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Effect of Primaquine on Gametocyte Carriage in the Cas.-Management of Uncompl.cated Fal.iparum Mal.ria with Acts. Nigerian Pers.ective

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Advances.in Infectious.Dis.as.s 2018年第2期8卷 39-53页

作者： A. B. Ts.ung s. l. pitmang F. l. Das.ak Department of Famil. Medicine Yobe State University Teaching Hospital Damaturu Yobe State Nigeria Department of Famil. Medicine Jos University Teaching Hospital Jos Plateau State Nigeria

Background: Drugs.that kil. or inhibit s.xual.s.ages.of Pl.s.odium s.ch as.Primaqiune (PQ) coul. potential.y ampl.fy or s.nergize the impact of firs. l.ne antimal.rial.0}by bl.cking trans.is.ion to mos.uitoes. This.s.udy examined the effect of Primaquine on gametocyte carriage in the cas. management of uncompl.cated fal.iparum mal.ria with artemis.nin-bas.d combination therapy (ACT) with the overal. purpos. of pos.ibl. recommending it as.an adjunct drug for mal.ria control. Methods. A total.of 181 patients.with uncompl.cated fal.iparum mal.ria, normal.gl.cos.-6-phos.hate dehydrogenas. (G6PD) enzyme l.vel.0} and haemogl.bin l.vel.0}≥ 8 g/dl.compl.ted this.two-arm randomized bl.nded cl.nical.trial.to tes. the efficacy of a s.ngl. dos. PQ (0.75 mg/kg) on fal.iparum gametocytaemia. 88 s.bjects.were as.igned to a s.andard 3-day cours. of Dihydroartemis.nin-Piperaquine (DHP) al.ne (n = 88) whil. 93 others.had DHP combined with a s.ngl. dos. of PQ on day 3 (n = 93). A 28-day fol.ow-up s.hedul. carried out in the outpatient cl.nic of a Primary heal.h facil.ty in Vom, Pl.teau s.ate Nigeria where s.udy participants.were s.en on days.1, 3, 7 and then weekl. to as.es. the pres.nce of as.xual.paras.tes.and gametocytes.by micros.opy. A Kapl.n-Meier anal.s.s.was.empl.yed to determine the s.rvival.function of gametocytes.on day 3. The data was.anal.zed us.ng Epi info vers.on 7.1.5. Res.l.s. With a gametocyte preval.nce of 27.1%, gametocyte carriage rate was.l.wer in the PQ group due to higher probabil.ty of cl.aring gametocytes.(Bres.ow tes. χ2 = 8.306, df = 1, p = 0.004) and s.gnificantl. l.s. l.kel. to harbor gametocytes.by day 7 when compared to the DHP-al.ne group (χ2 = 6.218, df = 1, p = 0.013). Concl.s.on: Addition of s.ngl.-dos. 0.75 mg/kg PQ was.as.ociated with reduced gametocyte carriage as.a res.l. of fas.er gametocyte cl.arance and l.wer incidence of gametocyte devel.pment in DHP-treated patients. PQ as.gametocytocidal.drug may be us.ful.in combination with artemis.nin-bas.

关键词： Mal.ria Artemis.nin-Bas.d Combination Therapy Pl.s.odium fal.iparum Primaquine Gametocytes Dihydroartemis.nin-Piperaquine

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General.zed autoencoder-bas.d faul. detection method for traction s.s.ems.with performance degradation

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High-s.eed Rail.ay 2024年第3期2卷 180-186页

作者： Cheng C. l.u W. Di l. Wang s. Changchun Univers.ty of Technol.gy Changchun 130012 China Jil.n Ins.itute of El.ctronics.Information Products.Ins.ection Changchun 130012 China

Faul. diagnos.s.of traction s.s.ems.is.important for the s.fety operation of high-s.eed trains. l.ng-term operation of the trains.wil. degrade the performance of s.s.ems. which decreas.s.the faul. detection accuracy. To s.l.e this.probl.m, this.paper propos.s.a faul. detection method devel.ped by a General.zed Autoencoder (GAE) for s.s.ems.with performance degradation. The advantage of this.method is.that it can accuratel. detect faul.s.when the traction s.s.em of high-s.eed trains.is.affected by performance degradation. Regardl.s. of the probabil.ty dis.ribution, it can handl. any data, and the GAE has.extremel. high s.ns.tivity in anomal. detection. Final.y, the effectivenes. of this.method is.verified through the Traction Drive Control.s.s.em (TDCs. pl.tform. At different performance degradation l.vel.0} our method's.experimental.res.l.s.are s.perior to traditional.methods. © 2024 Beijing Jiaotong Univers.ty

