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The relations.ip between DNA fragmentation and the intens.ty of morphologically abnormal human s.ermatozoa

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As.an pacific Journal of Reproduction 2024年第1期13卷 22-27页

作者： Mercedes.González-Martínez Pas.ual s.nchez-Martín Carmen López-Fernández s.ephen D.johnston Jaime Gos.lvez Clínica Ginemed Unidad de ReproducciónSevillaSpain Department of Biology Universidad Autónoma de MadridCantoblancoMadridSpain s.hool of Environment The University of QueenslandGattonAustralia s.hool of Veterinary s.ience The University of QueenslandGattonAustralia

Objective:To determine the relations.ip between teratozoos.ermia and s.erm DNA fragmentation(s.F)in the human ***:This.retros.ective s.udy included 100 normozoos.ermic men as.a control cohort(abnormal forms.14%),210 patients.with a high level of abnormal forms.≤4%)and 65 patients.pres.nting with a moderate level of abnormal forms.>4%to≤14%)bas.d on the World Health Organization *** morphology was.as.es.ed us.ng bright field *** DNA fragmentation was.as.es.ed us.ng the s.erm chromatin dis.ers.on ***-parametric analys.s.were conducted to examine the relations.ip between abnormal s.erm morphology and s.erm DNA fragmentation;receiver operating characteris.ic(ROC)analys.s.were conducted to as.es. s.ns.tivity and s.ecificity of this.***:A correlation analys.s.revealed that the higher the proportion of abnormal s.ermatozoa in the ejaculate,the higher the level of s.F(s.earman's.Rho=-0.230;Ps.gnificant differences.in the proportion of s.F were found when all cohorts.were compared(Ps. s.gnificant differences.were als. retained when the different cohorts.were compared *** analys.s.s.owed a moderate but s.gnificant predictive value for s.F to differentiate patients.with different levels.of ***:Although analys.s.of a more continuous.range of values.for teratozoos.ermia would help further clarify any caus.l relations.ip with s.F,there is.clearly a s.nergis.ic or coincident affiliation between thes. variables.that needs.to be acknowledged by the clinician when interpreting the s.ermiogram.

关键词： Teratozoos.ermia s.erm morphology s.erm DNA fragmentation Male factor Human reproduction Human fertility

Nitrate reduction capacity of the oral microbiota is.impaired in periodontitis.potential implications.for s.s.emic nitric oxide availability

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International Journal of Oral s.ience 2024年第1期16卷 52-61页

作者： Bob T.Ros.er William johnston Miguel Carda-Diéguez Annabel s.mps.n Elena Cabello-Yeves.Krys.yna Piela Robert Reilly Alejandro Artacho Chris.Eas.on Mia Burleigh s.auna Culs.aw Alex Mira Department of Genomics.and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical s.iences Glasgow Caledonian UniversityGlasgowUK Oral s.iences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK s.ort and Phys.cal Activity Res.arch Ins.itute University of the West of ScotlandBlantyreScotland Ins.ituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has.been propos.d to be important for oral health and res.lts.in nitric oxide formation that can improve cardiometabolic conditions. s.udies.of bacterial compos.tion in s.bgingival plaque s.gges. that nitrate-reducing bacteria are as.ociated with periodontal health, but the impact of periodontitis.on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has.not been evaluated. The current s.udy aimed to evaluate how periodontitis.affects.the NRC of the oral microbiota. Firs., 16s.rRNA s.quencing data from five different countries.were analyzed, revealing that nitratereducing bacteria were s.gnificantly lower in s.bgingival plaque of periodontitis.patients.compared with healthy individuals.P s.ts.with n = 20–82 s.mples.per datas.t). s.condly, s.bgingival plaque, s.liva, and plas.a s.mples.were obtained from 42 periodontitis.patients.before and after periodontal treatment. The oral NRC was.determined in vitro by incubating s.liva with 8 mmol/L nitrate(a concentration found in s.liva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. s.livary NRC was.found to be diminis.ed in periodontal patients.before treatment(P s.90 days.pos.-treatment. Additionally, the s.bgingival levels.of nitrate-reducing bacteria increas.d after treatment and correlated negatively with periodontitis.as.ociated bacteria(P s.gnificant effect of periodontal treatment on the bas.line s.liva and plas.a nitrate and nitrite levels.was.found, indicating that differences.in the NRC may only be revealed after nitrate intake. Our res.lts.s.gges. that an impaired NRC in periodontitis.could limit dietary nitrate-derived nitric oxide levels. and the effect on s.s.emic health s.ould be explored in future s.udies.

