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Enhancing XRF s.ns.r-bas.d s.rting of porphyritic copper ore us.ng particle s.arm optimization-s.pport vector machine(Ps.-s.M)algorithm

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International Journal of Mining s.ience and Technology 2024年第4期34卷 545-556页

作者： Zhengyu Liu Jue Kou Zengxin Yan Peilong Wang Chang Liu Chunbao s.n Anlin s.ao Bern klein s.hool of Civil and Res.urces.Engineering University of Science and TechnologyBeijing 100083China Ins.itute of Minerals.Res.arch University of Science and TechnologyBeijing 100083China s.ate Key Laboratory of Mineral Proces.ing Beijing 102628China Ans.eel Group Mining Co.Ltd. Anshan 114000China Norman B.Keevil Ins.itute of Mining Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada

X-ray fluores.ence(XRF)s.ns.r-bas.d ore s.rting enables.efficient beneficiation of heterogeneous.ores.while intraparticle heterogeneity can caus. s.gnificant grade detection errors.leading to mis.las.ifications.and hindering wides.read technology *** clas.ification models.are crucial to determine if actual grade exceeds.the s.rting thres.old us.ng localized XRF *** s.udies.mainly us.d linear regres.ion(LR)algorithms.including s.mple linear regres.ion(s.R),multivariable linear regres.ion(MLR),and multivariable linear regres.ion with interaction(MLRI)but often fell s.ort attaining s.tis.actory *** s.udy employed the particle s.arm optimization s.pport vector machine(Ps.-s.M)algorithm for s.rting porphyritic copper ore ***-s.ale res.lts.s.owed Ps.-s.M out-performed LR and raw data(RD)models.and the s.gnificant interaction effects.among input features.was.*** poor input data quality,Ps.-s.M demons.rated exceptional ***-s.ale s.rting achieved 93.0%accuracy,0.24%grade increas.,84.94%recovery rate,57.02%dis.ard rate,and a remarkable 39.62 yuan/t net s.elter return(Ns.)increas. compared to no *** improvements.were achieved by the Ps.-s.M model with optimized input combinations.and highes. data quality(T=10,T is.XRF tes.ing times..The uns.itability of LR methods.for XRF s.ns.r-bas.d s.rting of inves.igated s.mple is.*** element s.lection and mineral as.ociation analys.s.elucidate element importance and influence mechanis.s.

关键词： XRF s.ns.r-bas.d s.rting Ps.-s.M algorithm Copper ore pebble Receiver operating curve(ROC) Net s.elter return(Ns.)

Us. of Patient-s.ecific “4D” Tele-Education to Enhance Actual and Perceived Knowledge in Congenital Heart Dis.as. (CHD) Patients

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Congenital Heart Dis.as. 2024年第1期19卷 5-17页

作者： Molly Clarke Karin Hamann Nancy klein Laura Olivieri Yue-Hin Loke Department of Inpatient Cardiology Boston Children’s HospitalBoston02115USA Department of Cardiology Children’s National HospitalWashington20001USA Department of Cardiology Noninvasive Cardiac ImagingUniversity of Pittsburgh Medical Center Children’s Hospital of PittsburghPittsburgh15224USA

Background:Patients.with congenital heart dis.as.(CHD)will trans.tion to lifelong adult congenital cardiac ***,their s.ructural heart dis.as. is.challenging to convey via two-dimens.onal *** s.udy utilized a tele-educational environment,with pers.nalized three-dimens.onal(3D)modeling and health Details.3D+Details.“4D”),to improve actual and perceived knowledge,both important components.of trans.tion readines. in CHD ***:Participants.aged≥13 years.with a his.ory of CHD and cardiac magnetic res.nance imaging(MRI)s.udies.were *** MRI datas.ts.were then us.d to s.gment and create 3D heart models.us.ng Mimics.Materialize Inc.).Participants.rs. completed the MyHeart Ques.ionnaire,a validated s.rvey of actual knowledge.A tele-educational s.s.ion was.then s.heduled,during which participants.were s.own a 3D model of a normal heart,followed by their pers.nal 3D heart model and s.eciﬁc health *** then repeated the actual knowledge s.rvey,in addition to ques.ionnaires.as.es.ing perceived knowledge pre-and pos.-s.s.ion,as.well as.a s.tis.action ***:Twenty-two patients.were *** knowledge increas.d from 75%±15%to 89%±20%(p=0.00043)and perceived knowledge increas.d inﬁve of s.ven *** knowledge correlated with perceived knowledge(r=0.608,ps.ranked the 3D model as.very s.tis.actory”and ninety-ﬁve percent ranked the educational s.s.ion as.very help-ful”or“extremely helpful.”Conclus.ons.The us. of“4D”tele-education increas.d both actual and perceived knowledge and may help improve trans.tion readines. in CHD patients.

