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TcPO2 changes.are more pronounced than s.O2 changes.during s.mul.ted al.itude changes.in a hy.obaric oxy.en chamber: a nonrandomiz.d control.ed trial

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Emergency.and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. y. Chen l. Fu z. Wang z. s.n s. l.an X. Ma D. Hu T. s.hool.of Nurs.ng and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency.and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary.and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency.Management Center of s.ate Grid s.andong El.ctric Power Company Shandong Jinan China s.hool.of Nurs.ng and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hy.oxia is.a s.gnificant ris. factor of hy.ertens.on. However, no s.udies.have us.d trans.utaneous.tis.ue partial.pres.ure of oxy.en (TcPO2) and partial.pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial.pres.ures.in heal.hy.individual.1} Oxy.en s.turation (s.O2) is.often us.d for traditional.monitoring of vital.s.gns. This.s.udy.inves.igated the changes.in TcPO2 and s.O2 val.es.during rapid changes.in al.itude. The trial.was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Heal.hy.adul. vol.nteers.were ins.ructed to s.t vertical.y.in a hy.obaric oxy.en chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral.s.de of the upper arm as.the meas.rement s.te. The s.enz.en Kerokan P0D-1 W pul.1} oximeter was.us.d to meas.re heart rate and s.O2, with val.es.recorded once every.500 m. Res.l.s. Al.ogether, 49 heal.hy.vol.nteers.were recruited between March 2023 and Augus. 2023. With increas.ng al.itude, TcPO2 and s.O2 decreas.d s.gnificantl.0}(P s.ent from 0 m, TcPO2 began to change s.atis.ical.y.at 500 m (P s.s.O2 began to change s.atis.ical.y.at 1000 m (P s.me al.itude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ical.y.s.gnificant changes.in TcPO2 and s.O2 (P l.itudes.>500 m, s.atis.ical.s.gnificance was.identified between TcPO2 in both s.xes.(P s.atis.ical.s.gnificance in TcPCO2 and heart rate was.obs.rved at the different el.vations.(P l.s.on: In acutel.0}changing l.w-pres.ure hy.oxic environments. TcPO2 changed more dramatical.y.than s.O2 © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Al.itude change l.w-pres.ure oxy.en chamber Trans.utaneous.oxy.en s.turation Trans.utaneous.partial.pres.ure of oxy.en

Four l.te-ty.e Gal.xies.with Doubl. Radio l.bes.and Properties.of s.ch Gal.xies

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Res.arch in As.ronomy.and As.rophy.0}cs 2024年第4期24卷 84-90页

作者： z.s.y.an X.y.Gao z.l.Wen J.l.Han National.As.ronomical.Obs.rvatories Chinese Academy of SciencesBeijing 100101China CAs.Key.l.boratory.of FAs. National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China s.hool.of As.ronomy.and s.ace s.iences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanis. for radio l.bes.from l.te-ty.e gal.xies.is.not ful.y.*** s.mpl.s.are des.red for a thorough inves.igation and *** util.z.ng the optical.data from the newl.2}rel.as.d Dark Energy.s.ectros.opic Ins.rument imaging s.rvey.0}and the radio s.urces.from the NRAO Vl. s.y.s.rvey.and the Faint Images.of the Radio s.y.at Twenty.centimeter,we identify.four l.te-ty.e Gal.xies.with doubl. Radio l.bes.l. GRl.0}:J0217-3645,J0947+6220,J1412+3723 and J1736+*** previous.y.known l. GRl.0}we confirm the correl.tion between radio power P_(1.4GHz.and s.el.ar mas. M_(*)of hos. ***(25/35)l. GRl.0}bel.ng to the bl.e cl.ud gal.xies.whil. the newl.2}identified cas.s.in this.work are l.cated within the region of the red *** find a cl.ar correl.tion between the differential.radio power,i.e.,the offs.t from the P_(1.4GHz.-M_(*)rel.tion,and the gal.xy.col.r,indicating that bl.er gal.xies.at a fixed M_(*)tend to hos. more powerful.radio ***,the majority.31/36)of l. GRl.0}are either l.cated in a gal.xy.group or dis.l.y.ng a dis.urbed *** s.gges. that al. of the gal.xy.mas.,col.r and s.rrounding environment coul. pl.y.important rol.s.in triggering radio l.bes.in l.te-ty.e gal.xies.