关键词： impaired intake nitrate

Multimodel Approach for Intelligent Control and Applications

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Journal of Donghua Univers.ty(Englis. Edition) 2004年第3期21卷 15-20页

作者： Abdelkader El Kamel Pierre borne Ecole Centrale de Lille LAIL BP: 48 F59651 Villeneuve d' Ascq Cedex FranceEcole Centrale de Lille LAIL BP: 48 F59651 Villeneuve d' Ascq Cedex France

The us. of the multimodel approach in the modelling, analys.s.and control of non-linear complex and/or ill-defined s.s.ems.was.advocated by many res.archers. This.approach s.ppos.s.the definition of a s.t of local models.valid in a given region or domain. Different s.rategies.exis. in the literature and are generally bas.d on a partitioning of the non-linear s.s.em’s.full range of operation into multiple s.aller operating regimes.each of which is.as.ociated with a locally valid model or controller. However, mos. of thes. s.rategies. which s.ppos. the determination of thes. local models.as.well as.their validity domain, remain arbitrary and are generally fixed thanks.to a certain a priori knowledge of the s.s.em whatever its.order. Recently, we have propos.d a new approach to derive a multimodel bas.s.which allows.us.to limit the number of models.in the bas.s.to almos. four models. Meanwhile, the trans.tion problem between the different models. which may us. either a s.mple commutation or a fus.on technique, remains.s.ill aris.. In this.plenary talk, a fuzzy fus.on technique is.pres.nted and has.the following main advantages. （1） us. of a fuzzy partitioning in order to determine the validity of each model which enhances.the robus.nes. of the s.lution; 2 introduction, bes.des.the four extreme models. of another model, called average model, determined as.an average of the boundary models.

关键词： multimodel fuzzy fus.on average model

s.ability of Dirac Equation in Four-Dimens.onal Gravity

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Chines. Phys.cs.Letters 2017年第6期34卷 10-13页

作者： F. s.fari H. Jafari J. s.deghi s. J. johnston D. Baleanu Department of Mathematics University of Mazandaran Babolsar Iran Phys.cs.Department University of Mazandaran Babolsar 4716-95447 Iran Department of Mathematical s.iences University of South Africa UNISA 0003 South Africa Department of Mathematics Faculty of Art and Science Cankaya University Balgat 06530 Turkey Ins.itute of s.ace s.iences Magurele-Bueharest Romania

We introduce the Dirac equation in four-dimens.onal gravity which is.a generally covariant form. We choos. the s.itable variable and s.lve the corres.onding equation. To s.lve s.ch equation and to obtain the corres.onding bis.inor, we employ the factorization method which introduces.the as.ociated Laguerre polynomial. The as.o- ciated Laguerre polynomials.help us.to write the Dirac equation of four-dimens.onal gravity in the form of the s.ape invariance equation. Thus.we write the s.ape invariance condition with res.ect to the s.condary quantum number. Finally, we obtain the s.inor wave function and achieve the corres.onding s.ability of condition for the four-dimens.onal gravity s.s.em.

关键词： s.ability of Dirac Equation in Four-Dimens.onal Gravity

Identification of epididymis.s.ecific trans.ripts.in the mous. and rat by trans.riptional profiling

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As.an Journal of Andrology 2007年第4期9卷 522-527页

作者： Daniel s. johnston Terry T. Turner Jos.ua N. Finger Tracy L. Owts.haruk Gregory s. Kopf s.ott A. Jelins.y Contraception Women＇s Health and Musculoskeletal Biology Wyeth Research Collegeville PA 19426 USA Department of Urology University of Virginia Health Science System Charlottesville VA 22908 Cell Biology University of Virginia Health Science System Charlottesville VA 22908 USA Biological Technologies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA

As.part of our efforts.to identify novel contraceptive targets.in the epididymis.we performed trans.riptional profiling on each of the 10 and 19 s.gments.of the mous. and rat epididymidis. res.ectively, us.ng Affymetrix whole genome microarrays. A total of 17 096 and 16 360 probe s.ts.repres.nting trans.ripts.were identified as.being expres.ed in the s.gmented mous. and rat epididymal trans.riptomes. res.ectively. Comparis.n of the expres.ed murine trans.ripts.agains. a mous. trans.riptional profiling databas. derived from 22 other mous. tis.ues.identified 77 trans.ripts.that were expres.ed uniquely in the epididymis. The expres.ion of thes. genes.was.further evaluated by revers. trans.ription polymeras. chain reaction （RT-PCR） analys.s.of RNA from 21 mous. tis.ues. RT-PCR analys.s.confirmed epididymis.s.ecific expres.ion of Defens.n Beta 13 and identified two additional genes.with expres.ion res.ricted only to the epididymis.and tes.is. Comparis.n of the 16 360 expres.ed trans.ripts.in the rat epididymis.with data of 21 other tis.ues.from a rat trans.riptional profiling databas. identified 110 trans.ripts.s.ecific for the epididymis. s.xty-two of thes. trans.ripts.were further inves.igated by qPCR analys.s. Only Defens.n 22 （E3 epididymal protein） was.s.own to be completely s.ecific for the epididymis. In addition, 14 trans.ripts.s.owed more than 100-fold s.lective expres.ion in the epididymis. The products.of thes. genes.might play important roles.in epididymal and/or s.erm function and further inves.igation and validation as.contraceptive targets.are warranted. The res.lts.of the s.udies.des.ribed in this.report are available at the Mammalian Reproductive Genetics.（MRG） Databas. （http：//mrg. ***/）. （As.an J Androl 2007July; 9： 522-527）

关键词： mous. rat epididymis trans.riptional profiling contraception microarray epididymis.s.ecific epididymis.s.lective

s.gment boundaries.of the adult rat epididymis.limit inters.itial s.gnaling by potential paracrine factors.and s.gments.los. differential gene expres.ion after efferent duct ligation

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As.an Journal of Andrology 2007年第4期9卷 565-573页

作者： Terry T. Tumer Daniel s. johnston s.ott A. Jelins.y Jos. L. Toms.g Jos.ua N. Finger Department of Urology University of Virginia Health Science System Charlottesville VA 22908 US Cell Biology University of Virginia Health Science System Charlottesville VA 22908 US Contraception Women＇s Health and Musculoskeletal Biology Wyeth Research Collegeville PA 19426 USA Biological Technologies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA

The epididymis.is.divided into caput, corpus.and cauda regions. organized into intraregional s.gments.s.parated by connective tis.ue s.pta （CTs.. In the adult rat and mous. thes. s.gments.are highly differentiated. Regulation of thes. s.gments.is.by endocrine, lumicrine and paracrine factors. the relative importance of which remains.under inves.igation. Here, the ability of the CTs.to limit s.gnaling in the inters.itial compartment is.reviewed as.is.the effect of 15 days.of unilateral efferent duct ligation （EDL） on ips.lateral s.gmental trans.riptional profiles. Inter-s.gmental microperifus.ons.of epidermal growth factor （EGF）, vas.ular endothelial growth factor （VEGFA） and fibroblas. growth factor 2 （FGF2） increas.d phos.horylation of mitogen activated protein kinas. （MAPK） in s.gments.1 and 2 of the rat epididymis.and the effects.of all factors.were limited by the CTs.s.parating the s.gments. Microan＇ay analys.s.of s.gmental gene expres.ion determined the effect of 15 days.of unilateral EDL on the trans.riptome-wide gene expres.ion of rat s.gments.1-4. Over 11 000 genes.were expres.ed in each of the four s.gments.and over 2 000 trans.ripts.in s.gment 1 res.onded to deprivation of tes.icular lumicrine factors. s.gments.1 and 2 of control tis.ues.were the mos. trans.riptionally different and EDL had its.greates. effects.there. In the abs.nce of lumicrine factors. all four s.gments.regres.ed to a trans.riptionally undifferentiated s.ate, cons.s.ent with the les. differentiated his.ology. Deprivation of lumicrine factors.could s.imulate an individual gene＇s.expres.ion in s.me s.gments.yet s.ppres. it in others. s.ch res.lts.reveal a higher complexity of the regulation of rat epididymal s.gments.than that is.generally appreciated. （As.an J Androl 2007 July; 9： 565-573）

关键词： efferent duct ligation dedifferentiation proximal epididymis

Frequent mutations.of the CA s.mple s.quence repeat in intron 1 of EGFR in mis.atch repair-deficient colorectal cancers

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World Journal of Gas.roenterology 2008年第7期14卷 1053-1059页

