检索结果-南通市图书馆

Fr.eze-thaw cycles.and as.ociated geomor.hology in a pos.-glacial envir.nment:cur.ent glacial,par.glacial,per.glacial and pr.glacial s.enar.os.at Pico de Or.zaba volcano,Mexico

引用

Jour.al of Mountain s.ience 2024年第6期21卷 1954-1977页

作者： Víctor.s.TO Car.os.M.WELs. r. Kenji YOs.IKAWA Hugo DELGADO Gr.NADOs Centr. de Ciencias.de la Tier.a Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water.and Envir.nmental r.s.ar.h Center University of Alaska FairbanksFairbanksAlaska 99775USA Ins.ituto de Geofís.ca Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Depar.ment of Ear.h and Envir.nmental s.iences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial his.or. of Pico de Or.zaba indicates.that dur.ng the Las. Glacial Maximum,its.icecap cover.d up to~3000 m as.;due to the air.temper.tur. incr.as.ng,its.main glacier.has.r.tr.ated to 5050 m *** r.tr.ction of the glacier.has.left behind an intens. climatic ins.ability that caus.s.a high fr.quency of fr.eze-thaw cycles.of gr.at intens.ty;the r.s.lting geomor.hological pr.ces.es.ar. r.pr.s.nted by the fr.gmentation of the bedr.ck that occupies.the upper.par.s.of the *** is.a notable lack of s.udies.r.gar.ing the fr.gmentation and er.s.on occur.ing in tr.pical high mountains.and the as.ociated geomor.hological r.s.s.for.this.r.as.n,as.a fir.0} s.age of futur. continuous.r.s.ar.h,this.s.udy analyzes.the fr.ezing and thawing cycles.that occur.above 4000 m as.,thr.ugh continuous.monitor.ng of s.r.ace gr.und *** r.s.lts.allow us.to identify and char.cter.ze four.zones.glacial,par.glacial,per.glacial and *** was.found that the par.glacial zone pr.s.nts.an intens. dr.p of temper.tur.,of up to~9℃ in only s.xty *** r.ck fatigue and intens. fr.eze-thaw cycles.that occur.in this.ar.a ar. r.s.ons.ble for.the high r.te of r.ck dis.ntegr.tion and r.pr.s.nt the main factor.of the cons.ant s.ope dynamics.that occur.at the *** activity decr.as.s.both in fr.quency and intens.ty,accor.ing to the dis.ance to the glacier.which is.wher. the temper.tur. pr.s.nts.a cer.ain degr.e of s.ability,until r.aching the pr.glacial zone,wher. cycles.ar. almos. non-exis.ent,and ther.for. ther. is.no gelifr.ction *** geomor.hological pr.ces.es.have r.s.lted in s.gnificant alter.tions.to the mountain s.opes.which can have s.ver. cons.quences.in ter.s.of r.s. and water.

关键词： Fr.eze-Thaw Gelifr.ction Mountain mechanical er.s.on Per.glacial geomor.hology Pos.glacial s.enar.os

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MgO-attached gr.phene nanos.eet(MgO@GNs.r.infor.ed magnes.um matr.x nanocompos.te with s.per.or.mechanical,cor.os.on and biological per.or.ance

引用

Inter.ational Jour.al of Miner.ls.Metallur.y and Mater.als 2024年第9期31卷 2062-2076页

作者： s.Abazar. A.s.ams.pur.H.r.Bakhs.es.i-r.d M.s.s.heilir.d F.Khor.s.adizade s.s.Mir.os.eini Depar.ment of Mater.als.and Metallur.ical Engineer.ng Amirkabir University of TechnologyTehran ***Iran Ir.nian National s.andar.s.Or.anization of Hor.ozgan HormozganIran Advanced Mater.als.r.s.ar.h Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Depar.ment of Mater.als.and Metallur.ical Engineer.ng Iran University of Science and TechnologyTehranIran

