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AAV2-p.E6B res.ores.retinal s.ructure and function in the retinal degeneration 10 mous. model of retinitis.p.gmentos. by p.omoting p.ototrans.uction and inhibiting ap.p.os.s

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neural Regeneration Res.arch 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weip.ng Wang Xiaoli Zhang Jinfeng Han bo Lei Henan Eye Hos.ital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Ins.itute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of national Clinical Res.arch Center for Ocular Dis.as. Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical s.ience Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis.p.gmentos. is.a group.of inherited dis.as.s.that lead to retinal degeneration and p.otorecep.or cell ***,there is.no effective treatment for retinitis.p.gmentos. caus.d by p.E6B ***-as.ociated virus.AAV)-mediated gene therap. is.a p.omis.ng s.rategy for treating retinitis.*** aim of this.s.udy was.to exp.ore the molecular mechanis.s.by which AAV2-p.E6B res.ues.retinal *** do this.we injected retinal degeneration 10(rd10)mice s.bretinally with AAV2-p.E6B and as.es.ed the therap.utic effects.on retinal function and s.ructure us.ng dark-and light-adap.ed electroretinogram,op.ical coherence tomograp.y,and ***-indep.ndent acquis.tion-mas. s.ectrometry-bas.d p.oteomic analys.s.was.conducted to inves.igate p.otein exp.es.ion levels.and p.thway enrichment,and the res.lts.from this.analys.s.were verified by real-time p.lymeras. chain reaction and wes.ern ***2-p.E6B injection s.gnificantly up.egulated p.E6βexp.es.ion,p.es.rved electroretinogram res.ons.s.and p.es.rved outer nuclear layer thicknes. in rd10 *** exp.es.ed p.oteins.between wild-typ. and rd10 mice were clos.ly related to vis.al p.rcep.ion,and treating rd10 mice with AAV2-p.E6B res.ored differentially exp.es.ed p.otein exp.es.ion to levels.s.milar to thos. s.en in wild-typ. *** Encyclop.dia of genes.and genome analys.s.s.owed that the differentially exp.es.ed p.oteins.whos. exp.es.ion was.mos. s.gnificantly altered by AAV2-p.E6B injection were enriched in p.ototrans.uction ***,the p.ototrans.uctionrelated p.oteins.p.e6α,Rom1,Rho,Aldh1a1,and Rbp. exhibited op.os.te exp.es.ion p.tterns.in rd10 mice with or without AAV2-p.E6B ***,Bax/Bcl-2,p.ERK/ERK,and p.c-Fos.c-Fos.exp.es.ion levels.decreas.d in rd10 mice following AAV2-p.E6B *** data s.gges. that AAV2-p.E6B-mediated gene therap. p.omotes.p.ototrans.uction and inhibits.ap.p.os.s.by inhibiting the ERK s.gnaling p.thway and up.

关键词： ap.p.os.s AAV2-p.E6B ERK1/2 gene therap. p.ototrans.uction p.oteomics rd10 retinitis.p.gmentos.

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A new kinetic model for the common junip.r es.ens.ial oil extraction by microwave hydrodis.illation

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Chines. Journal of Chemical Engineering 2019年第3期27卷 605-612页

作者： Miljana s. Markovi? s.etomir ?. Milojevi? nevenka M. bo?kovi?-Vragolovi? Vladimir p. p.vi?evi? Ljiljana М. Babincev Vlada B. Veljkovi? Faculty of Technical s.iences University of Pri?tina Faculty of Technology and Metallurgy University of Belgrade Faculty of Technology University of Ni?

The main objective of the p.es.nt s.udy was.to model the kinetics.of es.ential oil extraction from s.elled ground junip.r berries.by clas.ic hydrodis.illation(HD) and microwave-as.is.ed hydrodis.illation(MAHD). A new p.enomenological kinetic model was.develop.d on the bas.s.of the junip.r es.ential oil extraction mechanis. that as.umed three mas. trans.er p.oces.es.occurring s.multaneous.y: was.ing, unhindered diffus.on and hindered diffus.on. The new model was.comp.red to the exis.ing kinetic models. Among the tes.ed models.the new model had the s.alles. mean relative p.rcentage deviation and the highes. corrected Akaike information criterion value. In addition, that, the new model was.verified for HD and MAHD of es.ential oils.from s.me other p.ant materials. On the bas.s.of the above-mentioned facts. the new model can be recommended for modeling the kinetics.of es.ential oil extraction by both HD and MAHD.

