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Retinal microvasculature is a potential biomarker for acute mountain sickness

science China(Life sciences) 2023年第6期66卷 1290-1302页

作者： Yuan Xie Diya Yang Alex s.huang Yiquan Yang Ying Han Yunxiao sun Kai Cao Huaizhou Wang shizheng Wu Qiang Zhu Guozhong Wang Tianyi Wu Ningli Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing100005China The Viterbi Family Department of Ophthalmology Shiley Eye InstituteUniversity of CaliforniaSan DiegoCA92121USA Department of Ophthalmology University of CaliforniaSan FranciscoCA94143USA Institution of Geriatric Qinghai Provincial Hospital Xining810007China Department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Department of Hyperbaric and Hypobaric Chamber Civil Aviation General HospitalBeijing100025China National Key Laboratory of High Altitude Medicine China High Altitude Medical Research InstituteXining810012China

Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMs).However,studies on cerebral blood flow in AMs have been mostly restricted to gross cerebrovascular endpoints as opposed to the *** study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNs),during early-stage AMs using a hypobaric *** study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)*** coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the *** AMspositive group had the largest increases in RPC flow density in the nasal sector(AMs-positive,?3.21±2.37;AMs-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMs symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMs outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage *** OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNs microvascular changes and AMs development during risk assessment of individuals at high altitudes.

关键词： optical coherence tomography angiography retinal microvasculature acute mountain sickness

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回肠克罗恩病影像学狭窄和内镜下狭窄的临床结果区分

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国际医学放射学杂志 2024年第1期 124-124页

作者： L.shi Y.Wang X.shen R.Mao J.Meng s.huang 李桂来

摘要目的克罗恩病（CD）中基于不同定义的肠管狭窄的临床不良后果（CAO）的差异很少有文献报道。研究旨在比较回肠CD的CAO，影像学狭窄（Rs）和内镜下狭窄（Es），并

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基于二维关节型人体模型和EM算法的人体跟踪(英文)

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自动化学报 2003年第3期29卷 332-344页

作者： Thomas s.huang Beckman Institute UIUC Urbana

提出一种跟踪单眼图像序列中的行人 ,并恢复其运动参数的新方法 .在跟踪中采用了基于sPM (scaledPrismatModel)扩展的二维纸板人模型取代三维人体模型 ,以获取更快的计算速度 .作者使用EM算法在概率框架下进行运动估计 ,同时 ,算法也考... 详细信息

提出一种跟踪单眼图像序列中的行人 ,并恢复其运动参数的新方法 .在跟踪中采用了基于sPM (scaledPrismatModel)扩展的二维纸板人模型取代三维人体模型 ,以获取更快的计算速度 .作者使用EM算法在概率框架下进行运动估计 ,同时 ,算法也考虑了混合的运动模型和运动约束 ,以减小解的搜索空间 .

关键词：人体跟踪二维关节型人体模型 EM算法运动参数图像序列运动模型

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TiO2 nanosheets synthesized by atomic layer deposition for photocatalysis

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Progress in Natural science:Materials International 2016年第5期26卷 493-497页

作者： Riyanto Edy Yuting Zhao Gaoshan s.huang Jianjun J.shi Jing Zhang Alexander A.solovev Yongfeng Mei state Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and Engineering Donghua University Department of Materials science Fudan University College of science Donghua University

Two-dimensional TiOnanosheets were synthesized by atomic layer deposition(ALD) on dissolvable sacrificial polymer layer. The photocatalytic performance of free-standing TiOnanosheets prepared with different numbers of ALD cycles(100, 300, 500, and 1000) were investigated by evaluating the degradation rates of methyl orange solutions. It is shown that the photocatalytic activity increases due to Tidefect and the locally ordered structures in amorphous TiOnanosheets. The difference in the surface areas of nanosheets may also play a crucial role in the photocatalytic activity. The results obtained in this work can have potential applications in fields like water splitting and dye-sensitized solar cells.