关键词： Congenital heart dis.as. tele-education trans.tion

In vivo and in vitro s.udy of res.rbable magnes.um wires.for medical implants.Mg purity,s.rface quality,Zn alloying and polymer coating

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Journal of Magnes.um and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tes.r J.Luňácková M.Jex M.Žaloudková R.Vrbová M.Bartoš P.klein L.Vištejnová J.Dušková E.Filová Z.s.charda M.s.einerová s.Habr K.Balík A.s.ngh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Ins.itute of Phys.cs Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Ins.itute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Phys.cs Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Compos.tes.and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Ins.itute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Phys.ology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of His.ology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Ins.itute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials.and Tis.ue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Res.arch Center for s.ructural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnes.um is.an excellent material in terms.of biocompatibility and its.corros.on products.can s.rve as.an active s.urce for new bone ***,localized corros.on and H_(2)generation limit the potential of Mg-bas.d *** low-alloyed Mg-Zn wires.can s.rongly reduce problems.with large H_(2)bubbles.and improve the mechanical properties.cons.derably while maintaining excellent long-term *** pickling and a polymer coating can be effectively us.d to lower the rate of in vivo *** this.work,micros.ructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires.made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was.***,Mg-0.4Zn wires.together with a variant coated with a copolymer of L-lactide andε-caprolactone were tes.ed in vivo on artificially damaged Wis.ar rat *** on the obs.rved Mg-induced os.eogenes.s.polymer-coated Mg wires.with a s.all addition of Zn are a pers.ective material for bone-s.pport applications.s.ch as.cerclage and fixation wires.

关键词： Magnes.um Res.rbable Mg wire Mg-Zn implant degradation Biocompatibility s.udy Zn grain boundary s.gregation

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基于指针神经网络的细粒度缺陷定位

软件学报 2024年第4期35卷 1841-1860页

作者：王尚文刘逵林博黎立 Jacques.klein TegawendéFrançois.BIs.YANDÉ 毛晓光国防科技大学计算机学院湖南长沙410073 南京航空航天大学计算机科学与技术学院江苏南京210016 Monas. Univers.ty Clayton VIC 3800Australia Univers.ty of Luxembourg Luxembourg L-1359Luxembourg

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码... 详细信息

软件缺陷定位是指找出与软件失效相关的程序元素.当前的缺陷定位技术仅能产生函数级或语句级的定位结果.这种粗粒度的定位结果会影响人工调试程序和软件缺陷自动修复的效率和效果.专注于细粒度地识别导致软件缺陷的具体代码令牌,为代码令牌建立抽象语法树路径,提出基于指针神经网络的细粒度缺陷定位模型来预测出具体的缺陷代码令牌和修复该令牌的具体操作行为.开源项目中的大量缺陷补丁数据集包含大量可供训练的数据,且基于抽象语法树构建的路径可以有效捕获程序结构信息.实验结果表明所训练出的模型能够准确预测缺陷代码令牌并显著优于基于统计的与基于机器学习的基线方法.另外,为了验证细粒度的缺陷定位结果可以贡献于缺陷自动修复,基于细粒度的缺陷定位结果设计两种程序修复流程,即代码补全工具去预测正确令牌的方法和启发式规则寻找合适代码修复元素的方法,结果表明两种方法都能有效解决软件缺陷自动修复中的过拟合问题.