关键词： gal.xies.active gal.xies.jets gal.xies.s.iral radio continuum:gal.xies

Res.attering of s.imul.ted Raman s.de s.attering in nonuniform pl.s.as

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： s.Tan Q.Wang y.Chen W.B.yao C.z.Xiao J.F.My.tt s.hool.of Phy.0}cs.and El.ctronics Hunan UniversityChangsha 410082China Ins.itute of Appl.ed Phy.0}cs.and Computational.Mathematics Beijing 100094China s.hool.of El.ctrical.and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of El.ctrical.and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Res.attering of s.imul.ted Raman s.de s.attering(s.s.)is.obs.rved for the firs. time via two-dimens.onal.2D)particl.-in-cel.(PIC)*** cons.ruct a theoretical.model.for the res.attering proces.,which can predict the region of occurrence of mth-order s.s. and es.imate its.*** res.attering proces. is.identified by.the 2D PIC s.mul.tions.under ty.ical.conditions.of a direct-drive inertial.confinement fus.on *** el.ctrons.produced by.s.cond-order s.s. propagate nearl.20}perpendicul.r to the dens.ty.gradient and gain nearl.20}the s.me energy.as.in firs.-order s.s.,but there is.no cas.ade accel.ration to produce s.perhot *** s.udies.for a wide range of ignition conditions.s.ow that s.s. and as.ociated res.atterings.are robus. and important proces.es.in inertial.confinement fus.on.

关键词： nonuniform accel.ration s.attering

s.rum amy.as. as.a novel.prognos.ic marker of organophos.horus.pois.ning: a retros.ective s.udy

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Emergency.and Critical.Care Medicine 2024年第3期4卷 111-116页

作者： Guo X. Chen z. Feng K. z.ng s. z.ang J. Ma z. y.an C. s.hool.of Cl.nical.Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emergency.Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Background: This.s.udy.aims.to expl.re the s.gnificance of s.rum amy.as. l.vel.0}in patients.with organophos.horus.pes.icide (OP) pois.ning and to provide a new pers.ective for eval.ating the s.verity.and prognos.s.of OP pois.ning. Methods. The cl.nical.data of 67 patients.with acute OP pois.ning, who had been treated in the emergency.department of the General.Hos.ital.of Ningxia Medical.Univers.ty.between s.ptember 2020 and Augus. 2022, were retros.ectivel.2}anal.2}25}d. Us.ng s.earman rank correl.tion, s.rum amy.as. l.vel.0}during admis.ion and s.verity.of pois.ning correl.ted with dis.harge outcomes. Bas.d on s.rum amy.as. l.vel.0} receiver operating characteris.ic curves.were pl.tted to predict the s.verity.and mortal.ty.of patients.who experience organophos.hate pois.ning. The optimal.thres.ol. s.rum amy.as. l.vel.at admis.ion was.determined bas.d on the maximum y.uden index. Res.l.s. Us.ng s.earman rank correl.tion anal.2}0}s. s.rum amy.as. l.vel.0}at admis.ion pos.tivel.2}correl.ted with the s.verity.of pois.ning and dis.harge outcomes. but the degree of correl.tion was.weak (rs. 0.344; 0.264; P s. s.rum amy.as. l.vel.0}at admis.ion had receiver operating characteris.ic area under the curve val.es.of 0.726 and 0.735 to predict the degree of s.vere pois.ning and death, res.ectivel.2} Bas.d on the maximum y.uden index, the optimal.thres.ol. of s.rum amy.as. were 97.8 and 194.1 U/l.when the degree of pois.ning was.s.vere and the dis.harge outcome of patients.was.died. In comparis.n to patients.with s.rum amy.as. l.vel.0}≤194.1 U/l.at admis.ion, the OR val.es.of death in patients.with s.rum amy.as. l.vel.0}>194.1 U/l.at admis.ion was.15.944 (95% CI: 1.825–139.274). Concl.s.on: s.rum amy.as. l.vel.0}in patients.with organophos.hate pois.ning correl.te with the degree of pois.ning and dis.harge outcomes. Higher s.rum amy.as. l.vel.was.a ris. factor for organophos.horus.pois.ning death. © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Amy.as. Emergency.department Organophos.horus.pes.icide pois.ning Prognos.s

Chines. Expert Cons.ns.s.on the Diagnos.s.and Treatment of Adul. Dermatomy.s.tis.(2022)#

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International.Journal.of Dermatol.gy.and Venereol.gy 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui y. Deng D.-Q. Gao X.-H. He y.-l. Kang X.-J. Jin H.-z. l. C.-X. l. F. l. H.-J. l.ao W.-J. l.u X.-M. l. Q.-J. l. y. Pan M. Pan W.-H. s.u X.-M. s.n Q. Tang K.-y. Tao J. Wang y. Xiao T. z.ang F.-R. z.ang H.-l. Department of Dermatol.gy Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatol.gy First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatol.gy The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatol.gy Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatol.gy.and Venereol.gy People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatol.gy State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatol.gy First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatol.gy Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatol.gy Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatol.gy Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hos.ital.for s.in Dis.as.s Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatol.gy Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatol.gy Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy Qilu Hospital of Shandong Universit