关键词： TiO2 Atomic layer deposition Nanosheet Photocatalysis

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Central endoscopy reads in inflammatory bowel disease clinical trials:The role of the imaging core lab

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Gastroenterology Report 2014年第3期2卷 201-206页

作者： Harris Ahmad Tyler M.Berzin Hui Jing Yu Christopher s.huang Daniel s.Mishkin Medical Affairs BioClinica Inc.NewtownPennsylvaniaUSA Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBoston MAUSA section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Gastroenterology Granite Medical GroupBoston Medical CenterBostonMAUSA

Clinical trials in inflammatory bowel disease(IBD)are evolving at a rapid pace by employing central reading for endoscopic mucosal assessment in a field that was,historically,largely based on assessments by local *** transition from local to central reading carries with it numerous technical,operational,and scientific challenges,many of which can be resolved by imaging core laboratories(ICLs),a concept that has a longer history in clinical trials in a number of diseases outside the realm of *** IBD trials,ICLs have the dual goals of providing objective,consistent assessments of endoscopic findings using central-reading paradigms whilst providing important expertise with regard to operational issues and regulatory *** review focuses on current approaches to using ICLs for central endoscopic reading in IBD trials.

关键词： inflammatory bowel disease clinical trials imaging core laboratorie

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老年复杂糖尿病患者的潜在过度治疗

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中国全科医学 2016年第15期19卷 1737-1739页

作者： elbert s.huang 本刊编辑部芝加哥大学普通内科医学科伊利诺伊州芝加哥市不详

价值对于存在多种严重合并症及功能受限的老年人来说,强化血糖控制所带来的伤害很可能超过其所带来的益处。目的通过健康状况检测老年糖尿病患者的血糖控制水平,并评估糖尿病潜在过度治疗的发生率。设计、设定及参与者对国家健康与营养... 详细信息

价值对于存在多种严重合并症及功能受限的老年人来说,强化血糖控制所带来的伤害很可能超过其所带来的益处。目的通过健康状况检测老年糖尿病患者的血糖控制水平,并评估糖尿病潜在过度治疗的发生率。设计、设定及参与者对国家健康与营养调查研究中2001—2010年进行了糖化血红蛋白(HbA_(1c))测定的1 288例老年(≥65岁)糖尿病患者的资料进行横断面分析。所有分析具备复杂的调查设计以生成国家代表性评估。表现健康状况分类:非常复杂/差,至少有两项日常活动做起来困难,或者依赖透析;复杂/一般,至少有两项日常工具的使用困难,或存在至少3种慢性疾病;相对健康,不具备以上几点。主要结果及措施严格的血糖控制(HbA_(1c)<7.0%)以及糖尿病药物的使用很可能导致低血糖(胰岛素或磺酰脲类药物)。结果在1 288例老年糖尿病患者中,50.7%〔95%CI(46.6%,54.8%)〕的患者代表310万人〔95%CI(270,350)万人〕为相对健康状况,28.1%〔95%CI(24.8%,31.5%)〕的患者代表170万人〔95%CI(140,200)万人〕为复杂/一般的健康状况,21.2%〔95%CI(18.3%,24.4%)〕的患者代表130万人〔95%CI(110,150)万人〕为非常复杂/差的健康状况。总体来说,61.5%〔95%CI(57.5%,65.3%)〕的患者代表380万人〔95%CI(340,420)万人〕其HbA_(1c)<7.0%;这个比例在3种健康状况中无差别{62.8%〔95%CI(56.9%,68.3%)〕为相对健康状况,63.0%〔95%CI(57.0%,68.6%)〕为复杂/一般健康状况,56.4%〔95%CI(49.7%,62.9%)〕为非常复杂/差的健康状况(P=0.26)}。在HbA_(1c)<7.0%的老年患者中,54.9%〔95%CI(50.4%,59.3%)〕接受了胰岛素或磺酰脲类药物治疗;这个比例在各类健康状况糖尿病患者中近似。在研究涵盖的10年间,HbA_(1c)<7.0%的老年患者比例(P=0.34)、HbA_(1c)<7.0%且健康状况为复杂/一般或非常复杂/差的患者比例(P=0.27)、HbA_(1c)<7.0%健康状况为复杂/一般或非常复杂/差但接受胰岛素或磺酰脲类药物治疗的患者比例(P=0.65)均无明显变化。结论及意义尽管对于健康状况为复杂/一般或非常复杂/差的老年糖尿病患者来说,强化治疗所带来的伤害很可能超过其带来的益处,但是大多数患者2001—2010年已经达到了严格的血糖目标。大部分患者接受了胰岛素或磺酰脲类药物治疗,这可能导致严重的低血糖。本研究发现,有相当大比例的老年糖尿病患者接受了潜在过度治疗。

