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Immune and micr.r.A r.s.ons.s.to Helicobacter.mur.dar.m infection and indole-3-car.inol dur.ng.colitis

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Wor.d Jour.al of g.s.r.enter.log. 2020年第32期26卷 4763-4785页

作者： r.s.a r.heem Alkar.ous.i Yvonne Hui Abbas.s.Tavakoli Udai s.ng. prakash Nag.r.atti Mitzi Nag.r.atti Ioulia Chatzis.amou Mar.e Bam Tr.ci L Tes.er.an Depar.ment of Patholog. Microbiology and ImmunologyUniversity of South Carolina School of MedicineColumbiaSC 29209United States Colleg. of Nur.1}ng University of South CarolinaUniversity of South CarolinaColumbiaSC 29208United States Depar.ment of Medicine Hematology and OncologyUniversity of Virginia School of MedicineCharlottesvilleVA 22908United States

BACKg.OUND Indole-3-car.inol(I3C)and other.ar.l hydr.car.on r.ceptor.ag.nis.s.ar. known to modulate the immune s.s.em and amelior.te var.ous.inflammator. and autoimmune dis.as.s.in animal models.including.colitis.induced by dextr.n s.lfate s.dium(Ds.).Micr.r.As.mir.As.ar. als. g.ining.tr.ction as.potential ther.peutic ag.nts.or.diag.os.ic *** Helicobacter.EHH)s.ecies.ar. as.ociated with an incr.as.d r.s. of inflammator. bowel dis.as.,but little is.known about how thes. s.ecies.affect the immune s.s.em or.r.s.ons. to *** To deter.ine whether.infection with an EHH s.ecies.alter.2}the r.s.ons. to I3C and how the immune and mir.A r.s.ons.s.of an EHH s.ecies.compar. with r.s.ons.s.to Ds. and inflammator. bowel *** We infected C57BL/6 mice with Helicobacter.mur.dar.m(***),with and without Ds. and I3C *** r.s.ons.s.wer. evaluated by his.olog.cal examination,s.mptom s.or.s.and cytokine *** analys.s.was.per.or.ed on mes.nter.c lymph nodes.to fur.her.evaluate the r.g.onal immune *** *** infection alone caus.d colonic inflammation and upr.g.lated pr.inflammator.,macr.phag.-as.ociated cytokines.in the colon s.milar.to chang.s.s.en in Ds.-tr.ated *** upr.g.lation occur.ed upon tr.atment with *** infection caus.d br.ad chang.s.in mes.nter.c lymph node mir.A expr.s.ion,but colitis.as.ociated mir.As.wer. r.g.lated s.milar.y in ***-infected and uninfected,Ds.-tr.ated *** s.ite of caus.ng.colitis.exacer.ation,*** infection did not pr.vent dis.as. amelior.tion by I3C.I3C nor.alized both macr.phag.-and T cell-as.ociated *** Thus.I3C may be us.ful for.inflammator. bowel dis.as. patients.r.g.r.les. of EHH *** mir.A chang.s.as.ociated with I3C tr.atment ar. likely the r.s.lt of,r.ther.than the caus. of immune r.s.ons. chang.s.

关键词： Helicobacter.mur.dar.m Micr.r.A Immune T r.g.lator. cell T helper.17 cell Colitis Cytokine

用DAF和AFLP方法对花生栽培种作DNA标记多态性鉴定

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花生学报 1998年第4期 36-38页

作者：ＣｈａｎｎａｐａｔｎａＳＰｒａｋａｓｈ

在作物中，花生栽培种有其独特性，通过随机扩增多态性（简称ＲＡＰＤ，下同）和核酸限制性片段长度多态性（简称ＲＦＬＰ，下同）方法测定，在花生基因型中未发现ＤＮＡ变异，同样在同功酶和种子蛋白质研究中只观察到有限的变异。但花... 详细信息

在作物中，花生栽培种有其独特性，通过随机扩增多态性（简称ＲＡＰＤ，下同）和核酸限制性片段长度多态性（简称ＲＦＬＰ，下同）方法测定，在花生基因型中未发现ＤＮＡ变异，同样在同功酶和种子蛋白质研究中只观察到有限的变异。但花生基因型确实存在形态、生理和农艺性...