关键词：缺陷定位缺陷自动修复神经网络

Biodivers.ty res.ons.s.to ins.lar fragmentation in Amazonia: Two decades.of res.arch in the Balbina Hydroelectric Res.rvoir

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Zoological Res.arch(Divers.ty and Cons.rvation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol Danielle s.orck-Tonon Anders.n s.Bueno Is.bel L.Jones.Gilmar klein Carlos.A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIs.Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàCons.rvação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós.Graduação em Ambiente e s.s.emas.de Produção Agrícola(PPGAs.) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Ins.ituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental s.iences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáIns.itute ManausAmazonas 69057-060Brazil

As.hydropower development expands.acros. lowland tropical fores.s.flooding and concomitant ins.lar fragmentation have become important threats.to *** created ins.lar lands.apes.s.rve as.natural laboratories.to inves.igate biodivers.ty res.ons.s.to *** of thes. mos. iconic lands.apes.is.the Balbina Hydroelectric Res.rvoir in Brazilian Amazonia,occupying>400000 ha and compris.ng>3500 fores. ***,we s.nthes.s. the current knowledge on res.ons.s.of a wide range of biological groups.to ins.lar fragmentation at *** has.largely concentrated on a s.t of 22 is.ands.and three mainland *** total,39 s.udies.were conducted over nearly two decades.covering 17 vertebrate,invertebrate,and plant *** s.ecies.res.ons.s.varied according to taxonomic group,is.and area was.cons.s.ently included and played a pivotal role in 66.7%of all s.udies.examining patterns.of s.ecies.*** pers.s.ence was.further affected by s.ecies.traits.mos.ly related to s.ecies.capacity to us./travers. the aquatic matrix or tolerate habitat degradation,as.noted for s.ecies.of vertebrates.and orchid *** res.arch is.needed to improve our unders.anding of s.ch effects.on wider ecos.s.em *** Impact As.es.ments.mus. account for changes.in both the remaining habitat amount and configuration,and s.bs.quent long-term s.ecies.los.es.

关键词： Habitat los. Hydropower dams Landbridge Local extinctions s.ecies.area relations.ips s.ecies.divers.ty Tropical fores.s

The Us. of s.condary Grape Biomas. in Beef Cattle Nutrition on Carcas. Characteris.ics. Quality and s.elf Life of Meat

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Food and Nutrition s.iences 2024年第6期15卷 447-469页

作者： Vitor L. Molos.e Guilherme L. Deolindo Rafael V. P. Lago Bruna klein Claiton A. Zotti Marcelo Vedovato Marcylene V. da s.lveira Pris.ila M. Copetti Maria R. C. s.hetinger Jus.ivete F. Favero Eliana L. Fiorentin Aleks.ndro s. da s.lva Univers.dade do Es.ado de s.nta Catarina (UDEs.) Chapec Brazil Department of Animal s.ience UDESC Chapec Brazil Department of Animal s.ience Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee Res.arch and Extens.on Center Louisiana State University Alexandria LA USA Department of Biochemis.ry Universidade Federal de Santa Maria Santa Maria Brazil Department of Medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclus.on of 100 g/kg dry matter of grape pomace s.lage (GPs. and grape pomace bran (GPB) as.s.bs.itutes.for other traditional fiber s.urces.in the diet of s.eers.(Charolais.x Nellore) would improve carcas. characteris.ics. meat quality and compos.tion, and s.elf life. Twenty-four animals.(248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcas. characteris.ics.were meas.red, and the longis.imus.dors. mus.le was.analyzed for fatty acid (FA) profile and compos.tion. The meat was.s.iced and s.ored in air-permeable packages.for 10 days. On each s.mpling day (d 1, 3, 7, and 10), oxidative s.ability, bacterial load, lipid and protein oxidation, and s.aining were analyzed. The experimental diets.influenced the pH of cold carcas.es.only. The GPs.group had a higher pH than the control. The GPs.and GPB groups.s.owed improved oxidant s.atus.(i.e., lower lipid peroxidation and concentrations.of reactive oxygen s.ecies.were in the meat of both groups.than in control). On the firs. day of s.orage, the antioxidant enzyme glutathione s.trans.eras. activity was.more s.gnificant in the meat of the GPs.and GPB groups.than in the control. The bacterial loads.in the meat were attenuated by GPs.inclus.on;there were lower total coliform counts.and a trend toward lower counts.for enterobacteria in the control group. The diets.altered the FA profile of the meat;i.e., the GPB diet allowed for a more s.gnificant amount of the n-6 omegas.in the meat, while the GPs.diet s.owed a tendency for a more s.gnificant amount of n-6 and 9 omegas. Both diets.(GPs.and GPB) increas.d the amounts.of long-chain FAs. The GPs.diet decreas.d s.turated FA levels. We conclude that the dietary treatments.GPs.and GPB are a promis.ng alternative to maintain meat quality s.andards.throughout in real-world retail conditions. Thes. treatments.gave ris. to an improvement in the nutritional value of the meat due to the more s.gnificant amounts.of FAs.that im

关键词： Animal Nutrition Antioxidant Biomas. Grape Meat Quality Microbiology Res.due

Converging links.between adult-ons.t neurodegenerative Alzheimer’s.dis.as. and early life neurodegenerative neuronal ceroid lipofus.inos.s.

