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Journal of Magnesium and Alloys 2018年第2期6卷 145-163页

作者： G.Vedabouriswaran s.aravindan Department of Mechanical Engineering Indian Institute of Technology DelhiIndia

surface metal matrix composite is produced on the as cast Magnesium Rare Earth alloy-RZ 5 by single pass friction stir processing using various micro/nano sized reinforcement particles namely Boron Carbide(B_(4)C),Multi Walled Carbon Nano Tubes(MWCNTs),and a mixture of ZrO_(2)+Al_(2)O_(3)*** grained metal matrix composites having the grain size ranging 0.8μm to 1.87μm are *** boundary pinning by the reinforcement particles has resulted in the transformation of coarse grained(∼81μm)base material into fine grained(structure and the presence of reinforcements at the stir zone have resulted in increased and improved mechanical properties of the developed *** ranging between 125 HV and 403 HV is ***-axial Tensile Testing of the developed composites exhibited improvement in tensile *** matrix composites developed using various reinforcements exhibited an increase in strength ranges between 250 MPa and 320 MPa.

关键词： Friction stir processing Magnesium Rare Earth alloy-RZ 5 B4C MWCNT ZrO2+Al2O3 Microhardness Grain boundary pinning

Multi-objective Optimization of Continuous Drive Friction Welding Process Parameters Using Response surface Methodology with Intelligent Optimization Algorithm

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Journal of Iron and steel Research International 2015年第10期22卷 954-960页

作者： P.M.AJITH T.M.AFsAL HUsAIN P.sATHIYA s.aravindan Department of Production Engineering National Institute of Technology Department of Mechanical Engineering Indian Institute of Technology Delhi

The optimum friction welding （FW） parameters of duplex stainless steel （Dss） UNs $32205 joint was determined. The experiment was carried out as the central composite array of 30 experiments. The selected input parameters were friction pressure （F）, upset pressure （U）, speed （s） and burn-off length （B）, and responses were hardness and ultimate tensile strength. To achieve the quality of the welded joint, the ultimate tensile strength and hardness were maximized, and response surface methodology （RsM） was applied to create separate regression equations of tensile strength and hardness. Intelligent optimization technique such as genetic algorithm was used to predict the Pareto optimal solutions. Depending upon the application, preferred suitable welding parameters were selected. It was inferred that the changing hardness and tensile strength of the friction welded joint influenced the upset pressure, friction Pressure and speed of rotation.

关键词： friction welding response surface methodology genetic algorithm Pareto front multi-objective optimization duplex stainless steel

Evaluation of physical and mechanical properties of AZ91D/siC composites by two step stir casting process

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Journal of Magnesium and Alloys 2015年第1期3卷 52-62页

作者： s.aravindan P.V.Rao K.Ponappa Department of Mechanical Engineering Indian Institute of Technology-DelhiDelhi 110016India Department of Mechanical Engineering Kongu Engineering CollegePerundurai 638052India

Magnesium alloy(AZ91D)composites reinforced with silicon carbide particle with different volume percentage were fabricated by two step stir casting *** effect of changes in particle size and volume fraction of siC particles on physical and mechanical properties of composites were evaluated under as cast and heat treated(T6)*** experimental results were compared with the standard theoretical *** results reveal that the mechanical properties of composites increased with increasing siC particles and decrease with increasing particle *** of particles and fractured surface were studied through sEM and the presence of elements is revealed by EDs study.