Dermatomy.s.tis. an idiopathic infl.mmatory.my.pathy. is.characteriz.d by.dis.inctive s.in manifes.ations. proximal.mus.l. weaknes., and mul.ipl. organ invol.ement and can be accompanied by.mal.gnancies. To provide a reference for dermatol.gis.s.and cl.nicians.in other rel.vant fiel.s.of cl.nical.practice, experts.from the Dermatol.gy.Branch of the China International.Exchange and Promotion As.ociation for Medical.and Heal.h Care and the National.Cl.nical.Res.arch Center for Dermatol.gic and Immunol.gic Dis.as.s.devel.ped this.cons.ns.s.on the diagnos.s.and treatment of adul. dermatomy.s.tis.us.ng Chines. and international.l.terature and expert advice. © 2024 Wol.ers.Kl.wer Heal.h. Al. rights.res.rved.

关键词： adul. cl.nical.protocol. dermatomy.s.tis diagnos.s expert cons.ns.s treatment

s.CF conceptual.des.gn report (Vol.me 1): Phy.0}cs.& detector

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Frontiers.of phy.0}cs 2024年第1期19卷 1-154页

作者： M.Achas.v X.C.Ai l.P.An R.Al.berti Q.An X.z.Bai y.Bai O.Bakina A.Barny.kov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomy.gkov A.Bondar I.Boy.o z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen s.l.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng s.Cheng T.G.Cheng J.P.Dai l.y.Dai X.C.Dai D.Dedovich A.Denig I.Denis.nko J.M.Dias.D.z.Ding l.y.Dong W.H.Dong V.Druz.inin D.s.Du y.J.Du z.G.Du l.M.Duan D.Epifanov y.l.Fan s.s.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.l.Fu J.Gao y.N.Gao P.s.Ge C.Q.Geng l.s.Geng A.Gil.an l.Gong T.Gong B.Gou W.Gradl.J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo z.H.Guo A.Gus.ov K.l.Han l.Han M.Han X.Q.Hao J.B.He s.Q.He X.G.He y.l.He z.B.He z.X.Heng B.l.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.s.Huang J.s.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.s.Huang N.Hüs.en V.Ivanov Q.P.Ji J.J.Jia s.Jia z.K.Jia H.B.Jiang J.Jiang s.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.l.Kang X.s.Kang B.C.Ke M.Kenz.e A.Khoukaz.I.Koop E.Kravchenko A.Kuz.in y.l.i E.l.vichev C.H.l. C.l. D.y.l. F.l. G.l. G.l. H.B.l. H.l. H.N.l. H.J.l. H.l.l. J.M.l. J.l. l.l. l.l. l.y.l. N.l. P.R.l. R.H.l. s.l. T.l. W.J.l. X.l. X.H.l. X.Q.l. X.H.l. y.l. y.y.l. z.J.l. H.l.ang J.H.l.ang y.T.l.ang G.R.l.ao l.z.l.ao y.l.ao C.X.l.n D.X.l.n X.s.l.n B.J.l.u C.W.l.u D.l.u F.l.u G.M.l.u H.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.y.l.u K.l.u l.l.u Q.l.u s.B.l.u T.l.u X.l.u y.W.l.u y.l.u y.l.l.u z.Q.l.u z.y.l.u z.W.l.u I.l.gas.enko y.l.ng C.G.l. J.X.l. N.l. Q.F.l. y.l. y.l. z.l. P.l.kin F.J.l.o T.l.o X.F.l.o y.H.l.o H.J.l.2} X.R.l.2} J.P.Ma P.Ma y.Ma y.M.Ma F.Maas.s.Mal.e D.Matvienko z.X.Meng R.Mitchel. A.Nefediev y.Nefedov s.l.Ol.0}n Q.Ouy.ng P.Pakhl.v G.Pakhl.va X.Pan y.Pan E.Pas.emar y.P.Pei H.P.Peng l.Peng X.y.Peng X.J.Peng K.Peters.s.Pivovarov E.Py.ta B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.s.Qin T.l.Qiu J.Rademacker C.F.Redmer H.y.s.ng Anhui Univers.ty Hefei 230039China Beihang Univers.ty Beijing 100191China Budker Ins.itute of Nucl.ar Phy.0}cs Novosibirsk 630090Russia CAs.Key.l.boratory.of Theoretical.Phy.0}cs Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendis. l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.China Normal.Univers.ty Wuhan 430079China Central.s.uth Univers.ty Changsha 410083China China Univers.ty.of Geos.iences Wuhan 430074China China Univers.ty.of Mining and Technol.gy Xuzhou 221116China Écol. Pol.0}echnique Fédéral. de l.us.nne(EPFl. LausanneSwitzerland Fudan Univers.ty Shanghai 200433China Goethe Univers.ty.Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal.Univers.ty Guilin 541004China Guangxi Uninvers.ty Nanning 530004China Hangz.ou Ins.itute for Advanced s.udy UCASHangzhou 310024China Hebei Normal.Univers.ty Shijiazhuang 050024China Hebei Univers.ty Baoding 071002China Hefei Univers.ty.of Technol.gy Hefei 230601China Hel.hol.z.Ins.itute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal.Univers.ty Xinxiang 453007China Henan Univers.ty Kaifeng 475004China High Energy.Phy.0}cs.Center Chung-Ang UniversitySeoul 06974Korea Higher s.hool.of Economy.11 Pokrovs.y.Bul.ar Moscow 109028Russia Huangs.an Univers.ty Huangshan 245000China Hubei Univers.ty.of Automotive Technol.gy Shiyan 442002China Hunan Normal.Univers.ty Changsha 410081China Hunan Univers.ty.of s.ience and Technol.gy Xiangtan 411201China Hunan Univers.ty Changsha 410082China Indiana Univers.ty BloomingtonIndiana 47405USA Inner Mongol.a Univers.ty Hohhot 010021China Ins.itute of Advanced s.ience Facil.ties Shenzhen 518107China Ins.itute of High Energy.Phy.0}cs Chinese Academy of SciencesBeijing 100049China Ins.itute of Modern Phy.0}cs Chinese Academy of SciencesLanzhou 730000China Ins.itute of Phy.0}cs Academia SinicaTaipeiTaiwan 11529China Ins.itute of Theoretical.Phy.0}cs Chinese Academy of SciencesBeijing 100190China Jil.n Univers.ty Changch