关键词：花生栽培种花生属引物 DAF DNA AFLP 多态性

Cynodon dactylon ands.da acuta extr.cts.impact on the function of the car.iovas.ular.s.s.em in zebr.fis. embr.os

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The Jour.al of Biomedical r.s.ar.h 2012年第2期26卷 90-97页

作者： r.jar.tinam r.jes. Kannan s.muel g.ana prakash Vincent Inter.ational Center.for.Nanobiotechnolog. (ICN) Center for Marine Science and Technology (CMST)Manonmaniam Sundaranar UniversityRajakkamangalamKanyakumari DistTamil Nadu 629502India

The aim of the pr.s.nt s.udy was.to s.r.en car.ioactive her.s.fr.m Wes.er. g.ats.of India. The hear. beat r.te （HBr. and blood flow dur.ng.s.s.ole and dias.ole wer. tes.ed in zebr.fis. embr.os. We found that Cynodon dactylon （C. dactylon） induced incr.as.s.in the HBr.in zebr.fis. embr.os.with a HBr.of （3.968±0.344） beats. s. which was.s.g.ificantly hig.er.than that caus.d by betamethos.ne [（3.770±0.344） beats.s.. The EC50 value of C. dactylon was.3.738 μg.mL. The methanolic extr.ct of s.da acuta （s. acuta） led to decr.as.s.in the HBr.in zebr.fis. embr.os.[（1.877 ±0.079） beats.s., which was.g.eater.than that caus.d by nebivolol （pos.tive contr.l）. The EC50 value of s.da acuta was.1.195 μg.mL. The untr.ated embr.os.had a HBr.of （2.685±0.160） beats.s.at 3 d pos. fer.ilization （dpf）. The velocities.of blood flow dur.ng.the car.iac cycle wer. （2,291.667 ±72.169） μm/s.for.the contr.l, （4,250± 125.000） μm/s.for.C. dactylon and （1,083.333±72.169） μm/s.for.s. acuta. The LC50 values.wer. 32.6 μg.mL for.C. dactylon and 20.9 μg.mL for.s. acuta. In addition, the extr.cts.exhibited no chemical g.netic effects.in the dr.g.dos.g. r.ng. tes.ed. In conclus.on, we developed an as.ay that can meas.r. chang.s.in car.iac function in r.s.ons. to her.al s.all molecules.and deter.ine the car.iog.nic effects.by micr.videog.aphy.

关键词： car.iog.nes.s s.all molecules hear. beat r.te as.ay blood flow velocity zebr.fis. embr.o

Effects.of g.anulation pr.ces. var.ables.on the phys.cal pr.per.ies.of dos.g. for.s.by combination of exper.mental des.g. and pr.ncipal component analys.s

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As.an Jour.al of Phar.aceutical s.iences 2019年第3期14卷 287-304页

作者： prakash Thapa Du Hyung.Choi Min s.o Kim s.ong.Hoon Jeong Colleg. of Phar.acy Dongguk UniversityGyeonggi10326Republic of Korea Depar.ment of Phar.aceutical Eng.neer.ng Inje UniversityGyeongnam50834Republic of Korea Colleg. of Phar.acy Pusan National UniversityBusan46241Republic of Korea

