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The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in early phase of cutting maneuvers in female athletes

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Journal of sport and Health science 2024年第3期13卷 376-386页

作者： Issei Ogasawara Ken Ohta Gajanan s.Revankar shoji Konda Yohei shimokochi Hideyuki koga Ken Nakata Department of Health and sport sciences Graduate School of MedicineOsaka UniversityToyonaka 560-0043Japan sports sensing Co. LTD.Fukuoka 815-0035Japan Department of Neurology Graduate School of MedicineOsaka UniversitySuita 565-0871Japan Department of Health and sport Management Osaka University of Health and Sport SciencesSennan-gun 590-0496Japan Department of Joint surgery and sports Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8519Japan

Background:Combined knee valgus and tibial internal rotation(VL+IR)moments have been shown to stress the anterior cruciate ligament(ACL)in several in vitro cadaveric *** utilize this knowledge for non-contact ACL injury prevention in sports,it is necessary to elucidate how the ground reaction force(GRF)acting point(center of pressure(CoP))in the stance foot produces combined knee VL+IR moments in risky maneuvers,such as ***,the effects of the GRF acting point on the development of the combined knee VL+IR moment in cutting are still ***:We first established the deterministic mechanical condition that the CoP position relative to the tibial rotational axis differentiates the GRF vector’s directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is posterior to the tibial rotational axis,the GRF vector is more likely to produce the combined knee VL+IR moment than when the CoP is anterior to the tibial rotational ***,we tested a stochastic aspect of our theory in a lab-controlled in vivo *** females performed 60˚cutting under forefoot/rearfoot strike conditions(10 trials each).The positions of lower limb markers and GRF data were measured,and the knee moment due to GRF vector was *** trials were divided into anterior-and posterior-CoP groups depending on the CoP position relative to the tibial rotational axis at each 10 ms interval from 0 to 100 ms after foot strike,and the occurrence rate of the combined knee VL+IR moment was compared between trial ***:The posterior-CoP group showed significantly higher occurrence rates of the combined knee VL+IR moment(maximum of 82.8%)at every time point than those of the anterior-CoP trials,as theoretically predicted by the deterministic mechanical ***:The rearfoot strikes inducing the posterior CoP should be avoided to reduce the risk of non-contact ACL injury associated with the com

关键词： Center of pressure Deterministic condition Foot strike pattern Injury mechanism Moment of ground reaction force

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基于动态增强MR成像药代动力学分析对口腔鳞状细胞癌放化疗疗效的预测与监测研究

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国际医学放射学杂志 2011年第5期 506-506页

作者： T.Chikui s.Kawano T.Kawazu M.Hatakenaka s.koga M.Ohga 刘婷 Department of Oral and Maxillofacial Radiology Faculty of Dental ScienceKyushu University

目的评估药代动力学是否有助于预测和监测口腔癌放化疗(CRT)疗效。方法共计23例行术前放化疗和手术治疗的口腔鳞状细胞癌病人纳入本研究,每例病人在放化疗

关键词：放疗口腔癌 MRI 药代动力学对比剂

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz s.A.Pikuz W.Yan T.M.Jeong s.singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.sasorov s.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo s.V.Bulanov T.Kawachi A.s.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon science(KPsI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFsA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AsCR PragueCzech Republic FZU-Institute of Physics AsCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine IsTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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silver Nanowire Electrodes: Conductivity Improvement Without Post-treatment and Application in Capacitive Pressure sensors

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Nano-Micro Letters 2015年第1期7卷 51-58页

作者： Jun Wang Jinting Jiu Teppei Araki Masaya Nogi Tohru sugahara shijo Nagao Hirotaka koga Peng He Katsuaki suganuma state Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology The Institute of scientific and Industrial Research Osaka University

Transparent electrode based on silver nanowires(Ag NWs) emerges as an outstanding alternative of indium tin oxide film especially for flexible electronics. However, the conductivity of Ag NWs transparent electrode is still dramatically limited by the contact resistance between nanowires at high transmittance. Polyvinylpyrrolidone(PVP) layer adsorbed on the nanowire surface acts as an electrically insulating barrier at wire–wire junctions, and some devastating post-treatment methods are proposed to reduce or eliminate PVP layer, which usually limit the application of the substrates susceptible to heat or pressure and burden the fabrication with high-cost, time-consuming, or inefficient processes. In this work, a simple and rapid pre-treatment washing method was proposed to reduce the thickness of PVP layer from 13.19 to0.96 nm and improve the contact between wires. Ag NW electrodes with sheet resistances of 15.6 and 204 X sq-1have been achieved at transmittances of 90 and 97.5 %, respectively. This method avoided any post-treatments and popularized the application of high-performance Ag NW transparent electrode on more substrates. The improved Ag NWs were successfully employed in a capacitive pressure sensor with high transparency, sensitivity, and reproducibility.

