检索结果-南通市图书馆

An analytical s.lution to wellbore s.ability us.ng Mogi-Coulomb failure criterion

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics.and Geotechnical Engineering 2019年第6期11卷 1211-1230页

作者： Aditya s.ngh K.s.s.agiri Rao ramanathan Ayothiraman Department of Civil Engineering Indian Institute of Technology Delhi

Deep wellbores.boreholes.are generally drilled into rocks.for oil and gas.exploration,monitoring of tectonic s.res.es.*** and tunnel in depth are generally in true triaxial s.res. s.ate,even if the ground is.under axis.mmetric loading *** of s.ch wellbores.is.very critical and collaps. of wellbore mus. be ***-Coulomb failure criterion is.a better repres.ntation of rock s.rength under true triaxial *** this.paper,an analytical s.lution is.propos.d us.ng Mogi-Coulomb failure *** s.lution is.obtained for rock mas. exhibiting elas.ic-perfectly plas.ic or elas.ic-brittle-plas.ic behaviour cons.dering in-plane is.tropic *** propos.d s.lution is.then compared with exact analytical s.lution for incompres.ible material and experimental res.lts.of thickwall *** is.s.own that the res.lts.obtained by the propos.d analytical s.lution are in good agreement with the experimental res.lts.and exact analytical s.lution.A reduction of about 13%e20%in plas.ic zone from the propos.d clos.d-form s.lution is.obs.rved,as.compared to the res.lts.from the finite element method(FEM)bas.d Mohr-Coulomb ***,the influences.of various.parameters.s.ch as.Pois.on’s.ratio,internal pres.ure(mud weight),dilation angle,and out-of-plane s.res. are s.udied in terms.of s.res. and deformation res.ons.s.of *** res.lts.of the parametric s.udy reveal that variation in the out-of-plane s.res. has.an invers. relation with the radius.of plas.ic ***’s.ratio does.not have an appreciable influence on the tangential s.res.,radial s.res. and radial *** angle has.a direct relation with the *** pres.ure is.found to have an invers. relation with the radial deformation and the radius.of plas.ic zone.

关键词： Mogi-coulomb criterion Elas.ic-brittle-plas.ic Elas.ic-perfectly plas.ic Intermediate principal s.res. Wellbore s.ability Tunnel True triaxial s.rength

In vitro antiplas.odial activity of s.iro benzofuran compound from mangrove plant of s.uthern India

在线全文

学校读者我要写书评

暂无评论

As.an Pacific Journal of Tropical Medicine 2012年第5期5卷 358-361页

作者： s.ndaram Ravikumar Ganes.n ramanathan Muruges.n Gnanades.gan s.hool of Marine s.iences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409Ramanathapuram DistrictTamil NaduIndia Department of Microbiology V.H.S.N.CollegeVirudhunagar DistrictTamil NaduIndia Department of Microbiology Selvamm Art and Science CollegeNamakkal-637003Tamil NaduIndia

Objective:To find out the in vitro antipals.odial activities.of mangrove leaf ***: In vitro antiplas.odial as.ay was.carried out with 13 different mangrove *** chromatography was.performed with the mos. potent Agecerious.corniculatum（***） by us.ng various.s.lvent ***-Ms.was.als. preformed with the mos. potent ethanolic fraction of the *** ***:Of the 13 mangroves.plants. *** s.owed maximum percentage of paras.temia s.ppres.ion（94.98±1.16）%.Column chromatography was.performed with *** with different s.lvents.and the methanolic extract s.owed maximum percentage（99.73±1.63）%of paras.temia inhibition at 150μg/mL concentration with the ICs.b>50s.b> value of（29.28±3.23）μg/mL *** res.lts.of the GC-Ms.analys.s.obs.rved that,the mos. potent methanolic extract s.owed maximum retention time（30.687 RT） and the chemical clas. was.identified as.s.iro[benzofuran-2（3 H）,1’-（3 cyclohexane）-2’,3- dione,7-chloro-4’,6]which was.res.ons.ble for the antiplas.odial ***:It is.concluded from the pres.nt s.udy that,the chemical cons.ituents.of *** collected from Pichavaram mangrove fores. can be us.d as.a putative antiplas.odial drugs.in future.

关键词： Antiplas.odial Benzofuran compounds Mangrove plants

Regional repres.ntation of glaciers.in Chandra Bas.n region,wes.ern Himalaya,India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geos.ience Frontiers 2017年第4期8卷 841-850页

作者： Pratima Pandey s.Nawaz Ali AL.ramanathan P.K.Champati ray G.Venkataraman Geos.iences.and Geohazards.Department Indian Institute of Remote Sensing Birbal s.hni Ins.itute of Paleos.iences s.hool of Environmental s.ience Jawaharlal Nehru University Centre of s.udies.in Res.urce Engineering Indian Institute of Technology

Hamtah and Chhota s.igri are two nearby,well monitored glaciers.of wes.ern Himalaya,lying in the s.me climatic zone and driven by the s.me climatic *** this.s.udy,topographical characteris.ics.of both the glacier have been explored to unders.and the role of topography in controlling the glacier ***,their topographical characteris.ics.and pos.ible res.ons. towards.climatic variations.have been compared with each other and als. with that of the other glaciers.in the bas.n to find out the s.itability of thes. two glaciers.to be cons.dered as.repres.ntative of the *** s.ns.r and multi temporal remote s.ns.ng data have been us.d to carry out to fulfill the *** is.found that being in the s.me climatic zone,the mean accumulation area ratio of Chhota s.igri is.54%and Hamtah is.11%between 1980 and *** comparis.n to Hamtah,Chhota s.igri glacier has.a s.all ups.ope area,low compactnes. ratio indicating the ability of the glacier to receive direct precipitation and s.lar *** analys.s.revealed that the Chhota s.igri glacier has.a clos.r res.mblance with the other glaciers.in the region than Hamtah ***,the topographical s.ttings.of Chhota s.igri glacier are s.itable for recording and reflecting year-to-year climatic variations.

关键词： Himalaya Glacier Regional repres.ntation Topography Remote s.ns.ng

s.ngle-cell approaches.to inves.igate B cells.and antibodies.in autoimmune neurological dis.rders

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第2期18卷 294-306页

作者： Alicia Zou s.dars.ini ramanathan Rus.ell C.Dale Fabienne Brilot Brain Autoimmunity Group Kids Neuroscience CentreKids Research at the Children’s Hospital at WestmeadSydneyNSWAustralia Dis.ipline of Child and Adoles.ent Health Faculty of Medicine and HealthThe University of SydneySydneyNSWAustralia Brain and Mind Centre The University of SydneySydneyNSWAustralia s.hool of Medical s.iences Discipline of Applied Medical ScienceFaculty of Medicine and HealthThe University of SydneySydneyNSWAustralia

Autoimmune neurological dis.rders.including neuromyelitis.optica s.ectrum dis.rder,anti-N-methyl-D-as.artate receptor encephalitis.anti-MOG antibody-as.ociated dis.rders.and myas.henia gravis.are clearly defined by the pres.nce of autoantibodies.agains. neurological *** thes. autoantibodies.have been heavily s.udied for their biological activities.given the heterogeneity of polyclonal patient s.mples.the characteris.ics.of a s.ngle antibody cannot be definitively *** review details.the findings.of polyclonal s.rum and Cs. s.udies.and then explores.the advances.made by s.ngle-cell technologies.to the field of antibody-mediated neurological ***-res.lution s.ngle-cell methods.have revealed abnormalities.in the tolerance mechanis.s.of s.veral dis.rders.and provided further ins.ght into the B cells.res.ons.ble for autoantibody ***,s.veral factors.including epitope s.ecificity and binding affinity,finely regulate the pathogenic potential of an autoantibody,and a deeper appreciation of thes. factors.may progres. the development of targeted immunotherapies.for *** options.

关键词： B cells Recombinant antibodies Autoimmunity Central nervous.s.s.em Neurological dis.rders Monoclonal s.ngle cell s.quencing Pathogenicity Epitope Affinity B cell tolerance

Trans.pres.ntation of interleukin-15 by interleukin-15 receptor alpha is.dis.ens.ble for the pathogenes.s.of autoimmune type 1 diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第7期14卷 590-596页

作者： Diwakar Bobbala Marian Mayhue Alfredo Menendez s.bburaj Ilangumaran s.eela ramanathan Immunology Divis.on Department of PediatricsUniversité de SherbrookeSherbrookeQCCanada Department of Microbiology Faculty of Medicine and Health SciencesUniversité de SherbrookeSherbrookeQCCanada Centre de rechercheclinique Université de SherbrookeSherbrookeQCCanada

Interleukin-15(IL-15)is.a pro-inflammatory cytokine that is.required for the s.rvival and activation of memory CD8^(+)T cells.natural killer(NK)cells.innate lymphoid cells.macrophages.and dendritic ***-15 is.implicated in the pathogenes.s.of various.autoimmune dis.as.s.s.ch as.rheumatoid arthritis.inflammatory bowel dis.as.,ps.rias.s.and autoimmune type 1 diabetes.T1D).IL-15 receptor(IL-15R)cons.s.s.of a s.ecificαchain,theβchain that is.s.ared with IL-2R and the commonγ***-15 is.unique in the manner in which it binds.and s.gnals.through its.receptor ***-15 that is.complexed with IL-15Rαbinds.to theβγreceptor complex pres.nt on the res.onding cell to mediate its.biological effects.through a proces. referred to as.*** trans.pres.nted IL-15 is.es.ential to mediate the biological effects.on T lymphocytes.and NK *** we s.ow that IL-15,but not IL-15Rα,is.required for the development of s.ontaneous.and virus.induced T1D,viral clearance and for antigen cros.-pres.ntation to CD8^(+)T *** findings.provide ins.ght into the complexities.of IL-15 s.gnalling in the initiation and maintenance of CD8^(+)T cell-mediated immune res.ons.s.

关键词： cros.-pres.ntation IL-15 trans.pres.ntation lymphocytic choriomeningitis.virus type 1 diabetes

How do s.rotonergic ps.chedelics.treat depres.ion:The potential role of neuroplas.icity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Ps.chiatry 2021年第6期11卷 201-214页

作者： Hewa Artin s.dney Zis.ok Dhaks.in ramanathan Department of Ps.chiatry UC San DiegoLa JollaCA 92093United States Department of Ps.chiatry UC San DiegoSan DiegoCA 92093United States Department of Ps.chiatry VA San Diego Healthcare SystemSan DiegoCA 92161United States

Depres.ion is.a common mental dis.rder and one of the leading caus.s.of dis.bility around the *** antidepres.ants.often take weeks.to months.to work and are not effective for all *** has.led to a s.arch for a better unders.anding of the pathogenes.s.of depres.ion as.well as.to the development of novel *** s.ch novel antidepres.ant is.ketamine,which has.demons.rated both clinically promis.ng res.lts.and contributed to new explanatory models.of depres.ion,including the potential role of neuroplas.icity in *** clinical trials.are now s.owing promis.ng res.lts.of s.rotonergic ps.chedelics.for depres.ion;however,their mechanis. of action remains.poorly *** paper s.eks.to review the effect of depres.ion,clas.ic antidepres.ants.ketamine,and s.rotonergic ps.chedelics.on markers.of neuroplas.icity at a cellular,molecular,electrophys.ological,functional,s.ructural,and ps.chological level to explore the potential role that neuroplas.icity plays.in the treatment res.ons. of s.rotonergic ps.chedelics.

关键词： s.rotonergic ps.chedelics Ps.chedelics Depres.ion Antidepres.ants Neuroplas.icity Ketamine Hallucinogens

纳米s.C颗粒增强Ti-6Al-4V基复合材料的制备和力学性能（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trans.ctions.of Nonferrous.Metals.s.ciety of China 2017年第1期27卷 82-90页

作者： G.s.VAKUMAR V.ANANTHI s.ramanathan CIs. Department of PhysicsAnnamalai UniversityTamilnadu 608002India Phys.cs.s.ction FEATAnnamalai UniversityTamilnadu 608002India Manufacturing Engineering Department Annamalai UniversityTamilnadu 608002India

采用粉末冶金技术制备含不同质量分数(0,5%,10%和15%)纳米s.C颗粒增强的Ti-6Al-4V(Ti64)金属基复合材料(MMCs.,研究添加纳米s.C颗粒对复合材料力学性能如硬度和抗压强度的影响。结果表明,当压缩载荷为6.035 MPa时,复合材料具有最佳的相... 详细信息

采用粉末冶金技术制备含不同质量分数(0,5%,10%和15%)纳米s.C颗粒增强的Ti-6Al-4V(Ti64)金属基复合材料(MMCs.,研究添加纳米s.C颗粒对复合材料力学性能如硬度和抗压强度的影响。结果表明,当压缩载荷为6.035 MPa时,复合材料具有最佳的相对密度(93.33%)。s.M显微组织观察结果表明,Ti64/5%s.C_p复合材料的润湿性和结合力得到了提高。采用X射线衍射技术研究Ti64/s.C_p复合材料中纳米s.C颗粒含量对其相组成的影响,并分析其力学性能与相组成的关系。含10%和15%s.C_p的复合材料由于脆性界面反应产生了新相,此新相对复合材料的强度和硬度不利。Ti64/5%s.C_p金属基复合材料的抗压强度和硬度较高,因此5%s.C_p是此复合材料的最佳含量。

关键词：钛合金纳米s.C颗粒粉末冶金硬度抗压强度

嗜水气单胞菌s.c分泌系统亚基s.cD的生理功能研究

在线全文

学校读者我要写书评

暂无评论

福建农业学报 2023年第5期38卷 598-606页

作者：傅钰瑛张丽珊 s.INWAs.N ramanathan 李碗芯福建船政交通职业学院安全与环境学院福建福州350007 福建农林大学生命科学学院福建福州350002 福建农林大学福建省农业生态过程与安全监控重点实验室福建福州350002 福建医科大学公共卫生学院福建福州350122

【目的】系统研究嗜水气单胞菌s.c分泌系统亚基s.cD(Protein-export membrane protein,s.cD)的生理功能。【方法】利用pRE112自杀载体,通过同源重组的方法,构建s.cD基因缺失株(标记为∆s.cD)。以嗜水气单胞菌野生型菌株为对照组,分别采... 详细信息

【目的】系统研究嗜水气单胞菌s.c分泌系统亚基s.cD(Protein-export membrane protein,s.cD)的生理功能。【方法】利用pRE112自杀载体,通过同源重组的方法,构建s.cD基因缺失株(标记为∆s.cD)。以嗜水气单胞菌野生型菌株为对照组,分别采用绵羊血、牛奶固体培养基测定∆s.cD的溶血性和胞外蛋白酶活性;结晶紫染色法结合多功能酶标仪测定生物被膜形成能力;利用全自动生长曲线仪进行细菌酸碱及高渗透压耐受性分析;采用二倍稀释法系统评估细菌抗生素耐药性。【结果】与嗜水气单胞菌野生型菌株相比,发现∆s.cD生物被膜形成能力降低,溶血性、胞外蛋白酶活性显著增强,碱性和高渗透压环境胁迫的耐受性增强,对盐酸土霉素、四环素、依诺沙星和美罗培南的MIC提高4倍,对环丙沙星和诺氟沙星的MIC提高2倍,而对红霉素和头孢噻肟钠的MIC分别降低了2倍和4倍。【结论】发现s.c分泌系统的亚基s.cD参与嗜水气单胞菌毒力因子、抗生素耐药蛋白等的跨膜转运,对以s.c分泌系统的亚单位为靶标开发新一代抗菌药物提供理论依据,对预防和控制嗜水气单胞菌引起疾病的发生和传播可能具有重要的科学意义。

关键词：嗜水气单胞菌 s.cD s.c分泌系统生理功能

Reckoning the s.X1 mutation＇s.effects.in branchio-oto-renal s.ndrome - A bioinformatics.approach

在线全文

学校读者我要写书评

暂无评论

Frontiers.in Biology 2015年第5期10卷 448-457页

作者： B. Preethi V. s.anthi K. ramanathan Indus.rial Biotechnology Divis.on School of Bio Sciences and Technology VIT University Vellore - 632014 Tamil Nadu India

Branchio-oto-renal s.ndrome （BOR） is.autos.mal dominant dis.rder which generates.hearing impairment and kidney failures.in affected individuals. The dis.as. genomic maps.were drawn back in recent years. demons.rating, mis.ens. mutations.res.ons.ble in dis.as. were located in s.X1, EYA1 and EYA2 genes. We try to uncover molecular biology of the s.ndrome with bioinformatics.pers.ective, taking s.X1 and EYA2 protein interaction at center point. The s.udy initiated with 23 natural mutations.of s.X1 gene. They were firs. analyzed with prediction s.rvers.like s.FT, PolyPhen2, I Mutant, s.Ps.GO, PHD-s.P and Panther, to identify their impact on their s.ructural s.ability and function. s.bs.quently it narrowed down to s.ven cons.s.ent with our ques.. They were analyzed on IUPred dis.rder prediction s.rver. Later s.X1 and its.all mutant proteins.were docked with EYA2 protein us.ng GRAMM-X s.rver. The binding affinity of docked s.ructures.was.analyzed us.ng DFIRE2 algorithm. The res.lts.jus.ify the earlier wet laboratory s.udies.and indicate the reas.n behind them. Finally we s.mmarize that the proven inactivity of all other mutants.is.due to the s.ructural dis.rder created by mutations. hence us.al molecular interaction is.hindered; s.rangely protein interaction takes.place at DNA binding s.te of s.X1 mutants.

关键词： branchio-oto-renal s.ndrome (BOR) hearing los. damaging mutations s.X1 EYA2 protein-protein interactions