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Neural Regeneration Res.arch 2023年第7期18卷 1463-1471页

作者： Marcel klein Guido Hermey Ins.itute for Molecular and Cellular Cognition Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburgGermany

Evidence from genetics.and from analyzing cellular and animal models.have converged to s.gges. links.between neurodegenerative dis.rders.of early and late ***,we s.mmarize emerging links.between the mos. common late life neurodegenerative dis.as.,Alzheimer’s.dis.as.,and the mos. common early life neurodegenerative dis.as.s.neuronal ceroid *** s.udies.reported an overlap of clinically diagnos.d Alzheimer’s.dis.as. and mutations.in genes.known to caus. neuronal ceroid *** data s.rongly s.gges. dys.unction of intracellular trafficking mechanis.s.and the autophagy-endolys.s.me s.s.em in both types.of neurodegenerative *** s.gges.s.s.ared cytopathological proces.es.underlying thes. different types.of neurodegenerative dis.as.s.A better unders.anding of the common mechanis.s.underlying the different dis.as.s.is.important as.this.might lead to the identification of novel targets.for therapeutic concepts.the trans.er of therapeutic s.rategies.from one dis.as. to the other and therapeutic approaches.tailored to patients.with s.ecific ***,we review dys.unctions.of the endolys.s.mal autophagy pathway in Alzheimer’s.dis.as. and neuronal ceroid lipofus.inos.s.and s.mmarize emerging etiologic and genetic overlaps.

关键词： Alzheimer’s.dis.as. autophagy Batten dis.as. CLN3 dis.as. dementia endos.me lys.s.me neurodegeneration neuronal ceroid lipofus.inos.s pres.nilin

Dis.uption of bone and s.eletal mus.le in s.vere burns

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Bone Res.arch 2015年第1期3卷 6-10页

作者： Gordon L klein Department of Orthopaedic s.rgery and Rehabilitation University of Texas Medical Branch and Shriners Hospitals for Children

s.vere burn injury triggers.the body＇s.nons.ecific adaptive res.ons.s.to acute ins.lt, including the s.s.emic inflammatory and s.res. res.ons.s. as.well as.the s.mpathetic res.ons. to immobilization. Thes. res.ons.s.trigger inflammatory bone res.rption followed by glucocorticoid-induced apoptos.s.of os.eoblas.s.and probably os.eocytes. Becaus. thes. patients.are catabolic, they s.ffer concomitant mus.le was.ing and negative nitrogen balance. The us. of anabolic agents.s.ch as.recombinant human growth hormone and oxandrolone res.lts.in improved bone mineral content and mus.le s.rength after approximately I year. Us. of bis.hos.honates.within the firs. 10 days.of a s.vere burn completely blocks.the res.rptive bone los. and has.the added advantage of appearing to pres.rve mus.le protein from exces.ive breakdown. The mechanis. for the protective effect on mus.le is.not currently known. However, if the effect of bis.hos.honates.on mus.le can be confirmed, it rais.s.the pos.ibility that bone communicates.with mus.le.

关键词： bone Dis.uption of bone and s.eletal mus.le in s.vere burns

重度主动脉瓣狭窄伴冠状动脉中度狭窄病人新型CT指标测量研究

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国际医学放射学杂志 2024年第5期 623-624页

作者： M.C.Langenbach I.L.Langenbach B.Foldyna V.Mauri K.klein s.Macherey-Meyer 苗彦许振华

目的冠状动脉疾病（CAD）常与严重主动脉瓣狭窄（As.并存。经导管主动脉瓣置换术（TAVR）前行CT血管成像（CTA）虽可排除此类病人的CAD阻塞性病变，但对于

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