关键词： silver nanowire Pre-treatment Transparent electrode Pressure sensor

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Co-Chairman’s Message

Co-Chairman’s Message

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The Fourth Asia-Pacific Conference on Environmental Electromagnetics

作者： Ryuji koga/Cochair Okayama University Japan Professor

＜正＞Electronics is a facet of the modern civilization and the dominant part of it, focused on consumer electronics, is carried in pan-pacific area now centered in far-east districts. Engineers who develop a new product, with better performance, easier to treat and with new function which had never claimed, will inevitably confront to EMC problems when they put their products to the market. They are young and enthusiastic to resolve the difficult subjects. CEEM’06 is the opportunity for the embarrassed engineers to find hints to untie entangled subject or lend other engineers an

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Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota sakai Minako Ito Kyoko Komai Mana Iizuka-koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura Department of Microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,sT2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that sT2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

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Development and Evaluation of an All Weather-Type solar Drying House to Make for Wood Pellet Material

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Open Journal of Applied sciences 2012年第3期2卷 153-162页

作者： Kimio Kanayama shinya koga Hiromu Baba Tomoyoshi sugawara Kitami Institute of Technology Kitami Japan Kyushu University Fukuoka Japan Marusho-Giken Co. Ltd. Ashoro Japan

To suppress the global environment pollutions, we tried to develop a new-type solar drying house by improving a typical agricultural green-house, so that an all weather-type solar drying house was invented ultimately. This house is capable to dry raw wood materials (Ogako) into suitable moisture content (Mc) to make a wood pellet. The all weather-type solar Ogako drying house is covered with a triple transparent film, and an open/close free-type shield sheet is spread along with house’s inner surface with a small space, which is opened when solar radiation is incident on the house in daytime and closed to prevent heat loss from the house while out of sun shining in night. Inside of the all weather-type solar Ogako drying house, there are four belt-conveyors over which four top radiation panels are hanged, and on which four Ogako agitators are touched, a turn-table, two hoppers, four small fans, and besides, a floor heating is molded in concrete floor. Also on the north wall outside the house, two insulated cylinders (chimney) are stood up vertically to exhaust inside moist air passively. Then, to make clearly the operation performance of the house, the drying tests for the proof examination were conducted nineteen times at first test site in Ashoro where is located east-central part of Hokkaido, Japan. As a result of the drying test for the proof examination, it was made clear that the all weather-type solar Ogako drying house is practically useful as a supplementary apparatus to produce the dried Ogako, and consequently to suppress CO2 exhaustion.

关键词： solar Energy and Biomass Energy Agricultural Green-House Ogako Drying House Wood Powder (Ogako) Wood Pellet Moisture Content (Mc) Decrease of Oil Consumption suppression of CO2 Exhaustion

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Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain

Identification of an adenylyl cyclase inhibitor for treating...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： susan s.KIM Kohei koga Giannina DEsCALZI Kunjumon I.VADAKKAN Bong-Kiun KAANG Deparment of Physiology University of TorontoToronto M5S1A8Canada Institute of Neuroscience the Fourth Military medical UniversityXi'an 710032China

＜正＞Objective Neuropathic pain,often caused by nerve injury,is commonly observed among patients with different *** its basic mechanisms are poorly understood,effective medications are limited. Previous investigations of basic pain mechanisms and drug discovery efforts have focused mainly on early sensory neurons such as dorsal root ganglion and spinal dorsal horn neurons,and few synaptic-level studies or new drugs are designed to target the injury-related cortical plasticity that accompanies neuropathic *** previous work has demonstrated that calcium-stimulated adenylyl cyclase 1（AC1） is critical for nerve injury-induced synaptic changes in the anterior cingulate *** Rational drug design and chemical screening,a variety of behavioral tests, electrophysiological methods and toxicity studies were performed in the present *** It was identified that a lead candidate AC1 inhibitor,NB001,was relatively selective for AC1 over other adenylate cyclase ***001 has an analgesic effect in animal models of neuropathic pain,without any apparent side effects when administered intraperitoneally or *** AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain.

关键词： adenylyl cyclase anterior cingulate cortex neuropathic pain

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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel

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World Journal of Gastroenterology 2018年第35期24卷 4036-4053页

作者： Keizo Hiraishi Lin-Hai Kurahara Miho sumiyoshi Yao-Peng Hu Kaori koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue Department of Physiology Graduate School of Medical Sciences Fukuoka University Department of Pathology Faculty of Medicine Fukuoka University Department of Gastroenterological surgery Faculty of Medicine Fukuoka University Department of Cell Biology University of Connecticut Health Center Department of Gastroenterology and Medicine Faculty of Medicine Fukuoka University College of Letters and science University of CaliforniaDavis

AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODs Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBs) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting ***^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel *** factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting *** from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. REsULTs Chronic treatment with TNBs caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO *** active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,*** counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-sMA) ,which were accompanied by a reduction in the phosphorylation of smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of ***,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen *** the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly *** The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis

关键词： Intestinal fibrosis Myofibroblast Transient receptor potential ankyrin 1 Crohn’s disease Collagen α-smooth muscle actin

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sTAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

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World Journal of Gastroenterology 2017年第37期23卷 6833-6844页

作者： Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio sata Hironori koga Akihiko Yoshimura Takuji Torimura Division of Gastroenterology Department of Medicine Kurume University School of Medi-cine Liver Cancer Division Research Center for Innovative Cancer Therapy Kurume University Kurume Clinical pharmacology Clinic Department of Diagnostic pathology Kurume University hospital Department of Microbiology Immun--ology Keio University School of Medicine

AIM To elucidate the role of sTAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODs We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic sTAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(sOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to *** Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic sTAT3-deficient mice as compared with control mice. sTAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic sTAT3-deficient livers as compared with control livers. sOX9 and YAP were upregulated in hepatic sTAT3-deficient *** sTAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration.

关键词： Hepatocellular carcinoma Ductular reaction signal transducer and activator of transcription 3 Yesassociated protein sex determining region Y-box9 Transdifferentiation

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