作者： Marie-Pierre Buis.ne Agnès.Wacrenier Chris.ophe Mariette Emmanuelle Leteurtre Fabienne Es.ande s.na Ais.i Amandine Ketele Annette Leclercq Nicole Porchet Thécla Les.ffleur Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire deBiochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Laboratoire d'Anatomie et CytologiePathologiques CHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Service de Chirurgie Digestiveet GénéraleCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire d'Anatomie et Cytologie PathologiquesCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837and Laboratoire de Biochimie etBiologie MoléculaireCHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire de Biochimie et Biologie MoléculaireCHRU de LilleLilleFrance Laboratoire d'Immunologie et GénétiqueTunis-ElManarTunisie Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837LilleFrance Laboratoire de Biochimie et Biologie Moléculaire CHRU de LilleLilleFrance Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire de Biochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance pres.nt addres. INs.RMU843 Université Paris 7Hpital R.DebréParisFrance

AIM:To inves.igate the polymorphic s.mple s.quencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-s.RⅠ),which is.known to affect theefficiency of gene trans.ription as.a putative target of themis.atch repair(MMR)machinery in colorectal ***:The CA-s.RⅠgenotype was.analyzed ina total of 86 primary colorectal tumors.s.lected upontheir micros.tellite ins.ability(Ms.)s.atus.42 with highfrequency Ms.(Ms.-H)and 44 micros.tellite s.able(Ms.)]and their res.ective normal *** effect of the CA-s.RⅠgenotype on the expres.ion of the EGFR gene was.valuated in 18 s.ecimens.us.ng quantitative real-timerevers. trans.ription PCR and ***:Mutations.in CA-s.RⅠwere detected in 86%(36 of 42)of Ms.-H colorectal tumors.and 0%(0 of 44)ofMs. tumors.indicating the EGFR gene as.a novel putatives.ecific target of the defective MMR s.s.em(Ps.ion of EGFR was.detected in mos. ofthe colorectal tumors.analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noas.ociation was.apparent between EGFR expres.ion andCA-s.RⅠs.atus.in tumors.or normal ***:Our res.lts.s.gges. that CA-s.RⅠs.quence does.not contribute to the regulation of EGFRtrans.ription in colon,and s.ould thus.not be cons.deredas.a promis.ng predictive marker for res.ons. to EGFRinhibitors.in patients.with colorectal cancer.

关键词： Epidermal growth factor receptor Micros.tellite ins.ability Allelic imbalance Gene polymorphis. Expres.ion Colorectal cancer

Metabolomics.for quality as.es.ment of poultry meat and eggs

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Food Quality and s.fety 2024年第1期8卷 27-40页

作者： M.s.Yoges.ari Jinap s.lamat Nuzul Noorahya Jambari Alf Khatib Mohd His.ammfariz Mohd Amin s.ganya Muruges. Laboratory of Food s.fety and Food Integrity Institute of Tropical Agriculture and Food SecurityUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Food s.ience Faculty of Food Science and TechnologyUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Pharmaceutical Chemis.ry Kulliyyah of PharmacyInternational Islamic University MalaysiaKuantanPahang Darul MakmurMalaysia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Department of Veterinary s.rvice Malays.a Federal Government Administration CentrePutrajayaMalaysia

The poultry indus.ry is.experiencing rapid growth *** accelerated growth has.led to multiple food fraud incidents.acros. the food s.pply chain,which cons.quently created a demand for precis. determination of quality poultry *** increas. in demand for precis. poultry production quality has.neces.itated advanced *** has.emerged as.a viable s.lution by offering detailed differentiation of biochemical indicators.throughout the poultry s.pply ***,this.s.udy provides.a means.to addres. ris. factors.affecting the poultry indus.ry without compromis.ng animal welfare,which is.a critical *** review focus.s.on important is.ues.related to poultry product quality *** adulteration has.es.alated in recent years.as.it is.driven by the increas.ng focus.on cons.ming high-quality and nutritious.***,there is.no s.ecifc guideline for s.ch determinations.es.ecially when appearance,texture,and tas.e can be manipulated by s.bs.ituting for food *** can pave the way for a deeper unders.anding of exis.ing and novel biochemical indicators.res.ons.ble for determining the quality of poultry meat and *** approach holds.the potential to enhance the overall quality of poultry meat and egg products.while als. preventing food fraud.

关键词： Poultry metabolomics welfare application authentication.

The Mys.ery of s.onehenge

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大学英语 2005年第6期 17-18页

作者： s.s.n s. johnston 夏琨

巨石阵是世界上最著名的奇观之一,它坐落在英格兰南部,是研究欧洲史前文明的重要历史文物。千百年来,它的形成和功用一直众说纷纭,从而使其平添了一种神奇魅力。

关键词：欧洲史前文明大学英语注释阅读练习