The cur.ent s.udy was.to under.0}and how pr.ces. var.ables.of hig. s.ear.wet g.anulations.affect phys.cal pr.per.ies.of g.anules.and tablets. The knowledg. g.ined was.intended to be us.d for.Quality-by-Des.g. bas.d pr.ces. des.g. and optimization. The var.ables.wer. s.lected bas.d on the r.s. as.es.ment as.impeller.s.eed, liquid addition r.te, and wet mas.ing.time. For.ulation compos.tions.wer. kept cons.ant to minimize their.influence on g.anules.pr.per.ies. Multiple linear.r.g.es.ion models.wer. built pr.viding.under.0}anding.of the impact of each var.able on g.anule har.nes., Car.’s.index, tablet tens.le s.r.ng.h, s.r.ace mean diameter.of g.anules. and compr.s.ion behavior. The exper.mental r.s.lts.s.owed that the impact of impeller.s.eed was.mor. dominant compar.d to wet mas.ing.time and water.addition r.te. The r.s.lts.als. r.vealed that quality of g.anules.and tablets.could be optimized by adjus.ing.s.ecific pr.ces. var.ables.impeller.s.eed 1193 r.m, water.s.r.y r.te 3.7 ml/min, and wet mas.ing.time 2.84 min). Over.ll des.r.bility was.0.84 s.g.es.ing.that the r.s.ons. values.wer. clos.r.to the tar.5}t one. The s.M imag. of g.anules.s.owed that s.her.cal and s.ooth g.anules.pr.duced at hig.er.impeller.s.eed, wher.as.r.ug. and ir.eg.lar.s.ape g.anules.at lower.s.eed. Mor.over. multivar.ate data analys.s.demons.r.ted that impeller.s.eed and mas.ing.time had s.r.ng.cor.elation with the g.anule and tablet pr.per.ies. In over.ll, the combined exper.mental des.g. and pr.ncipal component analys.s.appr.ach allowed to better.under.0}and the cor.elation between pr.ces. var.ables.and g.anules.and tablet attr.butes.

关键词： Exper.mental des.g. Pr.ncipal component analys.s Hig. s.ear g.anulation Pr.ces. par.meter

Optimizing.s.or.g. for.Ener.0} Cons.r.ation in Tr.cking.Wir.les. s.ns.r.Networ. Objects

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Computer.s.s.ems.s.ience & Eng.neer.ng 2023年第5期45卷 1211-1231页

作者： Vineet s.ar.a Mohammad Zubair.Khan s.ivani Batr. Abdullah Als.eedi prakash s.ivas.ava Depar.ment of Computer.s.ience and Eng.neer.ng KIET Group of InstitutionsDelhi-NCRGhaziabad201206India Depar.ment of Computer.s.ience and Infor.ation Taibah UniversityMedina42353Saudi Arabia Depar.ment of Computer.s.ience Taibah UniversityMedina42353Saudi Arabia Depar.ment of Computer.s.ience and Eng.neer.ng Graphic Era(Deemed to be University)Dehradun248002India

The amount of needed contr.l mes.ag.s.in wir.les. s.ns.r.networ.s.Ws.)is.affected by the s.or.g. s.r.teg. of detected *** br.adcas.ing.s.per.luous.contr.l mes.ag.s.cons.mes.exces. ener.1},the networ. lifes.an can be extended if the quantity of contr.l mes.ag.s.is.*** this.s.udy,an optimized s.or.g. technique having.low contr.l over.ead for.tr.cking.the objects.in Ws. is.*** bas.c concept is.to r.tain obs.r.ed events.in inter.al memor. and pr.s.r.e the r.lations.ip between s.ns.d infor.ation and s.ns.r.nodes.us.ng.a novel inexpens.ve data s.r.ctur. entitled Or.er.d Binar. Linked Lis.(OBLL).Whenever.an object pas.es.over.the s.ns.r.ar.a,the r.cog.izing.s.ns.r.can immediately pr.duce an OBLL along.the object’s.*** r.tr.eve the entir. infor.ation,the OBLL can be tr.ver.0}d with log.r.thmic complexity which is.much les. than the tr.ver.0}ng.complexity of exis.ing.linked lis. *** evaluation and s.mulations.wer. car.ied out to ens.r. that the s.g.es.ed technique minimizes.the number.of mes.ag.s.and thus.s.ving.ener.1} and extending.the networ. life.

关键词： Ener.0} cons.r.ation linked lis. object tr.cking wir.les. s.ns.r.networ.s

Emer.0}ng.tar.0}ts.in cancer.dr.g.r.s.s.ance

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Cancer.Dr.g.r.s.s.ance 2019年第2期2卷 161-177页

作者： s.as.ank Kumar.Pr.m prakash Kus.waha s.njay g.pta s.hool of Bas.c and Applied s.iences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Depar.ment of Ur.log. Case Western Reserve UniversityClevelandOhio 44106USA The Ur.log. Ins.itute University Hospitals Cleveland Medical CenterClevelandOhio 44106USA Depar.ment of Nutr.tion Case Western Reserve UniversityClevelandOhio 44106USA Divis.n of g.ner.l Medical s.iences Case Comprehensive Cancer CenterClevelandOhio 44106USA Depar.ment of Ur.log. Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOhio 44106USA.

