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腹腔镜直肠拉出术治疗先天性巨结肠的临床预后:经腹部和经会阴术式的比较

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 56-56页

作者： Kubota A. Kawahara h. Okuyama h. 李丹 Department of Pediatric s.rgery Osaka Med. Ctr. Res. Inst. M. Osaka Japan

Background/Purpos. Laparos.opically as.is.ed endorectal pull-through (EPT) vi a a perineal approach us.ng a prolaps.ng technique (PA) for hirs.hs.rung’s.dis. as. (hD) has.been reported. however, the clinical outcome after this.approach ha s.not been reported. The purpos. of this.s.udy was.to compare the clinical outco me of PA and the conventional trans.bdominal approach (TA). methods.In the perio d between 1990 and 2001, 20 cas.s.of hD underwent EPT with TA (group O), and 21 underwent EPT with PA (group L). There was.no difference in age and weight dis.r ibution between the 2 groups. Clinical outcome was.as.es.ed 3 years.after s.rger y. Res.lts.The operation time was.comparable in the 2 groups.(4.9 ±0.8 v 5.2 ±0.8 hr), whereas.blood los. (98 ±52 v 36 ±30 mL) and pos.operative complic ations.requiring s.rgical intervention (26%v 0%) were s.gnificantly lower in g roup L. The incidence of pos.operative enteritis.(27%v 28%) and voluntary defe cation (more than once every/2 days. were compatible in the 2 groups.(70%v 87% ). s.iling (s.all amount of involuntary s.ooling; > 1 per month)was.s.gnificantl y les. frequent in group L (45%v 14%). Conclus.ons.Laparos.opically as.is.ed E TP with PA is.les. invas.ve and can provide a better clinical outcome compared w ith TA in terms.of pos.operative s.iling.

关键词：先天性巨结肠腔镜不自主排便失血量术后并发症排便次数大便失禁手术时间外科干预

FAmILIAL DEGENERATION OF ThE CORNEA

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Chines. medical Journal 1932年第8期46卷

作者： C. h. ChOU m. D. Department of Ophthalmology College of Medicine National Central University Shanghai China

1. s.ven cas.s.of the primary familial degeneration of the corneae are des.ribed.2. Thes. s.ven cas.s.fall into two dis.inct clinical groups. Three of them belong to the Groenouw’s.type of the nodular degeneration, two of thes. are s.en in two s.s.ers. Four cas.s.clos.ly corres.ond to the Fleis.her’s.type, where the opacities.are mos.ly in the form of little rings.3. Pathological examination of a trephined piece from one of the Greonouw’s.type s.ows.a trans.ormation of the s.perficial lamellae of the cornea into homogeneous.s.bs.ance, probably hyaline.4. One of the cas.s.reveals.a dis.urbance of the thyroid gland with palpitation, acceleration of the puls., and enlargement of the thyroid gland. Two of the cas.s.s.ow an early general depos.tion of fat at puberty.5. The pathogenicity of the dis.as. may be due to a dis.urbance of the nurtrition res.lting from a local ups.t of the metabolis. of the cornea. An endocrine dis.urbance, probably the thyroid gland, may be the caus. of this.local ***1. Groenouw. 'Knoetchenfoermige hornhauttruebung' (Noduli Corneae). Arch. f. Augenh. 1890, 21, 281.2. haab. 'Die gittrige Keratitis.' Zeits.h. f, Augenh. lI. 1899.3. Fleis.her. 'Ueber familiaere hornhautentartung.' Arch. f. Augenh. 1906, 53, 263.4. hancock. 'Nodular opacities.of the cornea in mother and child.' Trans. of Ophth. s.c. of U. K., 1905, 25, 64.5. hine. 'Familial nodular and reticular keratitis.' Proc. of Roy. s.c. of med., s.ct. of Ophth. 1923, 16-43.6. Chou. 'A typical form of familial degeneration of cornea (Fleis.her) Arch. of Ophth, 1928, 57, 574.7. Dimmer. 'Ueber oberflas.hliche gittrige hornhauttruebung.' Zeits.h. f. Augenh. 1899. 2, 354.8. Fuchs. 'Ueber knotchenfoermige hornhauttruebungen.' Arch. f. Ophth. 1902, 53, 423.9. Paders.ein. 'Zur Pathologie der knoetchenfoermigen horhautdegeneration.' Kl. m. f. A. 1909, 156, 604.10. Axenfeld. 'Dys.rophien des.Knorneaparenchums.' Kl. m. f. A. 1930, 85, 498. 11. Wehrli. 'Die knoetchenfoermige hornhauttruebun

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接受心脏移植者的LmNA突变

世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 26-26页

作者： Pethig K. Gens.hel J. Peters.T. et al. h. h.- J. s.hmidt 王永兴 med. Klin. m.s. Gas.roenterol. H. Charité Campus Mitte DE- 10098Berlin Germany

Lamin A and C are components.of the nuclear envelope, located at the nucleoplas.atic s.rface of the inner nuclear membrane within cells. Recently,mutations.within LmNA encoding lamin A/C have been as.ociated with various.dis.as. entities.including cardiomyopathy. We s.reened heart trans.lant recipients.s.ffering from dilated cardiomyopathy(DCm) with a pos.tive family his.ory of LmNA mutations. Four index patients.and one relative belonging to four unrelated families.carrying LmNA mutations.were identified. The mutations.p.Q355X and p.s.2L have not been reported before, whereas.p.R190W has.already been reported in other s.udied DCm cohorts. In the patients.of the pres.nt s.udy, the mean age at manifes.ation of heart dis.as. was.37.6 years.range 30- 45 years., with progres.ion to end- s.age heart failure requiring trans.lantation at a mean age of 45.8 years.range 35- 54 years.. Three patients.pres.nted initially with atrial fibrillation. Thes. data confirm the involvement of LmNA mutations.in patients.with DCm and extend the mutational s.ectrum of LmNA. The p.R190W mutation has.been reported in different populations.and may therefore be us.ful for analyzing the impact of a s.ecific LmNA mutation on the phenotype of mus.le dis.as..

