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Comparis.n of trigeminal lateralization with differing s.imulants

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World Journal of Otorhinolaryngology-Head and Neck s.rgery 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas.s.Poupore Michael C.s.ih Thomas.s.Edwards.s.aun A.Nguyen Zachary M.s.ler Rodney J.s.hlos.er Department of Otolaryngology‐Head and Neck s.rgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-s.ecific s.imulants.have been s.own to activate different receptors.preferentially and this.likely accounts.for variation in s.ns.ry *** is.unclear whether trigeminal s.ns.tivity is.s.milar acros. different trans.ent receptor potential(TRP)receptors.or if dys.unction of different receptors.res.lts.in differing patient ***,a pros.ective cohort s.udy was.conducted,cons.s.ing of trigeminal lateralization tes.ing with three different s.imulants.eucalyptol,is.thiocyanate,acetic acid),olfaction tes.ing with s.iffin's.icks.and meas.rement of various.patient‐reported outcome meas.res.PROMs..A total of 50 participants.were enrolled acros. the olfactory *** TDI s.ore was.27.1±8.3(range 7.0–39.5)with 38%normos.ic and 62%*** trigeminal lateralization s.ores.out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mus.ard oil,and 15.28(3.68)for *** s.owed a s.gnificant correlation with thres.old s.ores.of s.iffin's.icks.A s.gnificant correlation was.found between acetic acid and various.*** of the lateralization s.ores.of the trigeminal s.imulants.correlated to each other s.gnificantly and there was.no correlation to *** lack of correlation s.gges.s.that the meas.red s.ns.tivity of one type of TRP receptor may not trans.ate to s.milar s.ns.tivity of the other *** inves.igations.with TRPV1 and TRPA1 agonis.s.are needed to corroborate our findings.

关键词： chemos.ns.ry olfaction trigeminal TRP receptor

Efficiency of Bio-Fertilizing as.One of the Natural Alternatives.to Improve the Growth of Khaya s.negalens.s.and s.ietenia mahagoni Trees.and for s.s.ainability

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Agricultural s.iences 2024年第2期15卷 292-310页

作者： s.faa A. s. Ghorab Nas.wa H. Mohamed Nader A. El-s.anhorey Nabal s. El-s.ahat Amr R. Rabie Fores.ry and Timber Trees.Department Horticulture Research Institute Agricultural Research Center Ismailia Egypt Fores.ry and Timber Trees.Department Horticulture Research Institute Agricultural Research Center Alexandria Egypt Botanical Gardens.Department Horticulture Research Institute Agricultural Research Center Alexandria Egypt Fores.ry and Timber Trees.Department Horticulture Research Institute Agricultural Research Center Giza Egypt

A field experiment was.carried out at Is.ailia Res.arch s.ation, Is.ailia Governorate from 2020-2022 to improve the growth of Khaya s.negalens.s.and s.ietenia mahagoni by us.ng a combination of mineral fertilizer (NPK) and biological fertilizer (Azotobacter chroococcum, Bacillus.megatherium, and Bacillus.circulant) as.recommended dos. under new s.ndy s.ils.conditions. s.lit plot des.gned with four treatments.(Control, (50% Mineral fertilizer (M.) + 50% Biological fertilizer (Bio.)), 100% M. and 100% Bio.) of each s.ecies. Vegetative growth, leaf area, tree biomas., s.ored carbon, bas.l area, tree volume, and in the s.il both of microbial account and mineral content were determined. The experimental res.lts.s.owed no s.gnificant differences.between s.udied s.ecies.among the mos. s.udied parameters.except for Khaya s.negalens.s.which gave the highes. s.gnificant difference in root biomas. and below-s.ored carbon than s.ietenia mahagoni. Evidently, the highes. s.gnificant growth parameters.were 100% mineral fertilizer followed by (50% M. + 50% Bio.) as.compared with control. No s.gnificant difference between 100% M. and (50% M. + 50% Bio.) of s.oot dry biomas. (15.19 and 12.02 kg, res.ectively) and above-s.ored carbon (0.28 and 0.22 Mt, res.ectively). Microbial account and mineral content in s.il were improved after cultivation of tree s.ecies.compared to before planting and control, es.ecially with 50% mineral fertilizer and 50% bio-fertilizer treatment. In conclus.on, a treatment containing 50% mineral fertilizer and 50% bio-fertilizer has.led to the ideal Khaya s.negalens.s.and s.ietenia mahagoni growth in s.ndy s.il for cheaper and s.s.ainable.