关键词： Magnesium alloy Metal-matrix composites(MMCs) Mechanical properties Casting Fractography

Multiobjective optimization of friction welding of UNs s32205 duplex stainless steel

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Defence Technology（防务技术） 2015年第2期11卷 157-165页

作者： P.M.AJITH Birendra Kumar BARIK P.sATHIYA s.aravindan Department of Production Engineering National Institute of Technology Department of Mechanical Engineering Indian Institute of Technology Delhi

The present study is to optimize the process parameters for friction welding of duplex stainless steel(Dss UNs s32205).Experiments were conducted according to central composite *** variables,as inputs of the neural network,included friction pressure,upsetting pressure,speed and burn-off *** strength and microhardness were selected as the outputs of the neural *** weld metals had higher hardness and tensile strength than the base material due to grain refinement which caused failures away from the joint interface during tensile *** to shorter heating time,no secondary phase intermetallic precipitation was observed in the weld joint.A multi-layer perceptron neural network was established for modeling *** various training algorithms,belonging to three classes,namely gradient descent,genetic algorithm and LevenbergeM arquardt,were used to train artificial neural *** optimization was carried out by using particle swarm optimization *** test was carried out by setting the optimized *** conformation test,maximum tensile strength and maximum hardness obtained are 822 MPa and 322 Hv,*** metallurgical investigations revealed that base metal,partially deformed zone and weld zone maintain austenite/ferrite proportion of 50:50.

关键词：多目标优化不锈钢焊接摩擦压力双相人工神经网络 UNs 拉伸强度优化工艺参数

Experimental Investigation on Friction Welding of UNs s32205 Duplex stainless steel

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Acta Metallurgica sinica(English Letters) 2014年第6期27卷 995-1007页

作者： P. M. Ajith P. sathiya s. aravindan Department of Production Engineering National Institute of Technology Department of Mechanical Engineering Indian Institute of Technology Delhi

UNs s 32205 duplex stainless steel specimens were joined by continuous drive friction welding process. The experiments were conducted as per the Taguchi（L16 orthogonal array） method. The friction welding process parameters such as heating pressure, heating time, upsetting pressure, upsetting time, and speed of rotation were fixed with low,medium, and high levels of range based on the machine capacity, and the required knowledge was acquired from the preliminary experiments. The joint characterization studies included micro structural examination and evaluation of mechanical properties of the joints. Microhardness variation, impact toughness, and tensile strength of the joints were evaluated. Neither a crack nor an incomplete bonding zone was observed. The tensile strength of the joints was higher than the strength of the base material, and the friction and upsetting pressures were found to influence the joint strength. The tensile strength of all the welds was observed to be increasing with an increase in the rotational speed. The toughness of the friction welds was evaluated at room temperature and also at subzero（cryo） temperature conditions. The toughness for friction welds was found to be superior to the fusion welds of duplex stainless steel at room temperature and cryo conditions. Weldments exhibited better corrosion resistance than the parent material.

关键词： Duplex stainless steel Hardness Tensile strength Toughness Microstructure Corrosion

MicroRNAs in neuroblastoma tumorigenesis,therapy resistance,and disease evolution

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Cancer Drug Resistance 2019年第4期2卷 1086-1105页

作者： Natarajan aravindan Karthikeyan subramanian Dinesh Babu somasundaram Terence s.Herman sheeja aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA stephenson Cancer Center Oklahoma CityOK 73104USA

Neuroblastoma(NB)deriving from neural crest cells is the most common extra-cranial solid cancer at *** originates within the peripheral sympathetic ganglia in adrenal medulla and along the midline of the ***,NB exhibits significant heterogeneity stretching from spontaneous regression to rapid progression to therapy ***(miRNAs,miRs)are small(19-22 nt in length)non-coding RNAs that regulate human gene expression at the post-transcriptional level and are known to regulate cellular signaling,growth,differentiation,death,stemness,and ***,the function of miRs in tumorigenesis,progression and resistance is of utmost importance for the understanding of dysfunctional cellular pathways that lead to disease evolution,therapy resistance,and poor clinical *** the last two decades,much attention has been devoted to understanding the functional roles of miRs in NB *** review focuses on highlighting the important implications of miRs within the context of NB disease progression,particularly miRs’influences on NB disease evolution and therapy *** this review,we discuss the functions of both the“oncomiRs”and“tumor suppressor miRs”in NB progression/therapy *** are the critical components to be considered during the development of novel miR-based therapeutic strategies to counter therapy resistance.

