PCR及T

关键词：老年人睾丸组织退化基因表达谱衰老遗传学

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sexual arousal,a role of histamine and orexin neurons

Sexual arousal,a role of histamine and orexin neurons

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中国睡眠研究会第九届学术年会

作者： Y.Zhao C.Anaclet M.Perier C.Buda T.H.Wang J.-s.lin Integrative Physiology of Brain Arousal systems Lyon Neuroscience Research CenterINSERM-U1028/CNRS-UMR 5292Faculty of MedicineClaude Bernard UniversityLyonFrance Department of Physiology Zhongshan School of MedicineSun Yat-Sen University

＜正＞sexual arousal ensures the necessary waking state allowing the anticipation and performance of sexual activities and so is a prerequisite for *** importance is uncontestable,but the mechanisms remain *** hypothesize that a full expression of such a behavioral state requires highly optimal convergent and divergent activities of the brain arousal systems notably histamine（HA）and orexins（Ox）*** test our hypothesis,we have designed a behavioral

关键词： sexual arousal sleep-wake histamine orexin sex hormones

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衔接元件磁泡存贮器可使存贮容量增大十倍

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系统工程与电子技术 1982年第8期 49-54页

作者： Yeong s.lin ,Ian L.sanders ,谢蔚文

新一代的衔接元件磁泡器件能够存贮的信息比坡莫合金人字形磁泡器件大约多十倍,并且还可以用标准光刻技术进行制作。研制中的器件具有4兆位/厘米2的存贮密度。人字形磁泡存贮器目前只能提供大约1兆位/厘米2的密度,而可以达到的密度约为... 详细信息

新一代的衔接元件磁泡器件能够存贮的信息比坡莫合金人字形磁泡器件大约多十倍,并且还可以用标准光刻技术进行制作。研制中的器件具有4兆位/厘米2的存贮密度。人字形磁泡存贮器目前只能提供大约1兆位/厘米2的密度,而可以达到的密度约为1.5兆位/厘米2,但是,这会超过光刻技术的能力。然而,用现行衔接盘器件加工法,看来可以达到16兆位/厘米2的密度。

关键词：磁泡磁壁存贮器人字形存储器坡莫合金自对准

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Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： lin Zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du Wang Rongjie lin Weihong Xu Department of spinal surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China school of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(sIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,sIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues self-sacrificial template Lithium-ion batteries sodium-ion batteries Potassium-ion batteries

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