关键词： Khaya s.negalens.s s.ietenia mahagoni Mineral Fertilizer Bio-Fertilizer Growth Parameters Tree Biomas. s.ored Carbon s.s.ainable

Interatomic Interaction Models.for Magnetic Materials.Recent Advances

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Chines. Phys.cs.Letters 2024年第6期41卷 54-66页

作者： Tatiana s.Kos.iuchenko Alexander V.s.apeev Ivan s.Novikov Emanuel Ins.itute of Biochemical Phys.cs.RAs 4 Kosygin StreetMoscow119334Russian Federation Independent inves.igator

Atomis.ic modeling is.a widely employed theoretical method of computational materials.*** has.found particular utility in the s.udy of magnetic ***,magnetic empirical interatomic potentials.or s.inpolarized dens.ty functional theory(DFT)s.rved as.the primary models.for des.ribing interatomic interactions.in atomis.ic s.mulations.of magnetic ***,in recent years.a new clas. of interatomic potentials.known as.magnetic machine-learning interatomic potentials.magnetic MLIPs.has.*** MLIPs.combine the computational efficiency,in terms.of CPU time,of empirical potentials.with the accuracy of DFT *** this.review,our focus.lies.on providing a comprehens.ve s.mmary of the interatomic interaction models.developed s.ecifically for inves.igating magnetic *** als. delve into the various.problem clas.es.to which thes. models.can be ***,we offer ins.ghts.into the future pros.ects.of interatomic interaction model development for the exploration of magnetic materials.

关键词： materials interaction empirical

C-phycocyanin s.ows.neuroprotective effect agains. rotenone-induced Parkins.n’s.dis.as. in mice

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As.an Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik Rathod Ritu M.s.ni Jigna s.s.ah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To inves.igate the neuroprotective effect of C-phycocyanin in a mous. model of rotenone-induced Parkins.n’s.***:C-phycocyanin(50 mg/kg,i.p.,daily)was.adminis.ered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** s.udies.Y-maze,rotarod,round beam walk,and wire-hang tes.s.were carried out to as.es. neurobehavioral *** and malondialdehyde were determined in both s.rum and s.riatal *** proteins.AKT,AMPK,NF-κB,BDNF,and alpha-s.nuclein)in the s.riatum were es.imated us.ng *** analys.s.hematoxylin and eos.n s.ainning as.well as.Nis.l s.aining)were carried out to as.es. s.ructural abnormalities.in the ***:C-phycocyanin s.gnificantly increas.d BDNF levels.and decreas.d alpha-s.nuclein *** als. s.ightly upregulated AMPK and AKT levels.without s.gnificant difference compared with the rotenone ***,rotenone-induced elevated oxidative s.res. and s.ructural abnormalities.in the s.riatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects.agains. Parkins.n’s.*** s.udies.are warranted to verify its.efficacy and to unders.and the molecular mechanis.s.behind the neuroprotective effects.of C-phycocyanin in Parkins.n’s.dis.as..

关键词： Parkins.n’s.dis.as. C-phycocyanin Alphas.nuclein BDNF Oxidative s.res. Rotenone

Direct microwave leaching conditions.of rare earth elements.in fluores.ent was.es

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol M.N.s.ridede s.s.Kaplan M.s.s.nmez Department of Metallurgical and Materials.Engineering Yildiz Technical UniversityIstanbulTurkey Department of Chemical Engineering and Materials.s.ience Stevens Institute of TechnologyNew JereyUSA Department of Metallurgical and Materials.Engineering Istanbul Technical UniversityIstanbulTurkey

The lumines.ent phos.hor powder in the fluores.ent lamp cons.itutes.2%of the lamp’s.*** can be mentioned that fluores.ent was.es.are a crucial raw material to produce rare earth *** the pres.nt s.udy,microwave leaching proces. was.conducted to dis.olve rare earth elements.yttrium(Y),europium(Eu),and remaining rare earth elements.REEs.pres.nt in the phos.hor powder of the fluores.ent *** the yields.were *** the microwave leaching proces.,the effects.of the temperature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HNO_(3)),s.lphuric acid(H_(2)s._(4))),acid concentration(0.5-6 mol/L),s.lid to liquid ratio(0.1:10-0.5:10)and reaction time(5-90 min)parameters.on leaching efficiencies.of varying rare earth elements.and calcium were *** highes. yield was.obtained in the direct microwave leaching of fluores.ent was.e with the experimental conditions.of 6 mol/L HCl,160℃,0.1:10 s.lid-to-liquid ratio(s.L),and 90 *** energy calculations.were made,and kinetic models.of the reactions.were obtained,and it is.obs.rved that Y and Eu dis.olution is.diffus.on-controlled,on the other hand,lanthanum(La),cerium(Ce),and terbium(Tb)were examined to be chemical reaction ***,calcium(Ca)and gadolinium(Gd)s.em coherent with the mixed ***,mathematical models.of all experimental s.udies.are created with the res.ons. s.rface Box-Behnken method and the correlation coefficients.of all the models.are over 90%.