关键词：糖尿病老年人过度治疗

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snapshotPrune: A Novel Bitcoin-Based Protocol Toward Efficient Pruning and Fast Node Bootstrapping

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Tsinghua science and Technology 2024年第4期29卷 1037-1052页

作者： Pengfei huang Xiaojun Ren Teng huang Arthur sandor Voundi Koe Duncan s Wong Hai Jiang Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006Chinaand also with Pazhou LabGuangzhou 510330China

Node synchronization is essential for the stability of the Bitcoin network. Critics have raised doubts about the ability of a new node to quickly and efficiently synchronize with the Bitcoin network and alleviate the storage pressure from existing full nodes to stockpile new data. Basic pruning and other techniques have been explored to address these concerns but have been insufficient to reduce node synchronization delay and effectively suppress the growth of synchronized data. In this study, we propose snapshotPrune, a novel pruning and synchronization protocol that achieves fast node bootstrapping in the Bitcoin blockchain. Real Bitcoin historical data are leveraged to measure the synchronization time and monitor the network traffic during node bootstrapping. The protocol requires data downloads that are 99.70% less than Bitcoin Core, 81% less than CoinPrune, and 60% less than snapshotsave, thereby saving 97.23% of download time. Findings show that the proposed design enhances the storage efficiency and reduces the node synchronization delay compared with existing techniques. We hypothesize that the efficiency of this protocol increases with the block height.

关键词： synchronization blockchain Unspent Transaction Output(UTXO)pruning snapshot fast bootstrapping

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The Granite Pegmatites of suchou

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地质学报 1949年第Z1期 157-170+184页

作者： Y. s.huang(National Nanking University and Geological survey of China) Eormerly National Central University

I. INTRODUCTIONThe pegmatites discussed in this paper occur entirely in the granite region of suchou (Wuhsien), Kiangsu and most of them are found within the marginal zone of the said igneous body. Although much work has been done on the suchou granite by former geologists [19; 13; 21; 12], there is no literature dealing particularly with the pegmatites which are in intimate

关键词： The Granite Pegmatites of suchou

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A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： Kevin huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(sOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and sO_(2) and in the anode by species such as s(or H_(2)s),siO_(2),and P_(2)(or PH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

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Global convergence in terrestrial gross primary production response to atmospheric vapor pressure deficit

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science China Life sciences 2024年第9期67卷 2016-2025页

作者： Chao huang Jingfeng huang Jingfeng Xiao Xing Li Hong s.He Yu Liang Fusheng Chen Hanqin Tian Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University CAs Key Laboratory of Forest Ecology and Management Institute of Applied Ecology Chinese Academy of Sciences Institute of Applied Remote sensing & Information Technology College of Environmental and Resource Sciences Zhejiang University Key Laboratory of Agricultural Remote sensing and Information systems Zhejiang Province Zhejiang University Earth systems Research Center Institute for the Study of Earth Oceans and Space University of New Hampshire Research Institute of Agriculture and Life sciences Seoul National University school of Natural Resources University of Missouri schiller Institute for Integrated science and society Department of Earth and Environmental Sciences Boston College

Atmospheric vapor pressure deficit（VPD） increases with climate warming and may limit plant growth. However, gross primary production（GPP） responses to VPD remain a mystery, offering a significant source of uncertainty in the estimation of global terrestrial ecosystems carbon dynamics. In this study, in-situ measurements, satellite-derived data, and Earth system Models（EsMs） simulations were analysed to show that the GPP of most ecosystems has a similar threshold in response to VPD: first increasing and then declining. When VPD exceeds these thresholds, atmospheric drought stress reduces soil moisture and stomatal conductance, thereby decreasing the productivity of terrestrial ecosystems. Current EsMs underscore CO2fertilization effects but predict significant GPP decline in low-latitude ecosystems when VPD exceeds the thresholds. These results emphasize the impacts of climate warming on VPD and propose limitations to future ecosystems productivity caused by increased atmospheric water demand. Incorporating VPD, soil moisture, and canopy conductance interactions into EsMs enhances the prediction of terrestrial ecosystem responses to climate change.

关键词： atmospheric water demands soil moisture stomatal conductance photosynthesis climate warming.

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