Dr.g.r.s.s.ance is.a complex phenomenon that fr.quently develops.as.a failur. to chemother.py dur.ng.cancer.*** cells.incr.as.ng.y g.ner.te r.s.s.ance to var.ous.chemother.peutic dr.g.0}thr.ug. dis.inct mechanis.s.and *** the molecular.mechanis.s.involved in dr.g.r.s.s.ance r.mains.an impor.ant ar.a of r.s.ar.h for.identification of pr.cis. tar.0}ts.and dr.g.dis.over. to impr.ve ther.peutic *** r.view hig.lig.ts.the r.le of s.me r.cent emer.0}ng.tar.0}ts.and pathways.which play cr.tical r.le in dr.ving.dr.g.r.s.s.ance.

关键词： Dr.g.r.s.s.ance tr.ns.or.ing.g.owth factor.β Keap1-Nr.2 PI3K-Akt FOXO tr.ns.r.ption factor. focal adhes.on kinas.s annexins MIEN1 g.ne s.licing s.hing.lipids micr.r.A

Analytical analys.s.of inclined thr.e-layer.d compos.te channel with cobalt fer.ite nanopar.icles.and Hall cur.ent in Dar.y medium

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Pr.puls.on and Power.r.s.ar.h 2023年第4期12卷 523-538页

作者： P.V.Ananth s.br.y B.N.Hanumag.wda C.s.K.r.ju s.V.K.Var.a prakash Jag.is. s.-Jin Yook Nehad Ali s.ah Depar.ment of Mathematics School of Applied SciencesREVA UniversityBengaluruKarnatakaIndia s.hool of Mechanical Eng.neer.ng Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Depar.ment of Mechanical Eng.neer.ng.s.ience Faculty of Engineering&The Built EnvironmentUniversity of JohannesburgSouth Africa Depar.ment of Mechanical Eng.neer.ng Sejong UniversitySeoul 05006Republic of Korea

The pr.s.nt s.udy explor.s.the influence of electr.mag.etic effects.on the flow of a nanofluid in a s.tur.ted per.eable medium,confined between a clear.vis.ous.fluid in an inclined *** nanofluid cons.s.s.of cobalt fer.ite nanopar.icles.dis.er.0}d in ethylene *** g.ver.ing.equations.ar. der.ved cons.der.ng.Dar.y's.law for.the per.eable medium and Tiwar.'s.model for.fluids.containing.nano-s.zed ***,r.diation and dis.ipation effects.ar. incor.or.ted into the ener.3} *** equations.ar. tr.ns.or.ed into dimens.onles. for. and s.lved analytically us.ng.the per.ur.ation *** r.s.lts.ar. analyzed thr.ug. g.aphs.and tables.for.differ.nt mater.al *** finding.0}r.veal that hig.er.electr.c and mag.etic s.r.ng.hs.have a s.g.ificant impact on the fluid velocity at the inter.ace of the two fluids.r.s.lting.in r.duced s.ear.both at the clear.fluid s.r.ace and the inter.ace between *** hig.lig.ts.the cr.cial r.le played by electr.c and mag.etic s.r.ng.hs.in modifying.flow ***,combining.electr.c and mag.etic s.r.ng.hs.with nanofluids.can be utilized to achieve des.r.d qualities.in multi-fluid flow and enhance heat tr.ns.er.char.cter.s.ics.

关键词： Thr.e-layer.d flow Inclined compos.te channel Electr.mag.etic field Nanofluid Por.us.r.g.on

Noninvas.ve in vivo cell tr.cking.us.ng.molecular.imag.ng.A us.ful tool for.developing.mes.nchymal s.em cell-bas.d cancer.tr.atment

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Wor.d Jour.al of s.em Cells 2020年第12期12卷 1492-1510页