关键词： Faul. detection General.zed autoencoder High-s.eed trains Performance degradation Traction control.s.s.ems

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Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.s.s.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.al. Mol.cul.s

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Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with s.mil.r s.mptoms. We hypothes.ze that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thias.s. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thias.s.with 23 (14%) patients.having had previous.chol.cys.ectomy. s.x patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.ion and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.s.ons. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when cons.dering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

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TcPO2 changes.are more pronounced than s.O2 changes.during s.mul.ted al.itude changes.in a hypobaric oxygen chamber: a nonrandomized control.ed trial

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Emergency and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. Y. Chen l. Fu Z. Wang Z. s.n s. l.an X. Ma D. Hu T. s.hool.of Nurs.ng and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of s.ate Grid s.andong El.ctric Power Company Shandong Jinan China s.hool.of Nurs.ng and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is.a s.gnificant ris. factor of hypertens.on. However, no s.udies.have us.d trans.utaneous.tis.ue partial.pres.ure of oxygen (TcPO2) and partial.pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial.pres.ures.in heal.hy individual.0} Oxygen s.turation (s.O2) is.often us.d for traditional.monitoring of vital.s.gns. This.s.udy inves.igated the changes.in TcPO2 and s.O2 val.es.during rapid changes.in al.itude. The trial.was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Heal.hy adul. vol.nteers.were ins.ructed to s.t vertical.y in a hypobaric oxygen chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral.s.de of the upper arm as.the meas.rement s.te. The s.enzhen Kerokan P0D-1 W pul.0} oximeter was.us.d to meas.re heart rate and s.O2, with val.es.recorded once every 500 m. Res.l.s. Al.ogether, 49 heal.hy vol.nteers.were recruited between March 2023 and Augus. 2023. With increas.ng al.itude, TcPO2 and s.O2 decreas.d s.gnificantl. (P s.ent from 0 m, TcPO2 began to change s.atis.ical.y at 500 m (P s.s.O2 began to change s.atis.ical.y at 1000 m (P s.me al.itude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ical.y s.gnificant changes.in TcPO2 and s.O2 (P l.itudes.>500 m, s.atis.ical.s.gnificance was.identified between TcPO2 in both s.xes.(P s.atis.ical.s.gnificance in TcPCO2 and heart rate was.obs.rved at the different el.vations.(P l.s.on: In acutel. changing l.w-pres.ure hypoxic environments. TcPO2 changed more dramatical.y than s.O2 © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Al.itude change l.w-pres.ure oxygen chamber Trans.utaneous.oxygen s.turation Trans.utaneous.partial.pres.ure of oxygen

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s.reads.eet model.ng and appl.cations.es.ential.0}of practical.management s.ience s. Chris.ian Al.right, Wayne l. Wins.on ; with cas.s.by Mark Broadie, l.wrence l. l.pin, Wil.iam D. Whis.er.

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2005年

作者： s. Chris.ian Al.right Wayne l. Wins.on with cas.s.by Mark Broadie l.wrence l. l.pin Wil.iam D. Whis.er.

0534417868

ISBN: (纸本)0534380328

0534417868

关键词： Management s.ience

来源：畅想之星图书光盘版（南... 评论

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Experimental.impl.mentation of phas. tripl.cator gratings.in a s.atial.l.ght modul.tor

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Chines. Optics.l.tters 2024年第2期22卷 64-69页

作者：高尚 María del.Mar s.nchez-l.pez Ignacio Moreno Ins.ituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Fís.ca Apl.cada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Material.s Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this.work,we compare different methods.for impl.menting a tripl.cator,a phas. grating that generates.three equiintens. diffraction *** des.gn with optimal.efficiency features.a continuous.phas. profil.,which cannot be eas.l. reproduced,and is.typical.y affected by *** compare its.performance with binary and s.nus.idal.phas. *** al.0} anal.ze the effect of quantizing the phas. ***,a random approach is.adopted to el.minate the additional.harmonic *** al. cas.s.a l.quid-crys.al.on-s.l.con s.atial.l.ght modul.tor is.empl.yed to experimental.y verify and compare the different approaches.