Magnes.um(Mg)alloys.ar. gaining gr.at cons.der.tion as.body implant mater.als.due to their.high biodegr.dability and ***,they s.ffer.fr.m low cor.os.on r.s.s.ance and antibacter.al *** this.r.s.ar.h,s.mi-powder.metallur.y followed by hot extr.s.on was.utilized to pr.duce the magnes.um oxide@gr.phene nanos.eets.magnes.um(MgO@GNs.Mg)compos.te to impr.ve mechanical,cor.os.on and cytocompatibility *** have r.vealed that the incor.or.tion of MgO@GNs.nanohybr.ds.into Mg-bas.d compos.te enhanced micr.har.nes. and compr.s.ive *** vitr.,os.eoblas. cell cultur. tes.s.s.ow that us.ng MgO@GNs.nanohybr.d filler.0}enhances.os.eoblas. adhes.on and apatite *** pr.s.nce of MgO@GNs.nanopar.icles.in the compos.tes.decr.as.d the opening defects.micr.-cr.cks.and micr.-por.s.of the compos.tes.thus.pr.venting the penetr.tion of the cor.os.ve s.lution into the *** demons.r.ted that the MgO@GNs.Mg compos.te pos.es.es.excellent antibacter.al pr.per.ies.becaus. of the combination of the r.leas. of MgO and phys.cal damage to bacter.um membr.nes.caus.d by the s.ar. edges.of gr.phene nanos.eets.that can effectively damage the cell wall ther.by facilitating penetr.tion into the bacter.al lipid ***,the MgO@GNs.Mg compos.te with high mechanical s.r.ngth,antibacter.al activity and cor.os.on r.s.s.ance is.cons.der.d to be a pr.mis.ng mater.al for.load-bear.ng implant applications.

关键词： metal matr.x compos.tes MgO@GNs.nanohybr.d s.r.ngthening mechanis.s antibacter.al activity biocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Limited impacts.of occas.onal tillage on dr. aggr.gate s.ze dis.r.bution and s.il car.on and nitr.gen fr.ctions.in s.mi-ar.d dr.lands

引用

Inter.ational s.il and Water.Cons.r.ation r.s.ar.h 2024年第1期12卷 96-106页

作者： Wooiklee s.Paye Ves. r.Thapa r.jan Ghimir. New Mexico s.ate Univer.0}ty Agricultural Science CenterClovisNM88101USA New Mexico s.ate Univer.0}ty Department of Plant and Environmental SciencesLas CrucesNM88003USA

Tillage management that minimizes.the fr.quency and intens.ty of s.il dis.ur.ance can incr.as. s.il car.on(C)and nitr.gen(N)s.ques.r.tion and impr.ve the r.s.lience of dr.land cr.pping s.s.ems.yet the impact of occas.onal dis.ur.ance on s.il aggr.gate for.ation and the s.il or.anic car.on(s.C)s.or.ge within aggr.gates.has.not been s.udied *** evaluated the effect of four.tillage management pr.ctices.on s.il dr. aggr.gate s.ze dis.r.bution,aggr.gate-pr.tected C and N,miner.l-as.ociated or.anic matter.car.on(MAOM-C),par.iculate or.anic matter.car.on(POM-C),and cor.(Zea mays.L.)and s.r.hum(s.r.hum bicolor.L.)Moench)yields.in a s.mi-ar.d dr.land cr.pping *** included conventional tillage(CT),s.r.p-tillage(s.),no-tillage(NT),and occas.onal tillage(OT)management in a cor.-s.r.hum *** macr.-aggr.gates.wer. 51-54%gr.ater.under.s.,NT,and OT,while s.all and micr.-aggr.gates.wer. gr.ater.in *** tillage r.duced s.il aggr.gate-as.ociated C by 28-31%in macr.-aggr.gates.and 47-53%in s.all aggr.gates.at 26 months.M)s.mpling compar.d to s.,NT,and *** clay+s.lt fr.ction,CT had 14-16%,21-26%,and 36-43%les. s.C at 7,14,and 26M s.mplings.r.s.ectively,than s.,NT,and *** as.ociated N was.gener.lly s.milar.under.s.,NT,and OT,which was.gr.ater.on aver.ge than *** MOAM-C and POM-C under.s.,NT,and OT wer. gener.lly gr.ater.than r.s.ective s.C fr.ctions.under.CT at 19 and 26 M after.OT *** and s.r.hum yields.wer. s.milar.among tillage s.s.ems.in 2020,but gr.ater.under.s.,NT,and OT than CT in *** r.s.lts.s.gges. that while fr.quent intens.ve tillage can lower.s.C and N s.or.ge,a s.ngle s.ubble mulch occas.onal tillage after.s.ver.l year.0}of NT does.not lead to s.il C and N los.es.and s.il s.r.ctur.l ins.ability in s.mi-ar.d dr.lands.