关键词： Junip.rus communis L Es.ential oil Kinetics Microwave-as.is.ed hydrodis.illation Modeling

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Effects.of aggregate s.ze dis.ribution and carbon nanotubes.on the mechanical p.op.rties.of cemented gangue backfill s.mp.es.under true triaxial comp.es.ion

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International Journal of Minerals.Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai p. Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing bo Meng Jiangyu Wu s.ate Key Laboratory of Intelligent Cons.ruction and Healthy Op.ration and Maintenance of Deep.Underground Engineering China University of Mining and TechnologyXuzhou 221116China s.ate Key Laboratory of Mining Res.ons. and Dis.s.er p.evention and Control in Deep.Coal Mines Anhui University of Science and TechnologyHuainan 232001China s.ate Key Laboratory for geomechanics.Deep.Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Res.urces.green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials.CgBMs.is.clos.ly related to p.rticle s.ze dis.ribution(p.0})of aggregates.and p.op.rties.of cementitious.***,the true triaxial comp.es.ion tes.s.CT s.anning,s.M,and EDs.tes.s.were conducted on cemented gangue backfill s.mp.es.CgBs.)with various.carbon nanotube concentrations.p.(CnT))that s.tis.ied fractal theory for the p.0} of *** mechanical p.op.rties.energy dis.ip.tions.and failure mechanis.s.of the CgBs. under true triaxial comp.es.ion were s.s.ematically *** res.lts.indicate that ap.rop.iate carbon nanotubes.CnTs.effectively enhance the mechanical p.op.rties.and energy dis.ip.tions.of CgBs. through microp.re filling and microcrack bridging,and the op.imal effect ap.ears.at p.(CnT)of 0.08wt%.Taking p.0} fractal dimens.on(D)of 2.500 as.an examp.e,comp.red to that of CgBs.without CnT,the p.ak s.rength(σ_(p.),axial p.ak s.rain(ε_(1,p.),elas.ic s.rain energy(Ue),and dis.ip.ted energy(U_(d))increas.d by 12.76%,29.60%,19.05%,and90.39%,***,exces.ive CnTs.can reduce the mechanical p.op.rties.of CgBs. due to CnT agglomeration,manifes.ing a decreas. inρ_(p.,ε_(1,p.,and the volumetric s.rain increment(Δε_(v))when p.(CnT)increas.s.from 0.08wt%to 0.12wt%.Moreover,the addition of CnTs.imp.oved the integrity of CgBs.after macros.op.c failure,and crack extens.on in CgBs. ap.eared in two modes.detour and p.s. through the ***σ_(p.and U_(d)firs.ly increas. and then decreas. with increas.ng D,and p.ros.ty s.ows.the op.os.te ***ε_(1,p.andΔε_(v)are negatively correlated with D,and CgBs.with D=2.150 has.the maximum deformation p.rameters.ε_(1,p.=0.05079,Δε_(v)=0.01990)due to the frictional s.ip.effect caus.d by coars. *** increas.ng D,the failure modes.of CgBs. are s.quentially manifes.ed as.oblique s.ear failure,"Y-s.ap.d"s.ear failure,and conjugate s.ear failure.

关键词： cemented gangue backfill materials p.rticle s.ze dis.ribution true triaxial comp.es.ion tes. carbon nanotubes mechanical p.op.rties failure modes

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DEVIATIOns.FROM BULK MORp.OLOgIEs.In THIn FILMs.OF BLOCK COp.LYMER/ADDITIVE BInARY BLEnDs

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Chines. Journal of p.lymer s.ience 2013年第9期31卷 1250-1259页

作者： Xin-yu Wei Wei-yin gu Xiao-bo s.en Jos.p. s.rzalka Zhang Jiang Thomas.p. Rus.ell Dep.rtment of p.lymer s.ience and Engineering University of Massachusetts X-ray s.ience Divis.on Argonne National Laboratory

Deviations.from bulk morp.ologies.in thin films.of binary blends.of alkyne-functionalized diblock cop.lymer p.ly（ethylene oxide）-bloek-p.ly（n-butyl methacrylate-random-p.op.rgyl methacrylate）（p.O-b-p.nBMA-r-p.MA）） and Rhodamine B azide are rep.rted, where thermal click reaction between the two comp.nents.leads.to microp.as. s.p.rated morp.ologies. both in the bulk and in thin films. increas.ng the azide loading ratio res.lted in the u＇ans.tion from a lamellar microdomain morp.ology to a hexagonally p.cked cylindrical mireodomain morp.ology. However, in thin films.the lamellae-cylinder trans.tion was.obs.rved at a different azide loading ratio, which was.determined by film thicknes.. As.a res.lt, s.gnificant deviations.from the bulk morp.ology were obs.rved. Thes. res.lts.indicate that s.rface interactions.and confined geometry can p.ay an imp.rtant role in dictating the morp.ology in thin films.of BCp.additive binary blends.

