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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Impact of varying carbon concentration in siC s/D asymmetric dual-k spacer for high performance and reliable FinFET

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Journal of semiconductors 2018年第10期39卷 17-22页

作者： Maisagalla Gopal Atul Awadhiya NANDakishor yadav s.k.Vishvakarma Vaibhav Neema Discipline of Electrical Engineering Indian Institute of Technology Indore Department of Electronics and Instrumentation Engineering Institute of Engineering and TechnologyDevi Ahilya University Department of Electronics and Telecommunication Engineering Institute of Engineering and TechnologyDevi Ahilya University

We propose a reliable asymmetric dual-k spacer with siC source/drain（s/D）pocket as a stressor for a si *** enhances the device performance in terms of electron mobility（eMobility）,current driving capabilities,transconductance（G_m）and subthreshold slope（ss）.The improved performance is an amalgamation of longitudinal tensile stress along the channel and reduced series *** analysed the variation in drive current for different values of carbon（C）mole fraction y in si_（1-y）C_*** is found that the mole fraction also helps to improve device lifetime,performance enhancement also pointed by transconductance variation with the gate *** the simulations are performed in the 3-D sentaurus TCAD *** proposed device structure achieved ION=2.17 mA/μm for si_（0.3）C_（0.7） and found that si_（0.5）C_（0.5） is more suitable for the perspective of a process variation effect for 14 nm as the gate *** introduce reliability issues and their solutions for si（1-y）Cy FinFET for the first time.

关键词： asymmetric dual-k spacer short channel effects (sCEs) siC s/D stressors reliability process variation

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Large time asymptotics for solutions to a nonhomogeneous Burgers equation

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Applied Mathematics and Mechanics(English Edition) 2010年第9期31卷 1189-1196页

作者： s.R.CHIDELLA M.k.yadav Department of Mathematics Indian Institute of Technology Madras

In this article, the solutions to a nonhomogeneous Burgers equation subject to bounded and compactly supported initial profiles are constructed. In an interesting study, kloosterziel （Journal of Engineering Mathematics 24, 213-236 （1990）） represented a solution to an initial value problem （IVP） for the heat equation, with an initial data in a class of rapidly decaying functions, as a series of self-similar solutions to the heat equation. This approach quickly revealed the large time behaviour for the solution to the IVP. Inspired by kloosterziel＇s approach, the solution to the nonhomogeneous Burgers equation is expressed in terms of the self-similar solutions to the heat equation. The large time behaviour of the solutions to the nonhomogeneous Burgers equation is obtained.

关键词： nonhomogeneous Burgers equation Hermite polynomials self-similar solutions

synthesis and characterization of pyrimidines analogues as anti-Alzheimer's agents

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Journal of Chinese Pharmaceutical sciences 2017年第11期26卷 834-846页

作者： yadav Rakesh Maan Monika yadav Divya Department of Pharmacy Banasthali University Banasthali-304022 Rajasthan India

Pyrimidine derivatives have been reported as neuroprotective agents useful for the treatment of various neurodegenerative disorders. In the present study, several pyrimidine analogues have been evaluated as neuroprotective agents in Morris water maze model. It was observed that pyrimidine derivatives 8–17 considerably improve learning, memory, and movement deficits in animal models. Biochemical estimations of brain serum of treated animals revealed suppression of oxidative and nitrosative stress, acetylcholinesterase activity, and other parameters which leads to neurodegeneration of brain. Of all the pyrimidine derivatives, thiomorpholine derivative 8 and piperazine ethanol derivative 17 were found to be the most active neuroprotective agents and produced effects comparable to standard drug rivastigmine in terms of behavioral, biochemical, and molecular aspects.

关键词： Alzheimer's disease Neurodegeneration Pyrimidine derivatives Biochemical tests

Mathematical model of micropolar fluid in two-phase immiscible fluid flow through porous channel

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Applied Mathematics and Mechanics(English Edition) 2018年第7期39卷 993-1006页

作者： P.k.yadav s.JAIsWAL B.D.sHARMA Department of Mathematics Motilal Nehru National Institute of Technology Allahabad

This paper is concerned with the flow of two immiscible fluids through a porous horizontal channel. The fluid in the upper region is the micropolar fluid/the Eringen fluid, and the fluid in the lower region is the Newtonian viscous fluid. The flow is driven by a constant pressure gradient. The presence of micropolar fluids introduces additional rotational parameters. Also, the porous material considered in both regions has two different permeabilities. A direct method is used to obtain the analytical solu- tion of the concerned problem. In the present problem, the effects of the couple stress, the micropolarity parameter, the viscosity ratio, and the permeability on the velocity profile and the microrotational velocity are discussed. It is found that all the physical parameters play an important role in controlling the translational velocity profile and the microrotational velocity. In addition, numerical values of the different flow parameters are computed. The effects of the different flow parameters on the flow rate and the wall shear stress are also discussed graphically.

关键词： micropolar fluid immiscible fluid porous medium couple stress microp=olarity parameter

sOLUTIONs OF A sYsTEM OF FORCED BURGERs EQUATION IN TERMs OF GENERALIZED LAGUERRE POLYNOMIALs

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Acta Mathematica scientia 2014年第5期34卷 1461-1472页

作者： Manoj k.yadav Department of Mathematics Indian Institute of Science

In this article, we obtain explicit solutions of a linear PDE subject to a class of ra-dial square integrable functions with a monotonically increasing weight function｜x｜n-1eβ｜x｜2/2,β ≥ 0, x ∈ Rn. This linear PDE is obtained from a system of forced Burgers equation via the Cole-Hopf transformation. For any spatial dimension n＆gt;1, the solution is expressed in terms of a family of weighted generalized Laguerre polynomials. We also discuss the large time behaviour of the solution of the system of forced Burgers equation.

关键词： forced Burgers equation radial Hermite functions generalized Laguerre poly-nomials self-similar solutions

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating