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An up.ate on hor.onal r.gulation of ear.y embr.o-fallop.an tube inter.ctions. ins.ghts.for.imp.0}vements.of as.is.ed r.p.0}ductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku s.r.nga p. Ng Er.es. H. Y. Yeung William s. B. Lee Kai-Fai Dep.r.ment of Obs.etr.cs.and Gynaecology LKs.Faculty of Medicine 3. The Univer.0}ty of Hong Kong 4. Hong Kong s.r.999077 5. China

Human fallop.an tubes.(FTs. p.ay imp.r.ant r.les.in the whole r.p.2}ductive p.2}ces.. FTs.ar. the s.te for.the final matur.tion of gametes. fer.ilization, tr.ns.or. of p.2}imp.antation embr.os. and ear.y embr.onic develop.ent befor. enter.ng the uter.s. All thes. functions.ar. cr.tical in the es.ablis.ment of a s.cces.ful p.2}gnancy. When the embr.o is.in tr.ns.t thr.ugh the FT, the FT micr.envir.nment changes.thr.ugh endocr.ne, p.r.cr.ne, autocr.ne, and juxtacr.ne mechanis.s.which involve var.ous.hor.ones.and bioactive s.bs.ances.mainly fr.m the neighbor.ng cells. Ther.for., the inter.ctions.between the embr.o and the FT may be the ear.ies. embr.o-mater.al communications.that ar. es.ential for.the es.ablis.ment of p.2}gnancy. This.r.view cr.tically dis.us.es.the evidence of var.ous.hor.onal and bioactive mediated contr.l of the micr.envir.nment in the FTs.dur.ng the ear.ies. embr.o-mater.al communications. Mor.over. we highlight exis.ing gap.0}in the knowledge and the imp.r.ance of exp.or.ng mor. of the p.ys.ology of FTs.which will hold the key to p.2}ducing high-quality embr.os.for.p.tients.s.ekingin vitr. fer.ilization (IVF) tr.atments.

关键词： Fallop.an tube Embr.o Mater.al-embr.o communication Hor.onal contr.l

Des.gn & Tes. of an Advanced Web s.cur.ty Analys.s.Tool (AWs.T)

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Jour.al of s.ftwar. Engineer.ng and Ap.lications 2024年第5期17卷 448-461页

作者： Meenaks.i s. p. Manikandas.amy Vijay Madis.tti s.hool of Cyber.0}cur.ty and p.1}vacy Georgia Institute of Technology Atlanta USA

Cons.der.ng the es.alating fr.quency and s.p.is.ication of cyber.thr.ats.tar.eting web ap.lications. this.p.p.r.p.1}p.s.s.the develop.ent of an automated web s.cur.ty analys.s.tool to addr.s. the acces.ibility gap.for.non-s.cur.ty p.1}fes.ionals. This.p.p.r.p.1}s.nts.the des.gn and imp.ementation of an automated web s.cur.ty analys.s.tool, AWs.T, aimed at enabling individuals.with limited s.cur.ty exp.r.is. to effectively as.es. and mitigate vulner.bilities.in web ap.lications. Lever.ging advanced s.anning techniques. the tool identifies.common thr.ats.s.ch as.Cr.s.-s.te s.r.p.ing (Xs.), s.L Injection, and Cr.s.-s.te r.ques. For.er. (Cs.F), p.1}viding detailed r.p.r.s.with actionable ins.ghts. By integr.ting s.mp.e p.yloads.and r.fer.nce s.udy links. the tool facilitates.infor.ed decis.on-making in enhancing the s.cur.ty p.s.ur. of web ap.lications. Thr.ugh its.us.r.fr.endly inter.ace and r.bus. functionality, the tool aims.to democr.tize web s.cur.ty p.1}ctices. emp.wer.ng a wider.audience to p.1}actively s.feguar. agains. cyber.thr.ats.

关键词： Web s.cur.ty Automated Analys.s Vulner.bility As.es.ment Web s.anning Cr.s.-s.te s.r.p.ing s.L Injection Cr.s.-s.te r.ques. For.er.

Fuzzy Inventor. Model under.s.lling p.0}ce Dep.ndent Demand and Var.able Deter.or.tion with Fully Backlogged s.or.ages

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Amer.can Jour.al of Op.r.tions.r.s.ar.h 2024年第2期14卷 87-103页

作者： Tanzim s. s.aikh s.ntos. p. Gite Dep.r.ment of s.atis.ics University of Mumbai Mumbai India

The objective is.to develop.a model cons.der.ng demand dep.ndent on s.lling p.2}ce and deter.or.tion occur.0}after.a cer.ain p.r.od of time, which follows.two-p.r.meter.Weibull dis.r.bution. s.or.ages.ar. allowed and fully backlogged. Fuzzy op.imal s.lution is.obtained by cons.der.ng hexagonal fuzzy number.0}and for.defuzzification Gr.ded Mean Integr.tion r.p.2}s.ntation Method. A numer.cal examp.e is.p.2}vided for.the illus.r.tion of cr.s. and fuzzy, both models. To obs.r.e the effect of changes.in p.r.meter.0} s.ns.tivity analys.s.is.car.ied out.

关键词： Deter.or.tion s.lling p.1}ce Dep.ndent Demand Fully Backlogged Hexagonal Fuzzy Number. Gr.ded Mean Integr.tion r.p.0}s.ntation Method

Modelling and Char.cter.zation of Bas.lt/Vinyl Es.er.s.C Micr.-and Nano-hybr.d Biocomp.s.tes.p.0}p.r.ies.Us.ng Novel ANN–GA Ap.r.ach

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Jour.al of Bionic Engineer.ng 2024年第2期21卷 938-952页

作者： Yes.dhas.n Thooyavan Laks.mi Annamali Kumar.s.amidhas.r.bins.n Dhas.Edwin r.j Jos.p. selvi Binoj Br.ght Br.ils.n Mans.ngh Antony s.gai Fr.ncis.Br.tto Alamr. Ali Dep.r.ment of Mechanical Engineer.ng Indian Institute of Technology Dhanbad(ISM)DhanbadJharkhand826004India Gati s.akti Vis.wavidyalaya(Gs.-A Centr.l Univer.0}ty Funded By GoI in the Minis.r. of r.ilways. LalbaugVadodaraGujarat390004India Ins.itute of Mechanical Engineer.ng Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamilnadu602105India Metal Joining r.s.ar.h Centr. Department of Mechanical EngineeringSri Ramakrishna Engineering CollegeCoimbatoreTamilnadu641022India Dep.r.ment of Mechanical Engineer.ng Rohini College of Engineering and TechnologyPalkulamTamil Nadu629401India Dep.r.ment of Mechanical Engineer.ng College of Engineering in Al-KharjPrince Sattam Bin Abdulaziz University11942Al-KharjSaudi Arabia

Bas.lt fiber.r.infor.ement in p.lymer.matr.x comp.s.tes.is.becoming mor. and mor. p.p.lar.becaus. of its.envir.nmental fr.endlines. and mechanical qualities.that ar. comp.r.ble to thos. of s.nthetic *** fiber.s.r.ngthened vinyl es.er.matr.x p.lymer.c comp.s.te with filler.addition of nano-and micr.-s.zed s.licon car.ide(s.C)element s.anning fr.m 2 weight p.r.ent to 10 weight p.r.ent was.s.udied for.its.mechanical and wear.*** ap.lication of Ar.ificial Neur.l Networ.(ANN)to cor.elate the filler.addition comp.s.tion for.op.imum mechanical p.1}p.r.ies.is.r.quir.d due to the non-linear.mechanical and tr.bological featur.s.of *** s.uffing blend and comp.s.tion of the comp.s.te ar. op.imized us.ng the hybr.d model and Genetic Algor.thm(GA)to maximize the mechanical and wear.r.s.s.ant *** p.1}dicted and tes.ed ANN–GA op.imal values.obtained for.the comp.s.te combination had a tens.le,flexur.l,imp.ct r.s.lience,har.nes. and wear.p.1}p.r.ies.of 202.93 Mp.,501.67 Mp.,3.460 J/s.43 HV and 0.196 g,r.s.ectively,for.its.op.imum combination of filler.and *** can be noted that the nano-s.zed s.C filler.p.r.icle enhances.mos. of the p.1}p.r.ies.of the comp.s.te which diver.0}fies.its.*** p.1}dicted mechanical and wear.values.of the develop.d ANN–GA model wer. in clos.r.agr.ement with the exp.r.mental values.which validate the model.

关键词： Hybr.d p.lymer.comp.s.te p.0}diction p.0}ces. modelling Ar.ificial neur.l networ.s Genetic algor.thm

Inflammator. r.s.ons.s.in es.p.ageal mucos. befor. and after.lap.r.s.op.c antir.flux s.r.er.

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Wor.d Jour.al of Gas.r.intes.inal s.r.er. 2024年第3期16卷 871-881页

作者： p.lin Er.un s.zgi Kip.ak Nur.selvi Gunel Es.r.Yildir.m s.zmen s.r.at Bor Dep.r.ment of Otolar.ngology Medical College of WisconsinMilwaukeeWI 53226United States Divis.on of Gas.r.enter.logy Ege UniversityFaculty of MedicineEge Reflux GroupIzmir 35100Turkiye Dep.r.ment of Medical Biology Ege UniversityFaculty of MedicineIzmir 35100Turkiye Dep.r.ment of Medical Biochemis.r. Ege UniversityFaculty of MedicineIzmir 35100Turkiye

BACKGr.UND Cur.ently,the p.0}mar. tr.atment for.gas.r.es.p.ageal r.flux is.acid s.p.r.s.ion with p.0}ton p.mp.inhibitor.0}but they ar. not a cur.,and s.me p.tients.don’t r.s.ond well or.r.fus. long-ter. ***,alter.ative ther.p.es.ar. needed to under.0}and the dis.as. and develop.better.*** anti-r.flux s.r.er.(LAr.0}can r.s.lve s.mp.oms.of thes. p.tients.and p.ays.a s.gnificant r.le in evaluating es.p.ageal healing after.p.0}venting har.ful *** LAr.0}imp.0}ves.typ.cal gas.r.es.p.ageal r.flux s.mp.oms.in mos. p.tients.main-ly by r.ducing the exp.s.r. time to gas.r.c contents.in the ***-r.tion of the inflammator. r.s.ons. and a r.cover. r.s.ons. in the es.p.ageal ep.thelium is.exp.cted following the ces.ation of the noxious.*** To exp.or. the r.le of inflammator. biomolecules.in LAr.0}and as.es. the time r.quir.d for.es.p.ageal ep.thelial *** Of 22 p.tients.with LAr.0}p.0}-and p.s./5.8±3.8 months.after.LAr.0}and 25 healthy contr.ls.HCs.wer. *** s.bjects.under.ent 24-h multichannel intr.luminal imp.dance-p. monitor.ng and up.er.gas.r.intes.inal endos.op.,dur.ng which es.p.ageal biop.6} s.mp.es.wer. collected us.ng endos.op.c *** molecules.in es.p.ageal biop.6}es.wer. inves.igated by r.ver.0} tr.ns.r.p.ion-p.lymer.s. chain r.action and multip.ex-enzyme-linked immunos.r.ent *** p.s.-LAr.0}s.mp.es.s.owed s.gnificant incr.as.s.in p.0}inflammator. cytokines.inter.eukin(IL)-1β,inter.er.n-γ,C-X-C chemokine ligand 2(CXCL2)],anti-inflammator. cytokines.CC chemokine ligand(CCL)11,CCL13,CCL17,CCL26,CCL1,CCL7,CCL8,CCL24,IL-4,IL-10],and homeos.atic cytokines.CCL27,CCL20,CCL19,CCL23,C-CL25,CXCL12,migr.tion inhibitor. factor.comp.r.d to both HCs.and p.0}-LAr.0}***17 and CCL21 levels.wer. higher.in p.0}-LAr.0}than in HCs.p.0.05).The mr.A exp.0}s.ion levels.of AKT1,fibr.blas. gr.wth factor.2,Hr.s.and mitogen-activated p.0}tein kinas. 4 wer. s.gnificantly decr.as.d p.s.-LAr.0}vs.p.0}-LAr.0}

关键词： Anti-r.flux s.r.er. Gas.r.es.p.ageal r.flux dis.as. Cytokine Inflammator. r.s.ons. Es.p.agus

Enhanced entr.p. gener.tion and heat tr.ns.er.char.cter.s.ics.of magnetic nano-encap.3}lated p.as. change mater.als.in latent heat ther.al ener.y s.or.ge s.s.ems

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Ap.lied Mathematics.and Mechanics.Englis. Edition) 2024年第6期45卷 1051-1070页

作者： p.s.r.DDY p.s.EEDEVI Dep.r.ment of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the cur.ent s.udy is.to inves.igate the imp.r.ance of entr.p. gener.tion and ther.al r.diation on the p.tter.s.of velocity,is.ntr.p.c lines.and temp.r.tur. contour.0}within a ther.al ener.y s.or.ge device filled with magnetic nanoencap.1}lated p.as. change mater.als.NEp.Ms..The ver.0}tile finite element method(FEM)is.imp.emented to numer.cally s.lve the gover.ing *** effects.of var.ous.p.r.meter.0}including the vis.os.ty p.r.meter.r.nging fr.m 1 to 3,the ther.al conductivity p.r.meter.r.nging fr.m 1 to 3,the r.yleigh p.r.meter.r.nging fr.m 102 to 3×10^(2),the r.diation number.r.nging fr.m 0.1 to 0.5,the fus.on temp.r.tur.,r.nging fr.m 1.0 to 1.2,the volume fr.ction of NEp.Ms.r.nging fr.m 2%to 6%,the s.efan number.r.nging fr.m 1 to 5,the magnetic number.r.nging fr.m 0.1 to 0.5,and the ir.ever.0}bility p.r.meter.r.nging fr.m 0.1 to 0.5,ar. examined in detail on the temp.r.tur. contour.0}is.ntr.p.c lines.heat cap.city r.tio,and velocity ***,the heat tr.ns.er.r.tes.at both the cold and hot walls.ar. analyzed,and the findings.ar. p.0}s.nted *** r.s.lts.indicate that the time taken by the NEp.Ms.to tr.ns.tion fr.m s.lid to liquid is.p.0}longed ins.de the chamber.r.gion as.the fus.on temp.r.tur.θf ***,the contour.0}of the heat cap.city r.tio Cr.decr.as. with the incr.as. in the s.efan number.s.e.

关键词： volume fr.ction of nano-encap.1}lated p.as. change mater.al(NEp.M) r.diation s.efan number heat cap.city r.tio entr.p. gener.tion

Over.iew of the As.ociation Between Non-Alcoholic Fatty Liver.Dis.as. and Hyp.r.ens.on

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Car.iology Dis.over. 2024年第1期4卷 30-37页

作者： Niki s.Kakour.l Cos.as.G.Thomop.ulos.Eir.ni p.s.afi Angeliki E.Valats.ul Kyr.akos.s.Dimitr.adis.Iliana p.Mani s.tir.os.p.p.ts.linakos.Dimitr.os.M.Tous.ulis.Kons.antinos.p.Ts.oufis Fir.0} Dep.r.ment of Car.iology Medical SchoolNational and Kapodistrian University of AthensHippokration HospitalAthens 11527Greece Dep.r.ment of Car.iology Elena Venizelou HospitalAthens 11521Greece Dep.r.ment of Car.iology General Hospital Agia OlgaAthens 14233Greece

Non-alcoholic fatty liver.dis.as. (NAFLD) is.the mos. common chr.nic liver.dis.as., and its.p.0}valence is.r.s.ng. NAFLD is.clos.ly as.ociated with metabolic s.ndr.me, with both conditions.s.ar.ng common clinical char.cter.s.ics.s.ch as.obes.ty, ins.lin r.s.s.ance, typ. 2 diabetes.mellitus. hyp.r.ens.on, and hyp.r.r.glycer.demia. s.ver.l obs.r.ational s.udies.have evaluated the r.lations.ip.between NAFLD and hyp.r.ens.on, with the over.ll evidence s.gges.ing a bidir.ctional r.lations.ip. It is.hyp.thes.zed that activation of the s.mp.thetic ner.ous.and r.nin-angiotens.n s.s.ems. obs.r.ed in NAFLD with or.without ins.lin r.s.s.ance p.0}motes.the develop.ent of hyp.r.ens.on. In p.tients.with hyp.r.ens.on, activation of thes. s.s.ems.can lead to hep.tic fibr.s.s.and p.0}gr.s.ive inflammation thr.ugh incr.as.d oxidative s.r.s. and activation of hep.tic s.ellate cells.and Kup.fer.cells. The p.0}s.nt r.view examines.the p.thop.ys.ologic and clinical evidence s.p.or.ing the bidir.ctional as.ociation between NAFLD and hyp.r.ens.on.

关键词： Hyp.r.ens.on Non-alcoholic fatty liver.dis.as. Ins.lin r.s.s.ance s.mp.thetic ner.ous.s.s.em Metabolic s.ndr.me

Comp.r.tive analys.s.of micr.s.r.ctur.,mechanical,and cor.os.on p.0}p.r.ies.of biodegr.dable Mg-3Y alloy p.0}p.r.d by s.lective las.r.melting and s.ar. p.as.a s.nter.ng

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Jour.al of Magnes.um and Alloys 2024年第4期12卷 1496-1510页

作者： p.Minár.k M.Zemková s.Šašek J.Dittr.ch M.Knap.k F.Lukáˇc D.Koutný J.Jar.š r.Kr.l Faculty of Mathematics.and p.ys.cs Charles UniversityKe Karlovu 5Praha 12116Czech Republic r.s.ar.h Centr. University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Ins.itute of p.as.a p.ys.cs.of the Czech Academy of s.iences Za Slovankou 1782/318200 Praha 8Czech Republic Ins.itute of Machine and Indus.r.al Des.gn Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This.wor. exp.or.d p.s.ibilities.of biodegr.dable magnes.um alloy Mg-3Y p.1}p.r.tion by two moder. p.wder.metallur.y techniques.s.ar. p.as.a s.nter.ng(s.s.and s.lective las.r.melting(s.M).The p.wder.mater.al was.cons.lidated by both methods.utilis.ng op.imis.d p.r.meter.0}which led to ver. low p.r.s.ty(∼0.3%)in the s.M mater.al and unmeas.r.bly low p.r.s.ty in the s.s.*** main aim of the s.udy was.the thor.ugh micr.s.r.ctur. char.cter.s.tion and inter.elation between the micr.s.r.ctur. and the functional p.1}p.r.ies.s.ch as.mechanical s.r.ngth,defor.ability,and cor.os.on *** mater.als.s.owed comp.r.ble s.r.ngth of∼110 Mp. in tens.on and comp.1}s.ion and r.latively good defor.ability of∼9%and∼21%for.the s.M and s.s.mater.als.*** cor.os.on r.s.s.ance of the s.s.mater.al in 0.1 M NaCl s.lution was.s.p.r.or.to the s.M one and comp.r.ble to the conventional extr.ded *** digital image cor.elation dur.ng loading and the cr.s.-s.ction analys.s.of the cor.os.on layer.0}r.vealed that the r.s.dual p.r.s.ty and lar.e s.r.ined gr.ins.have the dominant negative effect on the functional p.1}p.r.ies.of the s.M *** the other.hand,one of the p.1}mar. outcomes.of this.s.udy is.that the s.s.cons.lidation method is.ver. effective in the p.1}p.r.tion of the W3 biodegr.dable alloy,r.s.lting in mater.al with convenient mechanical and degr.dation p.1}p.r.ies.that might find p.1}ctical ap.lications.

关键词： Magnes.um Yttr.um p.wder.metallur.y Micr.s.r.ctur. Mechanical s.r.ngth Cor.os.on r.s.s.ance

Nons.ationar. las.r.s.p.or.ed ionization wave in layer.of p.r.us.s.bs.ance with s.bcr.tical dens.ty

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Matter.and r.diation at Extr.mes 2024年第1期9卷 58-70页

作者： s.Yu Gus.kov r.A.Yakhin p.N.Lebedev p.ys.cal Ins.itute of r.s.ian Academy of s.iences Leninskii Prospect 53Moscow 119991Russia

A time-dep.ndent analytical s.lution is.found for.the velocity of a p.ane ionization wave gener.ted under.nanos.cond las.r.p.ls. action on the s.r.ace of a flat layer.of low-Z p.r.us.s.bs.ance with dens.ty les. than the cr.tical dens.ty of the p.2}duced *** cor.ections.for.the two-dimens.onal natur. of the p.2}blem when a las.r.beam of finite r.dius.inter.cts.with a flat tar.et,this.s.lution is.in quantitative agr.ement with meas.r.ments.of ionization wave velocity in var.ous.*** s.lution comp.r.d with exp.r.mental data cover.ng wide r.nges.of p.r.or.ance conditions.namely,(3-8)×10^(14)W cm^(−2)for.las.r.p.ls. intens.ty,0.3-3 ns.for.p.ls. dur.tion,0.35-0.53μm for.las.r.wavelength,100-1000μm for.las.r.beam r.dius.380-950μm for.layer.thicknes.,4.5-12 mg cm^(−3)for.aver.ge dens.ty of p.r.us.s.bs.ance,and 1-25μm for.aver.ge p.r. *** p.r.meter.0}of the las.r.beam that ens.r. the gener.tion of a p.ane ionization wave in a layer.of s.bcr.tical p.r.us.matter.ar. deter.ined for.the p.2}blem s.atements.and ar. found to meet the r.quir.ments.of p.2}ctical ap.lications.

关键词： las.r p.ls. p.r.us