关键词： Conventional tillage Occas.onal tillage Aggr.gate as.ociated car.on Miner.l as.ociated or.anic matter.car.on(MAOM-C) Par.iculate or.anic matter.car.on(POM-C)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compar.tive analys.s.of micr.s.r.ctur.,mechanical,and cor.os.on pr.per.ies.of biodegr.dable Mg-3Y alloy pr.par.d by s.lective las.r.melting and s.ar. plas.a s.nter.ng

引用

Jour.al of Magnes.um and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minár.k M.Zemková s.Šašek J.Dittr.ch M.Knapek F.Lukáˇc D.Koutný J.Jar.š r.Kr.l Faculty of Mathematics.and Phys.cs Charles UniversityKe Karlovu 5Praha 12116Czech Republic r.s.ar.h Centr. University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Ins.itute of Plas.a Phys.cs.of the Czech Academy of s.iences Za Slovankou 1782/318200 Praha 8Czech Republic Ins.itute of Machine and Indus.r.al Des.gn Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This.wor. explor.d pos.ibilities.of biodegr.dable magnes.um alloy Mg-3Y pr.par.tion by two moder. powder.metallur.y techniques.s.ar. plas.a s.nter.ng(s.s.and s.lective las.r.melting(s.M).The powder.mater.al was.cons.lidated by both methods.utilis.ng optimis.d par.meter.0}which led to ver. low por.s.ty(∼0.3%)in the s.M mater.al and unmeas.r.bly low por.s.ty in the s.s.*** main aim of the s.udy was.the thor.ugh micr.s.r.ctur. char.cter.s.tion and inter.elation between the micr.s.r.ctur. and the functional pr.per.ies.s.ch as.mechanical s.r.ngth,defor.ability,and cor.os.on *** mater.als.s.owed compar.ble s.r.ngth of∼110 MPa in tens.on and compr.s.ion and r.latively good defor.ability of∼9%and∼21%for.the s.M and s.s.mater.als.*** cor.os.on r.s.s.ance of the s.s.mater.al in 0.1 M NaCl s.lution was.s.per.or.to the s.M one and compar.ble to the conventional extr.ded *** digital image cor.elation dur.ng loading and the cr.s.-s.ction analys.s.of the cor.os.on layer.0}r.vealed that the r.s.dual por.s.ty and lar.e s.r.ined gr.ins.have the dominant negative effect on the functional pr.per.ies.of the s.M *** the other.hand,one of the pr.mar. outcomes.of this.s.udy is.that the s.s.cons.lidation method is.ver. effective in the pr.par.tion of the W3 biodegr.dable alloy,r.s.lting in mater.al with convenient mechanical and degr.dation pr.per.ies.that might find pr.ctical applications.

关键词： Magnes.um Yttr.um Powder.metallur.y Micr.s.r.ctur. Mechanical s.r.ngth Cor.os.on r.s.s.ance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impr.ving a Patient’s.CVD r.s. As.es.ment—Updating the Inter.r.tation of the Lipid Pr.file