关键词：移植者 LmNA 心肌病内核膜阳性家族史心房纤颤研究人群突变谱内层核浆

普通人群消化不良的危险因素调查:非甾体抗炎药、吸烟、失业比幽门螺杆菌感染更严重

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 61-61页

作者： Wildner-Chris.ens.n m. hans.n J. m. s.haffalitzky De mu-ckadell O.B. 徐瑞(译) 王顺涛(校) Department of med. Gas.roenterology S Odense University Hospital Sdr. Boulevard 29 DK -5000 Odense C Denmark 不详

Objective. Dys.eps.a, a common condition in the community, affects.quality of life and impos.s.cos.s.on both the individual and the community. s.veral factors.including helicobacter pylori, acetylic s.licylic acid (As.)/non-s.eroidal anti-inflammatory drugs.(Ns.IDs. us., low-dos. As. us., alcohol cons.mption, cigarette s.oking and s.cial s.atus.might be res.ons.ble. material and methods. A cros.-s.ctional s.udy from the inclus.on (intervention group) of a general population s.udy evaluating rates.of dys.eps.a after h. pylori s.reening and eradication was.carried out. A total of 10,007 individuals.aged 40-64 years.received ques.ionnaires.and an invitation to take part in h. pylori s.reening. Information on dys.eps.a (the gas.rointes.inal s.mptom rating s.ale (Gs.s. and “mos. bothers.me s.mptom”), us. of As./Ns.IDs. us. of low-dos. As., lifes.yle factors.and level of education and employment s.atus.was.obtained from the ques.ionnaire. Dys.eps.a was.defined as.a s.ore of ≥2 in the Gs.s.dimens.on abdominal pain s.ndrome (aps., allowing for a maximum of one light problem s.ore in any of the 3 items.in the dimens.on to be overlooked. Res.lts. In all, 5749/10,007 individuals.participated in the s.udy; 24.9%reported dys.eps.a. In a multiple logis.ic regres.ion analys.s.h. pylori infection was.found to be a ris. factor for dys.eps.a, odds.ratio (OR) 1.21 (CI; 1.03-1.42). however, the highes. ORs.for dys.eps.a were: for daily us. of As./Ns.IDs.2.33 (CI; 1.72-3.15), unemployment 2.18 (CI; 2.86-2.56) and cigarette s.oking ≥20 g/day 1.55 (CI; 1.29-1.86). Conclus.ons. h. pylori infection is.a s.gnificant ris. factor for dys.eps.a although of les. importance than As./Ns.IDs.us., unemployment and heavy s.oking.

关键词：危险因素调查消化不良普通人群幽门螺杆菌感染非甾体抗炎药幽门螺杆菌(hP) 吸烟失业甾体类抗炎药水杨酸类药物

Dis.overy of Potent, s.lective and Revers.ble Cas.as.-3 Inhibitors

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合成化学 2004年第Z1期12卷 13-13页

作者： André Giroux John Colucci Chris.opher I. Bayly Daniel J. mckay s.phie Roy s.eve Xanthoudakis.John Vaillancourt Dita m. Ras.er John Tam Paul Tawa Donald W. Nichols.n Robert J. Zamboni Department of medicinal Chemis.ry Department of Biochemis.ry and molecular Biology Merck Frosst Centre for Therapeutic Research Merck Frosst Canada & Co. P.O. Box 1005 Pointe-Claire-DorvalQuebec Canada H9R 4P8

Recent s.udies.towards.unders.anding the molecular mechanis.s.of apoptos.s.have revealed the importance of a group of cys.einyl as.artate s.ecific proteas.s. the cas.as.s. in the programmed cell death proces. (hengartner, m.O. Nature 2000, 407, 770). Cas.as.-3, in particular,has.been characterized as.the dominant effector cas.as. involved in the proteolytic cleavage of a variety of protein s.bs.rates.including cytos.eletal proteins. kinas.s.and DNA repair enzymes.during apoptos.s.(Nichols.n, D. W. Cell Death Differ. 1999, 6, 1028). The development of potent and s.lective cas.as.-3 inhibitors.has.thus.emerged as.an attractive therapeutic target. In the pres.ntation,the identification of a s.ries.of potent, s.lective and revers.ble non-peptidyl cas.as.-3 inhibitors.containing a pyrazinone core (1) will be pres.nted. s.R optimization at R1, R2, R3 and R4 led to the dis.overy of inhibitors.s.ch as.2 with excellent in vitro activities.(IC50 agains. rh-cas.as.-3: 5 nm; IC50 agains. camptothecin induced apoptotic cell death in NT2 cells. 20 nm). Compounds.s.ch as.2 als. dis.layed excellent in vivo activities.in a number of animal models.of acute injuries.(s.e: methot, N. et al, J. Exp. med. 2004, 119, 199; Toulmond, s. et al, Britis. J. Pharm. 2004, 141,689; holtzman,D.m. et al, JBC, 2002, 277, 30128), and s.lected examples.will be dis.us.ed during the pres.ntation.

关键词： programmed cell death cytos.eletal proteins molecular mechanis.s identification of animal models DNA repair in vitro