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Nanocellulose isolation characterization and applications:a journey from non-remedial to biomedical claims

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Bio-Design and Manufacturing 2019年第3期2卷 187-212页

作者： sania Naz Joham s.ali Muhammad Zia Department of Biotechnology Quaid-i-Azam University IslamabadIslamabadPakistan

Cellulose is a renewable,biodegradable,ecofriendly and sustainable *** market of nanocellulose is comprehensively very high due to its *** of nanocellulose from bacteria and plant results in different morphology and size of ***,mechanical strength,biofabrication,crystallinity,high surface area per unit mass,hydrophilicity,porosity,transparency and non-toxicity of bacterial cellulose make it more *** extravagant nanoscaled three-dimensional network of cellulosic structures possess extraordinary properties for biomedical application,evidencing its usage in skin therapy,cardiovascular implants,cartilage meniscus implants,tissue engineering,bone tissue and neural implants,wound care products,drug delivery agents,tablet modification,tissue engineered urinary conduits,and synthesis of artificial *** due to potential benefits associated with nanocellulose effective and efficient techniques are required for the isolation of nanocellulose that should be economical,ecofriendly and non-toxic.

关键词： Nanocellulose Plant and bacterial source Extraction Applications

structural and Mechanistic studies of γ-Fe2O3 Nanoparticle as Capecitabine Drug Nanocarrier

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Chinese Journal of structural Chemistry 2018年第3期37卷 375-382页

作者： ETEBARI Nasfin MORsali ali BEYRAMABADI s.ali Department of Chemistry Mashhad BranchIslamic Azad UniversityMashhadIran&Research Center for Animal Development Applied Biology Mashhad BranchIslamic Azad UniversitG Mashhad 917568Iran

Using density functional theory,noncovalent interactions and four mechanisms of covalent functionalization of capecitabine anticancer drug onto γ-Fe2O3 nanoparticles have been *** molecular descriptors of noncovalent configurations were *** was specified that binding of capecitabine onto γ-Fe2O3 nanoparticles is thermodynamically *** and the gap of energy between LUMO and HOMO of capecitabine are higher than the noncovalent configurations,showing the reactivity of capecitabine increases in the presence of γ-Fe2O3 *** can bond to γ-Fe2O3 nanoparticles through OH（k1 mechanism）,NH（k2 mechanism）,CO（k3 mechanism） and F（k4 mechanism） *** activation energies,activation enthalpies and activation Gibbs free energies of these reactions were *** was specified that the k1 and k2 mechanisms are under thermodynamic control and k3 and k4 under kinetic *** results could be generalized to other similar drugs.

关键词： γ-Fe2O3 nanoparticles capecitabine density functional theory noncovalent and covalent functionalization mechanism

Microtechnology-based methods for organoid models

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Microsystems & Nanoengineering 2020年第1期6卷 381-393页

作者： Vanessa Velasco s.ali shariati Rahim Esfandyarpour Biochemistry Department Stanford UniversityPalo AltoCAUSA Department of Biomolecular Engineering Institute for the Biology of Stem CellsUniversity of CaliforniaSanta CruzCAUSA Department of Electrical Engineering University of CaliforniaIrvineCAUSA Department of Biomedical Engineering University of California IrvineIrvineCAUSA Henry samueli school of Engineering University of CaliforniaIrvineCAUSA

Innovations in biomaterials and stem cell technology have allowed for the emergence of novel three-dimensional(3D)tissue-like structures known as organoids and *** a result,compared to conventional 2D cell culture and animal models,these complex 3D structures have improved the accuracy and facilitated in vitro investigations of human diseases,human development,and personalized medical *** to the rapid progress of this field,numerous spheroid and organoid production methodologies have been ***,many of the current spheroid and organoid production techniques are limited by complexity,throughput,and *** and microscale platforms(e.g.,microfluidics and microprinting)have shown promise to address some of the current limitations in both organoid and spheroid *** and microfluidic devices have been shown to improve nutrient delivery and exchange and have allowed for the arrayed production of size-controlled culture areas that yield more uniform organoids and spheroids for a higher throughput at a lower *** this review,we discuss the most recent production methods,challenges currently faced in organoid and spheroid production,and microfabricated and microfluidic applications for improving spheroid and organoid ***,we focus on how microfabrication methods and devices such as lithography,microcontact printing,and microfluidic delivery systems can advance organoid and spheroid applications in medicine.