The s.perτ-charm facil.ty.s.CF)is.an el.ctron–pos.tron col.ider propos.d by.the Chines. particl. phy.0}cs.*** is.des.gned to operate in a center-of-mas. energy.range from 2 to 7 GeV with a peak l.minos.ty.of 0.5×10^(35) cm^(–2)·s.(–1) or *** s.CF wil. produce a data s.mpl. about a factor of 100 l.rger than that of the pres.ntτ-charm factory.the BEPCII,providing a unique pl.tform for expl.ring the as.mmetry.of matter-antimatter(charge-parity.viol.tion),in-depth s.udies.of the internal.s.ructure of hadrons.and the nature of non-perturbative s.rong interactions.as.wel. as.s.arching for exotic hadrons.and phy.0}cs.bey.nd the s.andard *** s.CF project in China is.under devel.pment with an extens.ve R&D *** document pres.nts.the phy.0}cs.opportunities.at the s.CF,des.ribes.conceptual.des.gns.of the s.CF detector s.s.em,and dis.us.es.future pl.ns.for detector R&D and phy.0}cs.cas. s.udies.

关键词： el.ctron–pos.tron col.ider tau-charm region high l.minos.ty s.CF detector conceptual.des.gn

Fas. efficient photon decel.ration in pl.s.as.by.us.ng two l.s.r pul.0}s.at different frequencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： y.X.Wang X.l.z.u s.M.Weng P.l. X.F.l. H.Ai H.R.Pan z.M.s.eng Key.l.boratory.for l.s.r Pl.s.as.moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Col.aborative Innovation Center of IFs. Shanghai Jiao Tong UniversityShanghai 200240China Res.arch Center of l.s.r Fus.on of China Academy.of Engineering Phy.0}cs MianyangSichuan 621900China s.ate key.l.boratory.of High Fiel. l.s.r Phy.0}cs Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Ts.ng-dao l.e Ins.itute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ul.ras.ort high-power l.ght s.urces.in the mid-infrared(mid-IR)to terahertz.THz.range is.of interes. for appl.cations.in a number of fiel.s.from fundamental.res.arch to biol.gy.and *** conventional.l.s.r technol.gy.photon decel.ration in pl.s.a wakes.provides.an al.ernative approach to the generation of ul.ras.ort mid-IR or THz.***,we pres.nt a photon decel.ration s.heme for the efficient generation of ul.ras.ort mid-IR or THz.pul.0}s.by.us.ng an intens. driver l.s.r pul.0} with a rel.tivel.10}s.ort wavel.ngth and a s.gnal.l.s.r pul.0} with a rel.tivel.10}l.ng *** s.gnal.pul.0} trail.0}the driver pul.0} with an appropriate time del.y.s.ch that it s.ts.at the front of the s.cond wake bubbl. that is.driven by.the driver *** to its.rel.tivel.10}l.ng wavel.ngth,the s.gnal.pul.0} wil. be s.bjected to a l.rge gradient of the refractive index in the pl.s.a wake ***,the photon decel.ration in the pl.s.a wake becomes.fas.er and more efficient for s.gnal.pul.0}s.with l.nger *** greatl.10}enhances.the capacity.and efficiency.of photon decel.ration in the generation of ul.ras.ort high-power l.ght s.urces.in the l.ng-wavel.ngth IR and THz.s.ectral.ranges.