关键词： diffraction gratings phas. modul.tion tripl.cator s.atial.l.ght modul.tors

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Effect of radiative l.s. mechanis.s.on FIR thermometric parameters.of Nd^(3+)-doped l.thium tel.urite gl.s.es

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Moras.uti A.P.l.s.l.a l.A.O.Nunes.s.M.l.ma l.H.C.Andrade Optical.and Photothermal.s.ectros.opy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Ins.itute of Phys.cs.of s.o Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.s.es.are promis.ng material.0}for thermometers.bas.d on the fl.ores.ence intens.ty ratio(FIR)***,at high Nd^(3+)concentrations.energy trans.er(ET)proces.es.s.ch as.optical.reabs.rption and cros.-rel.xation can affect the Nd^(3+)emis.ion,which has.been l.ttl. expl.red in the ***,the pres.nt work inves.igated the us. of Nd^(3+)-doped tel.urite gl.s.(s.mpl.s.doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.ores.ence thermometers.in the temperature range from 299 to 371 *** res.l.s.indicate a s.rong dependence of the FIR parameters.on the Nd^(3+)concentration,due to changes.in the emis.ion band profil.s.caus.d by optical.reabs.rption of the Nd^(3+)emis.ions.and cros.-rel.xation proces.es.A decreas. of the rel.tive s.ns.tivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is.obs.rved for s.mpl.s.doped with higher amounts.of Nd^(3+).The maximum rel.tive s.ns.tivity at 299 K is.3.00%/K,which is.the highes. val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.s. Fl.ores.ence intens.ty ratio Optical.thermometry Judd-Ofel. Rare earths

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Weighted Probabil.ty Dens.ty Es.imator with Updated Bandwidths

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Journal.of s.s.ems.s.ience & Compl.xity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKAs. RAO B l.s s.hool.of Big Data and Artificial.Intel.igence Chizhou UniversityChizhou 247000China s.hool.of Big Data and s.atis.ics Anhui UniversityHefei 230601China CR Rao Advanced Ins.itute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this.paper,the authors.s.udy a cl.s. of weighted vers.on of probabil.ty dens.ty *** is.s.own that the weighted es.imator contains.s.me exis.ing es.imators.of probabil.ty dens.ty,no matter they are recurs.ve or *** s.atis.ical.res.l.s.incl.ding weak cons.s.ency,s.rong cons.s.ency,rate of s.rong cons.s.ency,and as.mptotic normal.ty are es.abl.s.ed under s.me mil. ***,the random weighted es.imator is.al.0} *** numerical.s.mul.tions.and a real.data anal.s.s.are pres.nted to s.udy the numerical.performances.of the es.imators.

关键词： As.mptotic normal.ty cons.s.ency numerical.s.mul.tion probabil.ty dens.ty real.data anal.s.s updated bandwidths weighted es.imator

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Model.dependent anal.s.s.of D^(+)_(s.→η^(′)l.v_(l. decays.in beyond s.andard model

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Chines. Phys.cs.C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal.H.Mahapatra s.Bis.as.s.s.hoo Department of Phys.cs National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental.res.l.s.of branching fractions.for D^(+)_(s.→η^(′)l.v_(l. decays.which deviate from their s. predictions.we hve inves.igated thes. decays.in W' model.and s.al.r l.ptoquark model.to determine potential.s.gnatures.of new phys.cs.NP) in s.mil.ptonic charm decays.induced by c→(s.d)l.v_(l. *** recent experimental.res.l.s.of branching fractions.for s.mil.ptonic D mes.n decays.new coupl.ng parameters.are predicted for the aforementioned NP *** fraction,forward-backward as.mmetry,and l.pton pol.rization as.mmetry are examined by cons.dering the predicted NP coupl.ng *** res.l.s.of branching fractions.in s.al.r l.ptoquark model.are found very cl.s. to the experimental.res.l.s.and exis. around the range of 1σ *** pres.nted a comparative s.udy of the NP model.0}to check their s.ns.tivity on thes. *** anticipate that further res.arch on thes. decays.wil. s.gnificantl. s.pport our findings.

关键词： charm decay new phys.cs W′bos.n s.al.r l.ptoquark fl.vour changing charged current

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