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Defence Technology（防务技术） 2023年第1期19卷 1-11页

作者： Elango Natarajan Lídio Inacio Freitas M.s.santhosh Kalaimani Markandan Ammar Abdulaziz Majeed Al-Talib C.s.Hassan Faculty of Engineering Technology and Built EnvironmentUCSI UniversityKuala LumpurMalaysia Dili Institute of Technology DiliTimor-Leste selvam Composite Materials Research Laboratory Department of Mechanical EngineeringSelvam College of TechnologyTamil NaduIndia

suitability of s-Glass/carbon fiber reinforced polymer composite for submarine hull subjected to hydrostatic pressure has been investigated in the present *** materials have raised concerns owing to their decomposition due to low resistance towards salinity and hence polymer composites have been explored to showcase their mechanical stability to withstand transverse and impact *** this end,the mechanical properties of s-Glass/carbon fiber reinforced polymer composite were experimentally investigated and higher specific strength and stiffness of the composite in comparison to many metallic materials used for submarine hull were *** obtained experimental values were used for the static and dynamic crash analysis of the bow,stern and foil through Finite Element Analysis(FEA);where depth of travel was varied from sea surface level of 0-7000 *** assembly was later developed with the optimum shape and thickness of each *** also report the nonlinear crash analysis upon impact at velocity ranging from 3 to 21 m/***,kinetic energy,acceleration peak and internal energy in struck submarine revealed that travel depth 1750 m and 3500 m is recommendable,more particularly,crash safety factor of the submarine is found to be within limit when submarine encounters crash at 1750 m.

关键词： Crash Impact Design submarine Hull Bow stern Foil

Extracellular vesicles in Alzheimer’s disease:from pathology to therapeutic approaches

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Neural Regeneration Research 2023年第1期18卷 18-22页

作者： Marta Garcia-Contreras Avnesh s.Thakor Interventional Regenerative Medicine and Imaging Laboratory Department of RadiologyStanford UniversityPalo AltoCAUSA

Alzheimer’s disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive *** novel biomarkers for Alzheimer’s disease has the potential for patient risk stratification,early diagnosis,and disease monitoring in response to therapy.A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific *** addition,extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic *** is critical given the huge unmet need for novel treatment strategies for Alzheimer’s *** review summarizes and discusses the most recent findings in this field.

关键词： Alzheimer’s disease brain diagnostic extracellular vesicles isolation methods microglia neurodegenerative diseases neuroinflammation neurons therapy

Discipline Impact Factor: some of Its History, some of the Author's Experience of Its Application, the Continuing Reasons for Its Use and… Next Beyond

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Journal of Data and Information science 2020年第3期5卷 197-209页

作者： Vladimir s.Lazarev Belarusian National Technical University 16 Yakub Kolas StMinsk220013Republic of Belarus

Purpose: This work aims to consider the role and some of the 42-year history of the discipline impact factor(DIF) in evaluation of serial publications. Also, the original "symmetric" indicator called the "discipline susceptibility factor" is to be presented. Design/methodology/approach: In accordance with the purpose of the work, the methods are analytical interpretation of the scientific literature related to this problem as well as speculative explanations. The information base of the research is bibliometric publications dealing with impact, impact factor, discipline impact factor, and discipline susceptibility ***: Examples of the DIF application and modification of the indicator are given. It is shown why research and university libraries need to use the DIF to evaluate serials in conditions of scarce funding for subscription to serial publications, even if open access is available. The role of the DIF for evaluating journals by authors of scientific papers when choosing a good and right journal for submitting a paper is also briefly discussed. An original indicator "symmetrical" to the DIF(the "discipline susceptibility factor") and its differences from the DIF in terms of content and purpose of evaluation are also briefly *** limitations: The selection of publications for the information base of the research did not include those in which the DIF was only mentioned, used partially or not for its original purpose. Restrictions on the length of the article to be submitted in this special issue of the JDIs also caused exclusion even a number of completely relevant publications. Consideration of the DIF is not placed in the context of describing other derivatives from the Garfield impact factor. Practical implications: An underrated bibliometric indicator, viz. the discipline impact factor is being promoted for the practical application. An original indicator "symmetrical" to DIF has been proposed in order of searching serial publicatio

关键词： Discipline impact factor Discipline susceptibility factor Citation analysis Journals evaluation serials evaluation Information service

Isolation and characterization of marine biofilm forming bacteriafrom a ship＇s hull

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Frontiers in Biology 2018年第3期13卷 208-214页