关键词： printing culture biomaterials

Newtonian heating in stagnation point flow of Burgers fluid

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Applied Mathematics and Mechanics(English Edition) 2015年第1期36卷 61-68页

作者： T.HAYAT s.ali M.AWAIs M.s.ALHUTHali Department of Mathematics Quaid-i-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Faculty of Science King Abdulaziz University Faculty of Engineering sciences Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Department of Mathematics COMSATS Institute of Information Technology

The Newtonian heating effects in the stagnation point flow of a Burgers fluid are addressed in this paper. The boundary layer flow problems are stated in the spatial domain from zero to infinity. The solution expressions for the velocity and the temperature are obtained and examined for the influential variables. The tabulated values show comparison with the previous results. It is observed that the obtained results are in good agreement with the existing results in limiting sense.

关键词： Burgers fluid Newtonian heating series solutions

Analytical determination of non-local parameter value to investigate the axial buckling of nanoshells affected by the passing nanofluids and their velocities considering various modified cylindrical shell theories

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Chinese Physics B 2023年第4期32卷 511-528页

作者： soheil Oveissi Aazam Ghassemi Mehdi salehi s.ali Eftekhari saeed Ziaei-Rad Department of Mechanical Engineering Najafabad BranchIslamic Azad UniversityNajafabadIran Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran Department of Mechanical Engineering Isfahan University of TechnologyIsfahan 84156-83111Iran

We analytically determine the nonlocal parameter value to achieve a more accurate axial-buckling response of carbon nanoshells conveying nanofluids. To this end, the four plates/shells' classical theories of Love, Fl ¨ugge, Donnell, and sanders are generalized using Eringen's nonlocal elasticity theory. By combining these theories in cylindrical coordinates,a modified motion equation is presented to investigate the buckling behavior of the nanofluid-nanostructure-interaction problem. Herein, in addition to the small-scale effect of the structure and the passing fluid on the critical buckling strain,we discuss the effects of nanoflow velocity, fluid density(nano-liquid/nano-gas), half-wave numbers, aspect ratio, and nanoshell flexural rigidity. The analytical approach is used to discretize and solve the obtained relations to study the mentioned cases.

关键词： buckling nonlocal cylindrical shell model anofluid-nanostructure interaction carbon nanotubes

The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review

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Acta Pharmaceutica sinica B 2021年第7期11卷 1740-1766页

作者： Niranjan Das siddhartha Kumar Mishra Anusha Bishayee Eunüs s.ali Anupam Bishayee Department of Chemistry Iswar Chandra Vidyasagar CollegeBelonia-799155TripuraIndia Cancer Biology Laboratory Department of ZoologySchool of Biological SciencesDr.Harisingh Gour Central UniversitySagar-470003Madhya PradeshIndia Pine View school OspreyFL 34229USA Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Lake Erie College of Osteopathic Medicine BradentonFL 34211USA

The phytoecdysteroids(PEs)comprise a large group of biologically-active plant steroids,which have structures similar to those of insect-molting *** are distributed in plants as secondary metabolites that offer protection against phytophagus(plant-eating)*** insects consume the plants containing these chemicals,they promptly molt and undergo metabolic destruction;the insects eventually ***,ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to *** carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with aβ-side chain at *** essential characteristics of ecdysteroids are a cis-(5β-H)junction of rings A and B,a 7-en-6-one chromophore,and a trans(14α-OH)junction of rings C and *** only synthesize PEs from mevalonic acid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor;the most common PE is *** far,over 400 PEs have been identified and reported,and a compilation of 166 PEs originating from 1998 has been previously *** the present review,we have summarized 212 new PEs reported between 1999 and *** have also critically analyzed the biological,pharmacological,and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.