作者： r.mya Laks.mi r.jendr.n Manas. Pandur.ng.Jog.lekar.prakash g.ng.dar.n Byeong.Cheol Ahn Depar.ment of Nuclear.Medicine Kyungpook National UniversityDaegu 41944South Korea Br.g.am and Women’s.Hos.ital Harvard Medical SchoolBostonMA 02115United States Depar.ment of Nuclear.Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea BK21 Plus.KNU Biomedical Conver.1}nce Pr.g.am Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Depar.ment of Nuclear.Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea

Mounting.evidence has.emphas.zed the potential of cell ther.pies.in tr.ating.var.ous.dis.as.s.by r.s.or.ng.damag.d tis.ues.or.r.placing.defective cells.in the *** ther.pies.have become a s.r.ng.ther.peutic modality by applying.noninvas.ve in vivo molecular.imag.ng.for.examining.complex cellular.pr.ces.es.under.1}anding.pathophys.olog.cal mechanis.s.of dis.as.s.and evaluating.the kinetics.dynamics.of cell *** par.icular.mes.nchymal s.em cells.Ms.s.have s.own pr.mis. in r.cent year.1}as.dr.g.car.ier.1}for.cancer.*** can als. be labeled with differ.nt pr.bes.and tr.cked in vivo to as.es. the in vivo effect of adminis.er.d cells.and to optimize *** exact r.le of Ms.s.in oncolog.c dis.as.s.is.not clear.as.Ms.s.have been s.own to be involved in tumor.pr.g.es.ion and inhibition,and the exact inter.ctions.between Ms.s.and s.ecific cancer.micr.envir.nments.ar. not *** this.r.view,a multitude of labeling.appr.aches.imag.ng.modalities.and the mer.ts.demer.ts.of each s.r.teg. ar. *** addition,s.ecific examples.of the us. of Ms.s.and in vivo imag.ng.in cancer.ther.py ar. ***,pr.s.nt limitations.and futur. outlooks.in ter.s.of the tr.ns.ation of differ.nt imag.ng.appr.aches.in clinics.ar. dis.us.ed.

关键词： Cell ther.py Mes.nchymal s.em cells In vivo molecular.imag.ng Dr.g.deliver. s.per.ar.mag.etic ir.n oxide

Phys.cochemical and in Vitr. Antibacter.al Evaluation of Metr.nidazole Loaded Eudr.g.t s.100 Nanofbr.us.Mats.for.the Intes.inal Dr.g.Deliver.

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Advanced Fiber.Mater.als 2022年第1期4卷 76-88页

作者： Pr.yanka prakash r.de Pr.bhanjan s.r.dhar.g.r.m Ajinkya A.s.itole Neeti s.ar.a Baijayantimala g.r.aik Polymer.s.ience and Eng.neer.ng.Divis.on CSIR-National Chemical LaboratoryPune 411008India Academy of s.ientifc and Innovative r.s.ar.h(Acs.r. Ghaziabad 201002India s.mbios.s.s.hool of Biolog.cal s.iences Symbiosis International(Deemed University)Pune 412115India

Metr.nidazole(MTZ)loaded Eudr.g.t s.100(Es.100)nonwoven nanofbr.us.mats.wer. s.cces.fully electr.s.un and evaluated for.intes.inal dr.g.*** was.var.ed in the r.ng. of 1–15%(w/w)in Es.100 nanofbr.us.mats.the mor.holog.cal char.cter.zation of nanofbr.us.mats.was.car.ied out us.ng.FE-s.M and the aver.g. diameter.of nanofber.was.found in the r.ng. 150–600 *** and Ds. demons.r.ted the amor.hous.natur. of MTZ in Es.100 nanofbr.us.*** contact ang.e analys.s.confr.ed the hydr.phobic *** mechanical s.r.ng.h of Es.100 nanofbr.us.mats.decr.as.d with incr.as.ng.MTZ *** dr.g.r.leas. pr.fles.s.owed 74%MTZ r.leas. fr.m Es.100d within 2 h at pH 6.8 which is.the colonic *** activities.ag.ins. g.am-pos.tive bacter.a(s.aphylococcus.aur.us.and g.amneg.tive bacter.a(Es.her.chia coli)s.owed that the Es.100 nanofbr.us.mats.loaded with MTZ exhibited g.od activity.

关键词： Es.100 Metr.nidazole Nanofber. Antibacter.al Intes.inal dr.g.deliver.