作者： Kavitha s Vimala Raghavan school of Biosciences and Technology Vellore Institute of Technology Vellore-632-014 Tamil Nadu India Centre for Nanotechnology Researchl Vellore Institute of Technologyl Vellore-632 014 Tamil Nadu India

Background Diverse aquatic microorganisms are capable of colonizing living and non-living surfaces leading to the formation of biofilms. Commonly visualized as a slimy layer, these biofilms are filled with hundreds of other microorganisms compared to free living planktonic cells. Microbial surface colonization and surface-associated metabolic activities also exert several macroscale deleterious effects, including biofouling, biocorrosion and the persistence and transmission of harmful or pathogenic microorganisms and virulence determinants. The present study deals with the isolation and screening of marine bacteria for biofilm formation. The screened isolates were characterized and identified as Pychrobacter celer, Pychrobacter alimentarius and Kocuria rhizophila by 16s rRNA *** Biofilm forming bacteria were isolated by spread plate technique and subjected to screening by microtiter plate assay. The potent biofilm formers were identified by molecular characterization using 16s rRNA gene *** Twelve bacterial isolates were obtained by pour plate technique and subjected to biofilm assay. Among the 12 isolates three isolates which showed maximum biofilm formation were subjected to molecular characterizationby 16s rRNA gene sequencing method. The isolates were identified as Pychrobacter celer, Pychrobacter alimentarius and Kocuria rhizophila. The EPs produced by the three biofilm forming bacteria was extracted and the protein and carbohydrate content *** Among the isolates screened, isolate 8 (Kocuria rhizophila) produced maximum protein and carbohydrate which was also in accordance with the results of microtiter plate assay.

关键词： biofilm, MTP assay, extracellular polymeric substances, 16s rRNA gene sequencing, Psychrobacter, Kocuria

Distribution of the related weevil species sitophilus oryzae and s. zeamais in Brazil

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Insect science 2013年第6期20卷 763-770页

作者： Alberto s. Correa Luiz Orlando de Oliveira Lucas s. Braga Raul Narciso C. Guedes Departamento de Entomologia Universidade Federal de Vicosa Vicosa Brazil Departamento de Bioquimica e Biologia Molecular Universidade Federal de Vicosa Vicosa Brazil

The genus sitophilus （Coleoptera： Curculionidae） encompasses species of great economic importance as stored grain pests worldwide. Among these species, the maize and the rice weevils （sitophilus zeamais and sitophilus oryzae, respectively） are partic- ularly important in warmer climates. These two weevils exhibit closely morphological and ecological resemblance making difficult their proper identification and recognition of their distribution in grain-producing regions. Both species are recorded in south America and particularly in Brazil, but their respective distribution and prevalence were not yet assessed in the region. Therefore, several insect samples throughout Brazil were collected and subjected to morphological identification using male genitalia and also using molec- ular identification with species-specific primers designed for clear recognition of both the species. The primers were designed for the specific amplification of a gene fragment of the cytochrome oxidase subunit I, which exhibited high specificity during our prelimi- nary experiments with insects from six populations of known species （either s. zeamais or s. oryzae）. Both identification strategies provided the same results indicating preva- lence of the maize weevil s. zeamais throughout the country. Two hypotheses may explain such prevalence：（i） the likely host preference ofs. zeamais for maize because this is the most cultivated cereal in Brazil, and （ii） the prevalence ofs. zeamais in tropical regions as compared with s. oryzae, which is more disseminated in subtropical and temperate regions.

关键词： cytochrome oxidase subunit I distribution maize weevil rice weevil south America

Defining and predicting deep remission in patients with perianal fistulizing Crohn's disease on anti-tumor necrosis factor therapy

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World Journal of Gastroenterology 2017年第34期23卷 6197-6200页

作者： konstantinos papamichael adam s cheifetz Center for Inflammatory Bowel Diseases Division of GastroenterologyBeth-Israel Deaconess Medical CenterHarvard Medical School

Perianal fistulas can occur to up to one-third of patients with Crohn's disease(CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor(anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD. Nevertheless, current data suggest that sustained remission and long-term complete fistula healing can be achieved in only 30% to 50% of patients. Moreover, these percentages refer mostly to clinical rather than deep remission, defined as endoscopic and radiologic remission, which is quickly emerging as the preferred goal of therapy. Unfortunately, the therapeutic options for perianal fistulising CD are still limited. As such, it would be of great value to be able to predict, and more importantly, prevent treatment failure in these patients by early and continued optimization of antiTNF therapy. similar to ulcerative colitis and luminal CD, recent data demonstrate that higher infliximab concentrations are associated with better clinical outcomes in patients with perianal fistulising CD. This suggests that therapeutic drug monitoring and a treatto-trough therapeutic approach may emerge as the new standard of care for optimizing anti-TNF therapy in patients with perianal fistulising CD.