关键词： miRNAs progressive neuroblastoma therapy resistance oncomiRs tumor suppressor miRs tumor progression

ALK expression,prognostic significance,and its association with MYCN expression in MYCN non-amplified neuroblastoma

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World Journal of Pediatrics 2022年第4期18卷 285-293页

作者： Dinesh Babu somasundaram sheeja aravindan Nandita Gupta Zhongxin Yu Ashley Baker Natarajan aravindan Department of Radiation Oncology BMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA stephenson Cancer Center Oklahoma CityOKUSA Plainsboro NJUSA Department of Pathology BMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA Department of Pediatrics University of Oklahoma Health Sciences CenterOklahoma CityOKUSA

Neuroblastoma(NB),the most common cancer at infancy,is derived from a selective sympathoadrenal lineage of the neural crest cells[1-3].The majority of NB is found in children younger than 5 years(median age:2 years)and is rare in children older than 10 *** NB accounts for only 5-6%of the childhood cancers,it heavily contributes(about 15%)to pediatric cancer deaths[4,5].

关键词： neuroblastoma MYCN cancer

Cancer stem cells in neuroblastoma therapy resistance

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Cancer Drug Resistance 2019年第4期2卷 948-967页

作者： Natarajan aravindan Drishti Jain Dinesh Babu somasundaram Terence s.Herman sheeja aravindan Department of Radiation Oncology The University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA Department of Pathology The University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA Department of Anesthesiology The University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA stephenson Cancer Center Oklahoma CityOK 73104USA

Neuroblastoma(NB)is the most common cancer of infancy and accounts for nearly one tenth of pediatric cancer *** mortality rate has been attributed to the>50%frequency of relapse despite intensive,multimodal clinical therapy in patients with progressive *** the disease’s heterogeneity and developed resistance,attaining a cure after relapse of progressive NB is highly challenging.A rapid decrease in the timeline between successive recurrences is likely due to the ongoing acquisition of genetic rearrangements in undifferentiated NB-cancer stem cells(CsCs).In this review,we present the current understanding of NB-CsCs,their intrinsic role in tumorigenesis,their function in disease progression,and their influence on acquired therapy resistance and tumor *** particular,this review focus on the intrinsic involvement of stem cells and signaling in the genesis of NB,the function of pre-existing CsCs in NB progression and therapy response,the formation and influence of induced CsCs(iCsCs)in drug resistance and tumor evolution,and the development of a CsC-targeted therapeutic approach.

关键词： Neuroblastoma therapy resistance cancer stem cells clonal selection drug resistance induced cancer stem cell

Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu somasundaram Andrew Maher sheeja aravindan Zhongxin Yu Brian MBesch Natarajan aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

Characterization of microstructure, toughness, and chemical composition of friction-welded joints of UNs s32205 duplex stainless steel

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Friction 2014年第1期2卷 82-91页

作者： Puthuparambil Madhavan AJITH Paulraj sATHIYA sivanandam aravindan Department of Production Engineering National Institute of Technology Tiruchirappalli-620015TamilnaduIndia Department of Mechanical Engineering Indian Institute of Technology Delhi New Delhi-110016India

Friction welding is a solid-state joining process which is applied extensively because of its advantages such as low heat input,efficient application,ease in manufacturing,and environmental *** present study investigates the mechanical and metallurgical properties of UNs s32205 duplex stainless steel friction-welded *** process parameters,namely friction pressure,upsetting pressure,and rotational speed are individually varied from low level to high level(within the range of the machine setup)and their effects on the joint properties are *** partial-deformation zone had higher hardness than the weld and base *** toughness of the joints was evaluated at room temperature and at subzero temperature *** impact toughness of the friction-welded joints was found to be superior to fusion-joined duplex stainless steel in room and cryogenic conditions.

关键词： friction welding duplex stainless steel hardness toughness microstructure