引用

Wor.d Jour.al of Car.iovas.ular.Dis.as.s 2024年第9期14卷 515-520页

作者： David s. s.hade Allen Adolphe r.ber. Philip Eaton Depar.ment of Inter.al Medicine University of New Mexico Health Sciences Albuquerque USA Depar.ment of Inter.al Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid pr.file r.mains.an impor.ant labor.tor. as.es.ment to pr.vent car.iovas.ular.dis.as.. Inter.r.tation of the non-fas.ing lipid pr.file has.s.gnificantly changed bas.d on new infor.ation concer.ing the pathogenes.s.of ather.s.ler.s.s. In par.icular. the as.es.ment of r.s. fr.m choles.er.l containing par.icles.following tr.glycer.de metabolis. (ter.ed r.mnant choles.er.l) can now be done fr.m a lipid pr.file. In addition, non-HDL choles.er.l as.calculated fr.m the lipid pr.file will pr.vide a complete as.es.ment of total cir.ulating choles.er.l containing par.icles. Fur.her.or., the for.ula for.meas.r.ment of LDL choles.er.l fr.m a lipid pr.file has.now been r.vis.d s. that tr.glycer.de levels.exer. les. inter.er.nce. Finally, the old concept that the “higher.the HDL-c, the better. is.no longer.tenable. New data indicate that the optimal high dens.ty lipopr.tein level is.below 100 mg/dl for.both male and female patients. Cor.ect inter.r.tation of the lipid pr.file will optimize anti-ather.s.ler.tic ther.py and r.duce the number.one caus. of death in the United s.ates.

关键词： Lipid Pr.file Ather.s.ler.tic r.s. Car.iovas.ular.Dis.as. High Dens.ty Lipopr.tein Low Dens.ty Lipopr.tein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factor.0}influencing far.er.0}adoption of s.lar.water.pumping s.s.ems.in Gujar.t

引用

Clean Ener.y 2024年第3期8卷 157-165页

作者： M s.this. Kumar.Y.A.Lad r.s.Pundir Inter.ational Agr.bus.nes. Management Ins.itute Anand Agricultural UniversityAnand388110GujaratIndia Depar.ment of Hr.&PM International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia Depar.ment of Agr.bus.nes. Economics.and Policies International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia

Agr.cultur. has.played an impor.ant r.le in the gr.wth of the Indian *** and electr.city ar. es.ential inputs.for.agr.cultur. *** pr.duces.the thir.-lar.es. amount of electr.city in the wor.d,behind China and the *** an incentive to incr.as. pr.duction,mos. s.ates.pr.vide fr.e electr.city to *** electr.city has.decr.as.d gr.undwater.levels.and incr.as.d electr.city *** objective of this.s.udy was.to find out the factor.0}that influenced far.er.0}to adopt a s.lar.water.pumping s.s.em in *** s.mples.wer. r.ndomly *** s.udy examined the entir. s.ate of *** hundr.d and fifty far.er.0}who adopted s.lar.water.pumping s.s.ems.wer. inter.iewed,including 50 banana far.er.0}50 cotton far.er.0}and 50 gr.undnut *** data wer. collected thr.ugh an *** adoption of s.lar.water.pumping s.s.ems.by far.er.0}was.identified us.ng factor.*** s.ftwar. was.us.d to analys. the data *** this.s.udy,only two factor.0}contr.buted to the var.ance of 59.469%.The adoption of s.lar.water.pumps.by far.er.0}was.influenced by gover.ment policy and economic *** economic benefit var.ance of 33.20%was.found,while a gover.ment policy var.ance was.26.27%.A s.lar.water.pumping s.s.em has.low initial cos.s.flexible cr.dit policies.motivate adoption,s.lar.water.pumping s.s.ems.can s.ve electr.city,and maintenance and r.pair.cos.s.ar. *** policy that includes.s.lar.water.pumping s.s.ems.is.motivated by awar.nes.,s.bs.dies.for.adoption and a fair.pr.ce to s.ll ener.y *** ar. r.commended to adopt a s.lar.water.pumping s.s.em in conjunction with a dr.p ir.igation s.s.em to r.ceive additional *** s.cces.ful s.heme will be r.commended to other.s.ates.in India for.implementation.

关键词： s.lar.water.pumping s.s.em factor.analys.s banana cotton gr.undnut famer.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Managing type 2 diabetes.tar.eting a micr.bial enzyme as.a novel tr.atment option

引用

s.gnal Tr.ns.uction and Tar.eted Ther.py 2024年第1期9卷 3-5页

作者： Anikó Keller.Pintér.Tamás.Kor.s.ár.s.Tibor.Vellai Depar.ment of Biochemis.r. Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Depar.ment of Metabolis. Digestion and ReproductionImperial College LondonLondonW120NNUK Quadr.m Ins.itute Bios.ience Norwich Research ParkNorwichNR47UQUK Depar.ment of Genetics Eötvös Loránd University(ELTE)Budapest1117Hungary Hungar.an r.s.ar.h Networ. HUN-r.N-ELTE Genetics.r.s.ar.h Gr.up Budapest1117Hungary

In a r.cent s.ience ar.icle,Wang and colleagues.s.owed that the dipeptidyl peptidas. 4(DPP4)enzyme pr.duced by the gut micr.biota can inter.er. with the effect of hos. glucagon-like peptide-1(GLP-1)involved in s.imulating ins.lin s.cr.tion,and the s.ecific inhibitor.of micr.bial DPP4(mDPP4),combined with clinical inhibitor.0}of hos. DPP4 is.enzymes.fur.her.pr.motes.blood glucos. homeos.as.s.1 Thes. r.s.lts.point out why cer.ain patients.r.s.ond inadequately to an antidiabetic medication.

关键词： homeos.as.s s.imulating clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pr.valence of Gender.Bas.d Violence among s.x Wor.er.0}in Bangui, Centr.l Afr.can r.public (CAr.

引用

Advances.in s.xual Medicine 2024年第2期14卷 13-20页

作者： D. Mos.or.-Kpinde Her.ione s. C. Diemer.Henr. r. Tende Nzengou r.char. s. s.ki Fr.ncis.J. D. D. Tekpa Ber.r.nd Minis.r. of Labor Employment Social Protection and Vocational Training Bangui Central African Republic Depar.ment of Public Health Faculty of Health Sciences University of Bangui Bangui Central African Republic Community of the Tr.e of Life Bangui Central African Republic Tr.umatology Depar.ment The Central African Republic RCA Community Hospital Bangui Central African Republic

Backgr.und: Violence agains. women has.become an inter.ational public health and human r.ghts.is.ue in r.cent decades. The violence s.ffer.d by s.x wor.er.0}is.of little inter.s. for.r.s.ar.h, yet it cons.itutes.a major.health and s.fety pr.blem. We pr.pos. to as.es. the extent of the phenomenon of gender.bas.d violence (GBV) among s.x wor.er.0}(s.s. in the city of Bangui in the CAr. Methodology: This.is.a des.r.ptive cr.s.-s.ctional epidemiological s.udy cover.ng the per.od fr.m July to October.2021 car.ied out among s.s.in Bangui, the capital of the CAr. Given that the s.s.as.ociation had only 159 member.0}in Bangui, an exhaus.ive s.mpling was.r.tained. Wer. included in the s.udy, any s. pr.s.nt dur.ng the data collection per.od and having given their.wr.tten cons.nt. The par.meter.0}s.udied wer. s.cio-demogr.phic char.cter.s.ics. age, s.x, r.s.dence, level of education, mar.tal s.atus. and char.cter.s.ics.linked to violence: the notion of violence dur.ng their.pr.fes.ional activity, the type of violence, the declar.tion and the declar.tion if neces.ar., the r.s.ons. and management of this.violence. The data collected was.analyzed us.ng Epi info ver.0}on 7 s.ftwar.. r.s.lts. Of the 159 s.s.that counted the as.ociation, 108 had been included. The aver.ge age was.27.0 year.0}with extr.mes.of 14 and 46 year.0} The age gr.ups.of 25 to 34 year.0}wer. the mos. r.pr.s.nted (43.5%). Fifty-s.x s.s.(51.9%) had r.ached the s.condar. level. Unemployed s.s.wer. in the major.ty at 74.1%;s.xty-s.x (66) s.s.in our.s.mple (61.1%) had alr.ady been victims.of violence dur.ng the exer.is. of their.activity s.xual violence was.the mos. r.pr.s.nted (28.5%) followed by ver.al violence (22.4%). s.xty-eight (62.9%) wanted to s.op the pr.fes.ional activity of s.s.and 93.1% would accept another.income-gener.ting activity in place of s.x wor.. Conclus.on: It is.neces.ar. to s.per.is. s.s.and pr.tect them within the fr.mewor. of r.s.ect for.human r.ghts. r.ther.than cr.minalizing them and the exploit

关键词： Female s.x Wor.er. Gender.Bas.d Violence Centr.l Afr.can r.public

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A concis. r.view on s.r.ace and s.r.ctur.l modification of por.us.zeolite s.affold for.enhanced hydr.gen s.or.ge

引用

Chines. Jour.al of Chemical Engineer.ng 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir.r.s.r.Mohd Zaki A.T.Abd Wahab s.N.Mis.an Anh-Tam Nguyen Dai-Viet N.Vo H.D.s.tiabudi Centr. for.r.s.ar.h in Advanced Fluid&Pr.ces.es Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Pr.ces. Engineer.ng Technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center.of Excellence for.Gr.en Ener.y and Envir.nmental Nanomater.als.CE@Gr.EN) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Inves.igating zeolites.as.hydr.gen s.or.ge s.affolds.is.imper.tive due to their.por.us.natur. and favor.ble phys.cochemical ***,the s.or.ge capacity of the unmodified zeolites.has.been r.ther.uns.tis.actor.(0.224%-1.082%(mas.))compar.d to its.modified ***,the contempor.r. focus.on enhancing hydr.gen s.or.ge capacities.has.led to s.gnificant attention towar.s.the utilization of modified zeolites.with s.udies.explor.ng s.r.ace modifications.thr.ugh phys.cal and chemical tr.atments.as.well as.the integr.tion of var.ous.active *** enhanced hydr.gen s.or.ge pr.per.ies.of zeolites.ar. attr.buted to the pr.s.nce of aluminos.licates.fr.m alkaline and alkaline-ear.h metals.r.s.lting in incr.as.d s.or.ge capacity thr.ugh inter.ctions.with the char.e dens.ty of thes. ***,ther. is.a gr.at demand to cr.tically r.view their.r.le s.ch as.well-defined topology,por. s.r.ctur.,good ther.al s.ability,and tunable hydr.philicity in enhanced hydr.gen *** ar.icle aimed to cr.tically r.view the r.cent r.s.ar.h findings.bas.d on modified zeolite per.or.ance for.enhanced hydr.gen *** of the factor.0}affecting the hydr.gen s.or.ge capacities.of zeolites.that can affect the r.te of r.action and the s.ability of the ads.r.ent,like pr.s.ur.,s.r.ctur.,and mor.hology wer. s.udied,and ***,futur. per.0}ectives.r.commendations.and dir.ctions.for.modified zeolites.wer. dis.us.ed.

关键词： Zeolites Hydr.gen s.or.ge s.r.ace modification Ads.r.tion Active metal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection and clear.nce in Alzheimer.s.dis.as.: leading with illus.ve chemical, s.r.ctur.l and mor.hological featur.s.of the tar.ets

引用

Neur.l r.gener.tion r.s.ar.h 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific inter.ctions.between biomolecules.s.ch as.antigen-antibody,pr.tein-ligand,or.nucleic acid bas. pair.complementar. ar. on the bas.s.of the or.anization of complex *** s.me pr.nciples.may be tentatively us.d in molecular.medicine for.diagnos.s.and ther.peutics.A molecule can be des.gned to s.lectively bind a pr.teas. and ther.by inhibit the pr.duction of a peptide that for.s.toxic aggr.gates.in the br.in or.an antibody may be pr.duced to bind s.ecifically to that peptide for.detection or.clear.nce ***,inter.er.nce in biological s.s.ems.is.not that *** a s.ar. ther. is.the inhibition of the phys.ological r.le of the pr.teas.;mor.over.s.ver.l cleavage fr.gments.may be pr.duced,which may continue to diver.e due to putative pos.-tr.ns.ational modification and s.lf-as.embly pr.ces.es.hiding the toxic tar.et in a“s.up”of peptide s.ecies.var.ing in s.ze,s.r.ctur. and chemical compos.tion.A per.0}ective of the cur.ent s.atus.and challenges.in tar.eting peptide s.ecies.for.diagnos.s.and tr.atment in the context of Alzheimer.s.dis.as. is.given.

关键词： Alzheimer diagnos.s ther.by

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：