关键词： Inflammatory bowel disease Infliximab Adalimumab Magnetic resonance imaging Drug monitoring Fistula healing

Microbial manipulation as primary therapy for Crohn's disease

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World Journal of Gastroenterology 2013年第10期19卷 1513-1516页

作者： Randy s Longman Arun swaminath Division of Digestive and Liver Disease Department of MedicineColumbia University Medical CenterNew YorkNY 10032United States

While antimicrobials are clinically effective in preventing post-operative recurrence,the role for antibiotics in primary therapy for Crohn's disease(CD) remains *** recent multicenter phase 2 trial by Prantera et al received wide attention because it demonstrated an increase in the week 12 remission rate in patients with moderately active CD treated with rifaximin and renewed interest in microbial manipulation as primary therapy for *** this commentary,we discuss aspects of durability,immune cell polarization,and safety of microbial manipulation as primary therapy for CD.

关键词： Inflammatory bowel disease Rifaximin Microbiome

Brain repair for Parkinson's disease:is the answer in the matrix?

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Neural Regeneration Research 2018年第7期13卷 1187-1188页

作者： Niamh Moriarty Eilís Dowd Pharmacology & Therapeutics and Galway Neuroscience Centre National University of Ireland

Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophys... 详细信息

关键词： Brain repair for Parkinson’s disease:is the answer in the matrix

Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

Adenosine A1 receptor ligands bind toα-synuclein:implications forα-synuclein misfolding andα-synucleinopathy in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 809-834页

作者： Elisabet Jakova Mohamed Taha Moutaoufik Jeremy s.Lee Mohan Babu Francisco s.Cayabyab Department of surgery College of MedicineUniversity of SaskatchewanSaskatoonSKCanada Department of Chemistry and Biochemistry Faculty of ScienceUniversity of ReginaReginaSKCanada Department of Biochemistry Microbiology and ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada.

Background:Accumulatingα-synuclein(α-syn)aggregates in neurons and glial cells are the staples of many synucleinopathy disorders,such as Parkinson’s disease(PD).since brain adenosine becomes greatly elevated in ageing brains and chronic adenosine A1 receptor(A1R)stimulation leads to neurodegeneration,we determined whether adenosine or A1R receptor ligands mimic the action of known compounds that promoteα-syn aggregation(e.g.,the amphetamine analogue 2-aminoindan)or inhibitα-syn aggregation(e.g.,Rasagiline metabolite 1-aminoindan).In the present study,we determined whether adenosine,A1R receptor agonist N^(6)-Cyclopentyladenosine(CPA)and antago-nist 8-cyclopentyl-1,3-dipropylxanthine(DPCPX)could directly interact withα-syn to modulateα-syn aggregation and neurodegeneration of dopaminergic neurons in the substantia nigra(sN).Methods:Nanopore analysis and molecular docking were used to test the binding properties of CPA and DPCPX withα-syn in ***-Dawley rats were administered with 7-day intraperitoneal injections of the A1R ligands and 1-and 2-aminoindan,and levels ofα-syn aggregation and neurodegeneration were examined in the sN pars compacta and hippocampal regions using confocal imaging and Western ***:Using nanopore analysis,we showed that the A1R agonists(CPA and adenosine)interacted with the N-terminus ofα-syn,similar to 2-aminoindan,which is expected to promote a“knot”conformation andα-syn *** contrast,the A1R antagonist DPCPX interacted with the N-and C-termini ofα-syn,similar to 1-aminoindan,which is expected to promote a“loop”conformation that preventsα-syn *** docking studies revealed that adenosine,CPA and 2-aminoindan interacted with the hydrophobic core ofα-syn N-terminus,whereas DPCPX and 1-aminoindan showed direct binding to the N-and C-terminal hydrophobic *** imaging and Western blot analyses revealed that chronic treatments with CPA alone or in combination with 2-aminoindan increasedα-syn

关键词： Alpha-synucleinopathy Adenosine A1 receptor N6-cyclopentyladenosine 8-cyclopentyl-1 3-dipropylxanthine 1-aminoindan 2-aminoindan Neuroprotection Neurodegeneration Protein misfolding