关键词： Phytoecdysteroids secondary metabolites Antioxidant Anti-inflammatory Antimicrobial Antidiabetic Anticancer activity

A critical review of microplastics in aquatic ecosystems: Degradation mechanisms and removing strategies

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Environmental science and Ecotechnology 2024年第5期21卷 62-76页

作者： sameh s.ali Tamer Elsamahy Rania Al-Tohamy Jianzhong sun Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang212013China Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt

Plastic waste discarded into aquatic environments gradually degrades into smaller fragments,known as microplastics(MPs),which range in size from 0.05 to 5 *** ubiquity of MPs poses a significant threat to aquatic ecosystems and,by extension,human health,as these particles are ingested by various marine organisms including zooplankton,crustaceans,and fish,eventually entering the human food *** contamination threatens the entire ecological balance,encompassing food safety and the health of aquatic ***,developing effective MP removal technologies has emerged as a critical area of ***,we summarize the mechanisms and recently reported strategies for removing MPs from aquatic *** combining physical and chemical pretreatments with microbial degradation have shown promise in decomposing *** such as bacteria,fungi,algae,and specific enzymes are being leveraged in MP remediation *** advancements have focused on innovative methods such as membrane bioreactors,synthetic biology,organosilane-based techniques,biofilm-mediated remediation,and nanomaterial-enabled strategies,with nano-enabled technologies demonstrating substantial potential to enhance MP removal *** review aims to stimulate further innovation in effective MP removal methods,promoting environmental and social well-being.

关键词： Persistent organic pollutants Bioremediation Nanomaterial-enabled strategies Aquatic environment Ecotoxicity of microplastics

Influence of graphene nanoplatelet incorporation and dispersion state on thermal, mechanical and electrical properties of biodegradable matrices

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Journal of Materials science & Technology 2018年第6期34卷 1026-1034页

作者： sima Kashi Rahul K.Gupta Nhol Kao s.ali Hadigheh sati N.Bhattacharya Institute for Frontier Materials Deakin University Rheology and Materials Processing Group School of Engineering RMIT University school of Civil Engineering Faculty of Engineering and IT The University of Sydney

Graphene nanoplatelets （GNPs） were used as multifunctional nanofiller to enhance thermal and mechanical properties as well as electrical conductivity of two different biodegradable thermoplastics： poly lactide （PLA） and poly （butylene adipate-co-terephthalate）（PBAT）. Morphological investigations showed different levels of GNP dispersion in the two matrices, and consequently physical properties of the two systems exhibited dissimilar behaviours with GNP incorporation. Crystallinity of PLA, determined from differential scanning calorimetry, was observed to increase markedly with addition of GNPs in contrast to the decrease in crystallinity of PBAT. Isothermal and non-isothermal thermogravimetric analyses also revealed a more significant delay in thermal decomposition of PLA upon addition of GNPs compared to that of PBAT. Furthermore, results showed that increasing GNP content of PLA and PBAT nanocomposites influenced their Young＇s modulus and electrical conductivity in different ways. Modulus of PBAT increased continuously with increasing GNP loading while that of PLA reached a maximum at 9wt% GNPs and then decreased. Moreover, despite the higher conductivity of pure PBAT compared to pure PLA, conductivity of PLA/GNP nanocomposites overtook that of PBATIGNP nanocomposites above a certain GNP concentration. This demonstrated the determining effect of nanoplatelets dispersion state on the matrices properties.

关键词： Graphene Nanocomposite Poly lactide Poly butylene adipate-co-terephthalate Thermal stability Electrical conductivity Properties

EXPERIMENTAL AND FIELD sTUDY ON MINING-PIT MIGRATION

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International Journal of sediment Research 2002年第4期17卷 323-331页

作者： s.ali Akbar salehi NEYsHABOURI,ali FARHADZADEH,Ata AMINI Civil Engineering Dept. University of Tarbiat Modarres University of Tarbiat Modarres University of Tarbiat Modarres Assistant Professor P.O.Box14115-143 Tehran Iran Ph.D.student Msc.student

Rivers are one of the most essential sources of sand and gravel supply for civil works. However, undesirable effects of irregular in-stream mining have been reported on natural sources, environment and infrastructures close to rivers. Therefore, it is necessary to find the effects of mining on rivers in more details. This research concentrates on mining-pit migration phenomenon and its effects on the channel bed. This paper reports an experimental study on the migration of rectangular mining pits and variation of longitudinal profile in the channel bed composed of rather uniform sediments. Different values of widths and lengths were used for pit while pit depths and flow variables were kept constant. The results show that the migration speed changes with the length/width ratio of the pit. The migration speed in convection period is higher than that in diffusion period. In addition, by increasing the length or width, filling rate of pit increases, where the effect of width is more important than the effect of the length. Also is reported in this paper a field study on the changes of three pits excavated at different locations of a river. some similarities between the pit migration in the straight reach of the river and that of the experimental work is realized and presented.

关键词： Pit migration sand and gravel mining Experiment Field study