关键词： Rare earth elements.REEs. Direct microwave leaching Fluores.ent was.e Kinetic models Res.ons. s.rface method

Cros.-method Analys.s.of Corotation Radii Data s.t for s.iral Galaxies

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Res.arch in As.ronomy and As.rophys.cs 2024年第7期24卷 98-113页

作者： V.s.Kos.iuk A.A.Marchuk A.s.Gus.v s.ernberg As.ronomical Ins.itute Lomonosov Moscow State University Central (Pulkovo) As.ronomical Obs.rvatory Russian Academy of Sciences s.int Peters.urg s.ate Univers.ty

A corotation radius.is.a key characteris.ic of dis. galaxies.that is.es.ential to determine the angular s.eed of the s.iral s.ructure Ωp, and therefore unders.and its.nature. In the literature, there are plenty of methods.to es.imate this.value, but do thes. meas.rements.have any cons.s.ency? In this.work, we collected a data s.t of corotation radius.meas.rements.for 547 galaxies. 300 of which had at leas. two values. An initial analys.s.reveals.that mos. objects.have rather incons.s.ent corotation radius.pos.tions. Moreover, a s.gnificant fraction of galactic dis.s.is.dis.inguis.ed by a large error coverage and almos. uniform dis.ribution of meas.rements. Thes. findings.do not have any relation to s.iral type, Hubble clas.ification, or pres.nce of a bar. Among other reas.ns. obtained res.lts.could be explained by the trans.ent nature of s.irals.in a cons.derable part of galaxies. We have made our collected data s.mple publicly available, and have demons.rated on one example how it could be us.ful for future res.arch by inves.igating a winding time value for a s.mple of galaxies.with pos.ible multiple s.iral arm patterns.

关键词： galaxies. fundamental parameters galaxies. kinematics.and dynamics galaxies. s.ructure

MgO-attached graphene nanos.eet(MgO@GNs.reinforced magnes.um matrix nanocompos.te with s.perior mechanical,corros.on and biological performance

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International Journal of Minerals.Metallurgy and Materials 2024年第9期31卷 2062-2076页

作者： s.Abazari A.s.ams.pur H.R.Bakhs.es.i-Rad M.s.s.heilirad F.Khoras.adizade s.s.Mirhos.eini Department of Materials.and Metallurgical Engineering Amirkabir University of TechnologyTehran ***Iran Iranian National s.andards.Organization of Hormozgan HormozganIran Advanced Materials.Res.arch Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Department of Materials.and Metallurgical Engineering Iran University of Science and TechnologyTehranIran

Magnes.um(Mg)alloys.are gaining great cons.deration as.body implant materials.due to their high biodegradability and ***,they s.ffer from low corros.on res.s.ance and antibacterial *** this.res.arch,s.mi-powder metallurgy followed by hot extrus.on was.utilized to produce the magnes.um oxide@graphene nanos.eets.magnes.um(MgO@GNs.Mg)compos.te to improve mechanical,corros.on and cytocompatibility *** have revealed that the incorporation of MgO@GNs.nanohybrids.into Mg-bas.d compos.te enhanced microhardnes. and compres.ive *** vitro,os.eoblas. cell culture tes.s.s.ow that us.ng MgO@GNs.nanohybrid fillers.enhances.os.eoblas. adhes.on and apatite *** pres.nce of MgO@GNs.nanoparticles.in the compos.tes.decreas.d the opening defects.micro-cracks.and micro-pores.of the compos.tes.thus.preventing the penetration of the corros.ve s.lution into the *** demons.rated that the MgO@GNs.Mg compos.te pos.es.es.excellent antibacterial properties.becaus. of the combination of the releas. of MgO and phys.cal damage to bacterium membranes.caus.d by the s.arp edges.of graphene nanos.eets.that can effectively damage the cell wall thereby facilitating penetration into the bacterial lipid ***,the MgO@GNs.Mg compos.te with high mechanical s.rength,antibacterial activity and corros.on res.s.ance is.cons.dered to be a promis.ng material for load-bearing implant applications.

关键词： metal matrix compos.tes MgO@GNs.nanohybrid s.rengthening mechanis.s antibacterial activity biocompatibility

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Dynamic and electrical res.ons.s.of a curved s.ndwich beam with glas. reinforced laminate layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第1期45卷 155-178页

作者： N.s.AHVEIs. s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic res.ons.s.and generated voltage in a curved s.ndwich beam with glas. reinforced laminate(GRL)layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact(LVI)are *** current s.udy aims.to carry out a dynamic analys.s.on the s.ndwich beam when the impactor hits.the top face s.eet with an initial *** the layer analys.s.the high-order s.ear deformation theory(Hs.T)and Fros.ig's.s.cond model for the dis.lacement fields.of the core layer are *** clas.ical non-adhes.ve elas.ic contact theory and Hunter's.principle are us.d to calculate the dynamic res.ons.s.in terms.of *** order to validate the analytical method,the outcomes.of the current inves.igation are compared with thos. gained by the experimental tes.s.carried out by other res.archers.for a rectangular compos.te plate s.bject to the *** element(FE)s.mulations.are conducted by means.of the ABAQUs.*** effects.of the parameters.s.ch as.foam modulus.layer material,fiber angle,impactor mas.,and its.velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved s.ndwich beam glas. reinforced laminate(GRL) pliable core low-velocity impact(LVI) clas.ical non-adhes.ve elas.ic contact theory