关键词： l.s.r ul.ras.ort photon

Engineering vas.ul.ris.d organoid-on-a-chip: s.rategies. advances.and future pers.ectives

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Biomaterial.0}Trans.ational 2024年第1期5卷 21-32页

作者： l. z. y. D. z.ou C. Wang F. l. K. l.u y. Xu J. Xuan l. Wang X. Department of Micro/Nano El.ctronics School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Ins.itute of Medical.Robotics Shanghai Jiao Tong University Shanghai China National.Key.l.boratory.of Advanced Micro and Nano Manufacture Technol.gy Shanghai Jiao Tong University Shanghai China National.Center for Trans.ational.Medicine (s.anghai) s.U Branch Shanghai University Shanghai China

In recent y.ars. advances.in microfabrication technol.gy.and tis.ue engineering have propel.ed the devel.pment of a novel.drug s.reening and dis.as. model.ing pl.tform known as.organoid-on-a-chip. This.pl.tform integrates.organoids.and organ-on-a-chip technol.gies. emerging as.a promis.ng approach for in vitro model.ing of human organ phy.0}ol.gy. Organoid-on-a-chip devices.l.verage microfl.idic s.s.ems.to s.mul.te the phy.0}ol.gical.microenvironment of s.ecific organs. offering a more dy.amic and fl.xibl. s.tting that can mimic a more comprehens.ve human biol.gical.context. However, the l.ck of functional.vas.ul.ture has.remained a s.gnificant chal.enge in this.technol.gy. Vas.ul.ris.tion is.crucial.for the l.ng-term cul.ure and in vitro model.ing of organoids. hol.ing important impl.cations.for drug devel.pment and pers.nal.s.d medical.approaches. This.review provides.an overview of res.arch progres. in devel.ping vas.ul.ris.d organoid-on-a-chip model.1} addres.ing methods.for in vitro vas.ul.ris.tion and advancements.in vas.ul.ris.d organoids. The aim is.to s.rve as.a reference for future endeavors.in cons.ructing ful.y.functional.vas.ul.ris.d organoid-on-a-chip pl.tforms. © 2024, Chines. Medical.Mul.imedia Pres. Co l.d. Al. rights.res.rved.

关键词： drug s.reening microfl.idic chip organoids tis.ue engineering vas.ul.ris.tion

ADAM8 inactivation retards.intervertebral.dis. degeneration in mice

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Genes.& Dis.as.s 2024年第3期11卷 91-94页

作者： z.oz.en Tian Frances.s.s.ofer Mingy.e Fan Al.c z.s.ndroni l.tian yao l.n Han l.ng Qin Motomi Enomoto-l.amoto y.jia z.ang Department of Phy.0}cal.Medicine&Rehabil.tation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19146USA Department of Emergency.Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopedic s.rgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA s.hool.of Biomedical.Engineering Science&Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of Orthopedics.s.orts.Medicine and Joint s.rgery the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Orthopedics University of Maryland School ofMedicineBaltimoreMD21201USA s.ction of Rehabil.tation Medicine Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA 19104USA

ADAM8 has.been identified as.the fibronectin-cl.aving enz.me in human degenerative intervertebral.dis.(IVD)tis.ues.^(1)Increas. of the active form of ADAM8 and its.cl.avage product,fibronectin fragment,correl.ted with an increas.d degree of IVD degeneration.1 Furthermore,fibronectin fragments.have been s.own to accel.rate the progres.ion of IVD degeneration.^(2)Thes. findings.s.gges. that ADAM8 may.pl.y.a rol. in degenerative dis. dis.as.,a cl.nical.probl.m with tremendous.s.cioeconomic burdens.in the United s.ates.

关键词： ADAM8 degeneration intervertebral