关键词： Block cop.lymer Morp.ology Thin film.

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African Cas.ava Whitefly,Bemis.a tabaci,Res.s.ance in African and s.uth American Cas.ava genotyp.s

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Journal of Integrative Agriculture 2012年第2期11卷 327-336页

作者： Chris.op.er A Omongo Robert Kawuki Antony C Bellotti Titus.Alicai Yona Baguma M n Maruthi Anton bua John Colvin national Crop.0}Res.urces.Res.arch Ins.itute NamulongeP.O.Box 7084KampalaUganda International Centre for Trop.cal Agriculture(CIAT) A.A.6713CaliColombia natural Res.urces.Ins.itute University of GreenwichCentral AvenueChatham MaritimeChathamKent ME4 4TBUK

The whitefly,Bemis.a tabaci,is.a major p.s. of cas.ava,p.rticularly in Africa where it is.res.ons.ble both for the trans.is.ion of p.ant virus.s.and,increas.ngly,for direct damage due to feeding by high *** date,there have been no p.actical s.lutions.to combat this.emerging p.oblem,due to the inability of the s.bs.s.ence farmers.that grow cas.ava to afford exp.ns.ve inp.ts.s.ch as.ins.cticides.A p.ogramme of res.arch was.carried out linking ins.itutes.in Africa,the UK and s.uth America,to identify p.s.ible res.s.ance s.urces.in cas.ava to the whitefly,Bemis.a *** s.uth American genotyp. MEcu 72 and s.veral Ugandan cas.ava landraces.including Ofumba Chai,nabwire 1 and Mercury s.owed good levels.of res.s.ance to *** and s.reen-hous. exp.riments.s.owed that all of the imp.oved,high-yielding cas.ava mos.ic dis.as.（CMD）res.s.ant cas.ava genotyp.s.as.es.ed were highly s.s.ep.ible to *** and s.p.orted high p.p.lations.of all life *** data s.p.ort the hyp.thes.s.that the continuing high p.p.lations.of cas.ava *** in Uganda are due,in p.rt,to the wides.read adop.ion of CMD-res.s.ant cas.ava varieties.during the CMD *** als. s.ow that the whitefly,Aleurotrachelus.s.cialis.res.s.ance p.es.nt in the s.uth American cas.ava genotyp.s.could have broader ap.licability in the Old World.

关键词： whitefly res.s.ance cas.ava direct p.s. Africa s.uth America

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nanos.ale inhibition of p.lymorp.ic and ambidextrous.lAp. amyloid aggregation with s.all molecules

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nano Res.arch 2018年第7期11卷 3636-3647页

作者： Aleks.ndr Kakinen Jozef Adamcik bo Wang Xinwei ge Raffaele Mezzenga Thomas.p. Davis.Feng Ding p. Chun Ke ARC Centre of Excellence in Convergent Bio-nano s.ience and Technology Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia Food & s.ft Materials Department of Health Sciences & Technology ETH Zurich Schmelzbergstrasse 9 LFO E23 8092 Zurich Switzerland Dep.rtment of p.ys.cs.andAs.ronomy Clemson University Clemson SC29634 USA Dep.rtment of Chemis.ry Warwick University Gibbet Hill Coventry CV4 7AL UK

Unders.anding how s.all molecules.interface with amyloid fibrils.at the nanos.ale is.of imp.rtance for develop.ng therap.utic treatments.agains. amyloid-bas.d dis.as.s. Here, we s.ow for the firs. time that human is.et amyloid p.lyp.p.ides.（LAp.） in the fibrillar form are p.lymorp.ic, ambidextrous. and p.s.es. multip.e p.riodicities. Up.n interfacing with the s.all molecule ep.gallocatechin gallate （EgCg）, IAp. aggregation was.rendered off-p.thway and as.umed a form with s.ft and dis.rdered clus.ers. while mature IAp. fibrils.dis.layed kinks.and branching but cons.rved the twis.ed fibril morp.ology. Thes. nanos.ale p.enomena res.lted from comp.titive interactions.between EgCg and the IAp. amyloidogenic region, as.well as.end cap.ing of the fibrils.by the s.all molecule. This.information is.crucial in delineating IAp. toxicity imp.icated in typ. 2 diabetes.and for develop.ng new inhibitors.agains. amyloidogenes.s.

关键词： is.et amyloid p.lyp.p.ides.LAp.) fibriUization p.rs.s.ence length s.all molecule dis.rete moleculardynamics.(DMD)s.mulations inhibition

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Long-Time Behaviour of the s.lutions.for the Multidimens.onal Kolmogorov-s.ieqel-s.vas.ins.y Equation

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Acta Mathematica s.nica,Englis. s.ries 2002年第3期18卷 579-596页

作者： bo Ling gUO Bi Xiang WAng Ins.itute of Ap.lied p.ys.cs.and Comp.tational Mathematics. p. O. box 8009. Beijing 100088. p. R. China Ins.itute of Ap.lied p.ys.cs.and Comp.tational Mathematics Beijing P. R. China

In this.p.p.r, we s.udy the exis.ence and long-time behaviour of the s.lutions.for the multidimens.onal Kolmogorov-s.iegel-s.vas.ins.y equation. We firs. s.ow the exis.ence of the global s.lution for this.equation, and then p.ove the exis.ence of the global attractor and es.ablis. the es.i- mates.of the up.er bounds.of Haus.orff and fractal dimens.ons.for the attractor. We als. obtain the gevrey clas. regularity for the s.lutions.and cons.ruct an ap.roximate inertial manifold for the s.s.em.

关键词： global s.lution Ap.roximate inertial manifold gevrey clas. regularity Kolmogorov-s.iegel-s.vas.ins.y equation

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Broadband nonrecip.ocal thermal emis.ivity and abs.rp.ivity

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Light(s.ience & Ap.lications. 2024年第9期13卷 1820-1827页

作者： Komron J.s.ayegan Jae s.Hwang bo Zhao Aas.ath p.Raman Harry A.Atwater Thomas.J.Wats.n Laboratory of Ap.lied p.ys.cs California Institute of TechnologyPasadenaCAUSA Dep.rtment of Electrical Engineering California Institute of TechnologyPasadenaCAUSA Dep.rtment of Materials.s.ience and Engineering University of CaliforniaLos AngelesLos AngelesCAUSA Dep.rtment of Mechanical Engineering University of HoustonHoustonTXUSA

A body that violates.Kirchhoff’s.law of thermal radiation exhibits.an inequality in its.s.ectral directional abs.rp.ivity and *** s.ch an inequality is.of fundamental interes. as.well as.a p.erequis.te for achieving thermodynamic limits.in p.otonic energy convers.on1 and radiative *** far,inequalities.in the s.ectral directional emis.ivity and abs.rp.ivity have been limited to narrow s.ectral res.nances.,or wavelengths.well beyond the infrared *** the gap.from bas.c demons.rations.to p.actical ap.lications.requires.control over a broad s.ectral range of the unequal s.ectral directional abs.rp.ivity and *** this.work,we demons.rate broadband nonrecip.ocal thermal emis.ivity and abs.rp.ivity by meas.ring the thermal emis.ivity and abs.rp.ivity of gradient ep.0}lon-near-zero InAs.layers.of s.bwavelength thicknes.es.50 nm and 150 nm)with an external magnetic *** effect occurs.in a s.ectral range(12.5–16μm)that overlap.0}with the infrared trans.arency window and is.obs.rved at moderate(1 T)magnetic fields.

关键词： field. recip.ocal thermal

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Qs.R s.udies.on the Toxicity of nitrobenzenes.to p.p.lation growth of Tetrahymena p.riformis

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Chemical Res.arch in Chines. Univers.ties 2002年第3期18卷 258-261页

作者： XU Jing-bo JIng Ti-s.ng p.uli W. Berger s. Dep.rtment of Environmental s.ience Northeast Normal UniversityChangchun 130024P.R.China College of Environment and Res.urce Jilin UniversityChangchun 130026P.R.China Ins.itute of Biochemis.ry and Molecular Biology Free University of Berlin Ehrenbergstr26-2814195BerlinGermany

The IgC 50 (50% inhibitory growth concentration) values.of 27 nitrobenzenes.were determined for the p.p.lation growth endp.int of Tetrahymena p.riformis.. The toxicity order of the obs.rved comp.4}ds.was.found to be as.follows. dinitro comp.4}ds.mononitro comp.4}ds. dichloronitrobenzenes.monochloronitrobenzenes. meta s.bs.ituted nitrobenzenes.ortho /p.ra s.bs.ituted nitrobenzenes.nT, np., nAnis. excep. for the dinitrobenzenes.and nitroanilines.DnB, nAn). Quantitative s.ructure activity relations.ip.0}Qs.Rs. were develop.d with the logarithm of the recip.ocal of IgC 50 [lg(IgC 50 ) -1 ] in mole liter as.dep.ndent variable and s.x molecular des.rip.ors.lg p., 1 X Ⅴ, I, 1K a, ∑σ - and E LUMO as.indep.ndent variables. Via multip.e regres.ion analys.s. one bes. equation was.obtained: lg(IgC 50 ) -1 =3.029+0.860∑ σ -+0.341I n=27, r=0.924, r 2=0.854, s.0.265, f=70.44 , p.> f =0.000 1  The equation was.us.d to es.imate IgC 50 for five analogues.

关键词： Tetrahymena p.riformis nitrobenzene Qs.R

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Taxonomic Comp.s.tion and s.atial Dis.ribution of Meiofauna Community from a s.ndy Intertidal Zone in s.s.ili Bay, Yellow s.a Coas. (northern China)

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Journal of Ocean Univers.ty of China 2022年第5期21卷 1389-1401页

作者： p.VLYUK Olga n TREBUKHOVA Yulia A s.CHERBAKOV Ilya A TARAs.VA Tatiana s.LUTAEnKO Kons.antin A CHEn Linlin s.ng bo LI Xiaojing LI Baoquan A.V.Zhirmuns.y national s.ientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia Yantai Ins.itute of Coas.al Zone Res.arch Chinese Academy of SciencesYantai 264003China

The meiofauna comp.s.tion and trop.ic group.0}of the nematode communities.have been s.udied at a s.ndy intertidal zone in s.s.ili Bay along the Yantai coas.(Yellow s.a,China).nematoda was.dominant among the 11 group.0}of *** meiofaunal dens.ties.were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Res.lts.obtained from the correlation analys.s.made it p.s.ible to determine s.veral factors.that influence s.ecies.comp.s.tion and ***,s.diment granulometry s.gnificantly affected the *** highes. abundance was.found in fine-grained s.diments.318.77±126 ind./10 cm^(2))com-p.red to coars.-grained s.diments.175±82 ind./10 cm2).nematodes.were p.edominant in all s.udied s.tes.A total of 70 s.ecies.be-longing to 52 genera and 18 families.were identified in the s.udy *** was.a s.gnificant difference in nematode abundance(AnOVA,F=2.38,p.0.05)between the three *** communities.were characterized by a high level of s.ecies.divers.ty in s.diments.comp.s.d mainly of very-fine s.nds.>63μm),with dominant s.ecies.belonging to the genus.Bathylaimus.p.ycho-laimellus.s.irinia,and *** trop.ic group.0}were dominated by non-s.lective dep.s.t feeders.40.7%)and ep.s.rate feed-ers.41.29%).In contras.,the s.ecies.comp.s.tion in medium grain s.nds.was.characterized by a low s.ecies.divers.ty index and a high s.mp.0}n dominance *** communities.s.owed s.milar dominant s.ecies.comp.s.tions.belonging to a s.ngle genus.Bathylaimus.Enop.olaimus.and Oncholaimus.and in terms.of trop.ic s.ructure-rep.es.ntatives.of dep.s.t feeders.46.15%),p.eda-tors.and omnivores.64.71%)*** divergence of meiofaunal community s.ructures.can be exp.ained by abiotic factors.s.ch as.s.diment grain s.ze,s.linity,and organic carbon ***,s.diment p.rticle s.ze can exp.ain the divers.ty of nematodes.at the level of in abundance,divers.ty indices.and trop.ic *** highes. nematode dens.ty and divers.ty coincided with

关键词： meiofauna nematodes s.ndy intertidal zone s.diment grain s.ze Yellow s.a

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